Gene info: ID 54578

Gene: UGT1A6

GENE ID: 54578

Description: UDP glucuronosyltransferase family 1 member A6

Gene type: protein-coding

Location: 2q37.1

dbXrefs: Ensembl:ENSG00000167165 MIM:606431 Vega:OTTHUMG00000059122 UniprotKB:P19224

RefSeq: NC_000002.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 10

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.749e-1 (AD) 3.441e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SULT1C3	0.84
OR5H1	0.835
OR6K6	0.825
RPTN	0.811
PRAMEF1	0.81
C14orf177	0.806
OR9G4	0.805
C12orf74	0.805
SLC7A13	0.801
DEFB118	0.799

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C16orf95	-0.243
FAM43B	-0.237
MRPL46	-0.234
ZNF835	-0.233
DBP	-0.233
PLA2G6	-0.232
HDDC3	-0.231
MRM1	-0.23
ABCB8	-0.229
CORO2B	-0.229

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00197	Troglitazone	Small Molecule	97322-87-7	Investigational\|Withdrawn	Enzyme
DB00313	Valproic Acid	Small Molecule	99-66-1	Approved\|Investigational	Enzyme
DB00316	Acetaminophen	Small Molecule	103-90-2	Approved	Enzyme
DB00688	Mycophenolate mofetil	Small Molecule	128794-94-5	Approved\|Investigational	Enzyme
DB00818	Propofol	Small Molecule	2078-54-8	Approved\|Investigational	Enzyme
DB01024	Mycophenolic acid	Small Molecule	24280-93-1	Approved	Enzyme
DB08826	Deferiprone	Small Molecule	30652-11-0	Approved	Enzyme

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of UGT1A6 mRNA"	27818994
C053486	1,7-phenanthroline	"1,7-phenanthroline promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UGT1A6 protein]"	17967931
C053486	1,7-phenanthroline	"1,7-phenanthroline results in increased expression of UGT1A6 protein"	17967931
C033146	1-hydroxypyrene	UGT1A6 protein results in increased glucuronidation of 1-hydroxypyrene	15802387
C029350	1-naphthol	UGT1A6 protein results in increased glucuronidation of 1-naphthol	11324718
C029350	1-naphthol	beta-Naphthoflavone promotes the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]	7646562
C029350	1-naphthol	Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]	22265884
C029350	1-naphthol	Indomethacin inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]	22265884
C029350	1-naphthol	UGT1A6 protein results in increased glucuronidation of 1-naphthol	12756209\|2226588
C029350	1-naphthol	Methylcholanthrene promotes the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]	19023562
C029350	1-naphthol	Paraquat promotes the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]	19023562
C029350	1-naphthol	UGT1A6 gene polymorphism affects the metabolism of 1-naphthol	9429234
C029350	1-naphthol	UGT1A6 protein affects the metabolism of 1-naphthol	15336321
C029350	1-naphthol	UGT1A6 protein results in increased glucuronidation of 1-naphthol	12153725\|1902356
C029350	1-naphthol	UGT1A6 protein results in increased metabolism of 1-naphthol	9429234
C492600	(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate	"(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate affects the expression of UGT1A6 mRNA"	19176366
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of UGT1A6 mRNA"	24713691
C009828	2,4,5,2',5'-pentachlorobiphenyl	"2,4,5,2',5'-pentachlorobiphenyl results in increased expression of and results in increased activity of UGT1A6 protein"	15254343
C533342	2,4,6-triphenyl-1-hexene	"2,4,6-triphenyl-1-hexene results in decreased expression of UGT1A6 mRNA"	18560529
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of UGT1A6 mRNA"	21346803
C035208	2-amino-4,6-dinitrotoluene	"2-amino-4,6-dinitrotoluene affects the expression of UGT1A6 mRNA"	21346803
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A6 mRNA]]	25489928
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased activity of UGT1A6 protein	12948865
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of UGT1A6 mRNA	10220484\|1294886
C018855	2-tert-butylhydroquinone	AHR protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of UGT1A6 mRNA]	12948865
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of UGT1A6 mRNA	12948865
C018855	2-tert-butylhydroquinone	AHR protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of UGT1A6 mRNA]	12948865
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of UGT1A6 mRNA"	19144771
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of UGT1A6 mRNA"	19692669\|2095900
C090230	3,6-dihydroxychrysene	"UGT1A6 protein results in increased glucuronidation of 3,6-dihydroxychrysene"	7786300
C497701	3-ethylphenol	UGT1A6 gene polymorphism affects the metabolism of 3-ethylphenol	9429234
C497701	3-ethylphenol	UGT1A6 protein results in increased metabolism of 3-ethylphenol	9429234
C417190	4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine	"4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine results in increased expression of UGT1A6 mRNA"	19768707
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of UGT1A6 mRNA"	21346803
C068805	4-hydroxycoumarin	UGT1A6 gene polymorphism affects the metabolism of 4-hydroxycoumarin	9429234
C068805	4-hydroxycoumarin	UGT1A6 protein results in increased metabolism of 4-hydroxycoumarin	9429234
C024836	4-nitrophenol	UGT1A6 gene polymorphism affects the glucuronidation of 4-nitrophenol	15761113
C024836	4-nitrophenol	UGT1A6 gene SNP affects the glucuronidation of 4-nitrophenol	15284531
C024836	4-nitrophenol	UGT1A6 protein results in increased glucuronidation of 4-nitrophenol	15284531\|1576111
C024836	4-nitrophenol	UGT1A6 gene polymorphism affects the metabolism of 4-nitrophenol	9429234
C024836	4-nitrophenol	UGT1A6 protein results in increased glucuronidation of 4-nitrophenol	15921999
C024836	4-nitrophenol	UGT1A6 protein results in increased metabolism of 4-nitrophenol	9429234
C070058	4-trifluoromethylumbelliferyl iduronide	UGT1A6 protein results in increased glucuronidation of 4-trifluoromethylumbelliferyl iduronide	15357915
C087203	6-hydroxychrysene	UGT1A6 protein results in increased glucuronidation of 6-hydroxychrysene	7786300
C084236	7-hydroxy-4-trifluoromethylcoumarin	silybin inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]	15155549
C084236	7-hydroxy-4-trifluoromethylcoumarin	UGT1A6 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin	15155549
C031477	7-hydroxycoumarin	UGT1A6 gene polymorphism affects the metabolism of 7-hydroxycoumarin	9429234
C031477	7-hydroxycoumarin	UGT1A6 protein results in increased metabolism of 7-hydroxycoumarin	9429234
D000082	Acetaminophen	UGT1A6 protein results in increased glucuronidation of Acetaminophen	11903872
D000082	Acetaminophen	UGT1A6 protein results in increased glucuronidation of Acetaminophen	11903872
D000082	Acetaminophen	Acetaminophen results in decreased expression of UGT1A6 mRNA	29067470
D000082	Acetaminophen	UGT1A6 gene polymorphism affects the glucuronidation of Acetaminophen	15761113
D000082	Acetaminophen	UGT1A6 protein results in increased glucuronidation of Acetaminophen	11186135\|1190387
D000082	Acetaminophen	Acetaminophen results in decreased activity of UGT1A6 protein	16831125
D000082	Acetaminophen	Acetaminophen results in decreased expression of UGT1A6 mRNA	26772156
D000082	Acetaminophen	hyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A6 mRNA]	26772156
D000082	Acetaminophen	[NFE2L2 protein affects the expression of UGT1A6 mRNA] which affects the susceptibility to Acetaminophen	11134556
D000082	Acetaminophen	SOD1 affects the reaction [Acetaminophen results in decreased activity of UGT1A6 protein]	16831125
D000082	Acetaminophen	UGT1A6 protein results in increased glucuronidation of Acetaminophen	11903872
D000082	Acetaminophen	UGT1A6 protein results in increased glucuronidation of Acetaminophen	11903872
D000082	Acetaminophen	Acetaminophen affects the expression of UGT1A6 mRNA	12883083
D000082	Acetaminophen	UGT1A6 protein results in increased glucuronidation of Acetaminophen	16023900
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA]	22129741
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Vitamin K 3 results in increased activity of UGT1A6 promoter]	15336321
D000171	Acrolein	Acrolein results in increased expression of UGT1A6 mRNA	12763045
D020106	Acrylamide	Acrylamide results in increased expression of UGT1A6 mRNA	28959563
D000319	Adrenergic beta-Antagonists	UGT1A6 gene polymorphism affects the metabolism of Adrenergic beta-Antagonists	9429234
D000319	Adrenergic beta-Antagonists	UGT1A6 protein results in increased metabolism of Adrenergic beta-Antagonists	9429234
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of UGT1A6 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of UGT1A6 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of UGT1A6 mRNA	23630614
C103303	alitretinoin	alitretinoin results in decreased expression of UGT1A6 mRNA	14620509
C038491	allyl sulfide	allyl sulfide results in increased expression of UGT1A6 mRNA	19144771
C038491	allyl sulfide	allyl sulfide inhibits the reaction [Diethylnitrosamine results in decreased expression of UGT1A6 mRNA]	23494807
C038491	allyl sulfide	allyl sulfide inhibits the reaction [Diethylnitrosamine results in decreased expression of UGT1A6 protein]	23494807
C038491	allyl sulfide	allyl sulfide results in increased expression of UGT1A6 mRNA	19768707
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in increased expression of UGT1A6 mRNA	17785943
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of UGT1A6 mRNA	16483693
C030419	andrographolide	[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of UGT1A6 mRNA	19737545
C030419	andrographolide	andrographolide results in increased expression of UGT1A6 mRNA	19737545
D000840	Anisoles	UGT1A6 gene polymorphism affects the metabolism of Anisoles	9429234
D000840	Anisoles	UGT1A6 protein results in increased metabolism of Anisoles	9429234
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of UGT1A6 mRNA	28713220
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of UGT1A6 mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of UGT1A6 mRNA	23912714
C006632	arsenic trioxide	arsenic trioxide results in increased expression of UGT1A6 mRNA	20458559
D001205	Ascorbic Acid	UGT1A6 protein affects the reaction [Methylcholanthrene results in increased abundance of Ascorbic Acid]	8263600
D001241	Aspirin	Aspirin affects the expression of UGT1A6 mRNA	12800193
C051597	Bandrowski's base	Bandrowski's base results in increased expression of UGT1A6 mRNA	20566472
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of UGT1A6 mRNA	7587946
C030935	benz(a)anthracene	Dexamethasone promotes the reaction [benz(a)anthracene results in increased expression of UGT1A6 mRNA]	7587946
D001554	Benzene	UGT1A6 protein results in increased metabolism of Benzene	17479406
D001554	Benzene	Benzene affects the expression of UGT1A6 mRNA	15878777
D001554	Benzene	[Methylcholanthrene results in increased activity of UGT1A6 protein] which affects the metabolism of Benzene	1981726
C054191	benzo(a)pyrene-3,6-quinol	"UGT1A6 protein results in increased glucuronidation of benzo(a)pyrene-3,6-quinol"	7786300
C006703	benzo(b)fluoranthene	"[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA"	15566942
D019324	beta-Naphthoflavone	beta-Naphthoflavone promotes the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]	7646562
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of UGT1A6 mRNA	12948865\|1791726
D019324	beta-Naphthoflavone	[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of UGT1A6 mRNA	19737545
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of UGT1A6 mRNA	19144771\|1973754
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of UGT1A6 mRNA	12883083\|1911856
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of UGT1A6 mRNA	18164116
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of UGT1A6 mRNA	15566942
C022921	benzo(k)fluoranthene	"[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA"	15566942
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased activity of UGT1A6 protein	17065433
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of UGT1A6 mRNA	15566942\|1806139
D001564	Benzo(a)pyrene	GUSB protein promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A6 mRNA]	26438400
D001564	Benzo(a)pyrene	"[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA"	15566942
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of UGT1A6 mRNA	22342234
D001564	Benzo(a)pyrene	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A6 mRNA]]	25489928
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of UGT1A6 mRNA	25489928
D001564	Benzo(a)pyrene	Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A6 mRNA]	25489928
D001564	Benzo(a)pyrene	[Benzo(a)pyrene binds to AHR protein] which results in increased expression of UGT1A6	23656968
D001594	Benzyl Viologen	Benzyl Viologen results in increased expression of UGT1A6 mRNA	22846377
C006780	bisphenol A	bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]	18214896
C006780	bisphenol A	bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Serotonin]	18214896
C006780	bisphenol A	bisphenol A results in decreased expression of UGT1A6 mRNA	24214726
C006780	bisphenol A	bisphenol A affects the expression of UGT1A6 mRNA	25181051
C584056	BMS-764459	BMS-764459 results in increased expression of UGT1A6 mRNA	23831372
D002065	Buspirone	Buspirone results in increased expression of UGT1A6 mRNA	24136188
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of UGT1A6 mRNA	19144771
D002085	Butylhydroxybutylnitrosamine	Butylhydroxybutylnitrosamine results in decreased expression of UGT1A6 mRNA	15374950
D002085	Butylhydroxybutylnitrosamine	oltipraz inhibits the reaction [Butylhydroxybutylnitrosamine results in decreased expression of UGT1A6 mRNA]	15374950
C006862	butylphen	UGT1A6 gene polymorphism affects the metabolism of butylphen	9429234
C006862	butylphen	UGT1A6 protein results in increased metabolism of butylphen	9429234
C028031	cadmium acetate	cadmium acetate affects the expression of UGT1A6 mRNA	16249259
D002220	Carbamazepine	Carbamazepine results in increased expression of UGT1A6 mRNA	17381134
D002509	Cephaloridine	Cephaloridine results in increased expression of UGT1A6 mRNA	18500788
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in decreased expression of UGT1A6 mRNA	27174168
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of UGT1A6 mRNA	17851650
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of UGT1A6 mRNA	18178546\|2265931
C031180	chrysene	chrysene results in increased expression of UGT1A6 mRNA	15566942
C043561	chrysin	UGT1A6 protein affects the glucuronidation of chrysin	10950852
C039671	ciglitazone	[ciglitazone binds to PPARG protein alternative form] which results in increased expression of UGT1A6 mRNA	16197558
C020722	cinnamyl alcohol	cinnamyl alcohol results in increased expression of UGT1A6 mRNA	20566472
C019304	ciprofibrate	ciprofibrate results in increased expression of UGT1A6 mRNA	19144771
D002994	Clofibrate	Clofibrate results in increased expression of UGT1A6 mRNA	19144771
D002994	Clofibrate	Clofibrate results in increased expression of UGT1A6 mRNA	11328961
D002994	Clofibrate	Clofibrate results in increased expression of UGT1A6 protein	17967931
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of UGT1A6 mRNA	19376846
D003069	Coffee	Coffee results in increased expression of UGT1A6 mRNA	18028974
D003069	Coffee	NFE2L2 protein promotes the reaction [Coffee results in increased expression of UGT1A6 mRNA]	18028974
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of UGT1A6 mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of UGT1A6 mRNA	26577399
D003474	Curcumin	Curcumin results in increased expression of UGT1A6 mRNA	16819192
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Paraquat results in increased expression of UGT1A6 mRNA]	22846377
D016572	Cyclosporine	Cyclosporine results in decreased expression of UGT1A6 mRNA	20106945\|2798913
D016572	Cyclosporine	Cyclosporine results in increased expression of UGT1A6 mRNA	18172885
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of UGT1A6 mRNA	23726867
D003907	Dexamethasone	[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT1A6 mRNA	29222744
D003907	Dexamethasone	Dexamethasone results in increased expression of UGT1A6 mRNA	29222744
D003907	Dexamethasone	Dexamethasone promotes the reaction [benz(a)anthracene results in increased expression of UGT1A6 mRNA]	7587946
D003907	Dexamethasone	Dexamethasone results in increased expression of UGT1A6 mRNA	11328961\|1696222
D016190	Carboplatin	Carboplatin results in decreased expression of UGT1A6 mRNA	18172885
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in increased expression of UGT1A6 mRNA"	15566942
C041517	dibenzo(a,l)pyrene	"[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA"	15566942
D002945	Cisplatin	UGT1A6 protein affects the susceptibility to Cisplatin	16217747
D004008	Diclofenac	Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]	22265884
C121718	dicyclanil	dicyclanil results in increased expression of UGT1A6 mRNA	15664270
D004041	Dietary Fats	"1,7-phenanthroline promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UGT1A6 protein]"	17967931
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UGT1A6 mRNA	17967931
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UGT1A6 protein	17967931
D019422	Dietary Sucrose	"1,7-phenanthroline promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UGT1A6 protein]"	17967931
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UGT1A6 mRNA	17967931
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UGT1A6 protein	17967931
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of UGT1A6 mRNA	19144771
D004052	Diethylnitrosamine	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA]	22129741
D004052	Diethylnitrosamine	allyl sulfide inhibits the reaction [Diethylnitrosamine results in decreased expression of UGT1A6 mRNA]	23494807
D004052	Diethylnitrosamine	allyl sulfide inhibits the reaction [Diethylnitrosamine results in decreased expression of UGT1A6 protein]	23494807
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of UGT1A6 mRNA	18164116
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of UGT1A6 mRNA	18544905
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of UGT1A6 mRNA	23494807
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of UGT1A6 protein	23494807
D004052	Diethylnitrosamine	[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA	22467020
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA	18253720\|1877588
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA	22129741
D004052	Diethylnitrosamine	[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA	22687989
C472511	dimethylarsinous acid	dimethylarsinous acid results in increased expression of UGT1A6 mRNA	20886546
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene binds to AHR protein] which results in increased expression of UGT1A6"	23656968
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide affects the expression of UGT1A6 mRNA	12843640
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of UGT1A6 mRNA	20566472
D004221	Disulfiram	Disulfiram results in increased expression of UGT1A6 mRNA	20566472
D004237	Diuron	Diuron results in increased expression of UGT1A6 mRNA	21551480
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased expression of UGT1A6 mRNA"	26590097
D004731	Endotoxins	Endotoxins results in decreased expression of UGT1A6 mRNA	19356101
C073539	erucin	erucin results in increased expression of UGT1A6 protein	21132492
D004923	Erythrosine	Erythrosine results in decreased activity of UGT1A6 protein	16009655
D004923	Erythrosine	Erythrosine results in decreased activity of UGT1A6 protein	20041016
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of UGT1A6 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UGT1A6 mRNA	17942748
C076840	ethofenprox	[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA	22467020
D005054	Eugenol	Eugenol results in increased expression of UGT1A6 mRNA	20566472
D005204	Farnesol	UGT1A6 protein results in increased glucuronidation of Farnesol	15320866
C047360	felbamate	felbamate results in increased expression of UGT1A6 mRNA	17381134
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA	18253720\|1877588
D011345	Fenofibrate	Fenofibrate results in increased expression of UGT1A6 mRNA	18775883
C097920	ferric 8-hydroxyquinoline	ferric 8-hydroxyquinoline results in increased expression of UGT1A6 mRNA	22846377
C097920	ferric 8-hydroxyquinoline	Melatonin inhibits the reaction [ferric 8-hydroxyquinoline results in increased expression of UGT1A6 mRNA]	22846377
D018120	Finasteride	Finasteride results in increased expression of UGT1A6 mRNA	24136188
D005419	Flavonoids	Flavonoids results in decreased expression of UGT1A6 mRNA	18035473
D005480	Flurbiprofen	UGT1A6 protein results in increased glucuronidation of Flurbiprofen	15843492
D005485	Flutamide	Flutamide results in increased expression of UGT1A6 mRNA	24136188\|2648540
D004397	Fonofos	Fonofos results in decreased methylation of UGT1A6 promoter	22847954
D005505	Food Coloring Agents	Food Coloring Agents results in decreased activity of UGT1A6 protein	18686201
D005897	Glafenine	Glafenine results in decreased expression of UGT1A6 mRNA	24136188
D005978	Glutathione	Glutathione deficiency results in increased expression of UGT1A6 mRNA	15345336
C001335	hexachlorobutadiene	hexachlorobutadiene results in increased expression of UGT1A6 mRNA	21905055
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde results in increased expression of UGT1A6 mRNA	20566472
D012701	Serotonin	bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Serotonin]	18214896
D012701	Serotonin	UGT1A6 gene polymorphism affects the glucuronidation of Serotonin	15761113
D012701	Serotonin	UGT1A6 gene polymorphism affects the glucuronidation of Serotonin metabolite	15761113
D012701	Serotonin	UGT1A6 protein results in increased glucuronidation of Serotonin	15761113\|1576111
D012701	Serotonin	UGT1A6 protein results in increased glucuronidation of Serotonin metabolite	15761113
C031927	hydroquinone	UGT1A6 protein results in increased metabolism of hydroquinone	9118891
C001419	hydroxyphenytoin	UGT1A6 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin	15855726
D006923	Hymecromone	UGT1A6 protein results in increased glucuronidation of Hymecromone	11324718
D006923	Hymecromone	bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]	18214896
D006923	Hymecromone	Hymecromone results in increased activity of UGT1A6 protein	26875642
D006923	Hymecromone	licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A6 protein]	26875642
D006923	Hymecromone	UGT1A6 protein results in increased glucuronidation of Hymecromone	15802387\|1821489
D006923	Hymecromone	UGT1A6 gene polymorphism affects the metabolism of Hymecromone	9429234
D006923	Hymecromone	UGT1A6 protein results in increased metabolism of Hymecromone	9429234
D006923	Hymecromone	UGT1A6 protein results in increased glucuronidation of Hymecromone	16023900
C021304	hyperoside	hyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A6 mRNA]	26772156
D007052	Ibuprofen	[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT1A6 mRNA	29222744
D007052	Ibuprofen	Ibuprofen results in increased expression of UGT1A6 mRNA	29222744
D007200	Indican	Indican results in increased expression of UGT1A6 mRNA	20000589
C016517	indole-3-carbinol	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA]	22129741
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of UGT1A6 mRNA	21396975
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA	22129741
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole results in increased expression of UGT1A6 mRNA"	18061397
D007213	Indomethacin	Indomethacin inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]	22265884
C051890	irinotecan	UGT1A6 protein results in increased glucuronidation of irinotecan	15716465
D007501	Iron	[Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of UGT1A6 mRNA	22198552
C036643	isoeugenol	isoeugenol results in increased expression of UGT1A6 mRNA	20566472
D007559	Ivermectin	Ivermectin results in increased expression of UGT1A6 mRNA	26443706
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of UGT1A6 mRNA	26752646
D007660	Ketoprofen	UGT1A6 protein results in increased glucuronidation of Ketoprofen	15843492
D007660	Ketoprofen	UGT1A6 protein affects the metabolism of Ketoprofen	15336321
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of UGT1A6 mRNA	18544905
C045463	leflunomide	leflunomide results in increased expression of UGT1A6 mRNA	24136188
C070840	licochalcone A	licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A6 protein]	26875642
D001556	Lindane	Lindane results in increased expression of UGT1A6 mRNA	17785943
C506658	lorcaserin	UGT1A6 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin	22259019
D008550	Melatonin	Melatonin inhibits the reaction [ferric 8-hydroxyquinoline results in increased expression of UGT1A6 mRNA]	22846377
D008550	Melatonin	Melatonin inhibits the reaction [Paraquat results in increased expression of UGT1A6 mRNA]	22846377
D008727	Methotrexate	Methotrexate results in decreased expression of UGT1A6 mRNA	24449571
D008727	Methotrexate	Methotrexate results in increased expression of UGT1A6 mRNA	20854796
D008727	Methotrexate	UGT1A6 protein results in decreased susceptibility to Methotrexate	20854796
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of UGT1A6 mRNA	19118567\|2860143
D008748	Methylcholanthrene	Methylcholanthrene promotes the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]	19023562
D008748	Methylcholanthrene	Methylcholanthrene results in increased activity of UGT1A6 protein	1981726\|8263600
D008748	Methylcholanthrene	[Methylcholanthrene results in increased activity of UGT1A6 protein] which affects the metabolism of Benzene	1981726
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of UGT1A6 mRNA	11328961\|1902356
D008748	Methylcholanthrene	UGT1A6 protein affects the reaction [Methylcholanthrene results in increased abundance of Ascorbic Acid]	8263600
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of UGT1A6	9118891
C033069	methyl salicylate	UGT1A6 gene polymorphism affects the metabolism of methyl salicylate	9429234
C033069	methyl salicylate	UGT1A6 protein results in increased metabolism of methyl salicylate	9429234
C548427	monascusic acid A	monascusic acid A results in decreased activity of UGT1A6 protein	16009655
D009020	Morphine	UGT1A6 protein results in increased glucuronidation of Morphine	12920162
C035514	N-2-diazo-3,3,3-trifluoropropionyl-3,5,3'-triiodothyronine	"N-2-diazo-3,3,3-trifluoropropionyl-3,5,3'-triiodothyronine results in increased expression of UGT1A6 mRNA"	8635588
D009288	Naproxen	UGT1A6 protein results in increased glucuronidation of Naproxen	15843492
C051752	nefazodone	nefazodone results in increased expression of UGT1A6 mRNA	24136188
D009532	Nickel	[Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of UGT1A6 mRNA	22198552
C029938	nickel sulfate	nickel sulfate results in increased expression of UGT1A6 mRNA	20566472
C012655	nimesulide	nimesulide results in increased expression of UGT1A6 mRNA	24136188
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of UGT1A6 mRNA	19716841
C464660	obeticholic acid	obeticholic acid results in decreased expression of UGT1A6 mRNA	27939613
C025589	ochratoxin A	ochratoxin A results in increased expression of UGT1A6 mRNA	17316727
C026209	oltipraz	oltipraz inhibits the reaction [Butylhydroxybutylnitrosamine results in decreased expression of UGT1A6 mRNA]	15374950
C026209	oltipraz	oltipraz results in increased expression of UGT1A6 mRNA	15374950\|1914477
D009853	Omeprazole	Omeprazole results in increased expression of UGT1A6 mRNA	19118567
D009853	Omeprazole	[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA	22687989
D009853	Omeprazole	Omeprazole results in increased expression of UGT1A6 mRNA	19118567
D010269	Paraquat	Cycloheximide inhibits the reaction [Paraquat results in increased expression of UGT1A6 mRNA]	22846377
D010269	Paraquat	Melatonin inhibits the reaction [Paraquat results in increased expression of UGT1A6 mRNA]	22846377
D010269	Paraquat	Paraquat promotes the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]	19023562
D010269	Paraquat	Paraquat results in increased expression of UGT1A6 mRNA	19023562\|2284637
D010278	Parathion	Parathion results in decreased methylation of UGT1A6 promoter	22847954
D052638	Particulate Matter	Particulate Matter analog results in increased expression of UGT1A6 mRNA	15322212
C410127	PCB 180	PCB 180 results in increased expression of UGT1A6 protein	21458519
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether affects the expression of UGT1A6 mRNA	18978342
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of UGT1A6 mRNA	19162173
C031181	phenanthrene	phenanthrene results in increased expression of UGT1A6 mRNA	19457238
C031181	phenanthrene	"[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA"	15566942
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased expression of UGT1A6 protein	21132492
D010634	Phenobarbital	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A6 mRNA]]	25489928
D010634	Phenobarbital	Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A6 mRNA]	25489928
D010634	Phenobarbital	Phenobarbital results in increased expression of UGT1A6 mRNA	17381134\|1911856
D010634	Phenobarbital	Phenobarbital results in increased expression of UGT1A6 protein	17967931\|2409081
D019800	Phenol	UGT1A6 protein results in increased metabolism of Phenol	9118891
D010672	Phenytoin	Phenytoin results in increased expression of UGT1A6 mRNA	17381134
C085059	phloxine	phloxine results in decreased activity of UGT1A6 protein	20041016
C004479	pimagedine	pimagedine inhibits the reaction [Spermidine results in increased expression of UGT1A6 mRNA]	12763045
C006253	pirinixic acid	pirinixic acid results in increased expression of UGT1A6 mRNA	17151188
C006253	pirinixic acid	pirinixic acid results in increased expression of UGT1A6 protein	17151188
C006253	pirinixic acid	pirinixic acid results in increased expression of UGT1A6 mRNA	17151188
D010936	Plant Extracts	Plant Extracts results in increased expression of UGT1A6 mRNA	18061397
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in increased activity of UGT1A6 protein	7670183
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in increased expression of and results in increased activity of UGT1A6 protein	15254343
D011078	Polychlorinated Biphenyls	UGT1A6 protein results in increased glucuronidation of Polychlorinated Biphenyls analog	16006569
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of UGT1A6 mRNA	16155002
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of UGT1A6 protein	16155002
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of UGT1A6 mRNA	19144771
C033607	puerarin	UGT1A6 protein results in increased metabolism of puerarin	22648071
C030984	pyrene	"[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA"	15566942
C030984	pyrene	pyrene results in decreased expression of UGT1A6 mRNA	26160115
D011794	Quercetin	Quercetin results in increased expression of UGT1A6 mRNA	18094037
D011794	Quercetin	Quercetin results in increased expression of UGT1A6 mRNA	22334599
D012293	Rifampin	Rifampin results in increased expression of UGT1A6 mRNA	18094037
D012395	Rose Bengal	Rose Bengal results in decreased activity of UGT1A6 protein	20041016
D012503	Saponins	Saponins results in decreased expression of UGT1A6 mRNA	26590097
D012603	Scopoletin	UGT1A6 protein results in increased glucuronidation of Scopoletin	15802387
C009250	sevoflurane	sevoflurane affects the expression of UGT1A6 mRNA	15967596
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of UGT1A6 mRNA	25895662
C440975	silybin	silybin inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]	15155549
C440975	silybin	silybin metabolite results in decreased activity of UGT1A6 protein	15921999
D012838	Silymarin	Silymarin results in decreased activity of UGT1A6 protein	15921999
C017947	sodium arsenite	sodium arsenite results in decreased methylation of UGT1A6 gene	24570342
C017947	sodium arsenite	sodium arsenite results in increased expression of UGT1A6 mRNA	24570342\|2871322
D018038	Sodium Selenite	Sodium Selenite results in increased expression of UGT1A6 mRNA	18175754
D053260	Soot	Soot results in decreased expression of UGT1A6 mRNA	21914721
D013095	Spermidine	pimagedine inhibits the reaction [Spermidine results in increased expression of UGT1A6 mRNA]	12763045
D013095	Spermidine	Spermidine results in increased expression of UGT1A6 mRNA	12763045
D013148	Spironolactone	Spironolactone results in increased expression of UGT1A6 mRNA	19144771
D014284	Triiodothyronine	Triiodothyronine results in increased expression of UGT1A6 mRNA	11299074
D014284	Triiodothyronine	Vitamin A inhibits the reaction [Triiodothyronine results in increased expression of UGT1A6 mRNA]	11299074
D014284	Triiodothyronine	Triiodothyronine results in decreased expression of UGT1A6 mRNA	22086976
C012568	terbufos	terbufos results in decreased methylation of UGT1A6 promoter	22847954
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]	12948865
D013749	Tetrachlorodibenzodioxin	NR0B2 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]	11368516
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of UGT1A6 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to UGT1A6 5' UTR]	12948865
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to UGT1A6 5' UTR] which results in increased expression of UGT1A6 mRNA]	12948865\|1294886
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased activity of UGT1A6 protein	12948865
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA	10220484\|1136851
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of UGT1A6 protein	16155002
D013749	Tetrachlorodibenzodioxin	ARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]	11043581
D013749	Tetrachlorodibenzodioxin	NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]	19474220
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UGT1A6 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA	11043581\|1590242
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA	15716479
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]	12948865
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of UGT1A6 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA	11836014\|1294886
D013752	Tetracycline	Tetracycline results in decreased expression of UGT1A6 mRNA	19224547
D013853	Thioacetamide	Thioacetamide results in increased expression of UGT1A6 mRNA	23411599
D013974	Thyroxine	UGT1A6 protein affects the glucuronidation of Thyroxine	20655938
C032910	triadimefon	triadimefon results in increased expression of UGT1A6 mRNA	16643972
C009540	triclocarban	NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A6 mRNA]	22761658
C009540	triclocarban	triclocarban results in increased expression of UGT1A6 mRNA	22761658
D014274	Trifluralin	Trifluralin results in increased expression of UGT1A6 mRNA	18582544
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of UGT1A6 mRNA	12163651
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of UGT1A6 mRNA	21346803
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of UGT1A6 mRNA"	26179874
D014414	Tungsten	[Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of UGT1A6 mRNA	22198552
C012596	turmeric extract	turmeric extract results in increased expression of UGT1A6 mRNA	16819192
C112106	UAB 30	UAB 30 analog results in decreased expression of UGT1A6 mRNA	23292798
C112106	UAB 30	UAB 30 results in increased expression of UGT1A6 mRNA	23292798
C406224	valdecoxib	valdecoxib results in increased expression of UGT1A6 mRNA	24136188
D014635	Valproic Acid	UGT1A6 gene polymorphism affects the glucuronidation of Valproic Acid	15761113
D014635	Valproic Acid	UGT1A6 protein results in increased glucuronidation of Valproic Acid	15761113
D014635	Valproic Acid	Valproic Acid results in decreased expression of UGT1A6 mRNA	17381134
D001335	Vehicle Emissions	Vehicle Emissions analog results in increased expression of UGT1A6 mRNA	15322212
D001335	Vehicle Emissions	Vehicle Emissions analog results in increased expression of UGT1A6 mRNA	15541757
D014801	Vitamin A	Vitamin A deficiency results in decreased expression of UGT1A6 mRNA	12163651
D014801	Vitamin A	Vitamin A inhibits the reaction [Triiodothyronine results in increased expression of UGT1A6 mRNA]	11299074
D024483	Vitamin K 3	Acetylcysteine inhibits the reaction [Vitamin K 3 results in increased activity of UGT1A6 promoter]	15336321
D024483	Vitamin K 3	Vitamin K 3 results in increased activity of UGT1A6 promoter	15336321
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of UGT1A6 mRNA	15336321\|2284637
D014966	Xanthenes	Xanthenes results in decreased activity of UGT1A6 protein	18686201\|2004101
C088658	zoledronic acid	zoledronic acid results in decreased expression of UGT1A6 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001972	retinoic acid binding	NOT	IDA	20308471
GO:0008194	UDP-glycosyltransferase activity	-	IBA	21873635
GO:0015020	glucuronosyltransferase activity	-	IDA	22579593
GO:0015020	glucuronosyltransferase activity	-	TAS	-
GO:0042803	protein homodimerization activity	-	IDA	17179145
GO:0046982	protein heterodimerization activity	-	IDA	17179145

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006805	xenobiotic metabolic process	-	IDA	3141926
GO:0052695	cellular glucuronidation	-	IDA	22579593
GO:0052695	cellular glucuronidation	-	TAS	-
GO:0052696	flavonoid glucuronidation	-	IBA	21873635
GO:0052697	xenobiotic glucuronidation	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005783	endoplasmic reticulum	-	IDA	17179145
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IBA	21873635

KEGG ID	KEGG Term
hsa00040	Pentose and glucuronate interconversions
hsa00053	Ascorbate and aldarate metabolism
hsa00140	Steroid hormone biosynthesis
hsa00500	Starch and sucrose metabolism
hsa00514	Other types of O-glycan biosynthesis
hsa00830	Retinol metabolism
hsa00860	Porphyrin and chlorophyll metabolism
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450
hsa00983	Drug metabolism - other enzymes
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-156580	Phase II - Conjugation of compounds	TAS
R-HSA-156588	Glucuronidation	TAS
R-HSA-211859	Biological oxidations	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17424838	[Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning]. (2007 Jan)	Sun P	Wei Sheng Yan Jiu
23536561	Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer. (2013 Apr 1)	Garcia-Closas M	Cancer Res
14646291	Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and urinary 1-hydroxypyrene and 2-naphthol concentrations. (2003 May)	Kim YD	J Occup Health
18784359	Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population. (2008 Dec)	Sun P	Carcinogenesis
12167564	N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. (2002 Sep)	Ghosheh O	Drug Metab Dispos
24408517	Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed targeted proteomics. (2014 Apr)	Achour B	Drug Metab Dispos
19575027	Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility. (2009 Aug)	Polonikov AV	J Hum Genet
24445297	Commentary on "common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer." Garcia-Closas M, Rothman N, Figueroa JD, Prokunina-Olsson L, Han SS, Baris D, Jacobs EJ, Malats N, De Vivo I, Albanes D, Purdue MP, Sharma S, Fu YP, Kogevinas M, Wang Z, Tang W, Tardon A, Serra C, Carrato A, Garcia-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G Jr., Grubb R 3rd, Black A, Gapstur SM, Thun M, Diver WR, Weinstein SJ, Virtamo J, Hunter DJ, Caporaso N, Landi MT, Hutchinson A, Burdett L, Jacobs KB, Yeager M, Fraumeni JF Jr., Chanock SJ, Silverman DT, Chatterjee N, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.: Cancer Res 2013;73(7):2211-20 [Epub 2013 Mar 27]. (2014 Feb)	Scherr DS	Urol Oncol
25899702	Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland. (2016 Apr)	Lacko M	Head Neck
15247627	Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis. (2004 Jun)	Verlaan M	Pharmacogenetics