Gene: UGT1A8

54576
UDPGT|UDPGT 1-8|UGT-1H|UGT1-08|UGT1.8|UGT1A8S|UGT1H
UDP glucuronosyltransferase family 1 member A8
protein-coding
2q37.1
Ensembl:ENSG00000242366 MIM:606433 Vega:OTTHUMG00000059123 UniprotKB:Q9HAW9
NC_000002.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.729e-1 (AD)  3.607e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnEnzyme
DB00295MorphineSmall Molecule57-27-2Approved|InvestigationalEnzyme
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalEnzyme
DB00688Mycophenolate mofetilSmall Molecule128794-94-5Approved|InvestigationalEnzyme
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalEnzyme
DB00861DiflunisalSmall Molecule22494-42-4Approved|InvestigationalEnzyme
DB06230NalmefeneSmall Molecule55096-26-9Approved|Investigational|WithdrawnEnzyme
DB11633IsavuconazoleSmall Molecule241479-67-4Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C5432111,2,5,8-tetrahydroxy anthraquinone"UGT1A8 protein results in increased glucuronidation of 1,2,5,8-tetrahydroxy anthraquinone"14557274
C0348901,4-dihydroxyanthraquinone"UGT1A8 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone"14557274
C0907681-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"UGT1A8 protein results in increased glucuronidation of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"29285606
C0331461-hydroxypyreneUGT1A8 protein results in increased glucuronidation of 1-hydroxypyrene15802387
C0293501-naphtholUGT1A8 protein results in increased glucuronidation of 1-naphthol15502008
C0593542',4'-dihydroxychalcone"UGT1A8 protein results in increased glucuronidation of 2',4'-dihydroxychalcone"14557274
C1074972',5'-dihydroxychalcone"UGT1A8 protein results in increased glucuronidation of 2',5'-dihydroxychalcone"14557274
C0348892,6-dihydroxyanthraquinone"UGT1A8 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone"14557274
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A8 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]"15986396
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A8 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15310245
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A8 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15986396
C0013902-hydroxyestradiolUGT1A8 protein results in increased glucuronidation of 2-hydroxyestradiol15117964
C0249802-hydroxyestroneUGT1A8 protein results in increased glucuronidation of 2-hydroxyestrone15117964
C0228302-methoxyestradiolUGT1A8 protein results in increased glucuronidation of 2-methoxyestradiol15117964
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A8 mRNA]]25489928
C0608432-vanillinUGT1A8 protein results in increased glucuronidation of 2-vanillin15117964
C4828803-hydroxydesloratadineUGT1A8 protein results in increased glucuronidation of 3-hydroxydesloratadine15334623
C0352533-phenylpropionic acidUGT1A8 protein results in increased glucuronidation of 3-phenylpropionic acid15117964
C5830744,4'-hexafluorisopropylidene diphenol"UGT1A8 protein results in increased glucuronidation of and results in decreased activity of 4,4'-hexafluorisopropylidene diphenol"24349450
C0264184-hydroxyestroneUGT1A8 protein results in increased glucuronidation of 4-hydroxyestrone15117964
C0248364-nitrophenolUGT1A8 protein results in increased glucuronidation of 4-nitrophenol15802387
C0248364-nitrophenolUGT1A8 protein results in increased glucuronidation of 4-nitrophenol15502008
C1217077,3'-dihydroxy-4'-methoxyisoflavone"UGT1A8 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone"25044472
C0314777-hydroxycoumarinUGT1A8 protein results in increased glucuronidation of 7-hydroxycoumarin15502008
D000082AcetaminophenUGT1A8 protein results in increased glucuronidation of Acetaminophen15117964
D000082AcetaminophenUGT1A8 protein results in increased glucuronidation of Acetaminophen15502008
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of UGT1A8 gene27153756
C010078alizarinUGT1A8 protein results in increased glucuronidation of alizarin14557274
C006457alloinUGT1A8 protein results in increased glucuronidation of alloin14557274
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UGT1A8 mRNA16483693
C032186anthrarobinUGT1A8 protein results in increased glucuronidation of anthrarobin14557274
D047310ApigeninUGT1A8 protein results in increased glucuronidation of Apigenin14557274
D001152ArsenicalsArsenicals results in increased expression of UGT1A8 mRNA28625800
D001241AspirinUGT1A8 protein results in increased glucuronidation of Aspirin15117964
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of UGT1A8 mRNA19118567|2860143
D001564Benzo(a)pyreneUGT1A8 protein results in increased glucuronidation of Benzo(a)pyrene14557274
D001564Benzo(a)pyrene2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A8 mRNA]]25489928
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGT1A8 mRNA25489928
D001564Benzo(a)pyrenePhenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A8 mRNA]25489928
D001564Benzo(a)pyreneUGT1A8 protein results in increased glucuronidation of Benzo(a)pyrene metabolite15502008
C068337bergamottinUGT1A8 protein results in increased glucuronidation of bergamottin analog14557274
D004958EstradiolUGT1A8 protein results in increased glucuronidation of Estradiol15117964|1547222
D004958EstradiolUGT1A8 protein results in increased glucuronidation of Estradiol analog15472229|1789815
C004541biochanin AUGT1A8 protein results in increased glucuronidation of biochanin A14557274
C012776biphenylylacetic acidUGT1A8 protein results in increased glucuronidation of biphenylylacetic acid15117964
C006780bisphenol Abisphenol A results in decreased expression of UGT1A8 mRNA24214726
C040048caffeic acidUGT1A8 protein results in increased glucuronidation of caffeic acid15117964
D002211CapsaicinUGT1A8 protein results in increased glucuronidation of Capsaicin14557274
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with Valproic Acid] results in increased expression of UGT1A8 mRNA17617793
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of UGT1A8 mRNA27174168
D002726Chlorogenic AcidUGT1A8 protein results in increased glucuronidation of Chlorogenic Acid15117964
C043561chrysinUGT1A8 protein results in increased glucuronidation of chrysin14557274
C043561chrysinUGT1A8 protein results in increased glucuronidation of chrysin15502008
C029010cinnamic acidUGT1A8 protein results in increased glucuronidation of cinnamic acid15117964
D002995Clofibric AcidUGT1A8 protein results in increased glucuronidation of Clofibric Acid15117964
D003042CocaineCocaine affects the expression of UGT1A8 mRNA20187946
D003375CoumestrolUGT1A8 protein results in increased glucuronidation of Coumestrol14557274
D003474CurcuminUGT1A8 protein results in increased glucuronidation of Curcumin14557274
C004742daidzeinUGT1A8 protein results in increased glucuronidation of daidzein14557274
C041517dibenzo(a,l)pyrene"UGT1A8 protein results in increased glycosylation of dibenzo(a,l)pyrene"21780761
D004008DiclofenacUGT1A8 protein results in increased glucuronidation of Diclofenac15117964
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of UGT1A8 mRNA22129741
D004054DiethylstilbestrolPhenylbutazone inhibits the reaction [UGT1A8 protein results in increased glucuronidation of Diethylstilbestrol]23126256
D004054DiethylstilbestrolUGT1A8 protein results in increased glucuronidation of Diethylstilbestrol23126256
D004061DiflunisalUGT1A8 protein results in increased glucuronidation of Diflunisal15117964
D000875AnthralinUGT1A8 protein results in increased glucuronidation of Anthralin15117964
C037760diphenylacetic acidUGT1A8 protein results in increased glucuronidation of diphenylacetic acid15117964
D004318DoxycyclineDoxycycline promotes the reaction [Tobacco Smoke Pollution results in increased expression of UGT1A8 mRNA]22273977
D004318DoxycyclineDoxycycline results in increased expression of UGT1A8 mRNA22273977
D004642EmodinUGT1A8 protein results in increased glucuronidation of Emodin14557274
C071192entacaponeUGT1A8 protein results in increased glucuronidation of entacapone15802387
D060754EquolUGT1A8 protein results in increased glucuronidation of Equol14557274
D004964EstriolUGT1A8 protein results in increased glucuronidation of Estriol15117964
D004964EstriolUGT1A8 protein results in increased glucuronidation of Estriol analog15117964
D004964EstriolUGT1A8 protein results in increased glucuronidation of Estriol15502008
D004970EstroneUGT1A8 protein results in increased glucuronidation of Estrone15117964|1547222
D004970EstroneUGT1A8 protein results in increased glucuronidation of Estrone analog15472229
D004997Ethinyl EstradiolUGT1A8 protein results in increased glucuronidation of Ethinyl Estradiol analog17898154
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UGT1A8 mRNA17557909
D005047EtoposideUGT1A8 protein results in increased glucuronidation of Etoposide17151191
D005054EugenolUGT1A8 protein results in increased glucuronidation of Eugenol14557274
D015025ZearalenoneUGT1A8 protein results in increased glucuronidation of Zearalenone14557274
D005279FenoprofenUGT1A8 protein results in increased glucuronidation of Fenoprofen15117964
C004999ferulic acidUGT1A8 protein results in increased glucuronidation of ferulic acid15117964
C017875fisetinUGT1A8 protein results in increased glucuronidation of fisetin14557274
D005419FlavonoidsFlavonoids results in decreased expression of UGT1A8 mRNA18035473
D005480FlurbiprofenUGT1A8 protein results in increased glucuronidation of Flurbiprofen15117964
C007768formononetinUGT1A8 protein results in increased glucuronidation of formononetin14557274
D005665FurosemideUGT1A8 protein results in increased glucuronidation of Furosemide15117964
C037032galanginUGT1A8 protein results in increased glucuronidation of galangin14557274
D019833GenisteinUGT1A8 protein results in increased glucuronidation of Genistein14557274
C107601glabridinUGT1A8 protein results in increased glucuronidation of glabridin25765239
D020719Glucuronides"UGT1A8 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]"15986396
D005978GlutathioneGlutathione deficiency results in increased expression of UGT1A8 mRNA15345336
C013025hydratropic acidUGT1A8 protein results in increased glucuronidation of hydratropic acid15117964
D006923HymecromoneHymecromone results in increased activity of UGT1A8 protein26875642
D006923Hymecromonelicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A8 protein]26875642
D006923HymecromonePropofol promotes the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]15378558
D006923HymecromoneUGT1A8 protein results in increased glucuronidation of Hymecromone15378558|1580238
D006923HymecromoneUGT1A8 protein results in increased glucuronidation of Hymecromone15502008
D007052IbuprofenUGT1A8 protein results in increased glucuronidation of Ibuprofen15117964
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of UGT1A8 mRNA22129741
D007213IndomethacinUGT1A8 protein results in increased glucuronidation of Indomethacin15117964|1584349
D007216IndoprofenUGT1A8 protein results in increased glucuronidation of Indoprofen15117964
C051890irinotecanUGT1A8 protein results in increased glucuronidation of irinotecan15833930|1789815
C051890irinotecanUGT1A8 protein results in increased glucuronidation of irinotecan15833930
C040920isoliquiritigeninUGT1A8 protein results in increased glucuronidation of isoliquiritigenin14557274
C008216isovaleric acidUGT1A8 protein results in increased glucuronidation of isovaleric acid analog15117964
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UGT1A8 mRNA26752646
C006552kaempferolUGT1A8 protein results in increased glucuronidation of kaempferol14557274
C070840licochalcone Alicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A8 protein]26875642
D009637MasoprocolUGT1A8 protein results in increased glucuronidation of Masoprocol14557274
D008528Mefenamic AcidUGT1A8 protein results in increased glucuronidation of Mefenamic Acid15117964
D008727MethotrexateMethotrexate results in decreased expression of UGT1A8 mRNA20854796
D008748MethylcholanthreneMethylcholanthrene results in increased expression of UGT1A8 mRNA19118567|2860143
C033069methyl salicylateUGT1A8 protein results in increased glucuronidation of methyl salicylate15117964
C016599mono-(2-ethylhexyl)phthalateUGT1A8 protein results in increased glucuronidation of mono-(2-ethylhexyl)phthalate27071666
C008548morinUGT1A8 protein results in increased glucuronidation of morin14557274
D009020MorphineUGT1A8 protein results in increased glucuronidation of Morphine12920162
C005273naringeninUGT1A8 protein results in increased glucuronidation of naringenin14557274
C027329naringenin chalconeUGT1A8 protein results in increased glucuronidation of naringenin chalcone14557274
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of UGT1A8 mRNA17616710
D009853OmeprazoleOmeprazole results in increased expression of UGT1A8 mRNA19118567
D010634Phenobarbital2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A8 mRNA]]25489928
D010634PhenobarbitalPhenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A8 mRNA]25489928
D010634PhenobarbitalPhenobarbital results in increased expression of UGT1A8 mRNA19631232
D010653PhenylbutazonePhenylbutazone inhibits the reaction [UGT1A8 protein results in increased glucuronidation of Diethylstilbestrol]23126256
D010693PhloretinUGT1A8 protein results in increased glucuronidation of Phloretin14557274
C014758plumbaginUGT1A8 protein results in increased glucuronidation of plumbagin14557274
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A8 mRNA16155002
D015742PropofolPropofol promotes the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]15378558
D015742PropofolPropofol results in decreased activity of UGT1A8 protein15378558
C107773pterostilbeneUGT1A8 protein affects the glucuronidation of pterostilbene23965644
C033607puerarinUGT1A8 protein results in increased metabolism of puerarin22648071
D011794QuercetinUGT1A8 protein results in increased glucuronidation of Quercetin14557274
D011794QuercetinUGT1A8 protein results in increased glucuronidation of Quercetin15502008
C059514resveratrolUGT1A8 protein results in increased glucuronidation of resveratrol23965644
D020156Salicylic AcidUGT1A8 protein results in increased glucuronidation of Salicylic Acid15117964
D012603ScopoletinUGT1A8 protein results in increased glucuronidation of Scopoletin15802387
C009250sevofluranesevoflurane affects the expression of UGT1A8 mRNA15967596
D013467SulindacUGT1A8 protein results in increased glucuronidation of Sulindac15843492
C025463sulindac sulfoneUGT1A8 protein results in increased glucuronidation of sulindac sulfone15843492
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A8 mRNA16155002
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A8 mRNA28213091
D013943ThymolUGT1A8 protein results in increased glucuronidation of Thymol14557274
D014028Tobacco Smoke PollutionDoxycycline promotes the reaction [Tobacco Smoke Pollution results in increased expression of UGT1A8 mRNA]22273977
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of UGT1A8 mRNA22273977
D014635Valproic Acid[Carbon Tetrachloride co-treated with Valproic Acid] results in increased expression of UGT1A8 mRNA17617793
D014641Vanillic AcidUGT1A8 protein results in increased glucuronidation of Vanillic Acid15117964
C100058vanillinUGT1A8 protein results in increased glucuronidation of vanillin15117964
C111237vorinostatUGT1A8 protein results in increased glucuronidation of vorinostat25393417
C111237vorinostatvorinostat results in decreased expression of UGT1A8 mRNA18769122
C410959Z 338UGT1A8 protein affects the metabolism of Z 33815306208

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001972retinoic acid binding-IC20308471  
GO:0004857enzyme inhibitor activity-IDA19996319  
GO:0005496steroid binding-IDA19996319  
GO:0005504fatty acid binding-IDA19996319  
GO:0008194UDP-glycosyltransferase activity-IBA21873635  
GO:0015020glucuronosyltransferase activity-IDA18052087  19996319  20056724  20308471  
GO:0042803protein homodimerization activity-IDA17179145  
GO:0046982protein heterodimerization activity-IDA17179145  
GO ID GO Term Qualifier Evidence PubMed
GO:0006631fatty acid metabolic process-IC19996319  
GO:0008202steroid metabolic process-IC19996319  
GO:0009804coumarin metabolic process-IC19996319  
GO:0042573retinoic acid metabolic process-IC20308471  
GO:0043086negative regulation of catalytic activity-IEA-  
GO:0045922negative regulation of fatty acid metabolic process-IC19996319  
GO:0045939negative regulation of steroid metabolic process-IC19996319  
GO:0051552flavone metabolic process-IDA18052087  
GO:0052696flavonoid glucuronidation-IBA21873635  
GO:0052696flavonoid glucuronidation-IDA20056724  
GO:0052697xenobiotic glucuronidation-IBA21873635  
GO:0052697xenobiotic glucuronidation-IDA20056724  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA17179145  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa00053Ascorbate and aldarate metabolism
hsa00140Steroid hormone biosynthesis
hsa00500Starch and sucrose metabolism
hsa00514Other types of O-glycan biosynthesis
hsa00830Retinol metabolism
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156588GlucuronidationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15247627Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis. (2004 Jun)Verlaan MPharmacogenetics
12167564N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. (2002 Sep)Ghosheh ODrug Metab Dispos