Gene: UGT1A10

54575
UDPGT|UGT-1J|UGT1-10|UGT1.10|UGT1J
UDP glucuronosyltransferase family 1 member A10
protein-coding
2q37.1
Ensembl:ENSG00000242515 MIM:606435 Vega:OTTHUMG00000059121 UniprotKB:Q9HAW8
NC_000002.12
PubMed
0   ANCO-SNPs
OD|ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.729e-1 (AD)  3.560e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GADL10.747
KRTAP24-10.707
OR4D110.702
OR51D10.686
SLC15A10.681
OR51F10.676
FOXI20.672
BMP50.668
DCAF4L20.653
ASB90.644

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SORCS2-0.391
NTSR2-0.386
SLC1A4-0.376
HHATL-0.373
NDP-0.367
C2orf72-0.364
TPCN1-0.358
TTYH1-0.357
GABRG1-0.352
CABLES1-0.351

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnEnzyme
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalEnzyme
DB00316AcetaminophenSmall Molecule103-90-2ApprovedEnzyme
DB00675TamoxifenSmall Molecule10540-29-1ApprovedEnzyme
DB00678LosartanSmall Molecule114798-26-4ApprovedEnzyme
DB00688Mycophenolate mofetilSmall Molecule128794-94-5Approved|InvestigationalEnzyme
DB00749EtodolacSmall Molecule41340-25-4Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C5432111,2,5,8-tetrahydroxy anthraquinone"UGT1A10 protein results in increased glucuronidation of 1,2,5,8-tetrahydroxy anthraquinone"14557274
C0348901,4-dihydroxyanthraquinone"UGT1A10 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone"14557274
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"UGT1A10 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"15231852
C0331461-hydroxypyreneUGT1A10 protein results in increased glucuronidation of 1-hydroxypyrene15802387
C0593542',4'-dihydroxychalcone"UGT1A10 protein results in increased glucuronidation of 2',4'-dihydroxychalcone"14557274
C1074972',5'-dihydroxychalcone"UGT1A10 protein results in increased glucuronidation of 2',5'-dihydroxychalcone"14557274
C0348892,6-dihydroxyanthraquinone"UGT1A10 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone"14557274
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A10 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15310245
C0013902-hydroxyestradiolUGT1A10 protein results in increased glucuronidation of 2-hydroxyestradiol15117964
C0249802-hydroxyestroneUGT1A10 protein results in increased glucuronidation of 2-hydroxyestrone15117964
C0228302-methoxyestradiolUGT1A10 protein results in increased glucuronidation of 2-methoxyestradiol15117964
C0608432-vanillinUGT1A10 protein results in increased glucuronidation of 2-vanillin15117964
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of UGT1A10 mRNA"23196670
C0306823-chlorophenol3-chlorophenol results in increased expression of UGT1A10 mRNA18486366
C0352533-phenylpropionic acidUGT1A10 protein results in increased glucuronidation of 3-phenylpropionic acid15117964
C0264184-hydroxyestroneUGT1A10 protein results in increased glucuronidation of 4-hydroxyestrone15117964
C0248364-nitrophenolUGT1A10 protein results in increased glucuronidation of 4-nitrophenol15802387
C1217077,3'-dihydroxy-4'-methoxyisoflavone"UGT1A10 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone"25044472
D000082AcetaminophenUGT1A10 protein results in increased glucuronidation of Acetaminophen15117964|1789815
D000082AcetaminophenAcetaminophen results in decreased expression of UGT1A10 mRNA23333575|2677215
D000082AcetaminophenGenistein inhibits the reaction [Acetaminophen results in decreased expression of UGT1A10 mRNA]23333575
D000082Acetaminophenhyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A10 mRNA]26772156
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of UGT1A10 gene27153756
D000450AldosteroneUGT1A10 protein results in increased glucuronidation of Aldosterone19740398
C018447aldosterone 18-glucuronideUGT1A10 protein results in increased chemical synthesis of aldosterone 18-glucuronide19740398
C010078alizarinUGT1A10 protein results in increased glucuronidation of alizarin14557274
C006457alloinUGT1A10 protein results in increased glucuronidation of alloin14557274
C032186anthrarobinUGT1A10 protein results in increased glucuronidation of anthrarobin14557274
D047310ApigeninUGT1A10 protein results in increased glucuronidation of Apigenin14557274
D016718Arachidonic AcidUGT1A10 protein results in increased glucuronidation of Arachidonic Acid15231852
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in increased expression of UGT1A10 mRNA17639512
D001241AspirinUGT1A10 protein results in increased glucuronidation of Aspirin15117964
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of UGT1A10 mRNA26377693
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of UGT1A10 mRNA19118567|2860143
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGT1A10 mRNA15735009
D001564Benzo(a)pyreneUGT1A10 protein results in increased glucuronidation of Benzo(a)pyrene14557274
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGT1A10 mRNA20127859|2234223
C068337bergamottinUGT1A10 protein results in increased glucuronidation of bergamottin analog14557274
D004958EstradiolUGT1A10 protein results in increased glucuronidation of Estradiol15117964|1547222
D004958EstradiolUGT1A10 protein results in increased glucuronidation of Estradiol analog15472229
C004541biochanin AUGT1A10 protein results in increased glucuronidation of biochanin A14557274
C012776biphenylylacetic acidUGT1A10 protein results in increased glucuronidation of biphenylylacetic acid15117964
C006780bisphenol Abisphenol A results in decreased expression of UGT1A10 mRNA24214726
C040048caffeic acidUGT1A10 protein results in increased glucuronidation of caffeic acid15117964
D002211CapsaicinUGT1A10 protein results in increased glucuronidation of Capsaicin14557274
D002726Chlorogenic AcidUGT1A10 protein results in increased glucuronidation of Chlorogenic Acid15117964
C043561chrysinUGT1A10 protein results in increased glucuronidation of chrysin14557274
C029010cinnamic acidUGT1A10 protein results in increased glucuronidation of cinnamic acid15117964
D002995Clofibric AcidUGT1A10 protein results in increased glucuronidation of Clofibric Acid15117964
D003375CoumestrolUGT1A10 protein results in increased glucuronidation of Coumestrol14557274
D003474CurcuminUGT1A10 protein results in increased glucuronidation of Curcumin14557274
C004742daidzeinUGT1A10 protein results in increased glucuronidation of daidzein14557274
C041517dibenzo(a,l)pyrene"UGT1A10 protein results in increased glycosylation of dibenzo(a,l)pyrene"21780761
D004008DiclofenacDiclofenac affects the expression of UGT1A10 mRNA19022234
D004008DiclofenacUGT1A10 protein results in increased glucuronidation of Diclofenac15117964|2226588
D004041Dietary FatsDietary Fats results in decreased expression of UGT1A10 mRNA18042831
D004061DiflunisalUGT1A10 protein results in increased glucuronidation of Diflunisal15117964
D000875AnthralinUGT1A10 protein results in increased glucuronidation of Anthralin15117964
C037760diphenylacetic acidUGT1A10 protein results in increased glucuronidation of diphenylacetic acid15117964
D004318DoxycyclineDoxycycline promotes the reaction [Tobacco Smoke Pollution results in increased expression of UGT1A10 mRNA]22273977
D004318DoxycyclineDoxycycline results in increased expression of UGT1A10 mRNA22273977
D004642EmodinUGT1A10 protein results in increased glucuronidation of Emodin14557274
C071192entacaponeUGT1A10 protein results in increased glucuronidation of entacapone15802387
D060754EquolUGT1A10 protein results in increased glucuronidation of Equol14557274
D004964EstriolUGT1A10 protein results in increased glucuronidation of Estriol15117964
D004964EstriolUGT1A10 protein results in increased glucuronidation of Estriol analog15117964
D004970EstroneUGT1A10 protein results in increased glucuronidation of Estrone15117964|1547222
D004970EstroneUGT1A10 protein results in increased glucuronidation of Estrone analog15472229
D017308EtodolacUGT1A10 protein results in increased glucuronidation of Etodolac15535975
D005054EugenolUGT1A10 protein results in increased glucuronidation of Eugenol14557274
D015025ZearalenoneUGT1A10 protein results in increased glucuronidation of Zearalenone14557274
D005279FenoprofenUGT1A10 protein results in increased glucuronidation of Fenoprofen15117964
C004999ferulic acidUGT1A10 protein results in increased glucuronidation of ferulic acid15117964
C017875fisetinUGT1A10 protein results in increased glucuronidation of fisetin14557274
D005480FlurbiprofenUGT1A10 protein results in increased glucuronidation of Flurbiprofen15117964
C007768formononetinUGT1A10 protein results in increased glucuronidation of formononetin14557274
D005665FurosemideUGT1A10 protein results in increased glucuronidation of Furosemide15117964
C037032galanginUGT1A10 protein results in increased glucuronidation of galangin14557274
D019833GenisteinUGT1A10 protein results in increased glucuronidation of Genistein14557274
D019833GenisteinGenistein inhibits the reaction [Acetaminophen results in decreased expression of UGT1A10 mRNA]23333575
C107601glabridinUGT1A10 protein results in increased glucuronidation of glabridin25765239
D020719Glucuronides[UGT1A10 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of Glucuronides19408964
D005978GlutathioneGlutathione deficiency results in increased expression of UGT1A10 mRNA15345336
C013025hydratropic acidUGT1A10 protein results in increased glucuronidation of hydratropic acid15117964
D006923HymecromoneHymecromone results in increased activity of UGT1A10 protein26875642
D006923Hymecromonelicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A10 protein]26875642
D006923HymecromoneUGT1A10 protein results in increased glucuronidation of Hymecromone15802387|2226588
C021304hyperosidehyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A10 mRNA]26772156
C021304hyperosidehyperoside results in increased expression of UGT1A10 mRNA26772156
D007052IbuprofenUGT1A10 protein results in increased glucuronidation of Ibuprofen15117964
D007213IndomethacinUGT1A10 protein results in increased glucuronidation of Indomethacin15117964|2226588
D007216IndoprofenUGT1A10 protein results in increased glucuronidation of Indoprofen15117964
C051890irinotecanUGT1A10 protein affects the susceptibility to irinotecan15517893
C051890irinotecanUGT1A10 protein results in decreased activity of irinotecan15517893
C051890irinotecanUGT1A10 protein results in increased glucuronidation of irinotecan15716465|1789815
C040920isoliquiritigeninUGT1A10 protein results in increased glucuronidation of isoliquiritigenin14557274
C008216isovaleric acidUGT1A10 protein results in increased glucuronidation of isovaleric acid analog15117964
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UGT1A10 mRNA26752646
C006552kaempferolUGT1A10 protein results in increased glucuronidation of kaempferol14557274
D007660KetoprofenUGT1A10 protein results in increased glucuronidation of Ketoprofen15535975
C070840licochalcone Alicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A10 protein]26875642
D009637MasoprocolUGT1A10 protein results in increased glucuronidation of Masoprocol14557274
D008528Mefenamic AcidUGT1A10 protein results in increased glucuronidation of Mefenamic Acid15117964
D008727MethotrexateMethotrexate results in decreased expression of UGT1A10 mRNA20854796
D008748MethylcholanthreneMethylcholanthrene results in increased expression of UGT1A10 mRNA19118567|2860143
C033069methyl salicylateUGT1A10 protein results in increased glucuronidation of methyl salicylate15117964
C016599mono-(2-ethylhexyl)phthalateUGT1A10 protein results in increased glucuronidation of mono-(2-ethylhexyl)phthalate27071666
C008548morinUGT1A10 protein results in increased glucuronidation of morin14557274
D009020MorphineUGT1A10 protein results in increased glucuronidation of Morphine12920162
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of UGT1A10 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UGT1A10 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of UGT1A10 mRNA"25620056
D009288NaproxenUGT1A10 protein results in increased glucuronidation of Naproxen15535975
C005273naringeninUGT1A10 protein results in increased glucuronidation of naringenin14557274
C027329naringenin chalconeUGT1A10 protein results in increased glucuronidation of naringenin chalcone14557274
D009853OmeprazoleOmeprazole results in increased expression of UGT1A10 mRNA19118567
D000073878Palm OilPalm Oil results in decreased expression of UGT1A10 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of UGT1A10 mRNA18486366
D010693PhloretinUGT1A10 protein results in increased glucuronidation of Phloretin14557274
C014758plumbaginUGT1A10 protein results in increased glucuronidation of plumbagin14557274
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A10 mRNA16155002
C034467prostaglandin B1UGT1A10 protein results in increased glucuronidation of prostaglandin B115231852
C107773pterostilbeneUGT1A10 protein affects the glucuronidation of pterostilbene23965644
C033607puerarinUGT1A10 protein results in increased metabolism of puerarin22648071
C513428pyrachlostrobinpyrachlostrobin results in increased expression of UGT1A10 mRNA27029645
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in increased expression of UGT1A10 mRNA17639512
D011794QuercetinUGT1A10 protein results in increased glucuronidation of Quercetin14557274
C059514resveratrolUGT1A10 protein affects the glucuronidation of resveratrol23965644
C059514resveratrolUGT1A10 protein results in increased glucuronidation of resveratrol17991766
D020156Salicylic AcidUGT1A10 protein results in increased glucuronidation of Salicylic Acid15117964
D012603ScopoletinUGT1A10 protein results in increased glucuronidation of Scopoletin15802387
D013467SulindacUGT1A10 protein results in increased glucuronidation of Sulindac15843492
C025463sulindac sulfoneUGT1A10 protein results in increased glucuronidation of sulindac sulfone15843492
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A10 mRNA16155002
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of UGT1A10 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A10 mRNA25975270
D013943ThymolUGT1A10 protein results in increased glucuronidation of Thymol14557274
D014028Tobacco Smoke PollutionDoxycycline promotes the reaction [Tobacco Smoke Pollution results in increased expression of UGT1A10 mRNA]22273977
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of UGT1A10 mRNA22273977
C057693troglitazonetroglitazone results in increased expression of UGT1A10 mRNA19022234
D014641Vanillic AcidUGT1A10 protein results in increased glucuronidation of Vanillic Acid15117964
C100058vanillinUGT1A10 protein results in increased glucuronidation of vanillin15117964
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of UGT1A10 gene25560391
D014859WarfarinUGT1A10 protein results in increased metabolism of Warfarin19408964
D014859Warfarin[UGT1A10 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of Glucuronides19408964

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001972retinoic acid bindingNOTIDA20308471  
GO:0005080protein kinase C binding-IDA18556656  
GO:0008194UDP-glycosyltransferase activity-IBA21873635  
GO:0015020glucuronosyltransferase activity-IDA18052087  20056724  
GO:0015020glucuronosyltransferase activity-TAS-  
GO:0042803protein homodimerization activity-IDA17179145  
GO:0046982protein heterodimerization activity-IDA17179145  
GO ID GO Term Qualifier Evidence PubMed
GO:0051552flavone metabolic process-IDA18052087  
GO:0052695cellular glucuronidation-IDA20056724  
GO:0052695cellular glucuronidation-TAS-  
GO:0052696flavonoid glucuronidation-IBA21873635  
GO:0052697xenobiotic glucuronidation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA17179145  18556656  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa00053Ascorbate and aldarate metabolism
hsa00140Steroid hormone biosynthesis
hsa00500Starch and sucrose metabolism
hsa00514Other types of O-glycan biosynthesis
hsa00830Retinol metabolism
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156588GlucuronidationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12167564N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. (2002 Sep)Ghosheh ODrug Metab Dispos
19331232Genetic polymorphisms of smoking-related carcinogen detoxifying enzymes and head and neck cancer susceptibility. (2009 Feb)Lacko MAnticancer Res
29158248Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation. (2018 Feb)Liao MZDrug Metab Dispos