Gene: DLL4

54567
AOS6|hdelta2
delta like canonical Notch ligand 4
protein-coding
15q15.1
Ensembl:ENSG00000128917 MIM:605185 Vega:OTTHUMG00000172511 UniprotKB:Q9NR61
NG_046974.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.169e-1 (AD)  7.747e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC320.835
ICAM20.831
FLT40.824
MYCT10.818
FLT10.812
MMRN20.81
ESAM0.81
MECOM0.81
PKN30.808
ADAMTS10.808

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SP9-0.417
CRH-0.414
C1orf53-0.413
SMIM18-0.407
DLX1-0.405
KIT-0.402
FSTL5-0.39
SLC7A4-0.387
PPEF1-0.386
GAD2-0.384

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of DLL4 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of DLL4 mRNA28959563
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of DLL4 mRNA28522335
C006632arsenic trioxidearsenic trioxide results in decreased expression of DLL425088040
C015001arsenitearsenite results in increased methylation of DLL4 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DLL4 mRNA21569818|2719552
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DLL4 mRNA22610609
C006780bisphenol Abisphenol A results in decreased methylation of DLL4 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of DLL4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DLL4 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DLL4 gene20938992
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Oxygen results in increased expression of DLL4 mRNA]25203536
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DLL4 mRNA]27941970
D004041Dietary FatsDietary Fats results in increased expression of DLL4 mRNA18042831
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of DLL4 mRNA"27840820
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DLL4 mRNA22079256
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DLL4 gene20938992
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of DLL4 mRNA26752646|2743299
C045463leflunomideleflunomide results in increased expression of DLL4 mRNA28988120
C025340manganese chloridemanganese chloride results in increased expression of DLL4 mRNA17467022
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DLL4 gene20938992
D008727MethotrexateMethotrexate affects the expression of DLL4 mRNA18502557
D010100OxygenOxygen deficiency results in increased expression of DLL4 mRNA26516004
D010100Oxygencyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Oxygen results in increased expression of DLL4 mRNA]25203536
D010100OxygenOxygen results in increased expression of DLL4 mRNA25203536
D000073878Palm OilPalm Oil results in increased expression of DLL4 mRNA18042831
D010936Plant ExtractsPlant Extracts results in decreased expression of DLL4 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DLL4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of DLL4 mRNA22079256
D015237DinoprostDinoprost results in decreased expression of DLL4 mRNA21209419
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DLL4 mRNA23806026
D019821SimvastatinSimvastatin results in increased expression of DLL4 mRNA19109527
C017947sodium arsenitesodium arsenite results in decreased expression of DLL4 mRNA20308225
D012999SomanSoman results in decreased expression of DLL4 mRNA19281266
D012999SomanSoman results in increased expression of DLL4 mRNA19281266
D053260SootSoot results in decreased expression of DLL4 mRNA26551751
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of DLL4 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DLL4 promoter]19654925
C009495titanium dioxidetitanium dioxide results in decreased expression of DLL4 mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of DLL4 mRNA19042947
C057693troglitazonetroglitazone results in increased expression of DLL4 mRNA17569031
D014520UrethaneUrethane results in increased expression of DLL4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of DLL4 mRNA17292431
C025643vinclozolinvinclozolin results in increased expression of DLL4 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005112Notch binding-IEA-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI24025447  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0001525angiogenesis-ISS-  
GO:0001569branching involved in blood vessel morphogenesis-ISS-  
GO:0001974blood vessel remodeling-ISS-  
GO:0003208cardiac ventricle morphogenesis-ISS-  
GO:0003209cardiac atrium morphogenesis-ISS-  
GO:0003222ventricular trabecula myocardium morphogenesis-ISS-  
GO:0003344pericardium morphogenesis-ISS-  
GO:0007165signal transduction-TAS10837024  
GO:0007219Notch signaling pathway-TAS-  
GO:0007601visual perception-IEA-  
GO:0008015blood circulation-TAS10837024  
GO:0008285negative regulation of cell proliferation-IMP20616313  
GO:0010596negative regulation of endothelial cell migration-IMP20616313  
GO:0010628positive regulation of gene expression-IDA23388056  26491108  
GO:0010629negative regulation of gene expression-IDA23388056  
GO:0030217T cell differentiation-ISS-  
GO:0035912dorsal aorta morphogenesis-ISS-  
GO:0035924cellular response to vascular endothelial growth factor stimulus-IMP20616313  
GO:0044344cellular response to fibroblast growth factor stimulus-IDA20616313  
GO:0045746negative regulation of Notch signaling pathway-ISS-  
GO:0045747positive regulation of Notch signaling pathway-ISS-  
GO:0050767regulation of neurogenesis-IEA-  
GO:0060579ventral spinal cord interneuron fate commitment-IMP17728344  
GO:0061074regulation of neural retina development-ISS-  
GO:0061314Notch signaling involved in heart development-ISS-  
GO:0072554blood vessel lumenization-IEA-  
GO:0090051negative regulation of cell migration involved in sprouting angiogenesis-IDA23388056  
GO:0090051negative regulation of cell migration involved in sprouting angiogenesis-IMP20616313  
GO:1903588negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis-IDA23388056  
GO:2000179positive regulation of neural precursor cell proliferation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-1980145Signaling by NOTCH2TAS
R-HSA-1980150Signaling by NOTCH4TAS
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2660825Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantTAS
R-HSA-2660826Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantTAS
R-HSA-2691230Signaling by NOTCH1 HD Domain Mutants in CancerTAS
R-HSA-2691232Constitutive Signaling by NOTCH1 HD Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-2979096NOTCH2 Activation and Transmission of Signal to the NucleusIEA
R-HSA-2979096NOTCH2 Activation and Transmission of Signal to the NucleusTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusIEA
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26676959Shear stress, arterial identity and atherosclerosis. (2016 Mar)Lehoux SThromb Haemost
25962154Downregulation of notch signaling pathway in late preterm and term placentas from pregnancies complicated by preeclampsia. (2015)Fragkiadaki PPLoS One