Gene: MTMR12

54545
3-PAP|PIP3AP
myotubularin related protein 12
protein-coding
5p13.3
Ensembl:ENSG00000150712 MIM:606501 Vega:OTTHUMG00000161978 UniprotKB:Q9C0I1
NC_000005.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.246e-1 (AD)  5.111e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4078204chr5:32275361 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAPGEF20.92
MAPK140.918
CDC400.917
PHF200.913
DHX330.911
PHLPP20.911
TGFBRAP10.91
RALGAPB0.909
CCSAP0.907
RNF1110.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.519
OR4F29-0.501
S100A1-0.357
MYL3-0.347
CSAG1-0.338
S100A14-0.314
HEY2-0.312
COPZ2-0.298
MDFI-0.295
MTRNR2L10-0.289

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MTMR12 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of MTMR12 mRNA17562736
D001151ArsenicArsenic affects the methylation of MTMR12 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MTMR12 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of MTMR12 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MTMR12 mRNA"19150397
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MTMR12 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of MTMR12 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MTMR12 mRNA28628672
C584509C646 compoundC646 compound results in decreased expression of MTMR12 mRNA26191083
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MTMR12 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MTMR12 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MTMR12 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MTMR12 mRNA21266533
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of MTMR12 mRNA17490981
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of MTMR12 mRNA22634610
D017313FenretinideFenretinide results in increased expression of MTMR12 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MTMR12 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MTMR12 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MTMR12 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MTMR12 mRNA28628672
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MTMR12 mRNA23103053
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MTMR12 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MTMR12 mRNA"25554681
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MTMR12 mRNA19710929
D011441PropylthiouracilPropylthiouracil results in decreased expression of MTMR12 mRNA24780913
D012969Sodium FluorideSodium Fluoride results in increased expression of MTMR12 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTMR12 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTMR12 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MTMR12 mRNA21354282
D014635Valproic AcidValproic Acid affects the expression of MTMR12 mRNA25979313

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12847286  
GO:0019208phosphatase regulator activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006661phosphatidylinositol biosynthetic process-TAS-  
GO:0050790regulation of catalytic activity-IEA-  
GO:1901998toxin transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA16787938  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483255PI MetabolismTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-1660516Synthesis of PIPs at the early endosome membraneTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal