Gene: UGT1A7

54577
UDPGT|UDPGT 1-7|UGT-1G|UGT1-07|UGT1.7|UGT1G
UDP glucuronosyltransferase family 1 member A7
protein-coding
2q37.1
Ensembl:ENSG00000244122 MIM:606432 Vega:OTTHUMG00000059004 UniprotKB:Q9HAW7
NC_000002.12
PubMed
0   ANCO-SNPs
ND
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.719e-1 (AD)  3.416e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADH70.744
DNAJB30.715
SERPINB30.694
KRT370.69
SPINK50.685
MUC210.669
DAZ10.667
TMPRSS11B0.656
SERPINB40.653
TMPRSS11E0.653

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYS1-0.219
ACVR1C-0.213
STXBP6-0.203
PCDHB10-0.202
STEAP2-0.198
CCNO-0.197
CUX2-0.196
CBLN4-0.195
PIP5K1B-0.193
TMEM56-0.192

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnEnzyme
DB00688Mycophenolate mofetilSmall Molecule128794-94-5Approved|InvestigationalEnzyme
DB01024Mycophenolic acidSmall Molecule24280-93-1ApprovedEnzyme
ID Drug Name Action PubMed
C5432111,2,5,8-tetrahydroxy anthraquinone"UGT1A7 protein results in increased glucuronidation of 1,2,5,8-tetrahydroxy anthraquinone"14557274
C0348901,4-dihydroxyanthraquinone"UGT1A7 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone"14557274
C0331461-hydroxypyreneUGT1A7 protein results in increased glucuronidation of 1-hydroxypyrene15802387
C0293501-naphtholUGT1A7 protein results in increased glucuronidation of 1-naphthol24728488
C0293501-naphtholUGT1A7 protein results in increased glucuronidation of 1-naphthol9264550
C0293501-naphtholUGT1A7 protein results in increased glucuronidation of 1-naphthol15502008|2284637
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of UGT1A7 mRNA"17964624
C0593542',4'-dihydroxychalcone"UGT1A7 protein results in increased glucuronidation of 2',4'-dihydroxychalcone"14557274
C1074972',5'-dihydroxychalcone"UGT1A7 protein results in increased glucuronidation of 2',5'-dihydroxychalcone"14557274
C0348892,6-dihydroxyanthraquinone"UGT1A7 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone"14557274
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A7 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15310245
C0013902-hydroxyestradiolUGT1A7 protein results in increased glucuronidation of 2-hydroxyestradiol15117964
C0249802-hydroxyestroneUGT1A7 protein results in increased glucuronidation of 2-hydroxyestrone15117964
C0228302-methoxyestradiolUGT1A7 protein results in increased glucuronidation of 2-methoxyestradiol15117964
C0284052-naphtholUGT1A7 protein results in increased glucuronidation of 2-naphthol9264550
C0194992-nitrofluorene2-nitrofluorene results in increased expression of UGT1A7 mRNA14600272
C0608432-vanillinUGT1A7 protein results in increased glucuronidation of 2-vanillin15117964
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of UGT1A7 mRNA"19692669|2095900
C0902303,6-dihydroxychrysene"UGT1A7 protein results in increased glucuronidation of 3,6-dihydroxychrysene"7786300
C0352533-phenylpropionic acidUGT1A7 protein results in increased glucuronidation of 3-phenylpropionic acid15117964
C0264184-hydroxyestroneUGT1A7 protein results in increased glucuronidation of 4-hydroxyestrone15117964
C0264184-hydroxyestroneUGT1A7 protein results in increased glucuronidation of 4-hydroxyestrone9264550
C0286904-isopropylphenolUGT1A7 protein results in increased glucuronidation of 4-isopropylphenol9264550
C0248364-nitrophenolUGT1A7 protein results in increased glucuronidation of 4-nitrophenol24728488
C0248364-nitrophenolUGT1A7 protein results in increased glucuronidation of 4-nitrophenol15802387
C0248364-nitrophenolUGT1A7 protein results in increased glucuronidation of 4-nitrophenol9264550
C0248364-nitrophenolUGT1A7 protein results in increased glucuronidation of 4-nitrophenol15502008
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of UGT1A7 mRNA14600272
C0190464-phenylphenolUGT1A7 protein results in increased glucuronidation of 4-phenylphenol9264550
C0872036-hydroxychryseneUGT1A7 protein results in increased glucuronidation of 6-hydroxychrysene7786300
C1217077,3'-dihydroxy-4'-methoxyisoflavone"UGT1A7 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone"25044472
C0314777-hydroxycoumarinUGT1A7 protein results in increased glucuronidation of 7-hydroxycoumarin15502008
D000082AcetaminophenUGT1A7 protein results in increased glucuronidation of Acetaminophen15117964
D000082AcetaminophenUGT1A7 protein results in increased glucuronidation of Acetaminophen15502008
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of UGT1A7 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of UGT1A7 mRNA14600272
C010078alizarinUGT1A7 protein results in increased glucuronidation of alizarin14557274
C006457alloinUGT1A7 protein results in increased glucuronidation of alloin14557274
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in increased expression of UGT1A7 mRNA16940010
C032186anthrarobinUGT1A7 protein results in increased glucuronidation of anthrarobin14557274
D047310ApigeninUGT1A7 protein results in increased glucuronidation of Apigenin14557274
D001241AspirinUGT1A7 protein results in increased glucuronidation of Aspirin15117964
D001554BenzeneUGT1A7 protein results in increased metabolism of Benzene17479406
C054191benzo(a)pyrene-3,6-quinol"UGT1A7 protein results in increased glucuronidation of benzo(a)pyrene-3,6-quinol"7786300
C006703benzo(b)fluoranthene"[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A7 mRNA"15566942
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of UGT1A7 mRNA19118567|2860143
C022921benzo(k)fluoranthene"[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A7 mRNA"15566942
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGT1A7 mRNA15566942
D001564Benzo(a)pyrene"[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A7 mRNA"15566942
D001564Benzo(a)pyreneUGT1A7 protein results in increased glucuronidation of Benzo(a)pyrene14557274
D001564Benzo(a)pyreneUGT1A7 protein results in increased glucuronidation of Benzo(a)pyrene15502008
D001564Benzo(a)pyreneUGT1A7 protein results in increased glucuronidation of Benzo(a)pyrene metabolite15502008
C068337bergamottinUGT1A7 protein results in increased glucuronidation of bergamottin analog14557274
D004958EstradiolUGT1A7 protein results in increased glucuronidation of Estradiol15117964
D004958EstradiolUGT1A7 protein results in increased glucuronidation of Estradiol15502008
D001663BilirubinUGT1A7 protein results in increased glucuronidation of Bilirubin24728488
C004541biochanin AUGT1A7 protein results in increased glucuronidation of biochanin A14557274
C012776biphenylylacetic acidUGT1A7 protein results in increased glucuronidation of biphenylylacetic acid15117964
C006780bisphenol AUGT1A7 protein results in increased glucuronidation of bisphenol A24728488
C006780bisphenol AUGT1A7 protein results in increased glucuronidation of bisphenol A15502008
D002085ButylhydroxybutylnitrosamineButylhydroxybutylnitrosamine results in decreased expression of UGT1A7 mRNA15374950
D002085Butylhydroxybutylnitrosamineoltipraz inhibits the reaction [Butylhydroxybutylnitrosamine results in decreased expression of UGT1A7 mRNA]15374950
C006862butylphenUGT1A7 protein results in increased glucuronidation of butylphen9264550
D002104CadmiumCadmium results in decreased expression of UGT1A7 mRNA17327700
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of UGT1A7 mRNA17327700
C040048caffeic acidUGT1A7 protein results in increased glucuronidation of caffeic acid15117964
D002211CapsaicinUGT1A7 protein results in increased glucuronidation of Capsaicin14557274
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of UGT1A7 mRNA27174168
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of UGT1A7 mRNA18178546
D002726Chlorogenic AcidUGT1A7 protein results in increased glucuronidation of Chlorogenic Acid15117964
C031180chrysenechrysene results in increased expression of UGT1A7 mRNA15566942
C043561chrysinUGT1A7 protein results in increased glucuronidation of chrysin14557274
C043561chrysinUGT1A7 protein results in increased glucuronidation of chrysin15502008
C029010cinnamic acidUGT1A7 protein results in increased glucuronidation of cinnamic acid15117964
D002995Clofibric AcidUGT1A7 protein results in increased glucuronidation of Clofibric Acid15117964
D003375CoumestrolUGT1A7 protein results in increased glucuronidation of Coumestrol14557274
D003474CurcuminUGT1A7 protein results in increased glucuronidation of Curcumin14557274
C004742daidzeinUGT1A7 protein results in increased glucuronidation of daidzein14557274
D003907DexamethasoneDexamethasone results in increased expression of UGT1A7 mRNA19118567
C041517dibenzo(a,l)pyrene"[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A7 mRNA"15566942
C041517dibenzo(a,l)pyrene"UGT1A7 protein results in increased glycosylation of dibenzo(a,l)pyrene"21780761
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of UGT1A7 mRNA27392435
D004008DiclofenacUGT1A7 protein results in increased glucuronidation of Diclofenac24728488
D004008DiclofenacUGT1A7 protein results in increased glucuronidation of Diclofenac15117964
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] affects the expression of UGT1A7 mRNA17967931
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] affects the expression of UGT1A7 protein17967931
D004041Dietary FatsDietary Fats results in decreased expression of UGT1A7 protein17967931
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] affects the expression of UGT1A7 mRNA17967931
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] affects the expression of UGT1A7 protein17967931
D004061DiflunisalUGT1A7 protein results in increased glucuronidation of Diflunisal15117964
D000875AnthralinUGT1A7 protein results in increased glucuronidation of Anthralin15117964
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of UGT1A7 mRNA14600272
C037760diphenylacetic acidUGT1A7 protein results in increased glucuronidation of diphenylacetic acid15117964
D004237DiuronDiuron results in increased expression of UGT1A7 mRNA21551480
D004642EmodinUGT1A7 protein results in increased glucuronidation of Emodin14557274
C071192entacaponeUGT1A7 protein results in increased glucuronidation of entacapone15802387
D060754EquolUGT1A7 protein results in increased glucuronidation of Equol14557274
D004964EstriolUGT1A7 protein results in increased glucuronidation of Estriol15117964
D004964EstriolUGT1A7 protein results in increased glucuronidation of Estriol analog15117964
D004964EstriolUGT1A7 protein results in increased glucuronidation of Estriol15502008
D004970EstroneUGT1A7 protein results in increased glucuronidation of Estrone15117964
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Spironolactone] results in increased activity of UGT1A7 protein17686906
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of UGT1A7 protein17686906
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UGT1A7 mRNA15834898
C052488ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxzoleacetateUGT1A7 protein results in increased glucuronidation of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxzoleacetate15988124
D005054EugenolUGT1A7 protein results in increased glucuronidation of Eugenol14557274
D015025ZearalenoneUGT1A7 protein results in increased glucuronidation of Zearalenone14557274
D005279FenoprofenUGT1A7 protein results in increased glucuronidation of Fenoprofen15117964
C004999ferulic acidUGT1A7 protein results in increased glucuronidation of ferulic acid15117964
C017875fisetinUGT1A7 protein results in increased glucuronidation of fisetin14557274
D005480FlurbiprofenUGT1A7 protein results in increased glucuronidation of Flurbiprofen15117964
C007768formononetinUGT1A7 protein results in increased glucuronidation of formononetin14557274
D005665FurosemideUGT1A7 protein results in increased glucuronidation of Furosemide15117964
C037032galanginUGT1A7 protein results in increased glucuronidation of galangin14557274
D019833GenisteinUGT1A7 protein results in increased glucuronidation of Genistein14557274
D005978GlutathioneGlutathione deficiency results in increased expression of UGT1A7 mRNA15345336
C075375grepafloxacinUGT1A7 protein results in increased glucuronidation of grepafloxacin15769885
C013025hydratropic acidUGT1A7 protein results in increased glucuronidation of hydratropic acid15117964
D006923HymecromoneUGT1A7 protein results in increased glucuronidation of Hymecromone24728488
D006923HymecromoneHymecromone results in increased activity of UGT1A7 protein26875642
D006923Hymecromonelicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A7 protein]26875642
D006923HymecromoneUGT1A7 protein results in increased glucuronidation of Hymecromone15802387|2539341
D006923HymecromoneWarfarin affects the reaction [UGT1A7 protein results in increased glucuronidation of Hymecromone]25393417
D006923Hymecromone[Warfarin binds to and affects the activity of UGT1A7 protein] which affects the glucuronidation of Hymecromone25393417
D006923HymecromoneUGT1A7 protein results in increased glucuronidation of Hymecromone15502008
D007052IbuprofenUGT1A7 protein results in increased glucuronidation of Ibuprofen15117964
D007099ImipramineUGT1A7 protein results in increased glucuronidation of Imipramine9264550
D007213IndomethacinUGT1A7 protein results in increased glucuronidation of Indomethacin15117964|1584349
D007216IndoprofenUGT1A7 protein results in increased glucuronidation of Indoprofen15117964
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UGT1A7 mRNA25613284
C051890irinotecanUGT1A7 protein results in increased glucuronidation of irinotecan15716465|1583393
C051890irinotecanUGT1A7 protein results in increased glucuronidation of irinotecan15833930
C040920isoliquiritigeninUGT1A7 protein results in increased glucuronidation of isoliquiritigenin14557274
C008216isovaleric acidUGT1A7 protein results in increased glucuronidation of isovaleric acid analog15117964
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of UGT1A7 mRNA27392435
C544151jinfukangjinfukang results in increased expression of UGT1A7 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UGT1A7 mRNA26752646
C006552kaempferolUGT1A7 protein results in increased glucuronidation of kaempferol14557274
C070840licochalcone Alicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A7 protein]26875642
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of UGT1A7 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of UGT1A7 mRNA15980103
D009637MasoprocolUGT1A7 protein results in increased glucuronidation of Masoprocol14557274
D008528Mefenamic AcidUGT1A7 protein results in increased glucuronidation of Mefenamic Acid15117964
D008748MethylcholanthreneMethylcholanthrene results in increased expression of UGT1A7 mRNA19118567|2860143
C033069methyl salicylateUGT1A7 protein results in increased glucuronidation of methyl salicylate15117964
C016599mono-(2-ethylhexyl)phthalateUGT1A7 protein results in increased glucuronidation of mono-(2-ethylhexyl)phthalate27071666
C008548morinUGT1A7 protein results in increased glucuronidation of morin14557274
C104727moxifloxacinUGT1A7 protein results in increased glucuronidation of moxifloxacin15769885
D009173Mycophenolic AcidUGT1A7 protein results in increased glucuronidation of Mycophenolic Acid24728488
C005273naringeninUGT1A7 protein results in increased glucuronidation of naringenin14557274
C027329naringenin chalconeUGT1A7 protein results in increased glucuronidation of naringenin chalcone14557274
C464660obeticholic acidobeticholic acid results in decreased expression of UGT1A7 mRNA27939613
C016627octyl gallateUGT1A7 protein results in increased glucuronidation of octyl gallate9264550
D015242OfloxacinUGT1A7 protein results in increased glucuronidation of Ofloxacin15769885
C026209oltiprazoltipraz inhibits the reaction [Butylhydroxybutylnitrosamine results in decreased expression of UGT1A7 mRNA]15374950
D009853OmeprazoleOmeprazole results in increased expression of UGT1A7 mRNA19118567
D052638Particulate MatterParticulate Matter results in increased expression of UGT1A7 mRNA28341207
C086401pentabromodiphenyl etherpentabromodiphenyl ether affects the expression of UGT1A7 mRNA18978342
D010578PetroleumPetroleum results in increased expression of UGT1A7 mRNA25208076
C031181phenanthrene"[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A7 mRNA"15566942
D010634PhenobarbitalPhenobarbital results in increased expression of UGT1A7 mRNA16940010
D010693PhloretinUGT1A7 protein results in increased glucuronidation of Phloretin14557274
C014758plumbaginUGT1A7 protein results in increased glucuronidation of plumbagin14557274
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A7 mRNA16155002
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A7 mRNA19144771
D015742PropofolUGT1A7 protein results in increased glucuronidation of Propofol15502008
D011435Propyl GallateUGT1A7 protein results in increased glucuronidation of Propyl Gallate9264550
C033607puerarinUGT1A7 protein results in increased metabolism of puerarin22648071
C030984pyrene"[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A7 mRNA"15566942
D000644Quaternary Ammonium CompoundsUGT1A7 protein results in increased glucuronidation of Quaternary Ammonium Compounds9264550
D011794QuercetinUGT1A7 protein results in increased glucuronidation of Quercetin14557274
D011794QuercetinUGT1A7 protein results in increased glucuronidation of Quercetin15502008
C059514resveratrolUGT1A7 protein results in increased glucuronidation of resveratrol23965644
D020156Salicylic AcidUGT1A7 protein results in increased glucuronidation of Salicylic Acid15117964
D012603ScopoletinUGT1A7 protein results in increased glucuronidation of Scopoletin15802387
D012643SeleniumSelenium deficiency results in increased expression of UGT1A7 mRNA11444866
C076246sitafloxacinUGT1A7 protein results in increased glucuronidation of sitafloxacin15769885
D013148Spironolactone[Ethinyl Estradiol co-treated with Spironolactone] results in increased activity of UGT1A7 protein17686906
D013148Spironolactone[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of UGT1A7 protein17686906
D013148SpironolactoneSpironolactone results in increased activity of UGT1A7 protein17686906
D013148SpironolactoneSpironolactone results in increased expression of UGT1A7 protein17686906
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of UGT1A7 protein27239688
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A7 mRNA16155002
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A7 mRNA19144771
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A7 mRNA15716479
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A7 mRNA16054898|1817854
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UGT1A7 mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in increased expression of UGT1A7 protein20109541
D013974ThyroxineThyroxine results in increased expression of UGT1A7 mRNA17884940
D013943ThymolUGT1A7 protein results in increased glucuronidation of Thymol14557274
D014641Vanillic AcidUGT1A7 protein results in increased glucuronidation of Vanillic Acid15117964
C100058vanillinUGT1A7 protein results in increased glucuronidation of vanillin15117964
C100058vanillinUGT1A7 protein results in increased glucuronidation of vanillin9264550
D014859WarfarinWarfarin affects the reaction [UGT1A7 protein results in increased glucuronidation of Hymecromone]25393417
D014859WarfarinWarfarin binds to and affects the activity of UGT1A7 protein25393417
D014859Warfarin[Warfarin binds to and affects the activity of UGT1A7 protein] which affects the glucuronidation of Hymecromone25393417
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of UGT1A7 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001972retinoic acid binding-IDA20308471  
GO:0004857enzyme inhibitor activity-IDA19996319  
GO:0005080protein kinase C binding-IDA18556656  
GO:0008194UDP-glycosyltransferase activity-IBA21873635  
GO:0015020glucuronosyltransferase activity-IDA17179145  18052087  19996319  20056724  20308471  
GO:0042803protein homodimerization activity-IDA17179145  
GO:0046982protein heterodimerization activity-IDA17179145  
GO ID GO Term Qualifier Evidence PubMed
GO:0007588excretion-IC20056724  
GO:0009804coumarin metabolic process-IC19996319  
GO:0017144drug metabolic process-IC19996319  
GO:0042573retinoic acid metabolic process-IC20308471  
GO:0043086negative regulation of catalytic activity-IEA-  
GO:0051552flavone metabolic process-IC18052087  
GO:0052695cellular glucuronidation-IDA17179145  
GO:0052696flavonoid glucuronidation-IBA21873635  
GO:0052696flavonoid glucuronidation-IDA20056724  
GO:0052697xenobiotic glucuronidation-IBA21873635  
GO:0052697xenobiotic glucuronidation-IDA20056724  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA17179145  18556656  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa00053Ascorbate and aldarate metabolism
hsa00140Steroid hormone biosynthesis
hsa00500Starch and sucrose metabolism
hsa00514Other types of O-glycan biosynthesis
hsa00830Retinol metabolism
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156588GlucuronidationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25052559Active cigarette smoking, variants in carcinogen metabolism genes and breast cancer risk among pre- and postmenopausal women in Ontario, Canada. (2014 Sep-Oct)Cotterchio MBreast J
16724991Genetic polymorphisms of the uridine diphosphate glucuronosyltransferase 1A7 and colorectal cancer risk in relation to cigarette smoking and alcohol drinking in a Chinese population. (2006 Jun)Chen KJ Gastroenterol Hepatol
20193274[Association between genetic polymorphism of UGT1A7 and susceptibility of bladder cancer]. (2009 Dec 1)Liu JZhonghua Yi Xue Za Zhi
12167564N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. (2002 Sep)Ghosheh ODrug Metab Dispos
25899702Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland. (2016 Apr)Lacko MHead Neck
15247627Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis. (2004 Jun)Verlaan MPharmacogenetics
19331232Genetic polymorphisms of smoking-related carcinogen detoxifying enzymes and head and neck cancer susceptibility. (2009 Feb)Lacko MAnticancer Res
20534012Polymorphisms in CYP2A13 and UGT1A7 genes and head and neck cancer susceptibility in North Indians. (2010 Nov)Sharma ROral Dis