Gene info: ID 54541

Gene: DDIT4

GENE ID: 54541

Synonyms: Dig2|REDD-1|REDD1

Description: DNA damage inducible transcript 4

Gene type: protein-coding

Location: 10q22.1

dbXrefs: Ensembl:ENSG00000168209 MIM:607729 Vega:OTTHUMG00000183961 UniprotKB:Q9NX09

RefSeq: NC_000010.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.333e-1 (AD) 8.945e-2 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg20897136	chr10:74034667	DDIT4		3.900e-18	Smoking	27651444
cg01839993	chr10:74034644	DDIT4		2.900e-14	Smoking	27651444
cg04858631	chr10:74035570	DDIT4		4.100e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SCAMP2	0.742
CEBPD	0.74
SMOX	0.734
PXDC1	0.733
ZFP36L1	0.733
MCL1	0.725
TOB2	0.725
LRP10	0.723
SLC3A2	0.722
STOM	0.721

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PPEF1	-0.489
ABCC12	-0.488
ZNF860	-0.466
CDH7	-0.455
GPR61	-0.454
OR2W3	-0.449
CALHM1	-0.447
COL19A1	-0.445
PCDHAC1	-0.439
NXPH2	-0.433

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of DDIT4 mRNA	25596134
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of DDIT4 mRNA"	28903501
C495626	14-deoxy-11,12-didehydroandrographolide	"14-deoxy-11,12-didehydroandrographolide results in increased expression of DDIT4 mRNA"	22101062
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of DDIT4 mRNA	28329830
C051246	1-methylanthracene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of DDIT4 mRNA]	28329830
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of DDIT4 mRNA"	19095052
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of DDIT4 mRNA]"	19414516
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of DDIT4 mRNA"	21346803
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]	17307335
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein]	17307335
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of DDIT4 mRNA]	17307335
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of DDIT4 protein]	17307335
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of DDIT4 mRNA	17307335
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of DDIT4 protein	17307335
C006593	2-anthramine	2-anthramine results in increased expression of DDIT4 mRNA	23038007
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of DDIT4 mRNA	21983209
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDIT4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDIT4 mRNA"	27188386
C034343	4-aminobenzhydrazide	4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in increased expression of DDIT4 mRNA]	24530881
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of DDIT4 mRNA	19191707
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDIT4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDIT4 mRNA"	27188386
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of DDIT4 mRNA"	19936915
D000082	Acetaminophen	Acetaminophen results in increased expression of DDIT4 mRNA	21420995\|2906747
D000082	Acetaminophen	[Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of DDIT4 mRNA	17093179
D000082	Acetaminophen	Acetaminophen affects the expression of DDIT4 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of DDIT4 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DDIT4 mRNA]	17585979
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein]	21266191
D020106	Acrylamide	Acrylamide results in increased expression of DDIT4 mRNA	28959563
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of DDIT4 mRNA	19920212
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of DDIT4 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of DDIT4 mRNA	21632981\|2210060
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of DDIT4 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of DDIT4 mRNA	22484513\|2305219
C103505	AM 251	AM 251 results in increased expression of DDIT4 mRNA	16500647
D000638	Amiodarone	Amiodarone results in increased expression of DDIT4 mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DDIT4 mRNA	16483693
D016718	Arachidonic Acid	Arachidonic Acid results in increased expression of DDIT4 mRNA	16704987
D001115	Arecoline	Arecoline results in increased expression of DDIT4 mRNA	17682004
C006632	arsenic trioxide	arsenic trioxide results in increased expression of DDIT4 mRNA	22521957
C015001	arsenite	arsenite promotes the reaction [CEBPB protein binds to DDIT4 promoter]	16008523
C015001	arsenite	arsenite promotes the reaction [ELK1 protein binds to DDIT4 promoter]	16008523
C015001	arsenite	arsenite results in increased expression of DDIT4 mRNA	16008523
C015001	arsenite	GPX1 protein inhibits the reaction [arsenite results in increased expression of DDIT4 mRNA]	16008523
C015001	arsenite	SOD1 protein inhibits the reaction [arsenite results in increased expression of DDIT4 mRNA]	16008523
C015001	arsenite	arsenite results in decreased expression of DDIT4 mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of DDIT4 mRNA]	18929588
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of DDIT4 mRNA"	25757056
D001280	Atrazine	Atrazine results in increased expression of DDIT4 mRNA	25929836
D001280	Atrazine	Atrazine results in increased expression of DDIT4 mRNA	22378314
C406592	azaspiracid	azaspiracid results in increased expression of DDIT4 mRNA	21853993\|2893901
C547126	AZM551248	AZM551248 results in decreased expression of DDIT4 mRNA	22323515
D001507	Beclomethasone	Beclomethasone results in increased expression of DDIT4 mRNA	23656298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DDIT4 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DDIT4 mRNA	21569818
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DDIT4 mRNA"	19150397\|2038263
D004958	Estradiol	Estradiol affects the expression of DDIT4 mRNA	14699072
D004958	Estradiol	Estradiol results in decreased expression of DDIT4 mRNA	23019147
D004958	Estradiol	Estradiol results in increased expression of DDIT4 mRNA	19153601
D004958	Estradiol	Estradiol results in increased expression of DDIT4 mRNA	15289156
C044887	beta-methylcholine	beta-methylcholine affects the expression of DDIT4 mRNA	21179406
C095105	bexarotene	bexarotene results in increased expression of DDIT4 mRNA	17178900
C053541	bicalutamide	bicalutamide inhibits the reaction [[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]]	20032058
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of DDIT4 mRNA	25912373
C006780	bisphenol A	bisphenol A results in increased expression of DDIT4 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of DDIT4 mRNA	25270620
C006780	bisphenol A	bisphenol A results in increased expression of DDIT4 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of DDIT4 mRNA	24356939
C025703	bleomycetin	bleomycetin results in increased expression of DDIT4 mRNA	21040473
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of DDIT4 mRNA	23410634
C584509	C646 compound	C646 compound results in increased expression of DDIT4 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of DDIT4 mRNA	25596134
D002185	Cannabidiol	Cannabidiol results in increased expression of DDIT4 mRNA	21542829
C043211	carvedilol	carvedilol results in decreased expression of DDIT4 mRNA	27288437
D002509	Cephaloridine	Cephaloridine results in decreased expression of DDIT4 mRNA	18500788
C004656	chloroacetaldehyde	chloroacetaldehyde results in increased expression of DDIT4 mRNA	25596134
C100187	chloropicrin	chloropicrin affects the expression of DDIT4 mRNA	26352163
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DDIT4 gene	20938992
C059262	cidofovir	cidofovir affects the expression of DDIT4 mRNA	25596134
D002922	Ciguatoxins	Ciguatoxins affects the expression of DDIT4 mRNA	18353800
C012843	cinnamic aldehyde	cinnamic aldehyde results in decreased expression of DDIT4 mRNA	17178418
D004002	Clodronic Acid	Clodronic Acid results in increased expression of DDIT4 mRNA	25596134
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of DDIT4 mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of DDIT4 mRNA	17585979\|2381119
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DDIT4 mRNA]	17585979
C018021	cobaltous chloride	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]	17307335
C018021	cobaltous chloride	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein]	17307335
C018021	cobaltous chloride	cobaltous chloride results in increased expression of DDIT4 mRNA	17307335\|1937684
C018021	cobaltous chloride	cobaltous chloride results in increased expression of DDIT4 protein	17307335
C018021	cobaltous chloride	HIF1A protein affects the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]	17307335
C018021	cobaltous chloride	HIF1A protein promotes the reaction [SP1 protein promotes the reaction [cobaltous chloride results in increased expression of DDIT4]]	17307335
C018021	cobaltous chloride	[Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]	17307335
C018021	cobaltous chloride	[Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein]	17307335
C018021	cobaltous chloride	SP1 protein promotes the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]	17307335
C018021	cobaltous chloride	[cobaltous chloride co-treated with NGF protein] results in increased expression of DDIT4 mRNA	24989011
C018021	cobaltous chloride	[cobaltous chloride co-treated with NGF protein] results in increased expression of DDIT4 protein	24989011
C018021	cobaltous chloride	cobaltous chloride results in increased expression of DDIT4 mRNA	24386269
C018021	cobaltous chloride	rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in increased expression of DDIT4 mRNA]	24989011
C018021	cobaltous chloride	rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in increased expression of DDIT4 protein]	24989011
D003078	Colchicine	Colchicine results in decreased expression of DDIT4 mRNA	24211769
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of DDIT4 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of DDIT4 mRNA	21595052
D019327	Copper Sulfate	Copper Sulfate results in increased expression of DDIT4 mRNA	16283523\|1954981
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of DDIT4 mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of DDIT4 mRNA	19167446
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of DDIT4 mRNA	17654400
D003520	Cyclophosphamide	DDIT4 protein affects the susceptibility to Cyclophosphamide	16217747
D016572	Cyclosporine	Cyclosporine results in increased expression of DDIT4 mRNA	20106945\|2163298
D016572	Cyclosporine	Cyclosporine results in increased expression of DDIT4 mRNA	19770486
D016572	Cyclosporine	Cyclosporine results in increased expression of DDIT4 mRNA	25596134
D000069439	Dasatinib	Dasatinib results in increased expression of DDIT4 mRNA	20579391
D013759	Dronabinol	Dronabinol results in increased expression of DDIT4 mRNA	21542829
D003907	Dexamethasone	Dexamethasone results in decreased expression of DDIT4 mRNA	25047013
D003907	Dexamethasone	Dexamethasone results in increased expression of DDIT4	22733784
D003907	Dexamethasone	Dexamethasone results in increased expression of DDIT4 mRNA	17998272\|2273378
D003907	Dexamethasone	bicalutamide inhibits the reaction [[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]]	20032058
D003907	Dexamethasone	Dexamethasone results in increased expression of DDIT4 mRNA	20032058
D003907	Dexamethasone	Dexamethasone results in increased expression of DDIT4 protein	20032058
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]	20032058
D003907	Dexamethasone	[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of DDIT4 protein]	20032058
D003976	Diazinon	Diazinon affects the expression of DDIT4 mRNA	22546817
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DDIT4 mRNA	21266533\|2174549
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of DDIT4 mRNA	28962523
D002945	Cisplatin	Cisplatin results in decreased expression of DDIT4 mRNA	24211769
D002945	Cisplatin	Cisplatin results in increased expression of DDIT4 mRNA	21532991\|2559613
D002945	Cisplatin	Cisplatin results in increased expression of DDIT4 protein	21274007
D002945	Cisplatin	Cisplatin results in increased expression of DDIT4 mRNA	21151649\|2527062
D004008	Diclofenac	Diclofenac results in increased expression of DDIT4 mRNA	26934552
D004026	Dieldrin	Dieldrin affects the expression of DDIT4 mRNA	22546817
D004040	Dietary Carbohydrates	[Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of DDIT4 mRNA	17093179
D004041	Dietary Fats	Dietary Fats results in decreased expression of DDIT4 mRNA	18042831
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of DDIT4 mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of DDIT4 mRNA	15289156
C051904	dinophysistoxin 1	dinophysistoxin 1 results in increased expression of DDIT4 mRNA	21853993
D004050	Ditiocarb	Ditiocarb results in increased expression of DDIT4 protein	24764117
D004237	Diuron	Diuron results in decreased expression of DDIT4 mRNA	25152437
D004317	Doxorubicin	Doxorubicin results in increased expression of DDIT4 mRNA	25896364
D004318	Doxycycline	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of DDIT4 mRNA]	18089841
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of DDIT4 mRNA"	23811387
D052244	Endocrine Disruptors	Endocrine Disruptors results in decreased expression of DDIT4 mRNA	25198161
D000431	Ethanol	[sodium arsenite co-treated with Ethanol] results in increased expression of DDIT4 protein	22872060
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of DDIT4 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of DDIT4 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DDIT4 mRNA	17942748
D005047	Etoposide	DDIT4 protein affects the susceptibility to Etoposide	16217747
D015025	Zearalenone	Zearalenone results in increased expression of DDIT4 mRNA	25455459
D011345	Fenofibrate	Fenofibrate results in decreased expression of DDIT4 mRNA	25596134
D011345	Fenofibrate	Fenofibrate results in increased expression of DDIT4 mRNA	25596134
C000499	ferric oxide	ferric oxide analog results in decreased expression of DDIT4 mRNA	24525745
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of DDIT4 mRNA	28329830
C007738	fluoranthene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of DDIT4 mRNA]	28329830
D005472	Fluorouracil	Fluorouracil results in increased expression of DDIT4 mRNA	16510598\|1655759
C061365	flusilazole	flusilazole affects the expression of DDIT4 mRNA	21195148
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DDIT4 gene	20938992
D005557	Formaldehyde	Formaldehyde results in decreased expression of DDIT4 mRNA	20655997
C069837	fullerene C60	fullerene C60 results in decreased expression of DDIT4 mRNA	19167457
C106014	gedunin	gedunin results in increased expression of DDIT4 mRNA	17010675
C056507	gemcitabine	gemcitabine affects the expression of DDIT4 mRNA	17039268
D019833	Genistein	Genistein results in increased expression of DDIT4 mRNA	15289156
C004312	glycidol	glycidol results in decreased expression of DDIT4 mRNA	24915197
C010974	glyphosate	glyphosate results in increased expression of DDIT4 mRNA	25636363
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in increased expression of DDIT4 mRNA	19695318
C425931	GW 501516	[GW 501516 binds to PPARD protein] which results in increased expression of DDIT4 mRNA	16197558
C001329	helenalin	helenalin results in increased expression of DDIT4 protein	23123298
C409722	hexaconazole	hexaconazole affects the expression of DDIT4 mRNA	21195148
D017313	Fenretinide	Fenretinide results in increased expression of DDIT4 mRNA	15958647
D017313	Fenretinide	Fenretinide results in increased expression of DDIT4 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of DDIT4 mRNA	20044591\|2341063
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of DDIT4 mRNA	16008523
C031927	hydroquinone	hydroquinone results in increased expression of DDIT4 mRNA	23416264
C013038	hydroxyhydroquinone	4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in increased expression of DDIT4 mRNA]	24530881
C013038	hydroxyhydroquinone	hydroxyhydroquinone results in increased expression of DDIT4 mRNA	24530881
C475919	hydroxytamoxifen	GPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of DDIT4 mRNA]	19153601
C475919	hydroxytamoxifen	hydroxytamoxifen results in increased expression of DDIT4 mRNA	19153601
C492448	ICG 001	ICG 001 results in increased expression of DDIT4 mRNA	26191083
D007069	Ifosfamide	Ifosfamide results in increased expression of DDIT4 mRNA	25596134
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DDIT4 mRNA	25613284
C051890	irinotecan	irinotecan results in increased expression of DDIT4 mRNA	20097248
D007545	Isoproterenol	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of DDIT4 mRNA]	18089841
D007545	Isoproterenol	Isoproterenol results in increased expression of DDIT4 mRNA	18089841\|2000320
C544151	jinfukang	jinfukang results in increased expression of DDIT4 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of DDIT4 mRNA	23086925
C410337	K 7174	K 7174 results in increased expression of DDIT4 mRNA	24086573
C119620	kenpaullone	kenpaullone results in decreased expression of DDIT4 mRNA	17993264
C008261	lead acetate	lead acetate results in increased expression of DDIT4 mRNA	21829687
C045463	leflunomide	leflunomide results in increased expression of DDIT4 mRNA	28988120
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of DDIT4 mRNA	16415329
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles results in decreased expression of DDIT4 mRNA	24525745
C013099	mancozeb	mancozeb results in increased expression of DDIT4 protein	24764117
D008344	Maneb	Maneb results in increased expression of DDIT4 protein	24764117
D008687	Metformin	Metformin results in decreased expression of DDIT4 mRNA	25596134
D008694	Methamphetamine	DDIT4 protein promotes the reaction [Methamphetamine results in decreased phosphorylation of MTOR protein]	26825372
D008694	Methamphetamine	DDIT4 protein promotes the reaction [Methamphetamine results in increased expression of BECN1 protein]	26825372
D008694	Methamphetamine	DDIT4 protein promotes the reaction [Methamphetamine results in increased expression of CASP3 protein modified form]	26825372
D008694	Methamphetamine	DDIT4 protein promotes the reaction [Methamphetamine results in increased expression of DDIT4 protein]	26825372
D008694	Methamphetamine	DDIT4 protein promotes the reaction [Methamphetamine results in increased expression of PARP1 protein modified form]	26825372
D008694	Methamphetamine	DDIT4 protein results in increased susceptibility to Methamphetamine	26825372
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in increased expression of DDIT4 mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of DDIT4 mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of DDIT4 protein	26825372
D008701	Methapyrilene	Methapyrilene results in increased expression of DDIT4 mRNA	22484513
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DDIT4 gene	20938992
D008727	Methotrexate	Methotrexate results in increased expression of DDIT4 mRNA	17379860
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of DDIT4 mRNA	23179753\|2718838
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of DDIT4 mRNA	26011545
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DDIT4 mRNA"	20188158
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of DDIT4 mRNA	25234470
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of DDIT4 mRNA	24810058
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of DDIT4	24764117
D008775	Methylprednisolone	Methylprednisolone results in increased expression of DDIT4 protein	21931329
D008775	Methylprednisolone	Testosterone inhibits the reaction [Methylprednisolone results in increased expression of DDIT4 protein]	21931329
D015735	Mifepristone	Mifepristone results in decreased expression of DDIT4 mRNA	17584828
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]	20032058
D016685	Mitomycin	DDIT4 protein affects the susceptibility to Mitomycin	16217747
D008942	Mitoxantrone	DDIT4 protein affects the susceptibility to Mitoxantrone	16217747
C437683	motexafin gadolinium	motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of DDIT4 mRNA]	16357179
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of DDIT4 mRNA	16357179
C437683	motexafin gadolinium	Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of DDIT4 mRNA]	16357179
C500085	muraglitazar	muraglitazar results in increased expression of DDIT4 mRNA	21515302
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of DDIT4 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of DDIT4 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of DDIT4 mRNA"	25620056
C031721	naphthalene	naphthalene results in increased expression of DDIT4 mRNA	18978301
D009285	Naphthoquinones	Naphthoquinones results in increased expression of DDIT4 mRNA	23811387
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of DDIT4 mRNA	19812364
C010463	n-hexanal	n-hexanal affects the expression of DDIT4 mRNA	26880647
C022838	nickel chloride	nickel chloride results in increased expression of DDIT4 mRNA	17312168
C022838	nickel chloride	nickel chloride affects the expression of DDIT4 mRNA	22110744\|2254681
C028007	nickel monoxide	nickel monoxide results in decreased expression of DDIT4 mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of DDIT4 mRNA	18651567
D009538	Nicotine	Nicotine results in increased expression of DDIT4 mRNA	23825647
D009538	Nicotine	Nicotine results in increased expression of DDIT4 mRNA	17456735
C570896	NSC305787	NSC305787 results in increased expression of DDIT4 mRNA	27137931
C570897	NSC668394	EZR protein affects the reaction [NSC668394 results in increased expression of DDIT4 mRNA]	27137931
C570897	NSC668394	NSC668394 results in increased expression of DDIT4 mRNA	27137931
C570897	NSC668394	NSC668394 results in increased expression of DDIT4 mRNA	27137931
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of DDIT4 mRNA	20971185
C025589	ochratoxin A	ochratoxin A metabolite results in decreased expression of DDIT4 mRNA	24356939
C025589	ochratoxin A	ochratoxin A results in decreased expression of DDIT4 mRNA	24356939
D016627	Oxidopamine	Oxidopamine results in increased expression of DDIT4	24764117
D000069463	Olive Oil	Olive Oil analog affects the expression of DDIT4 mRNA	17349074
C507134	ON 01910	ON 01910 results in increased expression of DDIT4 mRNA	22351695
C055122	orlistat	orlistat results in increased expression of DDIT4 mRNA	18796435
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in increased expression of DDIT4 mRNA	24888373
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of DDIT4 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of DDIT4 mRNA	25729387
D010100	Oxygen	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of DDIT4 mRNA]	17307335
D010100	Oxygen	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of DDIT4 protein]	17307335
D010100	Oxygen	Oxygen deficiency results in increased expression of DDIT4 mRNA	17307335\|2423605
D010100	Oxygen	Oxygen deficiency results in increased expression of DDIT4 protein	17307335
D010100	Oxygen	Oxygen results in decreased expression of DDIT4 protein	19587783
D010100	Oxygen	SP1 protein affects the reaction [Oxygen deficiency results in increased expression of DDIT4 mRNA]	17307335
D010100	Oxygen	HIF1A protein affects the reaction [Oxygen deficiency results in increased expression of DDIT4 mRNA]	17307335
D010100	Oxygen	Oxygen deficiency results in increased expression of DDIT4	24764117
D010126	Ozone	Ozone results in increased expression of DDIT4 mRNA	17460151
D000073878	Palm Oil	Palm Oil results in decreased expression of DDIT4 mRNA	18042831
C016030	pantogab	pantogab results in increased expression of DDIT4 mRNA	17379144
D010269	Paraquat	Paraquat results in increased expression of DDIT4 mRNA	23613995
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of DDIT4 mRNA	26705709
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of DDIT4 mRNA	24642059
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of DDIT4 mRNA	18692542
D010578	Petroleum	Petroleum affects the expression of DDIT4 mRNA	25208076
D010634	Phenobarbital	Phenobarbital affects the expression of DDIT4 mRNA	19159669
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of DDIT4 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of DDIT4 mRNA	19270015\|1948288
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of DDIT4 mRNA	15728792
C006253	pirinixic acid	pirinixic acid results in increased expression of DDIT4 mRNA	18445702\|2381119
D008926	Plicamycin	[Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]	17307335
D008926	Plicamycin	[Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein]	17307335
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in increased expression of DDIT4 mRNA	24888373
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in increased expression of DDIT4 mRNA	19695318
D059808	Polyphenols	Polyphenols results in decreased expression of DDIT4 mRNA	16293270
D011137	Polystyrenes	Polystyrenes results in increased expression of DDIT4 mRNA	25102311
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of DDIT4 mRNA	28903501
D011374	Progesterone	Progesterone results in increased expression of DDIT4 mRNA	18037150\|2179573
C045950	propiconazole	propiconazole results in increased expression of DDIT4 mRNA	21278054
C010313	pseudocumene	pseudocumene results in decreased expression of DDIT4 protein	17337753
D011794	Quercetin	Quercetin results in decreased expression of DDIT4 mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of DDIT4 mRNA	19729006
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of DDIT4 mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of DDIT4 mRNA	14699072
D011899	Ranitidine	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of DDIT4 mRNA	16415329
C059514	resveratrol	resveratrol results in increased expression of DDIT4 mRNA	25866375
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of DDIT4 mRNA	19167446
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of DDIT4 mRNA	25905778
C009172	rhodioloside	rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in increased expression of DDIT4 mRNA]	24989011
C009172	rhodioloside	rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in increased expression of DDIT4 protein]	24989011
C547185	riccardin D	riccardin D results in increased expression of DDIT4 mRNA	24069304
C089730	rosiglitazone	rosiglitazone results in increased expression of DDIT4 mRNA	21515302
D012402	Rotenone	Rotenone results in increased expression of DDIT4	24764117
C010327	salinomycin	salinomycin results in increased expression of DDIT4 mRNA	22215106
C093642	SB 203580	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of DDIT4 mRNA]	28329830
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in increased expression of DDIT4 mRNA	19564919
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of DDIT4 mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of DDIT4 mRNA	19073995
D012834	Silver	Silver results in increased expression of DDIT4 mRNA	26014281\|2895954
C017947	sodium arsenite	[sodium arsenite co-treated with Ethanol] results in increased expression of DDIT4 protein	22872060
C017947	sodium arsenite	sodium arsenite results in decreased expression of DDIT4 mRNA	25270620
C016104	sodium bichromate	sodium bichromate results in increased expression of DDIT4 mRNA	25993096
D053260	Soot	Soot results in increased expression of DDIT4 mRNA	26551751
C471405	sorafenib	sorafenib promotes the reaction [ATF4 protein results in increased expression of DDIT4 protein]	21601561
C471405	sorafenib	[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT4 protein	21601561
C471405	sorafenib	[[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein	21601561
C471405	sorafenib	[[[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein] which results in decreased expression of BIRC5 protein	21601561
C471405	sorafenib	sorafenib results in increased expression of DDIT4 protein	21601561
C471405	sorafenib	[sorafenib results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein	21601561
C471405	sorafenib	[[sorafenib results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein] which results in decreased expression of BIRC5 protein	21601561
C471405	sorafenib	[[sorafenib results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein] which results in increased susceptibility to TNFSF10 protein	21601561
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of DDIT4 mRNA	25905778
D013629	Tamoxifen	Tamoxifen affects the expression of DDIT4 mRNA	14699072
D013629	Tamoxifen	Tamoxifen affects the expression of DDIT4 mRNA	17555576\|2093736
C501413	tesaglitazar	tesaglitazar results in increased expression of DDIT4 mRNA	21515302
D013739	Testosterone	bicalutamide inhibits the reaction [[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]]	20032058
D013739	Testosterone	[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]	20032058
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]	20032058
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of DDIT4 protein]	20032058
D013739	Testosterone	Testosterone inhibits the reaction [Methylprednisolone results in increased expression of DDIT4 protein]	21931329
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DDIT4 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DDIT4 mRNA	22903824
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DDIT4 mRNA	21570461\|2468072
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DDIT4 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DDIT4 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DDIT4 mRNA	18691609\|2629044
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DDIT4 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in increased expression of DDIT4 mRNA	23409001\|2355797
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of DDIT4 mRNA	28065790
D019772	Topotecan	DDIT4 protein affects the susceptibility to Topotecan	16217747
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of DDIT4 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of DDIT4 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of DDIT4 mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of DDIT4 mRNA	16054129\|1737906
D014212	Tretinoin	Tretinoin results in decreased expression of DDIT4 mRNA	20488242
C034613	triacsin C	triacsin C results in increased expression of DDIT4 mRNA	16704987
C032910	triadimefon	triadimefon affects the expression of DDIT4 mRNA	21195148
C011559	tributyltin	tributyltin results in increased expression of DDIT4 mRNA	24356939
C011559	tributyltin	tributyltin results in decreased expression of DDIT4 mRNA	27614199
D014241	Trichloroethylene	Trichloroethylene results in increased expression of DDIT4 mRNA	25549359
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDIT4 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of DDIT4 mRNA	24935251\|2627250
C050414	tripterine	tripterine results in increased expression of DDIT4 mRNA	17010675
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT4 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of DDIT4 mRNA	29024780
C057693	troglitazone	troglitazone results in increased expression of DDIT4 mRNA	20846491
C057693	troglitazone	troglitazone results in increased expression of DDIT4 mRNA	21515302
D014415	Tunicamycin	Tunicamycin results in increased expression of DDIT4 mRNA	22378314
D014520	Urethane	Urethane results in increased expression of DDIT4 mRNA	28818685
C406224	valdecoxib	valdecoxib results in decreased expression of DDIT4 mRNA	24136188
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDIT4 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of DDIT4 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of DDIT4 mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in increased expression of DDIT4 mRNA	24383497\|2627250
D014638	Vanadates	Vanadates results in increased expression of DDIT4 mRNA	22714537
D014640	Vancomycin	Vancomycin results in increased expression of DDIT4 mRNA	18930951
C100058	vanillin	vanillin results in increased expression of DDIT4 mRNA	17178418
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of DDIT4 gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of DDIT4 mRNA	23034163
D000225	Adenine	Adenine results in decreased expression of DDIT4 mRNA	24211769
D024483	Vitamin K 3	Vitamin K 3 affects the expression of DDIT4 mRNA	23410634
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of DDIT4 mRNA"	25208076
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of DDIT4 mRNA"	25198161
C009684	withaferin A	Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein]	21266191
C009684	withaferin A	withaferin A results in increased expression of DDIT4 protein	21266191
D015032	Zinc	Zinc results in decreased expression of DDIT4 mRNA	20932299
D015032	Zinc	Zinc deficiency results in increased expression of DDIT4 mRNA	19111725
D015032	Zinc	Zinc results in increased expression of DDIT4 mRNA	17074742
D019345	Zinc Acetate	motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of DDIT4 mRNA]	16357179
D019345	Zinc Acetate	Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of DDIT4 mRNA]	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of DDIT4 mRNA	16357179
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of DDIT4 mRNA	17074742
C088658	zoledronic acid	zoledronic acid results in decreased expression of DDIT4 mRNA	25596134

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0071889	14-3-3 protein binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001666	response to hypoxia	-	IDA	20166753
GO:0001764	neuron migration	-	ISS	-
GO:0007420	brain development	-	ISS	-
GO:0008283	cell proliferation	-	ISS	-
GO:0010801	negative regulation of peptidyl-threonine phosphorylation	-	ISS	-
GO:0030182	neuron differentiation	-	ISS	-
GO:0032007	negative regulation of TOR signaling	-	IMP	20166753
GO:0032984	protein-containing complex disassembly	-	IEA	-
GO:0033137	negative regulation of peptidyl-serine phosphorylation	-	ISS	-
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	-	ISS	-
GO:0045820	negative regulation of glycolytic process	-	IEA	-
GO:0048011	neurotrophin TRK receptor signaling pathway	-	ISS	-
GO:0051607	defense response to virus	-	IDA	21478870
GO:0071549	cellular response to dexamethasone stimulus	-	IEA	-
GO:0072593	reactive oxygen species metabolic process	-	IEA	-
GO:1901216	positive regulation of neuron death	-	ISS	-
GO:1902532	negative regulation of intracellular signal transduction	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005622	intracellular	-	IDA	-
GO:0005737	cytoplasm	-	IDA	12453409
GO:0005739	mitochondrion	-	IEA	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa04150	mTOR signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-5628897	TP53 Regulates Metabolic Genes	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27189933	Emerging role for regulated in development and DNA damage 1 (REDD1) in the regulation of skeletal muscle metabolism. (2016 Jul 1)	Gordon BS	Am J Physiol Endocrinol Metab
21621604	Incomplete protection of genetic integrity of mature spermatozoa against oxidative stress. (2011 Jul)	Linschooten JO	Reprod Toxicol