Gene: UGT1A4

54657
HUG-BR2|UDPGT|UDPGT 1-4|UGT-1D|UGT1-04|UGT1.4|UGT1A4S|UGT1D
UDP glucuronosyltransferase family 1 member A4
protein-coding
2q37.1
Ensembl:ENSG00000244474 MIM:606429 Vega:OTTHUMG00000059119 UniprotKB:P22310
NC_000002.12
PubMed
0   ANCO-SNPs
ND
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.673e-1 (AD)  3.380e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR6N10.815
OR5B30.799
UGT2A10.785
LMX1A0.775
SERPINB110.774
OR4E20.754
OR4K170.733
NXPE10.719
OR5A20.71
KIR3DL30.708

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTSR2-0.229
IQCD-0.211
HHATL-0.208
SDC4-0.203
TMEM221-0.197
FGFR3-0.196
SLC1A4-0.195
GABRG1-0.195
HSPB2-0.194
SLC14A1-0.192

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnEnzyme
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalEnzyme
DB00363ClozapineSmall Molecule5786-21-0ApprovedEnzyme
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalEnzyme
DB00683MidazolamSmall Molecule59467-70-8Approved|IllicitEnzyme
DB00831TrifluoperazineSmall Molecule117-89-5Approved|InvestigationalEnzyme
DB00910ParicalcitolSmall Molecule131918-61-1Approved|InvestigationalEnzyme
DB04953EzogabineSmall Molecule150812-12-7Approved|InvestigationalEnzyme
DB06216AsenapineSmall Molecule65576-45-6ApprovedEnzyme
DB09262ImidafenacinSmall Molecule170105-16-5Approved|InvestigationalEnzyme
DB11827ErtugliflozinSmall Molecule1210344-57-2Approved|InvestigationalEnzyme
DB13874EnasidenibSmall Molecule1446502-11-9Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"UGT1A4 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"15231852
C0331461-hydroxypyreneUGT1A4 protein results in increased glucuronidation of 1-hydroxypyrene15802387
C05598720-hydroxy-5,8,11,14-eicosatetraenoic acid"UGT1A4 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid"15231852
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A4 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]"15986396
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A4 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15310245
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A4 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15986396
C0067574-biphenylamineUGT1A4 protein results in increased glucuronidation of 4-biphenylamine15840509
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneUGT1A4 gene polymorphism results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone14871856
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneUGT1A4 protein results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone14871856
C033541afloqualoneTrifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone]15475412
C033541afloqualoneUGT1A4 protein results in increased glucuronidation of afloqualone15475412
D000738AndrosteroneUGT1A4 protein SNP results in increased glucuronidation of Androsterone analog15708967
D016718Arachidonic AcidUGT1A4 protein results in increased glucuronidation of Arachidonic Acid15231852
D017636Asbestos, Amphibole"Asbestos, Amphibole results in decreased expression of UGT1A4 protein"20855422
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of UGT1A4 mRNA19118567
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased activity of UGT1A4 protein17065433
C006780bisphenol Abisphenol A results in decreased expression of UGT1A4 mRNA24214726
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of UGT1A4 mRNA17851650
D003024ClozapineUGT1A4 protein SNP results in increased glucuronidation of Clozapine15708967
D003367CotinineUGT1A4 protein results in increased glucuronidation of Cotinine14570768|1614160
C041517dibenzo(a,l)pyrene"UGT1A4 protein results in increased glycosylation of dibenzo(a,l)pyrene"21780761
D004008DiclofenacUGT1A4 protein results in increased glucuronidation of Diclofenac15843492
D005204FarnesolUGT1A4 protein results in increased glucuronidation of Farnesol15320866
D005290Ferric CompoundsFerric Compounds results in decreased expression of UGT1A4 mRNA24035972
D018120FinasterideFinasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Imipramine]25448279
D018120FinasterideFinasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]25448279
D005480FlurbiprofenUGT1A4 protein results in increased glucuronidation of Flurbiprofen15843492
D020719Glucuronides"UGT1A4 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]"15986396
C007908hecogeninhecogenin inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]25448279
C007908hecogenin[hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine20092275
C007908hecogeninhecogenin results in decreased activity of UGT1A4 protein20092275
C001419hydroxyphenytoinUGT1A4 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin15855726
D007099ImipramineFinasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Imipramine]25448279
D007099ImipramineUGT1A4 protein affects the metabolism of Imipramine15286053
D007099ImipramineUGT1A4 protein results in increased glucuronidation of Imipramine14570768|2544827
D007099ImipramineUGT1A4 protein SNP results in increased glucuronidation of Imipramine15708967
D007213IndomethacinUGT1A4 protein results in increased glucuronidation of Indomethacin15843492
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UGT1A4 mRNA26752646
D007660KetoprofenUGT1A4 protein results in increased glucuronidation of Ketoprofen15843492
C047781lamotrigine[Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine19845433
C047781lamotrigine[pirinixic acid results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine19845433
C047781lamotrigine[Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine19845433
C047781lamotrigineUGT1A4 protein results in increased glucuronidation of lamotrigine17151188|1984543
C070840licochalcone Alicochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein]26875642
D008070Lipopolysaccharides[usnic acid co-treated with Lipopolysaccharides] results in increased expression of UGT1A4 mRNA22777745
D008727MethotrexateMethotrexate results in increased expression of UGT1A4 mRNA20854796
D008748MethylcholanthreneMethylcholanthrene results in increased expression of UGT1A4 mRNA19118567
D009538NicotineUGT1A4 protein results in increased glucuronidation of Nicotine14570768|1614160
C010257N'-nitrosoanabasineUGT1A4 protein results in increased glucuronidation of N'-nitrosoanabasine18238858
C032978N'-nitrosoanatabineUGT1A4 protein results in increased glucuronidation of N'-nitrosoanatabine18238858
C008655N'-nitrosonornicotineUGT1A4 protein results in increased glucuronidation of N'-nitrosonornicotine18238858
C464660obeticholic acidobeticholic acid results in decreased expression of UGT1A4 mRNA27939613
D009853OmeprazoleOmeprazole results in increased expression of UGT1A4 mRNA19118567
D010634PhenobarbitalPhenobarbital results in increased activity of UGT1A4 protein19845433
D010634Phenobarbital[Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine19845433
C006253pirinixic acidpirinixic acid results in increased activity of UGT1A4 protein19845433
C006253pirinixic acid[pirinixic acid results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine19845433
C006253pirinixic acidpirinixic acid results in increased expression of UGT1A4 mRNA17151188
C006253pirinixic acidpirinixic acid results in increased expression of UGT1A4 protein17151188
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased activity of UGT1A4 protein16155002|1984543
D011285Pregnenolone Carbonitrile[Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine19845433
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A4 mRNA16155002
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A4 protein16155002
D000644Quaternary Ammonium CompoundsUGT1A4 protein results in increased glucuronidation of Quaternary Ammonium Compounds9264550
C115070ranirestatUGT1A4 protein results in increased glucuronidation of ranirestat15013842
C115070ranirestatUGT1A4 protein results in increased glycosylation of ranirestat15013842
C064294sarpogrelateUGT1A4 protein results in increased glucuronidation of sarpogrelate metabolite23704698
C046297sarsasapogeninUGT1A4 protein SNP results in decreased glucuronidation of sarsasapogenin15708967
C009237senecionine[hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine20092275
C009237senecionineUGT1A4 protein results in increased glycosylation of senecionine20092275
D013467SulindacUGT1A4 protein results in increased glucuronidation of Sulindac15843492
C025463sulindac sulfoneUGT1A4 protein results in increased glucuronidation of sulindac sulfone15843492
D013629TamoxifenUGT1A4 protein results in increased glucuronidation of Tamoxifen15135306
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of UGT1A4 protein16155002
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A4 mRNA16155002|1843381
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A4 protein16155002
D013749TetrachlorodibenzodioxinUGT1A4 promoter SNP affects the susceptibility to Tetrachlorodibenzodioxin18433817
C009540triclocarbanNR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A4 mRNA]22761658
C009540triclocarbantriclocarban results in increased expression of UGT1A4 mRNA22761658
D014268TrifluoperazineFinasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]25448279
D014268Trifluoperazinehecogenin inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]25448279
D014268Trifluoperazinelicochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein]26875642
D014268TrifluoperazineTrifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone]15475412
D014268TrifluoperazineTrifluoperazine results in increased activity of UGT1A4 protein26875642
D014268TrifluoperazineUGT1A4 protein results in increased glucuronidation of Trifluoperazine15135306|1547541
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of UGT1A4 mRNA"26743178
C057693troglitazonetroglitazone results in decreased expression of UGT1A4 mRNA19631733
C057693troglitazonetroglitazone results in increased expression of UGT1A4 mRNA19631733
C073339usnic acid[usnic acid co-treated with Lipopolysaccharides] results in increased expression of UGT1A4 mRNA22777745
C073339usnic acidusnic acid results in increased expression of UGT1A4 mRNA21953288|2277774
D014635Valproic AcidValproic Acid results in decreased methylation of UGT1A4 gene29154799
D017967Zinc CompoundsZinc Compounds results in decreased expression of UGT1A4 mRNA24035972

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001972retinoic acid bindingNOTIDA20308471  
GO:0008194UDP-glycosyltransferase activity-IBA21873635  
GO:0015020glucuronosyltransferase activity-IDA1898728  22579593  
GO:0015020glucuronosyltransferase activity-TAS-  
GO:0042803protein homodimerization activity-IDA17179145  
GO:0046982protein heterodimerization activity-IDA17179145  
GO ID GO Term Qualifier Evidence PubMed
GO:0006789bilirubin conjugation-TAS-  
GO:0042167heme catabolic process-TAS-  
GO:0052695cellular glucuronidation-IDA22579593  
GO:0052695cellular glucuronidation-TAS-  
GO:0052696flavonoid glucuronidation-IBA21873635  
GO:0052697xenobiotic glucuronidation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA17179145  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa00053Ascorbate and aldarate metabolism
hsa00140Steroid hormone biosynthesis
hsa00500Starch and sucrose metabolism
hsa00514Other types of O-glycan biosynthesis
hsa00830Retinol metabolism
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156588GlucuronidationTAS
R-HSA-1643685DiseaseTAS
R-HSA-189445Metabolism of porphyrinsTAS
R-HSA-189483Heme degradationTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-5579016Defective UGT1A4 causes hyperbilirubinemiaTAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19593404Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking. (2009 Jul-Aug)Hubner RHMol Med
17576790Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10. (2007 Sep)Kaivosaari SMol Pharmacol
18223460The relationship between the response of clinical symptoms and plasma olanzapine concentration, based on pharmacogenetics: Juntendo University Schizophrenia Projects (JUSP). (2008 Feb)Nozawa MTher Drug Monit
21601426The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy. (2011 Jun)Gulcebi MIEpilepsy Res
12167564N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. (2002 Sep)Ghosheh ODrug Metab Dispos
16141602Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation. (2005 Aug)Nakajima MDrug Metab Pharmacokinet
27096250Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: Influence of polymorphism of UDP-glucuronosyltransferases and drug transporters. (2016 Aug)Milosheska DBr J Clin Pharmacol
20143052Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure--an impact similar to male gender or smoking in schizophrenic patients. (2010 May)Ghotbi REur J Clin Pharmacol
26137357Genetic and Clinical Factors Affecting Plasma Clozapine Concentration. (2015)Olsson EPrim Care Companion CNS Disord