Gene: DDX4

54514
VASA
DEAD-box helicase 4
protein-coding
5q11.2
Ensembl:ENSG00000152670 MIM:605281 Vega:OTTHUMG00000097044 UniprotKB:Q9NQI0
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.182e-1 (AD)  9.243e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TARBP10.697
OVGP10.688
KLHDC10.681
GOLGA8A0.676
ARMCX40.675
GK50.674
AMY2B0.673
ZNF3820.672
AHI10.665
RUFY20.665

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXJ1-0.412
CCDC102A-0.385
RHOD-0.376
MDFI-0.359
GHRHR-0.358
HSPB1-0.347
NKX6-1-0.346
EMP3-0.342
EVC2-0.341
WDR38-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DDX4 mRNA19933214
D019342Acetic AcidAcetic Acid affects the expression of DDX4 protein21296659
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of DDX4 gene28458013
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of DDX4 protein26072098
C011512alpha-naphthoflavone"alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DDX4 mRNA]"20562217
C015001arsenitearsenite results in decreased expression of DDX4 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of DDX4 mRNA]18929588
D001280AtrazineAtrazine results in increased expression of DDX4 mRNA25929836
D001374AzacitidineAzacitidine results in decreased methylation of DDX4 promoter26712470
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DDX4 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased methylation of DDX4 promoter23542452
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DDX4 mRNA23542452
C006780bisphenol Abisphenol A results in decreased methylation of DDX4 promoter26712470
C006780bisphenol Abisphenol A results in decreased methylation of DDX4 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of DDX4 mRNA25181051
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of DDX4 protein21296659
D002104CadmiumCadmium results in decreased expression of DDX4 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of DDX4 promoter26712470
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DDX4 protein22030410
D019327Copper SulfateCopper Sulfate results in decreased expression of DDX4 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of DDX4 mRNA19789285
C029892cupric chloridecupric chloride results in decreased expression of DDX4 protein22030410
D013759DronabinolDronabinol affects the expression of DDX4 mRNA29106691
D004026DieldrinDieldrin results in increased expression of DDX4 mRNA20438755
D004054DiethylstilbestrolDiethylstilbestrol results in decreased methylation of DDX4 promoter26712470
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DDX4 mRNA"20562217
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of DDX4 mRNA"20562217
D0151279,10-Dimethyl-1,2-benzanthracene"AHR protein affects the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DDX4 mRNA]"20562217
D0151279,10-Dimethyl-1,2-benzanthracene"alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DDX4 mRNA]"20562217
D004147DioxinsDioxins affects the expression of DDX4 mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased methylation of DDX4 promoter26712470
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DDX4 mRNA17475347|1760630
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DDX4 mRNA17222921
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DDX4 mRNA12075121
D005472FluorouracilFluorouracil results in increased expression of DDX4 protein21296659
C061365flusilazoleflusilazole results in decreased methylation of DDX4 promoter26712470
D005485FlutamideFlutamide results in decreased expression of DDX4 mRNA17222921
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of DDX4 mRNA22634610
C029891lead chloridelead chloride results in decreased expression of DDX4 protein22030410
C022838nickel chloridenickel chloride results in increased methylation of DDX4 promoter26712470
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased methylation of DDX4 promoter26712470
D013629TamoxifenTamoxifen results in decreased expression of DDX4 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DDX4 mRNA27618130
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DDX4 mRNA19933214
D014635Valproic AcidValproic Acid results in increased methylation of DDX4 promoter26712470
D014635Valproic AcidValproic Acid results in decreased methylation of DDX4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of DDX4 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DDX4 gene25560391
C016837zinc chloridezinc chloride results in decreased expression of DDX4 protein22030410

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007140male meiotic nuclear division-ISS-  
GO:0007141male meiosis I-ISS-  
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-ISS-  
GO:0010529negative regulation of transposition-ISS-  
GO:0030154cell differentiation-IEA-  
GO:0030317flagellated sperm motility-IMP21034600  
GO:0031047gene silencing by RNA-IEA-  
GO:0034587piRNA metabolic process-ISS-  
GO:0043046DNA methylation involved in gamete generation-ISS-  
GO:1990511piRNA biosynthetic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA21421998  
GO:0071546pi-body-ISS-  
GO:0071547piP-body-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-211000Gene Silencing by RNAIEA
R-HSA-5601884PIWI-interacting RNA (piRNA) biogenesisIEA
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24847019In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. (2014 Jul)Fowler PAHum Reprod