Gene: EGLN1

54583
C1orf12|ECYT3|HALAH|HIF-PH2|HIFPH2|HPH-2|HPH2|PHD2|SM20|ZMYND6
egl-9 family hypoxia inducible factor 1
protein-coding
1q42.2
Ensembl:ENSG00000135766 MIM:606425 Vega:OTTHUMG00000038027 UniprotKB:Q9GZT9
NG_015865.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.242e-1 (AD)  2.097e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07040244chr1:231555522EGLN17.500e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB100.909
UBL30.901
SGCB0.901
ZHX10.894
FBXL30.89
PPP1CC0.889
XPOT0.888
ZFR0.885
ZMPSTE240.884
NCOA40.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.778
OR4F29-0.767
C6orf10-0.148
HMHB1-0.145
NANOGNB-0.143
MTRNR2L3-0.142
XCL2-0.139
FCRL1-0.139
PATE3-0.138
MS4A1-0.137

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00126Vitamin CSmall Molecule50-81-7Approved|NutraceuticalTarget
DB01592IronSmall Molecule7439-89-6ApprovedTarget
DB04847RoxadustatSmall MoleculeInvestigationalTarget
DB07112N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINESmall MoleculeExperimentalTarget
DB08687FG-2216Small Molecule223387-75-5InvestigationalTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in increased expression of EGLN1 mRNA"19502547
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"EGLN1 mRNA promotes the reaction [1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine results in decreased expression of CA9 mRNA]"24403227
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"EGLN1 mRNA promotes the reaction [1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine results in decreased expression of EGLN3 mRNA]"24403227
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of EGLN1 mRNA28329830
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of EGLN1 mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of EGLN1 protein26194647
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in decreased expression of EGLN1 protein"22245592
C0415253,3',4,5'-tetrahydroxystilbene"[3,3',4,5'-tetrahydroxystilbene results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein"22245592
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in decreased expression of EGLN1 protein]"23466866
D000082AcetaminophenAcetaminophen results in decreased expression of EGLN1 mRNA21420995
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 mRNA]18072750
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 protein]18072750
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of EGLN1 mRNA]18072750
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EGLN1 mRNA16483693
C553921amurensin G[amurensin G results in decreased activity of SIRT1 protein] inhibits the reaction [Oxygen deficiency results in decreased expression of EGLN1 protein]22245592
C553921amurensin Gamurensin G results in increased expression of EGLN1 protein22245592
C030419andrographolideandrographolide results in increased expression of EGLN1 mRNA21134392
C030419andrographolideandrographolide results in increased expression of EGLN1 protein21134392|2729787
C030419andrographolideEGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]21134392
C030419andrographolideEGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]21134392
C030419andrographolideTGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 mRNA]21134392
C030419andrographolideTGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 protein]21134392
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EGLN1 mRNA24449571
D001205Ascorbic AcidEGLN1 mRNA affects the reaction [Ascorbic Acid results in increased expression of SP7 protein]21467157
D016589AstemizoleAstemizole results in increased expression of EGLN1 mRNA20221588
D001280AtrazineAtrazine results in increased expression of EGLN1 mRNA22378314
D001280AtrazineAtrazine results in decreased expression of EGLN1 mRNA27614199
C406592azaspiracidazaspiracid results in increased expression of EGLN1 mRNA28939011
C547126AZM551248AZM551248 results in decreased expression of EGLN1 mRNA22323515
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of EGLN1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EGLN1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EGLN1 mRNA"19150397
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of EGLN1 mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of EGLN1 mRNA]25566086
D001663BilirubinBilirubin results in decreased expression of EGLN1 mRNA20196124
C006780bisphenol Abisphenol A affects the expression of EGLN1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of EGLN1 mRNA25181051
C032036bromobenzene[bromobenzene co-treated with EGLN1 mutant form] results in increased expression of HIF1A protein24190904
C032036bromobenzene[bromobenzene co-treated with EGLN1 mutant form] results in increased expression of HMOX1 mRNA24190904
C032036bromobenzene[bromobenzene co-treated with EGLN1 mutant form] results in increased expression of PTGS2 mRNA24190904
D002104CadmiumCadmium results in decreased expression of EGLN1 mRNA21106446
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of EGLN1 mRNA24763279
D007464ClioquinolClioquinol results in decreased expression of EGLN1 mRNA19502547
C018021cobaltous chloridecobaltous chloride results in decreased expression of EGLN1 protein22245592
C018021cobaltous chloridecobaltous chloride results in increased expression of EGLN1 mRNA15695372|1950254
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of EGLN1 mRNA]22202117
C018021cobaltous chloridecobaltous chloride affects the expression of EGLN1 mRNA14686790
C018021cobaltous chloridecobaltous chloride results in increased expression of EGLN1 mRNA24386269
C018021cobaltous chloridecobaltous chloride results in increased expression of EGLN1 protein22982409
C026305cobalt sulfatecobalt sulfate results in increased expression of EGLN1 mRNA19502547
D019327Copper SulfateCopper Sulfate results in increased expression of EGLN1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of EGLN1 mRNA25562108
D003676DeferoxamineDeferoxamine results in decreased expression of EGLN1 protein22245592
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EGLN1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of EGLN1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of EGLN1 mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of EGLN1 mRNA27614199
D002117CalcitriolCalcitriol results in increased expression of EGLN1 mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of EGLN1 mRNA"22485181
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of EGLN1 mRNA28939011
D007980LevodopaLevodopa inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]25129099
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of EGLN1 mRNA25198161
C118739entinostatentinostat results in decreased expression of EGLN1 mRNA27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EGLN1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of EGLN1 mRNA23649840
C020748ferrous sulfateferrous sulfate results in increased activity of EGLN1 protein16649251
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of EGLN1 mRNA28329830
D005557FormaldehydeFormaldehyde results in decreased expression of EGLN1 mRNA23649840
D019833GenisteinGenistein results in decreased expression of EGLN1 mRNA21048042
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of EGLN1 mRNA24763279
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGLN1 mRNA25613284
D007501IronIron binds to EGLN1 protein16649251
C016527isoquercitrinisoquercitrin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]25129099
C544151jinfukangjinfukang results in decreased expression of EGLN1 mRNA27392435
D007854LeadLead affects the splicing of EGLN1 mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EGLN1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EGLN1 mRNA23649840
D008911Minocycline[[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]24292262
D008911Minocycline[[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein24292262
D008911MinocyclineMinocycline results in increased expression of EGLN1 protein24292262
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of EGLN1 mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of EGLN1 mRNA16357179
C500085muraglitazarmuraglitazar results in increased expression of EGLN1 mRNA21515302
C040015myricetinmyricetin results in decreased expression of EGLN1 protein22245592
C040015myricetin[myricetin results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein22245592
C022838nickel chloridenickel chloride results in decreased activity of EGLN1 protein16649251
C022838nickel chloridenickel chloride results in increased expression of EGLN1 mRNA17312168
C022838nickel chlorideHIF1A affects the reaction [nickel chloride results in increased expression of EGLN1 mRNA]12729255
C022838nickel chloridenickel chloride results in increased expression of EGLN1 mRNA12729255|1283993
C022838nickel chloridenickel chloride affects the expression of EGLN1 mRNA22110744
C017557nickel subsulfidenickel subsulfide affects the expression of EGLN1 mRNA12729255
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein"16579968|1697362
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein]"16579968
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein]"16579968
D016627Oxidopamineisoquercitrin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]25129099
D016627OxidopamineLevodopa inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]25129099
D016627OxidopamineOxidopamine results in increased expression of EGLN1 mRNA25129099
D016627OxidopamineRutin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]25129099
D019319Okadaic AcidOkadaic Acid results in increased expression of EGLN1 mRNA28939011
D010100OxygenOxygen deficiency results in increased expression of EGLN1 mRNA21106446
D010100Oxygenalpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 mRNA]18072750
D010100Oxygenalpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 protein]18072750
D010100Oxygen[amurensin G results in decreased activity of SIRT1 protein] inhibits the reaction [Oxygen deficiency results in decreased expression of EGLN1 protein]22245592
D010100Oxygen[IL15 protein co-treated with Oxygen deficiency] results in increased expression of EGLN1 mRNA27129235
D010100Oxygen[[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]24292262
D010100Oxygen[Oxygen deficiency co-treated with Tetrachlorodibenzodioxin] results in decreased expression of EGLN1 protein18072750
D010100OxygenOxygen deficiency results in decreased expression of EGLN1 protein22245592
D010100OxygenOxygen deficiency results in increased expression of EGLN1 mRNA19502547|2004264
D010100OxygenOxygen deficiency results in increased expression of EGLN1 protein18072750
D010100Oxygen[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 mRNA18072750
D010100OxygenOxygen deficiency results in increased expression of EGLN1 mRNA14686790|2088007
D010100Oxygen[Oxygen deficiency co-treated with AQP3 protein] results in increased expression of EGLN1 mRNA23545307
D010100OxygenOxygen deficiency results in increased expression of EGLN1 mRNA23545307
D010100OxygenEGLN1 protein affects the reaction [HIF1A protein affects the susceptibility to Oxygen]16899821
D052638Particulate MatterParticulate Matter results in decreased expression of EGLN1 mRNA19683567
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of EGLN1 mRNA27614199
D011794QuercetinQuercetin results in decreased expression of EGLN1 protein22245592
D011794Quercetin[Quercetin results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein22245592
C059514resveratrolresveratrol results in decreased expression of EGLN1 protein22245592
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein22245592
C089730rosiglitazonerosiglitazone promotes the reaction [PPARG protein binds to EGLN1 promoter]24338020
C089730rosiglitazonerosiglitazone results in increased expression of EGLN1 mRNA24338020
C089730rosiglitazonerosiglitazone results in increased expression of EGLN1 protein24338020
C089730rosiglitazonerosiglitazone results in increased expression of EGLN1 mRNA21515302
D012431RutinRutin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]25129099
D017673Sodium Chloride, Dietary"EGLN1 inhibits the reaction [Sodium Chloride, Dietary results in increased expression of HIF1A protein]"20308610
D017673Sodium Chloride, Dietary"EGLN1 inhibits the reaction [Sodium Chloride, Dietary results in increased expression of HMOX1 mRNA]"20308610
D017673Sodium Chloride, Dietary"EGLN1 inhibits the reaction [Sodium Chloride, Dietary results in increased expression of NOS2 mRNA]"20308610
D017673Sodium Chloride, Dietary"EGLN1 protein affects the susceptibility to Sodium Chloride, Dietary"24190904
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in decreased expression of EGLN1 mRNA"20308610
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in decreased expression of EGLN1 protein"20308610
C501413tesaglitazartesaglitazar results in increased expression of EGLN1 mRNA21515302
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of EGLN1 mRNA20189893
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 mRNA]18072750
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 protein]18072750
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of EGLN1 mRNA]18072750
D013749Tetrachlorodibenzodioxin[Oxygen deficiency co-treated with Tetrachlorodibenzodioxin] results in decreased expression of EGLN1 protein18072750
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 mRNA18072750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EGLN1 mRNA18072750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EGLN1 protein18072750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EGLN1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EGLN1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGLN1 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of EGLN1 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of EGLN1 mRNA27404394|2786577
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EGLN1 mRNA28065790
C483909torcetrapibtorcetrapib results in increased expression of EGLN1 mRNA23228038
D014212TretinoinTretinoin results in increased expression of EGLN1 mRNA23724009
C011559tributyltintributyltin results in decreased expression of EGLN1 mRNA27614199
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EGLN1 mRNA"26179874
D014520UrethaneUrethane results in increased expression of EGLN1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of EGLN1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EGLN1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased expression of EGLN1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EGLN1 gene25560391
C111237vorinostatvorinostat results in decreased expression of EGLN1 mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of EGLN1 mRNA"25198161
D015032Zinc"Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein]"16579968
D015032ZincZinc results in decreased expression of EGLN1 mRNA18316168
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of EGLN1 mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of EGLN1 mRNA16357179
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of EGLN1 mRNA]22202117
C016837zinc chloride"zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein]"16579968
D019287Zinc SulfateZinc Sulfate results in increased expression of EGLN1 mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15474027  15721254  16511565  17353276  19208626  20840591  
22286099  24169621  24681946  25974097  
GO:0008198ferrous iron binding-IDA28594552  
GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors-IDA22955912  
GO:0019899enzyme binding-ISS-  
GO:0031418L-ascorbic acid binding-IEA-  
GO:0031543peptidyl-proline dioxygenase activity-TAS16956324  
GO:0031545peptidyl-proline 4-dioxygenase activity-EXP12615973  12788921  22286099  
GO:0031545peptidyl-proline 4-dioxygenase activity-IDA11598268  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IDA16956324  
GO:0006879cellular iron ion homeostasis-IEA-  
GO:0018401peptidyl-proline hydroxylation to 4-hydroxy-L-proline-IDA11598268  
GO:0032364oxygen homeostasis-IDA16956324  
GO:0043433negative regulation of DNA-binding transcription factor activity-IDA16956324  
GO:0045765regulation of angiogenesis-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0051344negative regulation of cyclic-nucleotide phosphodiesterase activity-ISS-  
GO:0055008cardiac muscle tissue morphogenesis-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0060347heart trabecula formation-IEA-  
GO:0060412ventricular septum morphogenesis-IEA-  
GO:0060711labyrinthine layer development-IEA-  
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia-TAS-  
GO:0071731response to nitric oxide-IDA21601578  
GO:1901214regulation of neuron death-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IDA12615973  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenIEA
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaTAS
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaIEA
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262749Cellular response to hypoxiaIEA
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2262752Cellular responses to stressIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301715Hereditary Paraganglioma-Pheochromocytoma Syndromes (1993)Kirmani S-
25431923Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness. (2014 Nov 26)Zhang EInt J Mol Sci
24482100Hereditary gene mutations in Korean patients with isolated erythrocytosis. (2014 Jun)Jang JHAnn Hematol