Gene: CCDC93

54520
-
coiled-coil domain containing 93
protein-coding
2q14.1
Ensembl:ENSG00000125633 Vega:OTTHUMG00000058517 UniprotKB:Q567U6
NC_000002.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
8.251e-1 (AD)  4.967e-1 (ND)   (Frontal_Cortex)
4.320e-1 (AD)  5.731e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4142224chr2:117958614 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNRC6A0.934
POGZ0.917
EP4000.911
TTC170.904
SETD50.901
NFRKB0.898
PNISR0.898
TSC10.896
INTS30.894
CAD0.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.563
OR4F29-0.524
KLRC2-0.349
IAPP-0.288
PAGE4-0.273
SIM1-0.269
OXT-0.268
HMX2-0.267
FOXB1-0.265
AVP-0.263

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of CCDC93 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of CCDC93 mRNA17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCDC93 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of CCDC93 mRNA20678512
C006780bisphenol Abisphenol A affects the expression of CCDC93 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CCDC93 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CCDC93 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride affects the expression of CCDC93 mRNA22110744
D003042CocaineCocaine results in increased expression of CCDC93 mRNA17898221
D019327Copper SulfateCopper Sulfate results in increased expression of CCDC93 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of CCDC93 mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CCDC93 mRNA]27941970
D002117CalcitriolCalcitriol results in increased expression of CCDC93 mRNA16002434
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CCDC93 mRNA23649840
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCDC93 protein18951874
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CCDC93 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CCDC93 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CCDC93 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CCDC93 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCDC93 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CCDC93 mRNA25729387
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CCDC93 mRNA18593933
D010936Plant ExtractsPlant Extracts results in increased expression of CCDC93 mRNA23557933
D012822Silicon DioxideSilicon Dioxide results in increased expression of CCDC93 mRNA25351596
C016104sodium bichromatesodium bichromate results in increased expression of CCDC93 mRNA25993096
D012999SomanSoman results in increased expression of CCDC93 mRNA19281266
C061133tamibarotenetamibarotene results in decreased expression of CCDC93 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCDC93 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of CCDC93 mRNA25975270
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCDC93 protein18951874
D013853ThioacetamideThioacetamide results in increased expression of CCDC93 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CCDC93 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of CCDC93 mRNA15498508
C012589trichostatin Atrichostatin A results in increased expression of CCDC93 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of CCDC93 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of CCDC93 mRNA15901671
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CCDC93 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25355947  
GO ID GO Term Qualifier Evidence PubMed
GO:0006893Golgi to plasma membrane transport-IBA21873635  
GO:0006893Golgi to plasma membrane transport-IMP25355947  
GO:0015031protein transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005769early endosome-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25637605Genetic variation associates with susceptibility for cigarette smoke-induced neutrophilia in mice. (2015 Apr 1)Pouwels SDAm J Physiol Lung Cell Mol Physiol