Gene: SDK2

54549
-
sidekick cell adhesion molecule 2
protein-coding
17q25.1
Ensembl:ENSG00000069188 MIM:607217 Vega:OTTHUMG00000152726 UniprotKB:Q58EX2
NC_000017.11
SNP Mapped
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.064e-1 (AD)  8.648e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1858030chr17:73626530 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRNA40.784
PTPRS0.76
FOXRED20.735
ELFN20.729
XKR70.726
FOXK10.725
ZFP410.722
NOL90.719
LRRN20.716
TMEM184B0.715

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf87-0.456
CEACAM4-0.453
CD48-0.428
RNASE4-0.427
TFPI2-0.423
SLC16A12-0.419
IL18RAP-0.415
CXCR2-0.412
GNG11-0.411
MNDA-0.411

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SDK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SDK2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SDK2 gene27153756
D001280AtrazineAtrazine results in decreased expression of SDK2 mRNA25929836
D004958EstradiolEstradiol results in decreased expression of SDK2 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of SDK2 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SDK2 gene20938992
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SDK2 mRNA23640034
D002945CisplatinCisplatin results in decreased expression of SDK2 mRNA27594783
D004041Dietary FatsDietary Fats results in increased expression of SDK2 mRNA25016146
D004726EndosulfanEndosulfan results in decreased expression of SDK2 protein26722802
C024565ethylene dichlorideethylene dichloride results in increased expression of SDK2 mRNA28189721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SDK2 gene20938992
D017313FenretinideFenretinide results in decreased expression of SDK2 mRNA28973697
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SDK2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SDK2 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SDK2 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK2 mRNA"27188386
D009532NickelNickel results in decreased expression of SDK2 mRNA25583101
C005556propionaldehydepropionaldehyde results in increased expression of SDK2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of SDK2 mRNA24780913
C502851quinocetonequinocetone results in increased expression of SDK2 mRNA27046791
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SDK2 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of SDK2 gene28589171
C016766sulforafansulforafan results in decreased expression of SDK2 mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SDK2 mRNA21570461
C012589trichostatin Atrichostatin A results in decreased expression of SDK2 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SDK2 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of SDK2 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SDK2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SDK2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of SDK2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of SDK2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SDK2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-ISS-  
GO:0007416synapse assembly-ISS-  
GO:0010842retina layer formation-ISS-  
GO:0045216cell-cell junction organization-TAS-  
GO:0060219camera-type eye photoreceptor cell differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0045202synapse-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-373756SDK interactionsTAS
R-HSA-421270Cell-cell junction organizationTAS
R-HSA-446728Cell junction organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal