Gene: UGT1A9

54600
HLUGP4|LUGP4|UDPGT|UDPGT 1-9|UGT-1I|UGT1-09|UGT1-9|UGT1.9|UGT1A9S|UGT1AI|UGT1I
UDP glucuronosyltransferase family 1 member A9
protein-coding
2q37.1
Ensembl:ENSG00000241119 MIM:606434 Vega:OTTHUMG00000059124 UniprotKB:O60656
NC_000002.12
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.783e-1 (AD)  3.424e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04552Niflumic AcidSmall Molecule4394-00-7ApprovedTarget
DB04824PhenolphthaleinSmall Molecule77-09-8Approved|WithdrawnTarget
DB00062Human Serum AlbuminBiotechDrug9048-46-8ApprovedEnzyme
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnEnzyme
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalEnzyme
DB00316AcetaminophenSmall Molecule103-90-2ApprovedEnzyme
DB00327HydromorphoneSmall Molecule466-99-9Approved|IllicitEnzyme
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalEnzyme
DB00398SorafenibSmall Molecule284461-73-0Approved|InvestigationalEnzyme
DB00494EntacaponeSmall Molecule130929-57-6Approved|InvestigationalEnzyme
DB00502HaloperidolSmall Molecule52-86-8ApprovedEnzyme
DB00580ValdecoxibSmall Molecule181695-72-7Approved|Investigational|WithdrawnEnzyme
DB00688Mycophenolate mofetilSmall Molecule128794-94-5Approved|InvestigationalEnzyme
DB00712FlurbiprofenSmall Molecule5104-49-4Approved|InvestigationalEnzyme
DB00731NateglinideSmall Molecule105816-04-4Approved|InvestigationalEnzyme
DB00744ZileutonSmall Molecule111406-87-2Approved|Investigational|WithdrawnEnzyme
DB00749EtodolacSmall Molecule41340-25-4Approved|InvestigationalEnzyme
DB00762IrinotecanSmall Molecule97682-44-5Approved|InvestigationalEnzyme
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalEnzyme
DB00842OxazepamSmall Molecule604-75-1ApprovedEnzyme
DB00921BuprenorphineSmall Molecule52485-79-7Approved|Illicit|InvestigationalEnzyme
DB01015SulfamethoxazoleSmall Molecule723-46-6ApprovedEnzyme
DB01024Mycophenolic acidSmall Molecule24280-93-1ApprovedEnzyme
DB01050IbuprofenSmall Molecule15687-27-1ApprovedEnzyme
DB01283LumiracoxibSmall Molecule220991-20-8Approved|InvestigationalEnzyme
DB01685TopiroxostatSmall Molecule577778-58-6Approved|InvestigationalEnzyme
DB04953EzogabineSmall Molecule150812-12-7Approved|InvestigationalEnzyme
DB06204TapentadolSmall Molecule175591-23-8ApprovedEnzyme
DB06235VadimezanSmall MoleculeInvestigationalEnzyme
DB06292DapagliflozinSmall Molecule461432-26-8ApprovedEnzyme
DB06403AmbrisentanSmall Molecule177036-94-1Approved|InvestigationalEnzyme
DB06695Dabigatran etexilateSmall Molecule211915-06-9ApprovedEnzyme
DB06738KetobemidoneSmall Molecule469-79-4Approved|InvestigationalEnzyme
DB06739SeratrodastSmall Molecule112665-43-7ApprovedEnzyme
DB06741GavestinelSmall Molecule153436-22-7InvestigationalEnzyme
DB08896RegorafenibSmall Molecule755037-03-7ApprovedEnzyme
DB08907CanagliflozinSmall Molecule842133-18-0ApprovedEnzyme
DB08930DolutegravirSmall Molecule1051375-16-6ApprovedEnzyme
DB11633IsavuconazoleSmall Molecule241479-67-4Approved|InvestigationalEnzyme
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalEnzyme
DB11827ErtugliflozinSmall Molecule1210344-57-2Approved|InvestigationalEnzyme
DB13874EnasidenibSmall Molecule1446502-11-9Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C5432111,2,5,8-tetrahydroxy anthraquinone"UGT1A9 protein results in increased glucuronidation of 1,2,5,8-tetrahydroxy anthraquinone"14557274
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog results in increased expression of UGT1A9 mRNA"24273086
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of UGT1A9 protein22527513
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of UGT1A9 mRNA"19144771|2249639
C0348901,4-dihydroxyanthraquinone"UGT1A9 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone"14557274
C0907681-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"UGT1A9 protein results in increased glucuronidation of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"29285606
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"UGT1A9 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"15231852
C0331461-hydroxypyreneUGT1A9 protein results in increased glucuronidation of 1-hydroxypyrene15802387
C0293501-naphtholUGT1A9 protein results in increased glucuronidation of 1-naphthol15044611|1881629
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of UGT1A9 mRNA"25542188
C0549172,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid"2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid results in increased expression of UGT1A9 mRNA"25542188
C0600802,2-bis(bromomethyl)-1,3-propanediol"2,2-bis(bromomethyl)-1,3-propanediol results in increased expression of UGT1A9 mRNA"24273086
C0593542',4'-dihydroxychalcone"UGT1A9 protein results in increased glucuronidation of 2',4'-dihydroxychalcone"14557274
C1074972',5'-dihydroxychalcone"UGT1A9 protein results in increased glucuronidation of 2',5'-dihydroxychalcone"14557274
C0348892,6-dihydroxyanthraquinone"UGT1A9 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone"14557274
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A9 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]"15986396
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A9 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"11375903|1531024
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A9 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15986396
C0249802-hydroxyestroneUGT1A9 protein results in increased glucuronidation of 2-hydroxyestrone15117964
C0228302-methoxyestradiolUGT1A9 protein results in increased glucuronidation of 2-methoxyestradiol15117964
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Benzo(a)pyrene promotes the reaction [Phenobarbital results in increased expression of UGT1A9 mRNA]]25489928
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A9 mRNA]]25489928
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of UGT1A9 mRNA10220484
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of UGT1A9 mRNA"19144771
C0502243,5,5-trimethylhexanoylferrocene"3,5,5-trimethylhexanoylferrocene results in increased expression of UGT1A9 protein"22649188
C5830744,4'-hexafluorisopropylidene diphenol"UGT1A9 protein results in increased glucuronidation of and results in decreased activity of 4,4'-hexafluorisopropylidene diphenol"24349450
C0067574-biphenylamineUGT1A9 protein results in increased glucuronidation of 4-biphenylamine15840509
C0264184-hydroxyestroneUGT1A9 protein results in increased glucuronidation of 4-hydroxyestrone15117964
C0995654-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-olUGT1A9 protein results in increased glucuronidation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol11038164|2645212
C0995644-((methylnitrosoamino)-1-(3-pyridyl)but-1-yl)beta-omega-glucosiduronic acidUGT1A9 protein results in increased chemical synthesis of 4-((methylnitrosoamino)-1-(3-pyridyl)but-1-yl)beta-omega-glucosiduronic acid26452127
C0248364-nitrophenolUGT1A9 protein results in increased glucuronidation of 4-nitrophenol15044611|1580238
C0700584-trifluoromethylumbelliferyl iduronideUGT1A9 protein results in increased glucuronidation of 4-trifluoromethylumbelliferyl iduronide15357915
C1217077,3'-dihydroxy-4'-methoxyisoflavone"UGT1A9 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone"25044472
C0842367-hydroxy-4-trifluoromethylcoumarinsilybin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]15155549
C0842367-hydroxy-4-trifluoromethylcoumarinUGT1A9 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin15155549
C0314777-hydroxycoumarinUGT1A9 protein results in increased glucuronidation of 7-hydroxycoumarin15044611
D000082AcetaminophenAcetaminophen results in decreased expression of UGT1A9 mRNA29067470
D000082AcetaminophenUGT1A9 protein results in increased glucuronidation of Acetaminophen17898154
D000082AcetaminophenUGT1A9 protein results in increased glucuronidation of Acetaminophen16023900
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of UGT1A9 gene27153756
C010078alizarinUGT1A9 protein results in increased glucuronidation of alizarin14557274
C006457alloinUGT1A9 protein results in increased glucuronidation of alloin14557274
C038491allyl sulfideallyl sulfide results in increased expression of UGT1A9 mRNA19144771
C518327aloe emodinUGT1A9 protein results in increased glucuronidation of aloe emodin24854283
D0150571-Naphthylamine1-Naphthylamine results in decreased activity of UGT1A9 protein14744740
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UGT1A9 mRNA16483693
D000666Amphotericin BAmphotericin B affects the expression of UGT1A9 mRNA20623750
C032186anthrarobinUGT1A9 protein results in increased glucuronidation of anthrarobin14557274
D047310ApigeninUGT1A9 protein results in increased glucuronidation of Apigenin14557274
D016718Arachidonic AcidUGT1A9 protein results in increased glucuronidation of Arachidonic Acid15231852
C006632arsenic trioxidearsenic trioxide results in decreased expression of UGT1A9 mRNA17530438
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in increased expression of UGT1A9 mRNA17639512
C011677benoxaprofenUGT1A9 affects the susceptibility to benoxaprofen17880178
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of UGT1A9 mRNA17917264|1911856
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of UGT1A9 mRNA19144771
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A9 promoter]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [BRCA1 protein binds to UGT1A9 promoter]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [[BRCA1 protein binds to UGT1A9 promoter] which results in increased expression of UGT1A9 mRNA]21507987|2150798
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGT1A9 mRNA21507987
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGT1A9 protein21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A9 promoter]]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of UGT1A9 mRNA]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of UGT1A9 protein]21507987
D001564Benzo(a)pyreneUGT1A9 protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]21507987
D001564Benzo(a)pyreneUGT1A9 protein affects the susceptibility to Benzo(a)pyrene21507987
D001564Benzo(a)pyreneUGT1A9 protein results in increased glucuronidation of Benzo(a)pyrene14557274
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGT1A9 mRNA19770486|2012785
D001564Benzo(a)pyrene2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Benzo(a)pyrene promotes the reaction [Phenobarbital results in increased expression of UGT1A9 mRNA]]25489928
D001564Benzo(a)pyrene2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A9 mRNA]]25489928
D001564Benzo(a)pyrenePhenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A9 mRNA]25489928
C068337bergamottinUGT1A9 protein results in increased glucuronidation of bergamottin analog14557274
D004958EstradiolEstradiol results in decreased activity of UGT1A9 protein15378558
D004958EstradiolUGT1A9 protein results in increased glucuronidation of Estradiol15472229
D004958EstradiolUGT1A9 protein results in increased glucuronidation of Estradiol analog15472229
D001629BezafibrateUGT1A9 results in increased susceptibility to Bezafibrate17880178
C004541biochanin AUGT1A9 protein results in increased glucuronidation of biochanin A14557274
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of UGT1A9 mRNA26606162
C006780bisphenol Abisphenol A results in decreased expression of UGT1A9 mRNA24214726
C006780bisphenol AUGT1A9 protein polymorphism results in increased glucuronidation of bisphenol A26999266
C006780bisphenol AUGT1A9 protein results in increased glucuronidation of bisphenol A18990428|2699926
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of UGT1A9 mRNA26496021
C033560bropirimineUGT1A9 protein results in increased glucuronidation of bropirimine14555337
D002211CapsaicinUGT1A9 protein results in increased glucuronidation of Capsaicin14557274
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of UGT1A9 mRNA27174168
C035377chlorendic acidchlorendic acid results in increased expression of UGT1A9 mRNA24273086
C043561chrysinUGT1A9 protein affects the glucuronidation of chrysin10950852
C043561chrysinUGT1A9 protein results in increased glucuronidation of chrysin14557274
C027113chrysophanic acidUGT1A9 protein results in increased glucuronidation of chrysophanic acid24854283
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of UGT1A9 mRNA16197558
C019304ciprofibrateciprofibrate results in increased expression of UGT1A9 mRNA19144771
D002994ClofibrateClofibrate results in increased expression of UGT1A9 mRNA19144771|2249639
D002994ClofibratePPARA protein affects the reaction [Clofibrate results in increased expression of UGT1A9 mRNA]22496397
D002994Clofibrate[Clofibrate co-treated with Thyroxine] results in increased activity of UGT1A9 protein18219302
D002995Clofibric AcidUGT1A9 affects the susceptibility to Clofibric Acid17880178
D003367CotinineUGT1A9 protein results in increased glucuronidation of Cotinine16141602
D003375CoumestrolUGT1A9 protein results in increased glucuronidation of Coumestrol14557274
D003471CuprizoneCuprizone affects the expression of UGT1A9 mRNA27523638
D003471CuprizoneCuprizone results in decreased expression of UGT1A9 mRNA26577399
D003474CurcuminUGT1A9 protein results in increased glucuronidation of Curcumin14557274
C093628cyproconazolecyproconazole results in increased expression of UGT1A9 mRNA22334560
C004742daidzeinUGT1A9 protein results in increased glucuronidation of daidzein14557274
D003907DexamethasoneDexamethasone results in increased expression of UGT1A9 mRNA19144771
C041517dibenzo(a,l)pyrene"UGT1A9 protein results in increased glycosylation of dibenzo(a,l)pyrene"21780761
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of UGT1A9 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of UGT1A9 mRNA27392435
D004008DiclofenacUGT1A9 protein results in increased glucuronidation of Diclofenac15988124
D004041Dietary FatsDietary Fats results in decreased expression of UGT1A9 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of UGT1A9 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of UGT1A9 mRNA]19850644
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of UGT1A9 mRNA12843640
D004642EmodinUGT1A9 protein results in increased glucuronidation of Emodin14557274|2485428
C071192entacaponeUGT1A9 protein mutant form results in decreased glucuronidation of entacapone16344532
C071192entacaponeUGT1A9 protein results in increased glucuronidation of entacapone15044611|1580238
C109476epoxiconazoleepoxiconazole results in increased expression of UGT1A9 mRNA22334560
D060754EquolUGT1A9 protein results in increased glucuronidation of Equol14557274
D004970EstroneUGT1A9 protein results in increased glucuronidation of Estrone15472229
D004970EstroneUGT1A9 protein results in increased glucuronidation of Estrone analog15472229
C052488ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxzoleacetateUGT1A9 protein results in increased glucuronidation of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxzoleacetate15988124
D017308EtodolacUGT1A9 protein results in increased glucuronidation of Etodolac15535975
D005054EugenolUGT1A9 protein results in increased glucuronidation of Eugenol14557274
D015025ZearalenoneUGT1A9 protein results in increased glucuronidation of Zearalenone14557274
D005204FarnesolUGT1A9 protein results in increased glucuronidation of Farnesol15320866
C082360fipronilfipronil results in increased expression of UGT1A9 mRNA23962444
C017875fisetinUGT1A9 protein results in increased glucuronidation of fisetin14557274
D015725FluconazoleFluconazole affects the expression of UGT1A9 mRNA20623750
D0150732-AcetylaminofluoreneUGT1A9 protein results in increased glucuronidation of 2-Acetylaminofluorene analog11375903
D005480FlurbiprofenUGT1A9 protein results in increased glucuronidation of Flurbiprofen15843492
C007768formononetinUGT1A9 protein results in increased glucuronidation of formononetin14557274
C037032galanginUGT1A9 protein results in increased glucuronidation of galangin14557274
D019833GenisteinUGT1A9 protein results in increased glucuronidation of Genistein14557274|1598812
D005839GentamicinsGentamicins affects the expression of UGT1A9 mRNA20623750
C107601glabridinUGT1A9 protein results in increased glucuronidation of glabridin25765239
D020719Glucuronides"UGT1A9 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]"15986396
C004312glycidolglycidol results in decreased expression of UGT1A9 mRNA24915197
C075375grepafloxacinUGT1A9 protein results in increased glucuronidation of grepafloxacin15769885
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of UGT1A9 mRNA18791181
C410297HMR 1098UGT1A9 protein results in increased glucuronidation of HMR 109812867491
C001381hydroxycotinineUGT1A9 protein results in increased glucuronidation of hydroxycotinine16141602
C001419hydroxyphenytoinUGT1A9 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin15855726
D006923HymecromoneHymecromone results in increased activity of UGT1A9 protein26875642
D006923Hymecromonelicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A9 protein]26875642
D006923HymecromoneUGT1A9 protein results in increased glucuronidation of Hymecromone15378558|1580238
D006923HymecromoneUGT1A9 protein results in increased glucuronidation of Hymecromone16023900
D007052IbuprofenUGT1A9 protein results in increased glucuronidation of Ibuprofen15843492
D007213IndomethacinUGT1A9 protein results in increased glucuronidation of Indomethacin15843492
C051890irinotecanUGT1A9 protein results in increased glucuronidation of irinotecan15833930|1789815
C051890irinotecanUGT1A9 protein results in increased glucuronidation of irinotecan15833930
C040920isoliquiritigeninUGT1A9 protein results in increased glucuronidation of isoliquiritigenin14557274
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of UGT1A9 mRNA27392435
C544151jinfukangjinfukang results in increased expression of UGT1A9 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UGT1A9 mRNA26752646
C006552kaempferolUGT1A9 protein results in increased glucuronidation of kaempferol14557274
D007660KetoprofenUGT1A9 protein results in increased glucuronidation of Ketoprofen15535975|1584349
C070840licochalcone Alicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A9 protein]26875642
C070840licochalcone Alicochalcone A inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]26875642
C506658lorcaserinUGT1A9 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin22259019
C005498magnololmagnolol results in decreased activity of UGT1A9 protein26875642
C501277Mangifera indica extractMangifera indica extract results in decreased activity of UGT1A9 protein22815239
C501277Mangifera indica extractMangifera indica extract results in increased expression of UGT1A9 mRNA22815239
C013592mangiferinmangiferin results in increased expression of UGT1A9 mRNA22815239
D009637MasoprocolUGT1A9 protein results in increased glucuronidation of Masoprocol14557274
C011907melaminemelamine results in increased expression of UGT1A9 mRNA24273086
D008727MethotrexateMethotrexate results in decreased expression of UGT1A9 mRNA20854796
D008731MethoxychlorUGT1A9 protein results in increased glucuronidation of Methoxychlor metabolite15205390
D008748MethylcholanthreneMethylcholanthrene results in increased expression of UGT1A9 mRNA19118567
C518174MK-0524UGT1A9 protein results in increased glucuronidation of MK-052417132765
C016599mono-(2-ethylhexyl)phthalateUGT1A9 protein results in increased glucuronidation of mono-(2-ethylhexyl)phthalate27071666
C008548morinUGT1A9 protein results in increased glucuronidation of morin14557274
D009020MorphineUGT1A9 protein results in increased glucuronidation of Morphine12920162
C104727moxifloxacinUGT1A9 protein results in increased glucuronidation of moxifloxacin15769885
C523799MRK 003UGT1A9 results in increased susceptibility to MRK 00319903844
C500085muraglitazarUGT1A9 protein results in increased glucuronidation of muraglitazar17898154
D009173Mycophenolic AcidUGT1A9 gene SNP affects the metabolism of Mycophenolic Acid18498916
D009173Mycophenolic AcidUGT1A9 protein results in increased glucuronidation of Mycophenolic Acid18816295
D009173Mycophenolic AcidUGT1A9 protein results in increased metabolism of Mycophenolic Acid18498916
D009288NaproxenUGT1A9 protein results in increased glucuronidation of Naproxen15535975
C005273naringeninUGT1A9 protein results in increased glucuronidation of naringenin14557274|1881629
C027329naringenin chalconeUGT1A9 protein results in increased glucuronidation of naringenin chalcone14557274
D009538NicotineUGT1A9 protein results in increased glucuronidation of Nicotine14570768|1614160
C464660obeticholic acidobeticholic acid results in decreased expression of UGT1A9 mRNA27939613
D015242OfloxacinUGT1A9 protein results in increased glucuronidation of Ofloxacin15769885
D009853OmeprazoleOmeprazole results in increased expression of UGT1A9 mRNA19118567
D008939MitotaneMitotane results in increased expression of UGT1A9 mRNA25542188
D010076OxazepamUGT1A9 protein results in increased metabolism of Oxazepam12386133
C026256oxazepam glucuronideUGT1A9 protein results in increased abundance of oxazepam glucuronide12386133
D000073878Palm OilPalm Oil results in decreased expression of UGT1A9 mRNA18042831
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of UGT1A9 mRNA18281256
D010634Phenobarbital2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Benzo(a)pyrene promotes the reaction [Phenobarbital results in increased expression of UGT1A9 mRNA]]25489928
D010634Phenobarbital2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A9 mRNA]]25489928
D010634PhenobarbitalPhenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A9 mRNA]25489928
D010634PhenobarbitalPhenobarbital results in increased expression of UGT1A9 mRNA19631232
D010634Phenobarbitalpirinixic acid promotes the reaction [Phenobarbital results in increased expression of UGT1A9 mRNA]19631232
C008905physcioneUGT1A9 protein results in increased glucuronidation of physcione24854283
C006253pirinixic acidpirinixic acid promotes the reaction [Phenobarbital results in increased expression of UGT1A9 mRNA]19631232
C014758plumbaginUGT1A9 protein results in increased glucuronidation of plumbagin14557274
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A9 mRNA16155002
D011285Pregnenolone CarbonitrileNR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of UGT1A9 mRNA]22496397
D011285Pregnenolone Carbonitrile[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of UGT1A9 mRNA22496397
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A9 mRNA19144771|2249639
D011339ProbenecidUGT1A9 affects the susceptibility to Probenecid17880178
C045950propiconazolepropiconazole results in increased expression of UGT1A9 mRNA22334560
D015742Propofollicochalcone A inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]26875642
D015742PropofolPropofol results in decreased activity of UGT1A9 protein15378558
D015742PropofolUGT1A9 protein affects the metabolism of Propofol15286053
D015742PropofolUGT1A9 protein results in increased glucuronidation of Propofol12756209|1457076
D015742PropofolWarfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]25393417
D015742Propofol[Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol25393417
D011441PropylthiouracilPropylthiouracil results in decreased expression of UGT1A9 mRNA24780913
C034467prostaglandin B1UGT1A9 protein results in increased glucuronidation of prostaglandin B115231852
C107773pterostilbeneUGT1A9 protein affects the glucuronidation of pterostilbene23965644
C033607puerarinUGT1A9 protein results in increased metabolism of puerarin22648071
C513428pyrachlostrobinpyrachlostrobin results in increased expression of UGT1A9 mRNA27029645
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in increased expression of UGT1A9 mRNA17639512
D011794QuercetinUGT1A9 protein results in increased glucuronidation of Quercetin14557274
D000068898Raltegravir PotassiumUGT1A9 gene polymorphism affects the susceptibility to Raltegravir Potassium22371894
C115070ranirestatUGT1A9 protein results in increased glucuronidation of ranirestat15013842
C059514resveratrolUGT1A9 protein results in increased glucuronidation of resveratrol17991766|2396564
D012293RifampinRifampin results in increased expression of UGT1A9 mRNA25070100
D012293RifampinRifampin results in increased expression of UGT1A9 protein25070100
C064294sarpogrelateUGT1A9 protein results in increased glucuronidation of sarpogrelate metabolite23704698
D012603ScopoletinUGT1A9 protein results in increased glucuronidation of Scopoletin15044611|1580238
C009250sevofluranesevoflurane affects the expression of UGT1A9 mRNA15967596
C440975silybinsilybin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]15155549
C076246sitafloxacinUGT1A9 protein results in increased glucuronidation of sitafloxacin15769885
D013148SpironolactoneSpironolactone results in increased expression of UGT1A9 mRNA19144771
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of UGT1A9 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A9 mRNA10220484|1615500
D013749TetrachlorodibenzodioxinUGT1A9 protein results in increased glucuronidation of Tetrachlorodibenzodioxin metabolite15258113
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A9 mRNA]22496397
D013749TetrachlorodibenzodioxinNFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A9 mRNA]19474220
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UGT1A9 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of UGT1A9 mRNA22496397
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A9 mRNA19144771|1947422
D013974Thyroxine[Clofibrate co-treated with Thyroxine] results in increased activity of UGT1A9 protein18219302
D013943ThymolUGT1A9 protein results in increased glucuronidation of Thymol14557274
C066340tolcaponeUGT1A9 protein mutant form results in decreased glucuronidation of tolcapone16344532
C066340tolcaponeUGT1A9 protein results in increased glucuronidation of tolcapone16344532
C072782tri-(2-chloroisopropyl)phosphatetri-(2-chloroisopropyl)phosphate results in increased expression of UGT1A9 mRNA22268003
C009540triclocarbanNR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A9 mRNA]22761658
C009540triclocarbantriclocarban results in increased expression of UGT1A9 mRNA22761658
C009549triethyl phosphatetriethyl phosphate results in increased expression of UGT1A9 mRNA24273086
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of UGT1A9 mRNA"22268003|2427308
C541743tris(2,3-dibromopropyl)isocyanurate"tris(2,3-dibromopropyl)isocyanurate results in increased expression of UGT1A9 mRNA"24273086
C049232tris(2-ethylhexyl)phosphatetris(2-ethylhexyl)phosphate results in increased expression of UGT1A9 mRNA24273086
D014317Tritolyl PhosphatesTritolyl Phosphates results in increased expression of UGT1A9 mRNA24273086
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of UGT1A9 gene25560391
D014810Vitamin EVitamin E results in decreased expression of UGT1A9 mRNA28923436
D014859WarfarinWarfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]25393417
D014859WarfarinWarfarin binds to and affects the activity of UGT1A9 protein25393417
D014859Warfarin[Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol25393417
C410959Z 338UGT1A9 protein affects the metabolism of Z 33815306208

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001972retinoic acid binding-IDA20308471  
GO:0008194UDP-glycosyltransferase activity-IBA21873635  
GO:0015020glucuronosyltransferase activity-IDA18052087  20056724  20308471  22579593  
GO:0042803protein homodimerization activity-IDA17179145  
GO:0046982protein heterodimerization activity-IDA17179145  
GO ID GO Term Qualifier Evidence PubMed
GO:0006805xenobiotic metabolic process-IDA1910331  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0042573retinoic acid metabolic process-IC20308471  
GO:0051552flavone metabolic process-IDA18052087  
GO:0052695cellular glucuronidation-IDA22579593  
GO:0052696flavonoid glucuronidation-IBA21873635  
GO:0052696flavonoid glucuronidation-IDA20056724  
GO:0052697xenobiotic glucuronidation-IBA21873635  
GO:0052697xenobiotic glucuronidation-IDA20056724  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA17179145  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa00053Ascorbate and aldarate metabolism
hsa00140Steroid hormone biosynthesis
hsa00500Starch and sucrose metabolism
hsa00514Other types of O-glycan biosynthesis
hsa00830Retinol metabolism
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156588GlucuronidationTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17576790Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10. (2007 Sep)Kaivosaari SMol Pharmacol
12167564N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. (2002 Sep)Ghosheh ODrug Metab Dispos
24408517Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed targeted proteomics. (2014 Apr)Achour BDrug Metab Dispos
16141602Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation. (2005 Aug)Nakajima MDrug Metab Pharmacokinet
26802129Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo. (2016 Apr)Gufford BTDrug Metab Dispos