Gene: NDUFB11

54539
CI-ESSS|ESSS|NP17.3|Np15|P17.3
NADH:ubiquinone oxidoreductase subunit B11
protein-coding
Xp11.3
Ensembl:ENSG00000147123 MIM:300403 Vega:OTTHUMG00000021433 UniprotKB:Q9NX14
NG_052579.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUTA0.975
NDUFB100.964
PRDX50.963
SSU720.959
GPX40.958
CLTB0.958
COX6B10.958
PSMB60.957
CUEDC20.956
MRPS240.954

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.83
OR4F29-0.813
CXCR2-0.282
IL18RAP-0.277
KCNJ15-0.272
CLEC12A-0.27
FCGR3B-0.266
VNN2-0.262
PZP-0.262
CEACAM3-0.261

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NDUFB11 mRNA"28973690
D000082AcetaminophenAcetaminophen affects the expression of NDUFB11 mRNA17562736
D000242Cyclic AMPCyclic AMP results in increased phosphorylation of NDUFB11 protein17904600
D000242Cyclic AMPZalcitabine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein]17904600
D000242Cyclic AMPZidovudine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein]17904600
D001151ArsenicArsenic affects the methylation of NDUFB11 gene25304211
D001280AtrazineAtrazine results in decreased expression of NDUFB11 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NDUFB11 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of NDUFB11 mRNA23019147
C006780bisphenol Abisphenol A affects the expression of NDUFB11 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of NDUFB11 mRNA29027980
C006780bisphenol Abisphenol A results in increased expression of NDUFB11 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of NDUFB11 protein28903499
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of NDUFB11 mRNA23650126
D016047ZalcitabineZalcitabine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein]17904600
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NDUFB11 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NDUFB11 mRNA17361019
D004041Dietary FatsDietary Fats results in decreased expression of NDUFB11 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in decreased expression of NDUFB11 mRNA]19030233
C056933fumonisin B1fumonisin B1 results in decreased expression of NDUFB11 mRNA16221962
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of NDUFB11 mRNA22634610
D007213IndomethacinIndomethacin results in increased expression of NDUFB11 mRNA28201806
D007657Ketone BodiesKetone Bodies results in increased expression of NDUFB11 mRNA16807920
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of NDUFB11 mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of NDUFB11 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of NDUFB11 mRNA]"21673326
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NDUFB11 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NDUFB11 mRNA20936131
C023036perfluorooctanoic acidPPARA protein inhibits the reaction [perfluorooctanoic acid results in decreased expression of NDUFB11 mRNA]20936131
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of NDUFB11 mRNA25626140
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in decreased expression of NDUFB11 mRNA]19030233
C089730rosiglitazonerosiglitazone affects the expression of NDUFB11 mRNA22013433
D012402RotenoneRotenone affects the splicing of NDUFB11 mRNA23246602
D012402Rotenone[Rotenone results in decreased expression of HNRNPH1 protein] which affects the splicing of NDUFB11 mRNA23246602
D012402RotenoneRotenone results in increased expression of NDUFB11 mRNA19013527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NDUFB11 mRNA25270620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NDUFB11 mRNA20399798
D014050TolueneToluene affects the expression of NDUFB11 mRNA21827849
D014635Valproic AcidValproic Acid results in increased methylation of NDUFB11 gene29154799
D014635Valproic AcidValproic Acid affects the expression of NDUFB11 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NDUFB11 gene25560391
D015215ZidovudineZidovudine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein]17904600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0032981mitochondrial respiratory chain complex I assembly-IMP27626371  
GO:0032981mitochondrial respiratory chain complex I assembly-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005747mitochondrial respiratory chain complex I-IDA12611891  27626371  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-6799198Complex I biogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19494790Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat. (2009 Jul)Sapag APharmacogenet Genomics