Gene: UGT1A1

54658
BILIQTL1|GNT1|HUG-BR1|UDPGT|UDPGT 1-1|UGT1|UGT1A
UDP glucuronosyltransferase family 1 member A1
protein-coding
2q37.1
Ensembl:ENSG00000241635 MIM:191740 Vega:OTTHUMG00000059117 UniprotKB:P22309
NG_033238.1
PubMed
OD|ND
21   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.749e-1 (AD)  6.007e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4Q30.913
OR10K20.911
OR5F10.906
TSPY30.906
OR5M10.906
OR10AG10.906
KRTAP6-20.906
OR4C120.906
KRTAP27-10.906
OR5T20.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FUT9-0.257
B3GALT1-0.25
PLA2G6-0.242
CORO2B-0.238
PLEKHA6-0.231
BDH1-0.227
CCNF-0.227
SLC1A4-0.225
KIAA1671-0.225
GREB1-0.223

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04868NilotinibSmall Molecule641571-10-0Approved|InvestigationalTransporter
DB06589PazopanibSmall Molecule444731-52-6ApprovedTransporter
DB00173AdenineSmall Molecule73-24-5Approved|NutraceuticalEnzyme
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnEnzyme
DB00227LovastatinSmall Molecule75330-75-5Approved|InvestigationalEnzyme
DB00295MorphineSmall Molecule57-27-2Approved|InvestigationalEnzyme
DB00316AcetaminophenSmall Molecule103-90-2ApprovedEnzyme
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalEnzyme
DB00398SorafenibSmall Molecule284461-73-0Approved|InvestigationalEnzyme
DB00530ErlotinibSmall Molecule183321-74-6Approved|InvestigationalEnzyme
DB00586DiclofenacSmall Molecule15307-86-5ApprovedEnzyme
DB00641SimvastatinSmall Molecule79902-63-9ApprovedEnzyme
DB00678LosartanSmall Molecule114798-26-4ApprovedEnzyme
DB00688Mycophenolate mofetilSmall Molecule128794-94-5Approved|InvestigationalEnzyme
DB00704NaltrexoneSmall Molecule16590-41-3Approved|InvestigationalEnzyme
DB00712FlurbiprofenSmall Molecule5104-49-4Approved|InvestigationalEnzyme
DB00762IrinotecanSmall Molecule97682-44-5Approved|InvestigationalEnzyme
DB00773EtoposideSmall Molecule33419-42-0ApprovedEnzyme
DB00783EstradiolSmall Molecule50-28-2Approved|InvestigationalEnzyme
DB00788NaproxenSmall Molecule22204-53-1ApprovedEnzyme
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalEnzyme
DB00870SuprofenSmall Molecule40828-46-4Approved|WithdrawnEnzyme
DB00973EzetimibeSmall Molecule163222-33-1ApprovedEnzyme
DB01024Mycophenolic acidSmall Molecule24280-93-1ApprovedEnzyme
DB01045RifampicinSmall Molecule13292-46-1ApprovedEnzyme
DB01048AbacavirSmall Molecule136470-78-5Approved|InvestigationalEnzyme
DB01050IbuprofenSmall Molecule15687-27-1ApprovedEnzyme
DB01076AtorvastatinSmall Molecule134523-00-5ApprovedEnzyme
DB01095FluvastatinSmall Molecule93957-54-1ApprovedEnzyme
DB01420Testosterone propionateSmall Molecule57-85-2Approved|Investigational|WithdrawnEnzyme
DB01544FlunitrazepamSmall Molecule1622-62-4Approved|IllicitEnzyme
DB04953EzogabineSmall Molecule150812-12-7Approved|InvestigationalEnzyme
DB05039IndacaterolSmall Molecule312753-06-3ApprovedEnzyme
DB06210EltrombopagSmall Molecule496775-61-2ApprovedEnzyme
DB06510MuraglitazarSmall Molecule331741-94-7InvestigationalEnzyme
DB06626AxitinibSmall Molecule319460-85-0Approved|InvestigationalEnzyme
DB06741GavestinelSmall Molecule153436-22-7InvestigationalEnzyme
DB06817RaltegravirSmall Molecule518048-05-0ApprovedEnzyme
DB08896RegorafenibSmall Molecule755037-03-7ApprovedEnzyme
DB08930DolutegravirSmall Molecule1051375-16-6ApprovedEnzyme
DB11799BictegravirSmall Molecule1611493-60-7Approved|InvestigationalEnzyme
DB11827ErtugliflozinSmall Molecule1210344-57-2Approved|InvestigationalEnzyme
DB11943DelafloxacinSmall Molecule189279-58-1Approved|InvestigationalEnzyme
DB12070LetermovirSmall Molecule917389-32-3Approved|InvestigationalEnzyme
DB12332RucaparibSmall Molecule283173-50-2Approved|InvestigationalEnzyme
DB13874EnasidenibSmall Molecule1446502-11-9Approved|InvestigationalEnzyme
DB13878PibrentasvirSmall Molecule1353900-92-1Approved|InvestigationalEnzyme
DB13879GlecaprevirSmall Molecule1365970-03-1Approved|InvestigationalEnzyme
DB13952Estradiol acetateSmall Molecule4245-41-4Approved|InvestigationalEnzyme
DB13953Estradiol benzoateSmall Molecule50-50-0Approved|InvestigationalEnzyme
DB13954Estradiol cypionateSmall Molecule313-06-4Approved|InvestigationalEnzyme
DB13955Estradiol dienanthateSmall Molecule7732-97-0Approved|InvestigationalEnzyme
DB13956Estradiol valerateSmall Molecule979-32-8Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C5432111,2,5,8-tetrahydroxy anthraquinone"UGT1A1 protein results in increased glucuronidation of 1,2,5,8-tetrahydroxy anthraquinone"14557274
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in decreased expression of UGT1A1 mRNA"26894911
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of UGT1A1 protein22527513
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]"19196849
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of UGT1A1 mRNA"22496397
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of UGT1A1 mRNA"15004031|1598641
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of UGT1A1 protein"15986414|2781899
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of UGT1A1 mRNA]"22496397
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]"19196849
C0348901,4-dihydroxyanthraquinone"UGT1A1 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone"14557274
C0907681-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"UGT1A1 protein results in increased glucuronidation of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"29285606
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"UGT1A1 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"15231852
C0331461-hydroxypyreneUGT1A1 protein results in increased glucuronidation of 1-hydroxypyrene15802387
C0293501-naphtholUGT1A1 protein results in increased glucuronidation of 1-naphthol24728488
C05598720-hydroxy-5,8,11,14-eicosatetraenoic acid"UGT1A1 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid"15231852
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of UGT1A1 mRNA"25565004
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of UGT1A1 mRNA"17964624
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of UGT1A1 mRNA"20056577
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]17256720
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of UGT1A1 mRNA]15896333
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulforafan results in increased expression of UGT1A1 mRNA]15090468
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Apigenin results in increased expression of UGT1A1 mRNA]15090468
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in increased expression of UGT1A1 mRNA"24713691
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of UGT1A1 mRNA"24713691
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of UGT1A1 mRNA]"23756648
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl results in increased expression of and results in increased activity of UGT1A1 protein"15254343
C5333422,4,6-triphenyl-1-hexene"2,4,6-triphenyl-1-hexene results in decreased expression of UGT1A1 mRNA"18560529
C0593542',4'-dihydroxychalcone"UGT1A1 protein results in increased glucuronidation of 2',4'-dihydroxychalcone"14557274
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of UGT1A1 mRNA]15896333
C1074972',5'-dihydroxychalcone"UGT1A1 protein results in increased glucuronidation of 2',5'-dihydroxychalcone"14557274
C0348892,6-dihydroxyanthraquinone"UGT1A1 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone"12756209|1455727
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UGT1A1 mRNA"22138251|2381079
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A1 protein results in increased glucuronidation of and results in decreased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15708579
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UGT1A1 mRNA]"22138251
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of UGT1A1 mRNA"22138251|2381079
C5464602-amino-3-methyl-3H-imidazo(4,5-f)quinoline"2-amino-3-methyl-3H-imidazo(4,5-f)quinoline results in increased expression of UGT1A1 mRNA"23810796
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A1 promoter polymorphism affects the metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15986396
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A1 promoter polymorphism affects the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]"15986396
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A1 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]"15986396
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A1 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"11442279|1531024
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A1 protein results in increased glucuronidation of and results in decreased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15769885
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A1 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15986396
C0013902-hydroxyestradiolUGT1A1 protein results in increased glucuronidation of 2-hydroxyestradiol14871858|1511796
C0249802-hydroxyestroneUGT1A1 protein results in increased glucuronidation of 2-hydroxyestrone15117964
C0228302-methoxyestradiolUGT1A1 protein results in increased glucuronidation of 2-methoxyestradiol15117964
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of UGT1A1 mRNA20650352
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of UGT1A1 mRNA"19144771|2677088
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of UGT1A1 mRNA"19692669|2095900
C0454213,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine"3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine results in increased expression of UGT1A1 mRNA"23810796
C5575053',4'-dimethoxy-alpha-naphthoflavone"3',4'-dimethoxy-alpha-naphthoflavone results in decreased expression of UGT1A1 mRNA"21127131
C0902303,6-dihydroxychrysene"[Methylcholanthrene results in increased expression of UGT1A1 protein] which results in increased glucuronidation of 3,6-dihydroxychrysene"1435739
C0213383-hydroxybenzo(a)pyreneUGT1A1 protein results in increased glucuronidation of 3-hydroxybenzo(a)pyrene1435739
C4828803-hydroxydesloratadineUGT1A1 protein results in increased glucuronidation of 3-hydroxydesloratadine15334623
C4171904-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine"4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine results in increased expression of UGT1A1 mRNA"15673846
C5830744,4'-hexafluorisopropylidene diphenol"UGT1A1 protein results in increased glucuronidation of and results in decreased activity of 4,4'-hexafluorisopropylidene diphenol"24349450
C5162844-cumylphenol4-cumylphenol results in increased expression of UGT1A1 mRNA22214767
C0264184-hydroxyestroneUGT1A1 protein results in increased glucuronidation of 4-hydroxyestrone15117964
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in decreased activity of UGT1A1 protein26875642
C0248364-nitrophenolUGT1A1 protein results in increased glucuronidation of 4-nitrophenol24728488
C0248364-nitrophenolUGT1A1 protein results in increased glucuronidation of 4-nitrophenol15802387
C5014744-OH-2',3,3',4',5'-pentachlorobiphenyl"UGT1A1 protein results in increased glucuronidation of 4-OH-2',3,3',4',5'-pentachlorobiphenyl"16006569
C0700584-trifluoromethylumbelliferyl iduronideUGT1A1 protein results in increased glucuronidation of 4-trifluoromethylumbelliferyl iduronide15357915
C0229095-methoxypsoralen5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
C0229095-methoxypsoralen5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased activity of UGT1A1 protein"23950218
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of UGT1A1 mRNA"23950218
C0872036-hydroxychrysene[Methylcholanthrene results in increased expression of UGT1A1 protein] which results in increased glucuronidation of 6-hydroxychrysene1435739
C0872036-hydroxychryseneUGT1A1 protein results in increased glucuronidation of 6-hydroxychrysene1435739
C1217077,3'-dihydroxy-4'-methoxyisoflavone"UGT1A1 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone"25044472
C0842367-hydroxy-4-trifluoromethylcoumarinsilybin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]15155549
C0842367-hydroxy-4-trifluoromethylcoumarinUGT1A1 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin15155549
D000082AcetaminophenAcetaminophen results in decreased activity of UGT1A1 protein15593333
D000082AcetaminophenAcetaminophen results in decreased expression of UGT1A1 mRNA29067470
D000082AcetaminophenUGT1A1 protein results in increased glucuronidation of Acetaminophen17898154
D000082AcetaminophenAcetaminophen affects the expression of UGT1A1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of UGT1A1 mRNA23333575|2677215
D000082AcetaminophenGenistein inhibits the reaction [Acetaminophen results in decreased expression of UGT1A1 mRNA]23333575
D000082Acetaminophenhyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A1 mRNA]26772156
D000082AcetaminophenUGT1A1 gene mutant form results in increased susceptibility to Acetaminophen6776978
D016604Aflatoxin B1Aflatoxin B1 results in increased activity of UGT1A1 protein20015472
D016604Aflatoxin B1Curcumin promotes the reaction [Aflatoxin B1 results in increased activity of UGT1A1 protein]20015472
C103303alitretinoinalitretinoin results in increased expression of UGT1A1 mRNA14620509
C010078alizarinUGT1A1 protein results in increased glucuronidation of alizarin14557274
C006457alloinUGT1A1 protein results in increased glucuronidation of alloin14557274
C038491allyl sulfideallyl sulfide results in increased expression of UGT1A1 mRNA19695238
D024502alpha-Tocopherol[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]22389237
D009762o-AminoazotolueneNR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of UGT1A1 mRNA]21672546
D009762o-Aminoazotolueneo-Aminoazotoluene results in increased expression of UGT1A1 mRNA21672546
D000638AmiodaroneAmiodarone affects the expression of UGT1A1 mRNA18355885|1948338
D000639AmitriptylineAmitriptyline affects the expression of UGT1A1 mRNA18355885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UGT1A1 mRNA16483693
D000700AnalgesicsUGT1A1 gene mutant form affects the metabolism of Analgesics1203171
D000738AndrosteroneAndrosterone inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Diethylstilbestrol]23126256
D000781Anethole TrithioneAnethole Trithione results in increased activity of UGT1A1 protein8339252
C044613angelicae sinensis extractangelicae sinensis extract results in increased expression of UGT1A1 protein23441843
C032186anthrarobinUGT1A1 protein results in increased glucuronidation of anthrarobin14557274
D047310Apigenin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Apigenin results in increased expression of UGT1A1 mRNA]15090468
D047310ApigeninApigenin results in increased expression of UGT1A1 mRNA15090468
D047310Apigenin[sulforafan co-treated with Apigenin] results in increased expression of UGT1A1 mRNA15090468
D047310ApigeninUGT1A1 protein results in increased glucuronidation of Apigenin14557274
D016718Arachidonic AcidUGT1A1 protein results in increased glucuronidation of Arachidonic Acid15231852
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of UGT1A1 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of UGT1A1 mRNA23912714
D001151ArsenicArsenic results in increased expression of UGT1A1 mRNA27060662
D001241AspirinUGT1A1 gene mutant form results in increased susceptibility to Aspirin6776978
D001241AspirinUGT1A1 protein mutant form results in increased susceptibility to Aspirin3864191
D000069446Atazanavir SulfateAtazanavir Sulfate results in decreased activity of UGT1A1 protein19955297
D001280Atrazine[Endosulfan co-treated with Atrazine] results in increased expression of UGT1A1 mRNA24343343
D001280Atrazine[Endosulfan co-treated with Chlorpyrifos co-treated with Atrazine] results in increased expression of UGT1A1 mRNA24343343
C487081belinostatUGT1A1 gene polymorphism results in decreased glucuronidation of belinostat23382909
C487081belinostatUGT1A1 protein results in increased glucuronidation of belinostat23382909
C053561benzamidoximeUGT1A1 protein results in increased glucuronidation of and results in decreased activity of benzamidoxime15788365
D001553BenzbromaroneBenzbromarone affects the expression of UGT1A1 mRNA19483382
C054191benzo(a)pyrene-3,6-quinol"UGT1A1 protein results in increased glucuronidation of benzo(a)pyrene-3,6-quinol"1435739
D019324beta-Naphthoflavonebeta-Naphthoflavone promotes the reaction [[AHR protein binds to UGT1A1 enhancer] which results in increased expression of UGT1A1 mRNA]12566446|1256644
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased activity of UGT1A1 protein16399344
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of and results in increased activity of UGT1A1 protein12566446
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of UGT1A1 mRNA16399344|1791726
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of UGT1A1 protein16399344
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of UGT1A1 mRNA19144771
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of UGT1A1 mRNA19695238|2060781
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGT1A1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [[AHR protein binds to UGT1A1 enhancer] which results in increased expression of UGT1A1 mRNA]12566446|1256644
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A1 promoter]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [BRCA1 protein binds to UGT1A1 promoter]21507987
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [[BRCA1 protein binds to UGT1A1 promoter] which results in increased expression of UGT1A1 mRNA]21507987|2150798
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased activity of UGT1A1 protein17065433
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of and results in increased activity of UGT1A1 protein12566446
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGT1A1 mRNA20403331|2145854
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGT1A1 protein21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A1 promoter]]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of UGT1A1 mRNA]21507987
D001564Benzo(a)pyreneBRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of UGT1A1 protein]21507987
D001564Benzo(a)pyreneLuteolin inhibits the reaction [Benzo(a)pyrene results in increased expression of UGT1A1 mRNA]20403331
D001564Benzo(a)pyreneUGT1A1 protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]21507987
D001564Benzo(a)pyreneUGT1A1 protein affects the susceptibility to Benzo(a)pyrene21507987
D001564Benzo(a)pyreneUGT1A1 protein results in increased glucuronidation of Benzo(a)pyrene14557274
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGT1A1 mRNA20127859
D003374CoumarinsCoumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
D003374CoumarinsCoumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
C068337bergamottinUGT1A1 protein results in increased glucuronidation of bergamottin analog14557274
D004958Estradiol[Cycloheximide co-treated with Estradiol] results in decreased expression of UGT1A1 mRNA15072547
D004958EstradiolEstradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]15378558
D004958EstradiolEstradiol results in decreased activity of UGT1A1 protein15378558
D004958EstradiolEstradiol results in decreased expression of UGT1A1 mRNA15072547|1798269
D004958EstradiolFusidic Acid inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]27676153
D004958EstradiolUGT1A1 gene mutant form results in decreased glucuronidation of Estradiol analog17898154
D004958EstradiolUGT1A1 protein results in increased glucuronidation of Estradiol15117964|1547222
D004958EstradiolUGT1A1 protein results in increased glucuronidation of Estradiol analog15472229|1789815
D004958Estradiol[Warfarin binds to and results in decreased activity of UGT1A1 protein] which results in decreased glucuronidation of Estradiol25393417
D004958EstradiolWarfarin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]25393417
D004958Estradiol[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]22389237
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of UGT1A1 mRNA26496021
D004958EstradiolEstradiol affects the expression of UGT1A1 mRNA22389237|2477782
D004958Estradiol[Progesterone co-treated with Estradiol] affects the expression of UGT1A1 mRNA24777823
D024503beta-Tocopherol[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]22389237
D001663BilirubinUGT1A1 protein results in increased glucuronidation of Bilirubin24728488
D001663Bilirubin5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
D001663BilirubinBilirubin results in decreased activity of UGT1A1 protein15334623
D001663BilirubinBilirubin results in increased expression of UGT1A1 mRNA15382119
D001663Bilirubinchrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]10950852
D001663Bilirubinchrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
D001663BilirubinCoumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
D001663BilirubinIL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA]15382119
D001663Bilirubinimperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
D001663BilirubinUGT1A1 gene mutant form results in decreased glucuronidation of Bilirubin17898154
D001663BilirubinUGT1A1 protein results in increased glucuronidation of and results in decreased activity of Bilirubin15557560
D001663BilirubinUGT1A1 protein results in increased glucuronidation of Bilirubin15988124|1759928
D001663BilirubinUGT1A1 protein results in increased metabolism of Bilirubin23401472|2706066
D001663BilirubinUGT1A1 results in increased glucuronidation of Bilirubin25370011
D001663Bilirubin5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
D001663Bilirubinchrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
D001663BilirubinCoumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
D001663Bilirubinimperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
D001663BilirubinUGT1A1 protein results in increased glucuronidation of Bilirubin12153725|1592199
D001663BilirubinUGT1A1 protein results in increased glucuronidation of Bilirubin24403077
D001663BilirubinUGT1A1 protein results in increased metabolism of Bilirubin23950218
C004541biochanin AUGT1A1 protein results in increased glucuronidation of biochanin A14557274
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of UGT1A1 mRNA26894911
C006780bisphenol AUGT1A1 protein results in increased glucuronidation of bisphenol A24728488
C006780bisphenol Abisphenol A results in increased expression of UGT1A1 mRNA22214767
C006780bisphenol AUGT1A1 polymorphism affects the glucuronidation of bisphenol A22154984
C006780bisphenol AUGT1A1 protein polymorphism results in decreased glucuronidation of bisphenol A26999266
C006780bisphenol AUGT1A1 protein results in increased glucuronidation of bisphenol A18990428
C006780bisphenol Abisphenol A results in increased expression of UGT1A1 mRNA21932408
C006780bisphenol A[LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of UGT1A1 mRNA28123100
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of UGT1A1 mRNA]"23756648
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of UGT1A1 mRNA26496021
C492482bisphenol Bbisphenol B results in increased expression of UGT1A1 mRNA22214767
C011686boldineboldine results in increased expression of UGT1A1 mRNA25771127
C033560bropirimineUGT1A1 protein results in increased glucuronidation of bropirimine14555337
D002047BuprenorphineUGT1A1 protein results in increased glucuronidation of Buprenorphine12756209
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of UGT1A1 mRNA18227147
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of UGT1A1 mRNA19144771
D019256Cadmium ChlorideCadmium Chloride analog results in increased expression of UGT1A1 mRNA27060662
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of UGT1A1 mRNA11958953
D002110CaffeineCaffeine results in increased expression of UGT1A1 mRNA18227147
D002211CapsaicinUGT1A1 protein results in increased glucuronidation of Capsaicin14557274
D002220CarbamazepineCarbamazepine results in increased activity of UGT1A1 protein27413119
D002220CarbamazepineCarbamazepine results in increased expression of UGT1A1 mRNA27413119
D002220CarbamazepineCarbamazepine results in increased expression of UGT1A1 mRNA17381134
C043211carvedilolUGT1A1 gene polymorphism affects the glucuronidation of carvedilol16849011
C043211carvedilolUGT1A1 gene polymorphism affects the metabolism of carvedilol16849011
C043211carvedilolUGT1A1 protein results in increased glucuronidation of carvedilol14744946
D047188ChalconesChalcones analog results in increased expression of UGT1A1 protein23963778
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of UGT1A1 mRNA27174168
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of UGT1A1 mRNA16934159|1785165
D004390Chlorpyrifos[Endosulfan co-treated with Chlorpyrifos co-treated with Atrazine] results in increased expression of UGT1A1 mRNA24343343
D004390Chlorpyrifos[Endosulfan co-treated with Chlorpyrifos] results in increased expression of UGT1A1 mRNA24343343
C043561chrysin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]17256720
C043561chrysinchrysin inhibits the reaction [AHR protein binds to UGT1A1 promoter]17256720
C043561chrysinchrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]10950852
C043561chrysinchrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Ethinyl Estradiol]10950852
C043561chrysinchrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
C043561chrysinchrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Quercetin]11442279
C043561chrysinchrysin results in increased expression of UGT1A116003560
C043561chrysinchrysin results in increased expression of UGT1A1 mRNA10950852|1144227
C043561chrysinchrysin results in increased expression of UGT1A1 protein10950852|1144227
C043561chrysinpyrazolanthrone inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]17256720
C043561chrysinSB 203580 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]17256720
C043561chrysinU 0126 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]17256720
C043561chrysinUGT1A1 protein affects the glucuronidation of chrysin10950852
C043561chrysinUGT1A1 protein results in increased glucuronidation of chrysin14557274
C043561chrysinchrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
C043561chrysinchrysin results in increased expression of UGT1A1 mRNA25625231
C019304ciprofibrateciprofibrate results in increased expression of UGT1A1 mRNA19144771
D002994ClofibrateClofibrate affects the expression of UGT1A1 mRNA19483382
D002994ClofibrateClofibrate results in increased expression of UGT1A1 mRNA12851107|1717446
D002994ClofibrateClofibrate results in increased expression of UGT1A1 protein17967931
D002995Clofibric AcidClofibric Acid results in increased expression of UGT1A1 mRNA15771232
D002997ClomipramineClomipramine affects the expression of UGT1A1 mRNA18355885
D003022ClotrimazoleClotrimazole affects the expression of UGT1A1 mRNA15849716
D003024ClozapineClozapine results in increased expression of UGT1A1 mRNA18227147
D003069CoffeeCoffee results in increased expression of UGT1A1 mRNA25606436
D003069CoffeeNFE2L2 promoter polymorphism affects the reaction [UGT1A1 promoter polymorphism affects the susceptibility to Coffee]25606436
D003069CoffeeUGT1A1 promoter polymorphism affects the susceptibility to Coffee25606436
D003375CoumestrolUGT1A1 protein results in increased glucuronidation of Coumestrol14557274
D003474CurcuminCurcumin results in increased expression of UGT1A1 mRNA16819192
D003474CurcuminUGT1A1 protein results in increased glucuronidation of Curcumin14557274
D003474CurcuminCurcumin analog results in increased expression of UGT1A1 mRNA26991801
D003474CurcuminCurcumin analog results in increased expression of UGT1A1 protein26991801
D003474CurcuminCurcumin promotes the reaction [Aflatoxin B1 results in increased activity of UGT1A1 protein]20015472
D003513Cycloheximide[Cycloheximide co-treated with Estradiol] results in decreased expression of UGT1A1 mRNA15072547
D003513CycloheximideCycloheximide results in decreased expression of UGT1A1 mRNA15072547
C089595cylindrospermopsincylindrospermopsin results in increased expression of UGT1A1 mRNA23726867
C093628cyproconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of UGT1A1 mRNA29038839
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of UGT1A1 mRNA29038839
C093628cyproconazolecyproconazole results in increased expression of UGT1A1 mRNA29038839
C004742daidzeindaidzein results in increased activity of UGT1A1 protein16051636
C004742daidzeinUGT1A1 protein results in increased glucuronidation of daidzein14557274
C010902decabromobiphenyl etherdecabromobiphenyl ether analog results in increased expression of UGT1A1 mRNA26894911
C014347decitabinedecitabine results in increased expression of UGT1A1 mRNA23401472
C014347decitabineHNF1A protein promotes the reaction [decitabine results in increased expression of UGT1A1 mRNA]23401472
C479072delta-tocopherol[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]22389237
D003907DexamethasoneDexamethasone results in increased expression of UGT1A1 mRNA15557560|1556036
D003907DexamethasoneDexamethasone results in increased expression of UGT1A1 protein15557560
D003907Dexamethasone[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT1A1 mRNA29222744
D003907DexamethasoneDexamethasone promotes the reaction [Pregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA]16155002
D003907DexamethasoneDexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA]16155002
D003907DexamethasoneDexamethasone results in decreased expression of UGT1A1 mRNA19144771
D003907DexamethasoneDexamethasone results in increased expression of UGT1A1 mRNA21041162|2922274
D003907DexamethasoneDexamethasone results in increased expression of UGT1A1 mRNA15102944|2060781
C028009diallyl disulfidediallyl disulfide results in increased activity of UGT1A1 protein8339252
C042577diallyl trisulfidediallyl trisulfide results in increased expression of UGT1A1 mRNA20650352
C041517dibenzo(a,l)pyrene"UGT1A1 protein results in increased glycosylation of dibenzo(a,l)pyrene"21780761
D002945CisplatinUGT1A1 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCisplatin results in increased expression of UGT1A1 mRNA18289764
D002945CisplatinCisplatin results in increased expression of UGT1A1 protein22023808
D004008DiclofenacUGT1A1 protein results in increased glucuronidation of Diclofenac24728488
D004008DiclofenacDiclofenac results in decreased activity of UGT1A1 protein15334623|1559333
D004008DiclofenacDiclofenac results in increased expression of UGT1A1 mRNA18227147
D004008DiclofenacDiclofenac results in decreased expression of UGT1A1 mRNA19022234
C121718dicyclanildicyclanil results in increased expression of UGT1A1 mRNA15664270
D004041Dietary FatsDietary Fats results in decreased expression of UGT1A1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of UGT1A1 mRNA23756648
D004041Dietary Fats"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of UGT1A1 mRNA]"23756648
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UGT1A1 mRNA17967931
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UGT1A1 protein17967931
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UGT1A1 mRNA17967931
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UGT1A1 protein17967931
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of UGT1A1 mRNA19144771
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of UGT1A1 mRNA]"23756648
D004052Diethylnitrosamine[Mastic Resin co-treated with Diethylnitrosamine] results in increased expression of UGT1A1 mRNA18977376
D004054DiethylstilbestrolAndrosterone inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Diethylstilbestrol]23126256
D004054DiethylstilbestrolPhenylbutazone inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Diethylstilbestrol]23126256
D004054DiethylstilbestrolUGT1A1 protein results in increased glucuronidation of Diethylstilbestrol23126256
D004061DiflunisalDiflunisal results in decreased activity of UGT1A1 protein15593333
D002117CalcitriolCalcitriol results in increased expression of UGT1A1 mRNA21592394|2710755
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of UGT1A1 mRNA21592394
D004317DoxorubicinDoxorubicin results in decreased expression of UGT1A1 mRNA26335259
D004317Doxorubicin[Doxorubicin results in increased expression of NFE2L2 protein] which results in increased expression of UGT1A1 mRNA24211725
D004317Doxorubicin[Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in decreased expression of UGT1A1 mRNA]26335259
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of UGT1A1 mRNA"26590097
C070609EMD 53998EMD 53998 analog results in increased expression of UGT1A1 mRNA24977338
D004642EmodinUGT1A1 protein results in increased glucuronidation of Emodin14557274
D004726Endosulfan[Endosulfan co-treated with Atrazine] results in increased expression of UGT1A1 mRNA24343343
D004726Endosulfan[Endosulfan co-treated with Chlorpyrifos co-treated with Atrazine] results in increased expression of UGT1A1 mRNA24343343
D004726Endosulfan[Endosulfan co-treated with Chlorpyrifos] results in increased expression of UGT1A1 mRNA24343343
D004726EndosulfanEndosulfan results in increased expression of UGT1A1 mRNA24343343
D004731EndotoxinsEndotoxins results in increased expression of UGT1A1 mRNA22213127
D004731EndotoxinsEndotoxins results in decreased expression of UGT1A1 mRNA19356101
C071192entacaponeUGT1A1 protein results in increased glucuronidation of entacapone15802387
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of UGT1A1 mRNA24534155
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of UGT1A1 mRNA29038839
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of UGT1A1 mRNA29038839
C109476epoxiconazoleepoxiconazole results in increased expression of UGT1A1 mRNA29038839
D060754EquolUGT1A1 protein results in increased glucuronidation of Equol14557274
C073539erucin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of UGT1A1 mRNA]15896333
C073539erucin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of UGT1A1 mRNA]15896333
C073539erucinerucin results in increased expression of UGT1A1 mRNA15896333
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of UGT1A1 promoter27415467
D004964EstriolUGT1A1 protein results in increased glucuronidation of Estriol15117964
D004964EstriolUGT1A1 protein results in increased glucuronidation of Estriol analog15117964
D004967EstrogensUGT1A1 protein affects the metabolism of Estrogens15987428
D002393Estrogens, Catechol"UGT1A1 protein results in increased glucuronidation of and results in decreased activity of Estrogens, Catechol"15455371
D004970EstroneUGT1A1 protein results in increased glucuronidation of Estrone15117964|1547222
D004970EstroneUGT1A1 protein results in increased glucuronidation of Estrone analog15472229
D004997Ethinyl Estradiolchrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Ethinyl Estradiol]10950852
D004997Ethinyl EstradiolUGT1A1 gene mutant form results in decreased glucuronidation of Ethinyl Estradiol analog17898154
D004997Ethinyl EstradiolUGT1A1 protein affects the metabolism of Ethinyl Estradiol15286053
D004997Ethinyl EstradiolUGT1A1 protein results in increased glucuronidation of Ethinyl Estradiol12756209
D004997Ethinyl EstradiolUGT1A1 protein results in increased glucuronidation of Ethinyl Estradiol analog17898154
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of UGT1A1 mRNA27818225
D004997Ethinyl EstradiolUGT1A1 protein results in increased glucuronidation of Ethinyl Estradiol15921999
D005001EthionineEthionine affects the expression of UGT1A1 mRNA19483382
D005015EthoxyquinEthoxyquin results in increased expression of UGT1A1 mRNA19144771
D005015EthoxyquinEthoxyquin results in increased expression of UGT1A1 mRNA19695238
C052488ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxzoleacetateUGT1A1 protein results in increased glucuronidation of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxzoleacetate15988124
C098546ethyl tert-butyl etherethyl tert-butyl ether results in decreased expression of UGT1A1 mRNA24090815
D005047EtoposideUGT1A1 gene polymorphism affects the susceptibility to Etoposide12969965
D005047EtoposideUGT1A1 protein results in increased glucuronidation of Etoposide17151191
D005054EugenolUGT1A1 protein results in increased glucuronidation of Eugenol14557274
D000069438EzetimibeUGT1A1 protein results in increased glucuronidation of Ezetimibe14977865
D015025ZearalenoneUGT1A1 protein results in increased glucuronidation of Zearalenone14557274
D005204FarnesolUGT1A1 protein results in increased glucuronidation of Farnesol15320866
C047360felbamatefelbamate results in increased expression of UGT1A1 mRNA17381134
D011345FenofibrateFenofibrate results in increased expression of UGT1A1 mRNA25572481
C006012fenofibric acidfenofibric acid results in increased expression of UGT1A1 mRNA15771232
C082360fipronilfipronil results in increased expression of UGT1A1 mRNA23962444
C082360fipronilfipronil results in increased expression of UGT1A1 mRNA22447239|2396244
C534368fipronil sulfonefipronil sulfone results in increased expression of UGT1A1 mRNA22447239
C017875fisetinUGT1A1 protein results in increased glucuronidation of fisetin14557274
D005419FlavonoidsFlavonoids results in increased expression of UGT1A1 mRNA15104253
D005419FlavonoidsFlavonoids results in increased expression of UGT1A1 protein15104253
C012976flumequineflumequine results in decreased expression of UGT1A1 mRNA23681119
D005445FlunitrazepamFlunitrazepam results in decreased activity of UGT1A1 protein15334623
D005472FluorouracilUGT1A1 gene polymorphism affects the susceptibility to [Fluorouracil co-treated with irinotecan]18797458
D005480FlurbiprofenUGT1A1 protein results in increased glucuronidation of Flurbiprofen15843492
C007768formononetinUGT1A1 protein results in increased glucuronidation of formononetin14557274
C070081fulvestrantfulvestrant results in increased expression of UGT1A1 mRNA15072547
C039281furanfuran results in increased methylation of UGT1A1 gene22079235
D005665FurosemideFurosemide results in increased expression of UGT1A1 mRNA18227147
D005672Fusidic AcidFusidic Acid inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]27676153
C037032galanginUGT1A1 protein results in increased glucuronidation of galangin14557274
D024504gamma-Tocopherolgamma-Tocopherol results in increased expression of UGT1A1 mRNA19115203
D024504gamma-Tocopherol[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]22389237
D015248GemfibrozilGemfibrozil results in increased expression of UGT1A1 mRNA15771232
D019833GenisteinGenistein results in decreased activity of UGT1A1 protein16051636
D019833GenisteinGenistein results in decreased expression of UGT1A1 mRNA18634814
D019833GenisteinGenistein results in decreased expression of UGT1A1 protein18634814
D019833GenisteinUGT1A1 protein results in increased glucuronidation of Genistein14557274|1598812
D019833GenisteinGenistein inhibits the reaction [Acetaminophen results in decreased expression of UGT1A1 mRNA]23333575
D005839GentamicinsGentamicins results in decreased expression of UGT1A1 mRNA20849911|2206182
C063170Ginkgo biloba extractGinkgo biloba extract results in increased expression of UGT1A1 mRNA19034627
C477042ginkgolide Aginkgolide A results in increased expression of UGT1A1 mRNA19034627
C045856ginkgolide Bginkgolide B results in increased expression of UGT1A1 mRNA19034627
C507965ginsenoside 20S-protopanaxatriolginsenoside 20S-protopanaxatriol results in increased expression of UGT1A1 mRNA22780686
C107601glabridinUGT1A1 protein results in increased glucuronidation of glabridin25765239
D020719Glucuronides"UGT1A1 promoter polymorphism affects the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]"15986396
D020719Glucuronides"UGT1A1 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]"15986396
D020719Glucuronides[UGT1A1 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of Glucuronides19408964
C075375grepafloxacinUGT1A1 protein results in increased glucuronidation of grepafloxacin15769885
D006118GriseofulvinGriseofulvin affects the expression of UGT1A1 mRNA12735108
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of UGT1A1 mRNA20200218
C410297HMR 1098UGT1A1 protein results in increased glucuronidation of HMR 109812867491
C001419hydroxyphenytoinUGT1A1 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin15855726
C475919hydroxytamoxifenhydroxytamoxifen results in decreased expression of UGT1A1 mRNA15072547
D006923HymecromoneUGT1A1 protein results in increased glucuronidation of Hymecromone24728488
D006923HymecromoneEstradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]15378558
D006923HymecromoneHymecromone results in increased activity of UGT1A1 protein26875642
D006923Hymecromonelicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein]26875642
D006923HymecromoneUGT1A1 protein results in increased glucuronidation of Hymecromone15378558|1559333
C001654hyperforinhyperforin results in increased expression of UGT1A1 mRNA24259679
C021304hyperosidehyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A1 mRNA]26772156
C021304hyperosidehyperoside results in increased expression of UGT1A1 mRNA26772156
D007052IbuprofenUGT1A1 protein results in increased glucuronidation of Ibuprofen15843492
D007052Ibuprofen[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT1A1 mRNA29222744
D007052IbuprofenIbuprofen results in increased expression of UGT1A1 mRNA29222744
D007099ImipramineImipramine affects the expression of UGT1A1 mRNA18355885
C011582IMOL S-140IMOL S-140 results in increased expression of UGT1A1 mRNA26894911
C031534imperatorinimperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
C031534imperatorinimperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]17599282
D007200IndicanIndican results in increased expression of UGT1A1 mRNA20000589
D007213IndomethacinIndomethacin results in decreased activity of UGT1A1 protein15593333
D007213IndomethacinUGT1A1 protein results in increased glucuronidation of Indomethacin15843492
C051890irinotecan[Ketoconazole results in decreased activity of UGT1A1 protein] which results in decreased metabolism of irinotecan22447115
C051890irinotecanUGT1A1 gene mutant form results in decreased glucuronidation of irinotecan17898154
C051890irinotecanUGT1A1 gene polymorphism affects the susceptibility to [Fluorouracil co-treated with irinotecan]18797458
C051890irinotecanUGT1A1 gene polymorphism affects the susceptibility to irinotecan18300238|1847893
C051890irinotecanUGT1A1 promoter polymorphism affects the susceptibility to irinotecan15858133
C051890irinotecanUGT1A1 protein affects the metabolism of irinotecan15523087
C051890irinotecanUGT1A1 protein affects the susceptibility to irinotecan15517893
C051890irinotecanUGT1A1 protein polymorphism results in decreased glucuronidation of irinotecan12960109
C051890irinotecanUGT1A1 protein results in increased glucuronidation of and results in decreased activity of irinotecan15517893
C051890irinotecanUGT1A1 protein results in increased glucuronidation of irinotecan15655543|1571646
C051890irinotecanUGT1A1 protein results in increased metabolism of irinotecan23401472
C051890irinotecanUGT1A1 protein results in increased glucuronidation of irinotecan15833930
C051890irinotecanUGT1A1 protein results in increased glucuronidation of irinotecan metabolite24191041
C040920isoliquiritigeninUGT1A1 protein results in increased glucuronidation of isoliquiritigenin14557274
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UGT1A1 mRNA26752646
C006552kaempferolUGT1A1 protein results in increased glucuronidation of kaempferol14557274
D007654KetoconazoleKetoconazole results in decreased activity of UGT1A1 protein22447115
D007654Ketoconazole[Ketoconazole results in decreased activity of UGT1A1 protein] which results in decreased metabolism of irinotecan22447115
D007654KetoconazoleKetoconazole results in decreased expression of UGT1A1 mRNA16608920
D007654KetoconazoleKetoconazole affects the expression of UGT1A1 mRNA18355885
D007660KetoprofenKetoprofen results in decreased activity of UGT1A1 protein15593333
D007660KetoprofenUGT1A1 protein results in increased glucuronidation of Ketoprofen15843492
C099406L 742694L 742694 results in increased expression of UGT1A1 mRNA15102944
D007741Labetalol[Uridine Diphosphate Glucuronic Acid co-treated with UGT1A1 protein] results in increased glucuronidation of Labetalol18098064
D064747LansoprazoleLansoprazole results in increased expression of UGT1A1 mRNA25626140
C045463leflunomideleflunomide results in increased expression of UGT1A1 mRNA28988120
C070840licochalcone Alicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein]26875642
C027820ligustilideligustilide results in increased expression of UGT1A1 protein23441843
D001556LindaneLindane results in increased activity of UGT1A1 protein16641539
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of UGT1A1 mRNA"24972896
D008095Lithocholic Acid"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]"19196849
D008095Lithocholic AcidLithocholic Acid results in decreased expression of UGT1A1 mRNA19196849
D008095Lithocholic Acid"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]"19196849
D008095Lithocholic AcidNR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]19196849
D008095Lithocholic AcidPhenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]19196849
D047311LuteolinLuteolin inhibits the reaction [Benzo(a)pyrene results in increased expression of UGT1A1 mRNA]20403331
C501277Mangifera indica extractMangifera indica extract results in increased expression of UGT1A1 mRNA22815239
C013592mangiferinmangiferin results in decreased activity of UGT1A1 protein22815239
C013592mangiferinmangiferin results in increased expression of UGT1A1 mRNA22815239
D009637MasoprocolUGT1A1 protein results in increased glucuronidation of Masoprocol14557274
D000069997Mastic Resin[Mastic Resin co-treated with Diethylnitrosamine] results in increased expression of UGT1A1 mRNA18977376
D008468Meclizine[Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of UGT1A1 mRNA15272053
D008727MethotrexateMethotrexate results in increased expression of UGT1A1 mRNA20854796
D008731MethoxychlorUGT1A1 protein results in increased glucuronidation of Methoxychlor metabolite15205390
D008748MethylcholanthreneMethylcholanthrene results in increased expression of UGT1A1 mRNA19118567
D008748MethylcholanthreneMethylcholanthrene results in increased expression of UGT1A1 mRNA18203689
D008748MethylcholanthreneMethylcholanthrene results in increased expression of UGT1A1 protein1435739
D008748Methylcholanthrene"[Methylcholanthrene results in increased expression of UGT1A1 protein] which results in increased glucuronidation of 3,6-dihydroxychrysene"1435739
D008748Methylcholanthrene[Methylcholanthrene results in increased expression of UGT1A1 protein] which results in increased glucuronidation of 6-hydroxychrysene1435739
C059539midostaurinmidostaurin results in decreased expression of UGT1A1 mRNA20980353
C518174MK-0524UGT1A1 protein results in increased glucuronidation of MK-052417132765
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of UGT1A1 mRNA20024957
C008548morinUGT1A1 protein results in increased glucuronidation of morin14557274
D009020MorphineUGT1A1 protein results in increased glucuronidation of Morphine12920162
C104727moxifloxacinUGT1A1 protein results in increased glucuronidation of moxifloxacin15769885
C523799MRK 003UGT1A1 results in increased susceptibility to MRK 00319903844
C500085muraglitazarUGT1A1 protein results in increased glucuronidation of muraglitazar17898154
D009173Mycophenolic AcidUGT1A1 protein results in increased glucuronidation of Mycophenolic Acid24728488
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of UGT1A1 mRNA"29244179
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of UGT1A1 protein28549656
D009288NaproxenNaproxen results in decreased activity of UGT1A1 protein15593333
D009288NaproxenUGT1A1 protein results in increased glucuronidation of Naproxen15843492
C005273naringeninUGT1A1 protein results in increased glucuronidation of naringenin14557274
C027329naringenin chalconeUGT1A1 protein results in increased glucuronidation of naringenin chalcone14557274
D009544Niflumic AcidNiflumic Acid results in decreased activity of UGT1A1 protein15593333
C072936notoginsenoside R1notoginsenoside R1 results in increased expression of UGT1A1 mRNA25472953
C072936notoginsenoside R1NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of UGT1A1 mRNA]25472953
C072936notoginsenoside R1notoginsenoside R1 results in increased expression of UGT1A1 mRNA25472953
C464660obeticholic acidobeticholic acid results in increased expression of UGT1A1 mRNA27939613
D015242OfloxacinUGT1A1 protein results in increased glucuronidation of Ofloxacin15769885
C026209oltiprazoltipraz results in increased expression of UGT1A1 mRNA19144771
D009853OmeprazoleOmeprazole results in increased expression of UGT1A1 mRNA19118567
D009853OmeprazoleOmeprazole affects the expression of UGT1A1 mRNA19483382
D009853OmeprazoleOmeprazole results in increased expression of UGT1A1 mRNA25626140
D010098OxycodoneOxycodone results in increased expression of UGT1A1 mRNA23439660
D010100OxygenOxygen deficiency results in decreased expression of UGT1A1 mRNA19695866
D017239PaclitaxelPaclitaxel results in increased expression of UGT1A1 mRNA28242239
D017239PaclitaxelPaclitaxel results in increased expression of UGT1A1 protein28242239
D017239PaclitaxelTLR4 protein mutant form inhibits the reaction [Paclitaxel results in increased expression of UGT1A1 mRNA]28242239
D017239PaclitaxelTLR4 protein mutant form inhibits the reaction [Paclitaxel results in increased expression of UGT1A1 protein]28242239
D000073878Palm OilPalm Oil results in decreased expression of UGT1A1 mRNA18042831
C064276pantoprazolepantoprazole results in increased expression of UGT1A1 mRNA25626140
D010278ParathionParathion results in increased expression of UGT1A1 mRNA17982697
C410127PCB 180PCB 180 results in increased expression of UGT1A1 protein21458519
C033094perfluorobutyric acidperfluorobutyric acid analog results in increased expression of UGT1A1 mRNA21878386
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased expression of UGT1A1 mRNA27344344
C036567perfluorodecanoic acidPPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A1 mRNA]27344344
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of UGT1A1 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of UGT1A1 mRNA19045937
D015232DinoprostoneUGT1A1 protein mutant form results in increased chemical synthesis of Dinoprostone3864191
D010615PhenacetinUGT1A1 gene mutant form results in increased susceptibility to Phenacetin6776978
D010634PhenobarbitalPhenobarbital results in increased expression of and results in increased activity of UGT1A1 protein20932986
D010634PhenobarbitalPhenobarbital results in increased expression of UGT1A1 mRNA19084549
D010634PhenobarbitalNR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]19196849
D010634PhenobarbitalPhenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]19196849
D010634PhenobarbitalPhenobarbital results in increased expression of and results in increased activity of UGT1A1 protein20932986
D010634PhenobarbitalPhenobarbital results in increased expression of UGT1A1 mRNA15986414|1914477
D010634PhenobarbitalPhenobarbital results in increased expression of UGT1A1 protein15986414
D010634PhenobarbitalPhenobarbital results in decreased expression of UGT1A1 mRNA24090815
D010634PhenobarbitalPhenobarbital results in increased expression of and results in increased activity of UGT1A1 protein20932986
D010634PhenobarbitalPhenobarbital results in increased expression of UGT1A1 mRNA17381134|1916217
D010634PhenobarbitalPhenobarbital results in increased expression of UGT1A1 protein17967931
C033457phenobarbital quinidineIL1B protein inhibits the reaction [phenobarbital quinidine results in increased expression of UGT1A1 mRNA]15382119
C033457phenobarbital quinidinephenobarbital quinidine affects the expression of UGT1A115849716
C033457phenobarbital quinidinephenobarbital quinidine affects the expression of UGT1A1 mRNA15849716
C033457phenobarbital quinidinephenobarbital quinidine results in increased expression of UGT1A1 mRNA15382119
D010653PhenylbutazonePhenylbutazone inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Diethylstilbestrol]23126256
D010672PhenytoinPhenytoin affects the expression of UGT1A1 mRNA15849716
D010672PhenytoinPhenytoin results in increased expression of and results in increased activity of UGT1A1 protein27413119
D010672PhenytoinPhenytoin results in increased expression of UGT1A1 mRNA10421657|2741311
D010672PhenytoinPhenytoin results in increased expression of UGT1A1 protein10421657
D010672PhenytoinPhenytoin results in increased activity of UGT1A1 protein27413119
D010672PhenytoinPhenytoin results in increased expression of UGT1A1 mRNA17381134
C006253pirinixic acidpirinixic acid results in increased expression of UGT1A1 mRNA17151188
C006253pirinixic acidpirinixic acid results in increased expression of UGT1A1 protein17151188
C006253pirinixic acidpirinixic acid results in increased expression of UGT1A1 mRNA17151188|2381119
C006253pirinixic acidpirinixic acid affects the expression of UGT1A1 mRNA19483382
C013649plastochromanol 8plastochromanol 8 results in increased expression of UGT1A115269186
C014758plumbaginUGT1A1 protein results in increased glucuronidation of plumbagin14557274
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in increased expression of and results in increased activity of UGT1A1 protein15254343
D011078Polychlorinated BiphenylsUGT1A1 protein results in increased glucuronidation of Polychlorinated Biphenyls analog16006569
C058229polydatinUGT1A1 protein results in increased hydrolysis of polydatin metabolite17009167
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased activity of UGT1A1 protein16155002|2741311
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA16155002|2741311
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A1 protein16155002
D011285Pregnenolone CarbonitrileDexamethasone promotes the reaction [Pregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA]16155002
D011285Pregnenolone CarbonitrileNR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA]22496397
D011285Pregnenolone Carbonitrile[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of UGT1A1 mRNA22496397
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA19144771|2249639
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA19162173|2265931
C045362prochloraz[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of UGT1A1 mRNA29038839
D011374ProgesteroneProgesterone results in increased expression of UGT1A1 mRNA23012394|2301818
D011374Progesterone[Progesterone co-treated with NR1I2 protein] results in increased expression of UGT1A1 mRNA18098064
D011374Progesterone[Progesterone co-treated with Estradiol] affects the expression of UGT1A1 mRNA24777823
C045950propiconazolepropiconazole results in increased expression of UGT1A1 mRNA19409404|1942368
D011441PropylthiouracilPropylthiouracil affects the expression of UGT1A1 mRNA19483382
C034467prostaglandin B1UGT1A1 protein results in increased glucuronidation of prostaglandin B115231852
D015237DinoprostUGT1A1 protein mutant form results in increased chemical synthesis of Dinoprost3864191
C107773pterostilbeneUGT1A1 protein results in increased glucuronidation of pterostilbene23965644
C033607puerarinUGT1A1 protein results in increased metabolism of puerarin22648071
C513428pyrachlostrobinpyrachlostrobin results in increased expression of UGT1A1 mRNA27029645
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]17256720
C030984pyrene[AHR affects the susceptibility to pyrene] which affects the expression of UGT1A1 mRNA17618724
D011794Quercetinchrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Quercetin]11442279
D011794QuercetinQuercetin results in increased expression of UGT1A1 mRNA12756216
D011794QuercetinUGT1A1 protein results in increased glucuronidation of Quercetin11442279|1455727
D011794QuercetinQuercetin results in increased expression of UGT1A1 mRNA21565894
D064750RabeprazoleRabeprazole results in increased expression of UGT1A1 mRNA25626140
C115070ranirestatUGT1A1 protein results in increased glucuronidation of ranirestat15013842
C115070ranirestatUGT1A1 protein results in increased glycosylation of ranirestat15013842
C059514resveratrolresveratrol results in increased activity of UGT1A1 protein20716633
C059514resveratrolresveratrol results in increased expression of UGT1A1 mRNA17287390
C059514resveratrolresveratrol results in increased expression of UGT1A1 protein17287390
C059514resveratrolUGT1A1 protein results in increased glucuronidation of resveratrol17991766|2396564
C059514resveratrolresveratrol affects the expression of UGT1A1 mRNA15748624
C009166retinol acetate[LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of UGT1A1 mRNA28123100
D012293RifampinRifampin affects the expression of UGT1A1 mRNA15849716
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of UGT1A1 mRNA18098064
D012293RifampinRifampin results in increased expression of UGT1A1 mRNA15104253|1577123
D012293Rifampin[Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of UGT1A1 mRNA29162470
D019438RitonavirRitonavir affects the expression of UGT1A1 mRNA15849716
C089730rosiglitazonerosiglitazone results in increased expression of UGT1A1 mRNA25572481
D012503SaponinsSaponins results in decreased expression of UGT1A1 mRNA26590097
C093642SB 203580SB 203580 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]17256720
D012603ScopoletinUGT1A1 protein results in increased glucuronidation of Scopoletin15802387
C116890SemaxinibSemaxinib results in increased expression of UGT1A1 mRNA28424418
C009250sevofluranesevoflurane affects the expression of UGT1A1 mRNA15967596
C440975silybinsilybin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]15155549
C440975silybinsilybin metabolite results in decreased activity of UGT1A1 protein15921999
D012838SilymarinSilymarin results in decreased activity of UGT1A1 protein15921999
C076246sitafloxacinUGT1A1 protein results in increased glucuronidation of sitafloxacin15769885
C017947sodium arsenitesodium arsenite results in decreased expression of UGT1A1 mRNA17350061
D013148SpironolactoneSpironolactone results in increased expression of UGT1A1 mRNA19144771
D013148SpironolactoneSpironolactone results in increased activity of UGT1A1 protein12818378
D013148SpironolactoneSpironolactone results in increased expression of UGT1A1 mRNA12818378
C016766sulforafan2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulforafan results in increased expression of UGT1A1 mRNA]15090468
C016766sulforafan[sulforafan co-treated with Apigenin] results in increased expression of UGT1A1 mRNA15090468
C016766sulforafansulforafan results in decreased expression of UGT1A1 mRNA12949046
C016766sulforafansulforafan results in increased expression of UGT1A1 mRNA12151360|1275621
C016766sulforafansulforafan results in increased expression of UGT1A1 protein12151360
D013467SulindacSulindac results in increased activity of UGT1A1 protein17985343
D013467SulindacSulindac results in increased expression of UGT1A1 mRNA17985343
D013467SulindacUGT1A1 protein results in increased glucuronidation of Sulindac15843492
C025462sulindac sulfidesulindac sulfide results in increased activity of UGT1A1 protein17985343
C025462sulindac sulfidesulindac sulfide results in increased expression of UGT1A1 mRNA17985343
C025463sulindac sulfonesulindac sulfone results in increased activity of UGT1A1 protein17985343
C025463sulindac sulfonesulindac sulfone results in increased expression of UGT1A1 mRNA17985343
C025463sulindac sulfoneUGT1A1 protein results in increased glucuronidation of sulindac sulfone15843492
C473478sunitinibsunitinib results in increased expression of UGT1A1 mRNA26797788
C446685systhanesysthane results in increased expression of UGT1A1 mRNA19409404|1942368
D014284TriiodothyronineTriiodothyronine results in decreased expression of UGT1A1 mRNA11299074
D014284TriiodothyronineVitamin A inhibits the reaction [Triiodothyronine results in decreased expression of UGT1A1 mRNA]11299074
D014284TriiodothyronineTriiodothyronine results in decreased expression of UGT1A1 mRNA22086976
D013654Taurine[Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in decreased expression of UGT1A1 mRNA]26335259
D013654Taurine[Taurine binds to Zinc] which results in decreased expression of UGT1A1 mRNA26335259
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of UGT1A1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of UGT1A1 mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A affects the expression of UGT1A1 mRNA26988606
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of UGT1A1 mRNA28300664
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA]16399344
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of UGT1A1 mRNA29162470
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to UGT1A1 enhancer] which results in increased expression of UGT1A1 mRNA]12566446|1256644
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to UGT1A1 promoter]16399344|1725672
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to UGT1A1 promoter]16399344
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of UGT1A1 protein16155002|1639934
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of and results in increased activity of UGT1A1 protein12566446
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA16155002|1639934
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A1 protein16155002|1639934
D013749TetrachlorodibenzodioxinUGT1A1 protein results in increased glucuronidation of Tetrachlorodibenzodioxin metabolite15258113
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA]22496397
D013749TetrachlorodibenzodioxinDexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA]16155002
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UGT1A1 mRNA26377647
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of UGT1A1 mRNA]"23756648
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of UGT1A1 mRNA22496397
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA19144771|1947422
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A1 protein20194756
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A115993909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UGT1A1 mRNA16054898|2095900
C582340tetradecabromodiphenoxybenzenetetradecabromodiphenoxybenzene analog results in increased expression of UGT1A1 mRNA26894911
D013853ThioacetamideThioacetamide affects the expression of UGT1A1 mRNA19483382
D013853ThioacetamideThioacetamide results in decreased expression of UGT1A1 mRNA26222700
D013974ThyroxineThyroxine results in increased expression of UGT1A1 mRNA17884940
D013974ThyroxineUGT1A1 protein affects the glucuronidation of Thyroxine20655938
D013943ThymolUGT1A1 protein results in increased glucuronidation of Thymol14557274
D013963Thyroid HormonesUGT1A1 protein affects the metabolism of Thyroid Hormones15004031
D013988TiclopidineTiclopidine results in increased expression of UGT1A1 mRNA18227147
D013989TicrynafenTicrynafen results in increased expression of UGT1A1 mRNA18227147
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of UGT1A1 mRNA15289447
C082032tocotrienol, alpha"tocotrienol, alpha results in increased expression of UGT1A1"15269186
C082089tocotrienol, beta"tocotrienol, beta results in increased expression of UGT1A1"15269186
C082097tocotrienol, delta"tocotrienol, delta results in increased expression of UGT1A1"15269186
C032910triadimefontriadimefon results in increased expression of UGT1A1 mRNA19409404|1942368
D014241TrichloroethyleneTrichloroethylene results in increased expression of UGT1A1 mRNA19254012
C009540triclocarbanNR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A1 mRNA]22761658
C009540triclocarbantriclocarban results in increased expression of UGT1A1 mRNA22761658
D014260TriclosanTriclosan results in increased expression of UGT1A1 mRNA19910387
D014274TrifluralinTrifluralin results in increased expression of UGT1A1 mRNA18582544
D014303TrinitrotolueneTrinitrotoluene affects the expression of UGT1A1 mRNA21346803
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in increased expression of UGT1A1 mRNA26562049
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in increased expression of UGT1A1 mRNA27776230
C057693troglitazonetroglitazone results in increased expression of UGT1A1 mRNA25572481
C057693troglitazoneUGT1A1 protein results in increased glucuronidation of troglitazone11201174
C012596turmeric extractturmeric extract results in increased expression of UGT1A1 mRNA16819192
C113580U 0126U 0126 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]17256720
D014535Uridine Diphosphate Glucuronic Acid[Uridine Diphosphate Glucuronic Acid co-treated with UGT1A1 protein] results in increased glucuronidation of Labetalol18098064
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of UGT1A1 mRNA18687751
D014635Valproic AcidValproic Acid results in increased expression of UGT1A1 mRNA25084468
D014635Valproic AcidValproic Acid results in increased expression of UGT1A1 mRNA17381134
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of UGT1A1 gene25560391
D014801Vitamin AVitamin A inhibits the reaction [Triiodothyronine results in decreased expression of UGT1A1 mRNA]11299074
C111237vorinostatUGT1A1 gene polymorphism affects the susceptibility to vorinostat20479100
D014859WarfarinUGT1A1 gene SNP affects the susceptibility to Warfarin26223945
D014859WarfarinUGT1A1 polymorphism affects the susceptibility to Warfarin25312789
D014859WarfarinUGT1A1 protein results in increased metabolism of Warfarin19408964
D014859Warfarin[UGT1A1 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of Glucuronides19408964
D014859WarfarinWarfarin binds to and results in decreased activity of UGT1A1 protein25393417
D014859Warfarin[Warfarin binds to and results in decreased activity of UGT1A1 protein] which results in decreased glucuronidation of Estradiol25393417
D014859WarfarinWarfarin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]25393417
C104536xanthohumol"xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UGT1A1 mRNA]"22138251
C104536xanthohumolxanthohumol results in increased expression of UGT1A1 mRNA22138251
D015032Zinc[Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in decreased expression of UGT1A1 mRNA]26335259
D015032Zinc[Taurine binds to Zinc] which results in decreased expression of UGT1A1 mRNA26335259

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001972retinoic acid binding-IDA20308471  
GO:0004857enzyme inhibitor activity-IDA19996319  
GO:0005496steroid binding-IDA19996319  
GO:0008194UDP-glycosyltransferase activity-IBA21873635  
GO:0015020glucuronosyltransferase activity-IDA1898728  17179145  18052087  19996319  20056724  20308471  
22579593  
GO:0015020glucuronosyltransferase activity-TAS-  
GO:0019899enzyme binding-IEA-  
GO:0042803protein homodimerization activity-IDA17179145  
GO:0046982protein heterodimerization activity-IDA17179145  
GO ID GO Term Qualifier Evidence PubMed
GO:0001889liver development-IEA-  
GO:0006789bilirubin conjugation-TAS-  
GO:0006953acute-phase response-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0008202steroid metabolic process-IC19996319  
GO:0008210estrogen metabolic process-TAS8780690  
GO:0017144drug metabolic process-IC19996319  
GO:0031100animal organ regeneration-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0042167heme catabolic process-TAS-  
GO:0042573retinoic acid metabolic process-IC20308471  
GO:0042594response to starvation-IEA-  
GO:0043086negative regulation of catalytic activity-IEA-  
GO:0045939negative regulation of steroid metabolic process-IC19996319  
GO:0046483heterocycle metabolic process-IC19996319  
GO:0051552flavone metabolic process-IDA18052087  
GO:0052695cellular glucuronidation-IDA17179145  22579593  
GO:0052695cellular glucuronidation-TAS-  
GO:0052696flavonoid glucuronidation-IBA21873635  
GO:0052696flavonoid glucuronidation-IDA20056724  
GO:0052697xenobiotic glucuronidation-IBA21873635  
GO:0052697xenobiotic glucuronidation-IDA20056724  
GO:0070980biphenyl catabolic process-IEA-  
GO:0071361cellular response to ethanol-IEA-  
GO:0071385cellular response to glucocorticoid stimulus-IEA-  
GO:0071392cellular response to estradiol stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA17179145  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0034663endoplasmic reticulum chaperone complex-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0070069cytochrome complex-IEA-  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa00053Ascorbate and aldarate metabolism
hsa00140Steroid hormone biosynthesis
hsa00500Starch and sucrose metabolism
hsa00514Other types of O-glycan biosynthesis
hsa00830Retinol metabolism
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156588GlucuronidationTAS
R-HSA-1643685DiseaseTAS
R-HSA-189445Metabolism of porphyrinsTAS
R-HSA-189483Heme degradationTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-5579002Defective UGT1A1 causes hyperbilirubinemiaTAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23371916A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. (2013 Apr)Dai XGenet Epidemiol
21760472Bilirubin dependence on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index. (2012 Feb)Rodrigues CAm J Med Sci
22813462Deep understanding of the interaction between thienorphine and UDP-glucuronosyltransferase (UGT) isoforms. (2013 Feb)Dong RHXenobiotica
17347060Inheritance of hyperbilirubinemia: evidence for a major autosomal recessive gene. (2007 Apr)Clementi MDig Liver Dis
26751466Association between UGT1A1 Polymorphism and Risk of Laryngeal Squamous Cell Carcinoma. (2016 Jan 7)Huangfu HInt J Environ Res Public Health
25218365Diversified expression of aryl hydrocarbon receptor dependent genes in human laryngeal squamous cell carcinoma cell lines treated with beta-naphthoflavone. (2014 Nov 18)Brauze DToxicol Lett
29158248Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation. (2018 Feb)Liao MZDrug Metab Dispos
12167564N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. (2002 Sep)Ghosheh ODrug Metab Dispos
25086287Genetic variation underlying common hereditary hyperbilirubinaemia (Gilbert's syndrome) and respiratory health in the 1946 British birth cohort. (2014 Dec)Horsfall LJJ Hepatol
22273851Effects of cytochrome P450 1A1 and uridine-diphosphate-glucuronosyltransferase 1A1 allelic polymorphisms on the risk of development and the prognosis of head and neck cancers. (2012 Nov)Szanyi IEur J Cancer Prev
17498780The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. (2007 Aug 1)Chen BSci Total Environ
15099818Bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1) gene promoter polymorphisms and HPRT, glycophorin A, and micronuclei mutant frequencies in human blood. (2004 May 9)Grant DJMutat Res
15247627Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis. (2004 Jun)Verlaan MPharmacogenetics
27832386Association between UGT1A1*28*28 genotype and lung cancer in the Japanese population. (2017 Apr)Nishikawa YInt J Clin Oncol
26645279Phase II Drug-Metabolizing Polymorphisms and Smoking Predict Recurrence of Non-Muscle-Invasive Bladder Cancer: A Gene-Smoking Interaction. (2016 Feb)Lacombe LCancer Prev Res (Phila)
24408517Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed targeted proteomics. (2014 Apr)Achour BDrug Metab Dispos
29220881The UGT1A1*28 gene variant predicts long-term mortality in patients undergoing coronary angiography. (2018 Mar 28)Zulus BClin Chem Lab Med
12618960Evidence for a gene influencing serum bilirubin on chromosome 2q telomere: a genomewide scan in the Framingham study. (2003 Apr)Lin JPAm J Hum Genet
19821798Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system. (2010 Feb)Court MHDrug Metab Rev
25171434UGT1A1*28 is associated with greater decrease in serum K(+) levels following oral intake of procaterol. (2015 Apr)Yokoe NJ Asthma
20068078A CYP3A4 phenotype-based dosing algorithm for individualized treatment of irinotecan. (2010 Jan 15)van der Bol JMClin Cancer Res