Gene: PPA1

5464
HEL-S-66p|IOPPP|PP|PP1|SID6-8061
pyrophosphatase (inorganic) 1
protein-coding
10q22.1
Ensembl:ENSG00000180817 MIM:179030 Vega:OTTHUMG00000018399 UniprotKB:Q15181
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
7.972e-1 (AD)  1.683e-1 (ND)   (Frontal_Cortex)
9.832e-2 (AD)  3.137e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMA10.957
VAPA0.956
PSMA60.951
TAF70.951
EIF1B0.951
EMC40.951
PSMD140.949
GDI20.948
MAP1LC3B0.947
VDAC20.947

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.781
OR4F29-0.749
MTRNR2L6-0.253
KLRB1-0.252
P2RY14-0.241
MTRNR2L10-0.241
MTRNR2L9-0.238
C8orf74-0.227
GPR171-0.215
VNN3-0.214

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPA1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PPA1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of PPA1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of PPA1 protein22939915
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of PPA1 protein25499718
D020106AcrylamideAcrylamide results in increased expression of PPA1 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PPA1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPA1 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of PPA1 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of PPA1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PPA1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PPA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PPA1 gene28505145
C013418bromfenacoumbromfenacoum results in increased expression of PPA1 protein28903499
C022777bufalinbufalin results in decreased expression of PPA1 protein23091618
D002065BuspironeBuspirone results in decreased expression of PPA1 mRNA24136188
D000069287CapecitabinePPA1 protein results in increased susceptibility to Capecitabine16734730
D002509CephaloridineCephaloridine results in increased expression of PPA1 mRNA18500788
C100187chloropicrinchloropicrin affects the expression of PPA1 mRNA26352163
D019327Copper SulfateCopper Sulfate results in decreased expression of PPA1 mRNA19549813
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PPA1 mRNA28659758
D003907DexamethasoneDexamethasone results in increased expression of PPA1 mRNA25047013
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of PPA1 mRNA"25908611
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PPA1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of PPA1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of PPA1 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PPA1 mRNA28085963
C024629dimethyl phthalatedimethyl phthalate affects the expression of PPA1 mRNA26924002
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of PPA1 mRNA18242016
D004391DustDust results in decreased expression of PPA1 mRNA17805423
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PPA1 protein23301498
D005485FlutamideFlutamide results in increased expression of PPA1 mRNA24136188
C039281furanfuran binds to PPA1 protein22240984
D017313FenretinideFenretinide results in decreased expression of PPA1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PPA1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PPA1 mRNA27392435
C008435methyldithiocarbamatemethyldithiocarbamate results in increased expression of PPA1 mRNA18648088
C063855microcystin RRmicrocystin RR results in decreased expression of PPA1 protein19111056
C063855microcystin RRmicrocystin RR results in increased expression of PPA1 protein19111056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PPA1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PPA1 mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of PPA1 mRNA24136188
C012655nimesulidenimesulide results in increased expression of PPA1 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of PPA1 protein19716841
D010081OxazoloneOxazolone results in increased expression of PPA1 mRNA18242016
D010100OxygenOxygen deficiency affects the methylation of PPA1 promoter24205000
D010100OxygenOxygen deficiency results in increased expression of PPA1 mRNA24205000
D000073878Palm OilPalm Oil results in decreased expression of PPA1 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of PPA1 mRNA23892564
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PPA1 mRNA28659758
C006253pirinixic acidpirinixic acid results in decreased expression of PPA1 protein15226431
D011374ProgesteroneProgesterone results in decreased expression of PPA1 mRNA23018184
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PPA1 mRNA28659758
C018279sodium phosphatePPA1 protein results in increased hydrolysis of sodium phosphate10733883
D053260SootSoot results in increased expression of PPA1 mRNA22461453
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPA1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPA1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PPA1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of PPA1 mRNA23557971|2776080
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of PPA1 mRNA"18242016
D014212TretinoinTretinoin results in decreased expression of PPA1 mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased expression of PPA1 mRNA19448997
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PPA1 mRNA19042947
C080163trovafloxacintrovafloxacin results in decreased expression of PPA1 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPA1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PPA1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of PPA1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PPA1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004427inorganic diphosphatase activity-EXP656444  4130389  
GO:0004427inorganic diphosphatase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006418tRNA aminoacylation for protein translation-TAS-  
GO:0006796phosphate-containing compound metabolic process-IBA21873635  
GO:0006796phosphate-containing compound metabolic process-IEA-  
GO:0071344diphosphate metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS16130169  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-379716Cytosolic tRNA aminoacylationTAS
R-HSA-379724tRNA AminoacylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-71737Pyrophosphate hydrolysisTAS
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27666431Clinical significance and functional validation of PPA1 in various tumors. (2016 Oct)Luo DCancer Med