Gene: POU5F1

5460
OCT3|OCT4|OTF-3|OTF3|OTF4|Oct-3|Oct-4
POU class 5 homeobox 1
protein-coding
6p21.33
Ensembl:ENSG00000204531 MIM:164177 Vega:OTTHUMG00000031206 UniprotKB:Q01860
NC_000006.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FUT70.433
RAX20.43
ALOXE30.415
SLCO4A10.408
NFIL30.402
CEACAM190.395
GTF2IRD10.395
NAA160.395
PLAGL20.393
ZCCHC80.388

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HOXD1-0.27
OR4N2-0.258
ACY3-0.256
HMGB4-0.24
SNX22-0.233
LYPD8-0.226
HCG22-0.214
TMEM171-0.214
EPM2A-0.21
PDE11A-0.21

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00368NorepinephrineSmall Molecule51-41-2ApprovedTransporter
DB00988DopamineSmall Molecule51-61-6ApprovedTransporter
ID Drug Name Action PubMed
C5598531-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid promotes the reaction [LIF protein affects the reaction POU5F1 mRNA]26723917
C0534861,7-phenanthroline"1,7-phenanthroline results in decreased expression of POU5F1 protein"21111795
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of POU5F1 mRNA"25614096
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with sodium arsenite] results in decreased expression of POU5F1 protein23143138
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of POU5F1 protein23143138
C0228302-methoxyestradiol2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of POU5F1 mRNA]25822711
C0125873,5,6-trichloro-2-pyridinol"3,5,6-trichloro-2-pyridinol results in increased expression of POU5F1 mRNA"23220036
C0259463-methyladenine3-methyladenine results in increased expression of POU5F1 protein21681844
C4711094(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline"[4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline co-treated with sodium arsenite] results in decreased expression of POU5F1 protein"23143138
C4711094(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased expression of POU5F1 protein"23143138
C0415944-nonylphenol4-nonylphenol results in increased expression of POU5F1 mRNA20615461
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of POU5F1 mRNA20615461
C4833216-bromoindirubin-3'-oxime[Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] results in decreased expression of POU5F1 mRNA27693483
D000082AcetaminophenAcetaminophen results in decreased expression of POU5F1 mRNA29067470
D000082AcetaminophenAcetaminophen results in decreased expression of POU5F1 mRNA17585979
D019342Acetic AcidAcetic Acid results in decreased expression of POU5F1 protein21296659
D000111AcetylcysteineAcetylcysteine inhibits the reaction [decabromobiphenyl ether results in decreased expression of POU5F1 protein]26206603
C522924afatinibafatinib inhibits the reaction [EGF protein results in increased expression of POU5F1 protein]28787001
C522924afatinibafatinib results in decreased expression of POU5F1 protein28787001
C096920AGN 193109AGN 193109 inhibits the reaction [Tretinoin results in decreased expression of POU5F1 mRNA]16574651
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of POU5F1 protein23936228
D013196DihydrotestosteroneSHBG affects the reaction [Dihydrotestosterone results in increased expression of POU5F1 protein]23936228
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of POU5F1 mRNA21298039
D047310ApigeninApigenin results in decreased expression of POU5F1 protein22906706
D001151ArsenicArsenic affects the methylation of POU5F1 gene25304211
C006632arsenic trioxide[arsenic trioxide co-treated with FN1 protein] results in decreased expression of POU5F1 mRNA22641096
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Cobalt results in increased expression of POU5F1 protein]24497960
D001205Ascorbic AcidAscorbic Acid results in increased expression of POU5F1 mRNA21166886
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of POU5F1 mRNA28189605
C487081belinostatbelinostat results in increased expression of POU5F1 mRNA26272509
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of POU5F1 protein24497960
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]22132214|2755133
D004958EstradiolEstradiol results in increased expression of POU5F1 mRNA22132214|2755133
D004958EstradiolEstradiol results in increased expression of POU5F1 protein23391485|2755133
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of POU5F1 mRNA]22132214
D004958EstradiolMelatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]27551335
D004958EstradiolMelatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 mRNA]27551335
D004958EstradiolMelatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 protein]27551335
D004958EstradiolMetformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]22132214
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of POU5F1 mRNA17404688
D004958EstradiolEstradiol results in increased expression of POU5F1 mRNA20615461
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of POU5F1 mRNA28189605
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of POU5F1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of POU5F1 mRNA21786754
C006780bisphenol Abisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]27551335
C006780bisphenol Abisphenol A results in increased expression of POU5F1 mRNA27551335
C006780bisphenol Abisphenol A results in increased expression of POU5F1 protein23391485|2755133
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of POU5F1 mRNA28628672
C006780bisphenol AMelatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]27551335
C006780bisphenol AMelatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 mRNA]27551335
C006780bisphenol AMelatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 protein]27551335
C006780bisphenol Abisphenol A affects the methylation of POU5F1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of POU5F1 mRNA23719110|2409059
C006780bisphenol Abisphenol A results in increased expression of POU5F1 protein23719110
C006780bisphenol Abisphenol A affects the expression of POU5F1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of POU5F1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of POU5F1 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of POU5F1 mRNA28819136
C006780bisphenol Abisphenol A results in decreased expression of POU5F1 protein28819136
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of POU5F1 protein21296659
C018475butyraldehydebutyraldehyde results in decreased expression of POU5F1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of POU5F1 promoter22457795
D007631ChlordeconeChlordecone results in decreased expression of POU5F1 protein22906706
D004390ChlorpyrifosChlorpyrifos results in decreased expression of POU5F1 mRNA23220036
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of POU5F1 mRNA19654923
C074702chromium hexavalent ionMAP2K7 protein promotes the reaction [chromium hexavalent ion results in increased expression of POU5F1 mRNA]19654923
D002939CiprofloxacinCiprofloxacin results in increased expression of POU5F1 protein26947806
D002994ClofibrateClofibrate results in increased expression of POU5F1 mRNA17585979
D003035CobaltAscorbic Acid inhibits the reaction [Cobalt results in increased expression of POU5F1 protein]24497960
D003035CobaltCobalt promotes the reaction [SUMO1 protein results in increased expression of POU5F1 protein]24497960
D003035CobaltCobalt results in increased expression of and results in increased stability of POU5F1 protein24497960
D003035CobaltCycloheximide promotes the reaction [Cobalt results in increased expression of POU5F1 protein]24497960
C018021cobaltous chloride[EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of POU5F1 mRNA25805230
C018021cobaltous chloride[HIF1A protein results in increased susceptibility to cobaltous chloride] which results in increased expression of POU5F1 mRNA25805230
D003474Curcumin2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of POU5F1 mRNA]25822711
D003474CurcuminCurcumin results in increased expression of POU5F1 mRNA25822711|2723778
D003474CurcuminCurcumin results in increased expression of POU5F1 protein25822711
D003513CycloheximideCycloheximide promotes the reaction [Cobalt results in increased expression of POU5F1 protein]24497960
D003513CycloheximideCycloheximide promotes the reaction [nickel chloride results in increased expression of POU5F1 protein]24497960
C010902decabromobiphenyl etherAcetylcysteine inhibits the reaction [decabromobiphenyl ether results in decreased expression of POU5F1 protein]26206603
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of POU5F1 mRNA26206603
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of POU5F1 protein26206603
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased methylation of POU5F1 promoter26206603
C014347decitabinetrichostatin A promotes the reaction [decitabine affects the expression of POU5F1 mRNA]18440631
D003840Deoxycholic AcidDeoxycholic Acid results in increased expression of POU5F1 mRNA27151938
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of POU5F1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of POU5F1 mRNA28628672
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of POU5F1 mRNA28189605
D003907Dexamethasone[INS co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the expression of POU5F1 mRNA21350315
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of POU5F1 protein16916955
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in increased expression of POU5F1 mRNA20705681
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in increased expression of POU5F1 protein20705681
D002945Cisplatin[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of POU5F1 mRNA21342274
D002945Cisplatin[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of POU5F1 protein21342274
D002945CisplatinCisplatin results in increased expression of POU5F1 mRNA21618587
D002945CisplatinCisplatin results in increased expression of POU5F1 protein20074550|2161858
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of POU5F1 mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of POU5F1 mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in decreased expression of POU5F1 mRNA16931933
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of POU5F1 mRNA28123099|2828611
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of POU5F1 gene23968726
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of POU5F1 mRNA24834073
C118739entinostatentinostat results in increased expression of POU5F1 mRNA26272509
D000431EthanolEthanol results in decreased expression of POU5F1 protein19919524
D000431EthanolHBEGF protein inhibits the reaction [Ethanol results in decreased expression of POU5F1 protein]19919524
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of POU5F1 mRNA20227414
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of POU5F1 mRNA17606305
D005472FluorouracilFluorouracil results in decreased expression of POU5F1 protein21296659
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of POU5F1 mRNA]22132214
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of POU5F1 mRNA20044591
C499403icaritinicaritin results in decreased expression of POU5F1 mRNA19135036
D019469Indinavir[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of POU5F1 mRNA16931933
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of POU5F1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of POU5F1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of POU5F1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of POU5F1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the expression of POU5F1 mRNA21350315
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of POU5F1 mRNA26830473
C006552kaempferolkaempferol results in decreased expression of POU5F1 protein22906706
C006552kaempferolkaempferol results in increased expression of POU5F1 protein26683311
D007654KetoconazoleKetoconazole results in decreased expression of POU5F1 mRNA16574651
D007854LeadLead results in increased expression of POU5F1 protein25193092
C045463leflunomideleflunomide results in decreased expression of POU5F1 mRNA28988120
D018021Lithium ChlorideCTNNB1 protein promotes the reaction [Lithium Chloride results in increased expression of POU5F1 mRNA]20074550
D018021Lithium ChlorideCTNNB1 protein promotes the reaction [Lithium Chloride results in increased expression of POU5F1 protein]20074550
D018021Lithium ChlorideLithium Chloride results in increased expression of POU5F1 mRNA20069066|2007455
D018021Lithium ChlorideLithium Chloride results in increased expression of POU5F1 protein20074550
D018021Lithium ChlorideSFRP2 protein affects the reaction [Lithium Chloride results in increased expression of POU5F1 mRNA]20069066
C549232LLL12 compoundLLL12 compound results in decreased phosphorylation of POU5F1 protein23333246
C010480lupeollupeol results in decreased expression of POU5F1 protein20979057
D008550MelatoninMelatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]27551335
D008550MelatoninMelatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 mRNA]27551335
D008550MelatoninMelatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 protein]27551335
D008550MelatoninMelatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]27551335
D008550MelatoninMelatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 mRNA]27551335
D008550MelatoninMelatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 protein]27551335
D008550MelatoninMelatonin results in decreased expression of POU5F1 mRNA27551335
D008550MelatoninMelatonin results in decreased expression of POU5F1 protein27551335
D008687MetforminMetformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]22132214
D008687MetforminMetformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]]22132214
D008694MethamphetaminePOU5F1 gene SNP affects the susceptibility to Methamphetamine18316681
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of POU5F1 mRNA22555245|2800136
C015358methylparabenmethylparaben results in increased expression of POU5F1 mRNA27581495
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of POU5F1 mRNA22956148|2798975
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of POU5F1 mRNA]"19615344
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate results in decreased expression of POU5F1 mRNA"19615344
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of POU5F1 mRNA"23634900
C000621033napabucasinnapabucasin results in decreased expression of POU5F1 mRNA25605917
C022838nickel chlorideCycloheximide promotes the reaction [nickel chloride results in increased expression of POU5F1 protein]24497960
C022838nickel chloridenickel chloride results in increased expression of and results in increased stability of POU5F1 protein24497960
C022838nickel chloridenickel chloride results in increased expression of POU5F1 protein26962057
D009534NiclosamideNiclosamide results in decreased phosphorylation of POU5F1 protein23333246
D009538NicotineNicotine results in increased expression of POU5F1 mRNA23219715
D009538NicotineNicotine results in increased expression of POU5F1 protein23219715
D009538NicotineSNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]23219715
D009538NicotineNicotine results in increased expression of POU5F1 mRNA15612475|1574926
D009538NicotineTubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]15749260
D015739NocodazoleNocodazole results in decreased expression of POU5F1 protein21559451
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of POU5F1 mRNA"23220036
D010100OxygenOxygen deficiency results in increased expression of POU5F1 protein23725749
D010100OxygenOxygen deficiency results in decreased expression of POU5F1 mRNA16814746
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in increased expression of POU5F1 mRNA20705681
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in increased expression of POU5F1 protein20705681
C496932panobinostatpanobinostat results in increased expression of POU5F1 mRNA26272509
D052638Particulate MatterParticulate Matter results in increased expression of POU5F1 mRNA28846189
D052638Particulate MatterParticulate Matter results in increased expression of POU5F1 protein28846189
D052638Particulate MatterParticulate Matter results in decreased expression of POU5F1 protein20525899
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of POU5F1 protein28288859
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of POU5F1 mRNA25510869
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of POU5F1 protein25510869
C031181phenanthrenephenanthrene affects the reaction [Tretinoin results in decreased expression of POU5F1 protein]21111795
C031181phenanthrenephenanthrene results in decreased expression of POU5F1 protein21111795
D010637PhenolsulfonphthaleinPhenolsulfonphthalein results in increased expression of POU5F1 mRNA22132214
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of POU5F1 gene23968726
D010936Plant ExtractsHOTAIR mutant form inhibits the reaction [Plant Extracts analog results in increased expression of POU5F1 protein]25447409
D010936Plant ExtractsPlant Extracts analog results in increased expression of POU5F1 protein25447409
D010936Plant ExtractsPlant Extracts results in decreased expression of POU5F1 mRNA23557933
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of POU5F1 mRNA17404688
D011794QuercetinQuercetin results in decreased expression of POU5F1 protein22422628
D019257QuinpiroleDRD2 protein promotes the reaction [Quinpirole results in decreased expression of POU5F1 mRNA]27920206
D019257QuinpiroleQuinpirole results in decreased expression of POU5F1 mRNA27920206
C059514resveratrolresveratrol results in decreased expression of POU5F1 mRNA24305840
C059514resveratrolresveratrol results in decreased expression of POU5F1 mRNA21304978|2269295
C059514resveratrolresveratrol results in decreased expression of POU5F1 protein22692956
D019258Saquinavir[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of POU5F1 mRNA16931933
C511004SD-208SD-208 results in decreased expression of POU5F1 protein23725749
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of POU5F1 mRNA25895662
D020123SirolimusSirolimus results in increased expression of POU5F1 mRNA21681844
D020123SirolimusSirolimus results in increased expression of POU5F1 protein21681844
D012906SmokeHOTAIR mutant form inhibits the reaction [Smoke analog results in increased expression of POU5F1 protein]25447409
D012906SmokeSmoke analog results in increased expression of POU5F1 protein25447409|2552692
C017947sodium arsenite"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of POU5F1 mRNA]"19615344
C017947sodium arsenitesodium arsenite affects the expression of POU5F123052196
C017947sodium arsenitesodium arsenite affects the expression of POU5F1 mRNA20056578
C017947sodium arsenitesodium arsenite results in decreased expression of POU5F1 mRNA19615344
C017947sodium arsenite[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with sodium arsenite] results in decreased expression of POU5F1 protein23143138
C017947sodium arsenite"[4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline co-treated with sodium arsenite] results in decreased expression of POU5F1 protein"23143138
C017947sodium arsenite[OGG1 gene mutant form results in increased susceptibility to sodium arsenite] which affects the expression of POU5F1 protein26438402
C017947sodium arsenitesodium arsenite affects the expression of POU5F1 protein26438402
C017947sodium arsenitesodium arsenite results in decreased expression of POU5F1 protein23143138
C416927SU 6656SU 6656 results in decreased expression of POU5F1 protein23527294
D013629TamoxifenTamoxifen results in decreased expression of POU5F1 protein22906706
C021751tanshinonetanshinone results in increased expression of POU5F1 mRNA25186638
D013656Taurocholic AcidTaurocholic Acid results in increased expression of POU5F1 mRNA27151938
D013749TetrachlorodibenzodioxinMetformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]]22132214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]22132214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of POU5F1 mRNA22132214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of POU5F1 mRNA24058054
C009495titanium dioxidetitanium dioxide results in increased expression of POU5F1 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of POU5F1 mRNA16168501|1713896
D014212TretinoinTretinoin results in decreased expression of POU5F1 protein22906706
D014212TretinoinAGN 193109 inhibits the reaction [Tretinoin results in decreased expression of POU5F1 mRNA]16574651
D014212TretinoinEHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to POU5F1 promoter]]16415856
D014212TretinoinEHMT2 protein promotes the reaction [Tretinoin results in increased methylation of POU5F1 promoter]16415856
D014212TretinoinNR6A1 protein affects the reaction [Tretinoin results in decreased expression of POU5F1 mRNA]16166633
D014212Tretinoinphenanthrene affects the reaction [Tretinoin results in decreased expression of POU5F1 protein]21111795
D014212TretinoinTretinoin promotes the reaction [[HIST3H3 protein modified form binds to CBX1 protein] which binds to POU5F1 promoter]16415856
D014212TretinoinTretinoin results in decreased expression of POU5F1 mRNA16415856|1657465
D014212TretinoinTretinoin results in decreased expression of POU5F1 protein16415856|1644822
D014212TretinoinTretinoin results in increased methylation of POU5F1 promoter16415856
D014241TrichloroethyleneTrichloroethylene results in increased methylation of POU5F1 gene27618143
C012589trichostatin Atrichostatin A promotes the reaction [decitabine affects the expression of POU5F1 mRNA]18440631
C012589trichostatin Atrichostatin A results in increased expression of POU5F1 mRNA22723015|2627250
D014260TriclosanTriclosan results in decreased expression of POU5F1 mRNA24879426
D014260TriclosanTriclosan results in decreased expression of POU5F1 protein24879426
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of POU5F1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of POU5F1 mRNA29024780
D014403TubocurarineTubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]15749260
D014403TubocurarineTubocurarine results in decreased expression of POU5F1 mRNA15612475
C000621860UNC0642UNC0642 inhibits the reaction [EGF protein results in increased expression of POU5F1 protein]28787001
D014635Valproic AcidValproic Acid results in increased expression of POU5F1 mRNA22723015|2352703
D014635Valproic AcidValproic Acid affects the expression of POU5F1 mRNA27693483
D014635Valproic Acid[Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] results in decreased expression of POU5F1 mRNA27693483
D014635Valproic AcidValproic Acid results in decreased expression of POU5F1 mRNA27237783
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of POU5F1 protein20525899
C523798YM 155YM 155 results in decreased expression of POU5F1 protein28787001
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of POU5F1 mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of POU5F1 mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in decreased expression of POU5F1 mRNA16931933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IDA19409607  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA19409607  
GO:0003677DNA binding-IDA16153702  
GO:0003700DNA-binding transcription factor activity-IDA16153702  
GO:0003723RNA binding-HDA22658674  
GO:0005515protein binding-IPI11099378  11891324  15523054  18191611  19274063  19536159  
24048479  26687479  
GO:0031625ubiquitin protein ligase binding-IPI19274063  
GO:0035198miRNA binding-IDA18710938  19409607  
GO:0043565sequence-specific DNA binding-IDA20713518  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA19409607  
GO:0001714endodermal cell fate specification-IDA20713518  
GO:0001824blastocyst development-ISS-  
GO:0006355regulation of transcription, DNA-templated-IDA16153702  
GO:0006366transcription by RNA polymerase II-ISS-  
GO:0009611response to wounding-IEP17982423  
GO:0009653anatomical structure morphogenesis-TAS9814708  
GO:0009786regulation of asymmetric cell division-ISS-  
GO:0010468regulation of gene expression-IMP18388306  
GO:0035019somatic stem cell population maintenance-IDA19409607  
GO:0035019somatic stem cell population maintenance-IMP18388306  
GO:0035019somatic stem cell population maintenance-TAS-  
GO:0042789mRNA transcription by RNA polymerase II-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA20713518  
GO:0060965negative regulation of gene silencing by miRNA-IMP19409607  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IC16153702  
GO:0005634nucleus-IDA18000303  18191611  19274063  21828274  
GO:0005654nucleoplasm-IDA20458727  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA18281244  20458727  21828274  
GO:0005739mitochondrion-IDA-  
GO:0005829cytosol-IDA18000303  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-2892245POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiationTAS
R-HSA-2892247POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferationTAS
R-HSA-452723Transcriptional regulation of pluripotent stem cellsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26824036Potentially Functional Polymorphisms in POU5F1 Gene Are Associated with the Risk of Lung Cancer in Han Chinese. (2015)Niu RBiomed Res Int
24847019In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. (2014 Jul)Fowler PAHum Reprod