Gene: UGT1A3

54659
UDPGT|UDPGT 1-3|UGT-1C|UGT1-03|UGT1.3|UGT1A3S|UGT1C
UDP glucuronosyltransferase family 1 member A3
protein-coding
2q37.1
Ensembl:ENSG00000243135 MIM:606428 Vega:OTTHUMG00000059118 UniprotKB:P35503
NC_000002.12
PubMed
0   ANCO-SNPs
OD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.541e-1 (AD)  3.348e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnEnzyme
DB00227LovastatinSmall Molecule75330-75-5Approved|InvestigationalEnzyme
DB00295MorphineSmall Molecule57-27-2Approved|InvestigationalEnzyme
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalEnzyme
DB00434CyproheptadineSmall Molecule129-03-3ApprovedEnzyme
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalEnzyme
DB00641SimvastatinSmall Molecule79902-63-9ApprovedEnzyme
DB00678LosartanSmall Molecule114798-26-4ApprovedEnzyme
DB00712FlurbiprofenSmall Molecule5104-49-4Approved|InvestigationalEnzyme
DB00749EtodolacSmall Molecule41340-25-4Approved|InvestigationalEnzyme
DB00796Candesartan cilexetilSmall Molecule145040-37-5ApprovedEnzyme
DB00973EzetimibeSmall Molecule163222-33-1ApprovedEnzyme
DB01029IrbesartanSmall Molecule138402-11-6Approved|InvestigationalEnzyme
DB01050IbuprofenSmall Molecule15687-27-1ApprovedEnzyme
DB01076AtorvastatinSmall Molecule134523-00-5ApprovedEnzyme
DB01095FluvastatinSmall Molecule93957-54-1ApprovedEnzyme
DB01252MitiglinideSmall Molecule145375-43-5Approved|InvestigationalEnzyme
DB01544FlunitrazepamSmall Molecule1622-62-4Approved|IllicitEnzyme
DB04725LicofeloneSmall Molecule156897-06-2InvestigationalEnzyme
DB04953EzogabineSmall Molecule150812-12-7Approved|InvestigationalEnzyme
DB06210EltrombopagSmall Molecule496775-61-2ApprovedEnzyme
DB06230NalmefeneSmall Molecule55096-26-9Approved|Investigational|WithdrawnEnzyme
DB06403AmbrisentanSmall Molecule177036-94-1Approved|InvestigationalEnzyme
DB06510MuraglitazarSmall Molecule331741-94-7InvestigationalEnzyme
DB06741GavestinelSmall Molecule153436-22-7InvestigationalEnzyme
DB08860PitavastatinSmall Molecule147511-69-1ApprovedEnzyme
DB08930DolutegravirSmall Molecule1051375-16-6ApprovedEnzyme
DB11691NaldemedineSmall Molecule916072-89-4Approved|InvestigationalEnzyme
DB11943DelafloxacinSmall Molecule189279-58-1Approved|InvestigationalEnzyme
DB12070LetermovirSmall Molecule917389-32-3Approved|InvestigationalEnzyme
DB13874EnasidenibSmall Molecule1446502-11-9Approved|InvestigationalEnzyme
DB13919CandesartanSmall Molecule139481-59-7ExperimentalEnzyme
ID Drug Name Action PubMed
C0907681-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"UGT1A3 protein results in increased glucuronidation of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"29285606
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"UGT1A3 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"15231852
C0331461-hydroxypyreneUGT1A3 protein results in increased glucuronidation of 1-hydroxypyrene15802387
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of UGT1A3 mRNA"25542188
C08133124-norursodeoxycholic acidUGT1A3 protein results in increased glucuronidation of 24-norursodeoxycholic acid19889628
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"UGT1A3 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15310245
C0013902-hydroxyestradiolUGT1A3 protein results in increased glucuronidation of 2-hydroxyestradiol15117964
C0249802-hydroxyestroneUGT1A3 protein results in increased glucuronidation of 2-hydroxyestrone15117964
C0228302-methoxyestradiolUGT1A3 protein results in increased glucuronidation of 2-methoxyestradiol15117964
C0608432-vanillinUGT1A3 protein results in increased glucuronidation of 2-vanillin15117964
C4828803-hydroxydesloratadineUGT1A3 protein results in increased glucuronidation of 3-hydroxydesloratadine15334623
C0352533-phenylpropionic acidUGT1A3 protein results in increased glucuronidation of 3-phenylpropionic acid15117964
C5830744,4'-hexafluorisopropylidene diphenol"UGT1A3 protein results in increased glucuronidation of and results in decreased activity of 4,4'-hexafluorisopropylidene diphenol"24349450
C0264184-hydroxyestroneUGT1A3 protein results in increased glucuronidation of 4-hydroxyestrone15117964
C0248364-nitrophenolUGT1A3 protein results in increased glucuronidation of 4-nitrophenol15802387
C0700584-trifluoromethylumbelliferyl iduronideUGT1A3 protein results in increased glucuronidation of 4-trifluoromethylumbelliferyl iduronide15357915
C1217077,3'-dihydroxy-4'-methoxyisoflavone"UGT1A3 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone"25044472
D000082AcetaminophenUGT1A3 protein results in increased glucuronidation of Acetaminophen15117964
C033541afloqualoneUGT1A3 protein results in increased glucuronidation of afloqualone15475412
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UGT1A3 mRNA16483693
D016718Arachidonic AcidUGT1A3 protein results in increased glucuronidation of Arachidonic Acid15231852
D001241AspirinUGT1A3 protein results in increased glucuronidation of Aspirin15117964
C011677benoxaprofenUGT1A3 affects the susceptibility to benoxaprofen17880178
C053561benzamidoximeUGT1A3 protein results in increased glucuronidation of and results in decreased activity of benzamidoxime15788365
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of UGT1A3 mRNA19118567|2860143
D004958EstradiolEstradiol results in decreased expression of UGT1A3 mRNA16474171
D004958EstradiolUGT1A3 protein results in increased glucuronidation of Estradiol15117964|1547222
D004958EstradiolUGT1A3 protein results in increased glucuronidation of Estradiol analog15472229
D001663BilirubinBilirubin results in decreased activity of UGT1A3 protein15334623
C012776biphenylylacetic acidUGT1A3 protein results in increased glucuronidation of biphenylylacetic acid15117964
C006780bisphenol Abisphenol A results in decreased expression of UGT1A3 mRNA16474171|2421472
C006780bisphenol AUGT1A3 protein results in increased glucuronidation of bisphenol A18990428
C006780bisphenol Abisphenol A results in decreased expression of UGT1A3 mRNA27257137
C033560bropirimineUGT1A3 protein results in increased glucuronidation of bropirimine14555337
C040048caffeic acidUGT1A3 protein results in increased glucuronidation of caffeic acid15117964
D002635Chenodeoxycholic AcidChenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to UGT1A3 promoter]20189675
D002635Chenodeoxycholic Acid[Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to UGT1A3 promoter]] which results in increased expression of UGT1A3 mRNA20189675|2018967
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of UGT1A3 mRNA20189675|2717416
D002635Chenodeoxycholic AcidUGT1A3 protein affects the reaction [Chenodeoxycholic Acid affects the activity of NR1H4 protein]17058234
D002635Chenodeoxycholic AcidUGT1A3 protein results in increased glucuronidation of Chenodeoxycholic Acid17058234
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of UGT1A3 mRNA17851650
D002726Chlorogenic AcidUGT1A3 protein results in increased glucuronidation of Chlorogenic Acid15117964
C029010cinnamic acidUGT1A3 protein results in increased glucuronidation of cinnamic acid15117964
D002995Clofibric AcidUGT1A3 affects the susceptibility to Clofibric Acid17880178
D002995Clofibric AcidUGT1A3 protein results in increased glucuronidation of Clofibric Acid15117964
C031071decanoic acidUGT1A3 protein results in increased glucuronidation of decanoic acid16051554
D002945CisplatinUGT1A3 protein affects the susceptibility to Cisplatin16217747
D004008DiclofenacDiclofenac results in decreased activity of UGT1A3 protein15334623
D004008DiclofenacUGT1A3 protein results in increased glucuronidation of Diclofenac15117964|1584349
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of UGT1A3 mRNA22129741
D004054DiethylstilbestrolPhenylbutazone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Diethylstilbestrol]23126256
D004054DiethylstilbestrolUGT1A3 protein results in increased glucuronidation of Diethylstilbestrol23126256
D004061DiflunisalUGT1A3 protein results in increased glucuronidation of Diflunisal15117964
D000875AnthralinUGT1A3 protein results in increased glucuronidation of Anthralin15117964
C037760diphenylacetic acidUGT1A3 protein results in increased glucuronidation of diphenylacetic acid15117964
C071192entacaponeUGT1A3 protein results in increased glucuronidation of entacapone15802387
D004964EstriolUGT1A3 protein results in increased glucuronidation of Estriol15117964
D004964EstriolUGT1A3 protein results in increased glucuronidation of Estriol analog15117964
D004970EstroneUGT1A3 protein results in increased glucuronidation of Estrone15117964|1547222
D004970EstroneUGT1A3 protein results in increased glucuronidation of Estrone analog15472229
C052488ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxzoleacetateUGT1A3 protein results in increased glucuronidation of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxzoleacetate15988124
D017308EtodolacUGT1A3 protein results in increased glucuronidation of Etodolac15535975
D005047EtoposideUGT1A3 protein results in increased glucuronidation of Etoposide17151191
D000069438EzetimibeUGT1A3 protein results in increased glucuronidation of Ezetimibe14977865
D005204FarnesolUGT1A3 protein results in increased glucuronidation of Farnesol15320866
D011345FenofibrateFenofibrate results in increased expression of UGT1A3 mRNA17058234
D005279FenoprofenUGT1A3 protein results in increased glucuronidation of Fenoprofen15117964
C004999ferulic acidUGT1A3 protein results in increased glucuronidation of ferulic acid15117964
D005445FlunitrazepamFlunitrazepam results in decreased activity of UGT1A3 protein15334623
D005480FlurbiprofenUGT1A3 protein results in increased glucuronidation of Flurbiprofen15117964|1584349
D005665FurosemideUGT1A3 protein results in increased glucuronidation of Furosemide15117964
D019833GenisteinGenistein results in decreased expression of UGT1A3 mRNA16474171
D019833GenisteinUGT1A3 protein results in increased glucuronidation of Genistein15988124
C107601glabridinUGT1A3 protein results in increased glucuronidation of glabridin25765239
D005978GlutathioneGlutathione deficiency results in increased expression of UGT1A3 mRNA15345336
C075375grepafloxacinUGT1A3 protein results in increased glucuronidation of grepafloxacin15769885
C412815GW 4064[GW 4064 results in increased activity of NR1H4 protein] which results in increased expression of UGT1A3 mRNA20189675
C453899GW 7647GW 7647 promotes the reaction [Phenobarbital results in increased expression of UGT1A3 mRNA]19631232
C453899GW 7647GW 7647 results in increased expression of UGT1A3 mRNA19631232
C013025hydratropic acidUGT1A3 protein results in increased glucuronidation of hydratropic acid15117964
D006923HymecromoneHymecromone results in increased activity of UGT1A3 protein26875642
D006923Hymecromonelicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A3 protein]26875642
D006923HymecromoneUGT1A3 protein results in increased glucuronidation of Hymecromone15802387
D006923HymecromoneUGT1A3 protein results in increased glucuronidation of Hymecromone16023900
D007052IbuprofenUGT1A3 protein results in increased glucuronidation of Ibuprofen15117964|1584349
C093581indeneUGT1A3 protein results in increased glucuronidation of indene15843492
C016517indole-3-carbinolindole-3-carbinol affects the expression of UGT1A3 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of UGT1A3 mRNA22129741
D007213IndomethacinUGT1A3 protein results in increased glucuronidation of Indomethacin15117964|1584349
D007216IndoprofenUGT1A3 protein results in increased glucuronidation of Indoprofen15117964
C008216isovaleric acidUGT1A3 protein results in increased glucuronidation of isovaleric acid analog15117964
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UGT1A3 mRNA26752646
C006552kaempferolUGT1A3 mutant form affects the glucuronidation of kaempferol16738032
C006552kaempferolUGT1A3 protein results in increased glucuronidation of kaempferol16738032
D007660KetoprofenUGT1A3 protein results in increased glucuronidation of Ketoprofen15535975|1584349
C047781lamotrigineUGT1A3 protein results in increased glucuronidation of lamotrigine17151188
C030358lauric acidUGT1A3 protein results in increased glucuronidation of lauric acid16051554
C070840licochalcone Alicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A3 protein]26875642
D008095Lithocholic AcidLithocholic Acid results in increased expression of UGT1A3 mRNA20189675
D047311LuteolinUGT1A3 mutant form affects the glucuronidation of Luteolin16738032
D047311LuteolinUGT1A3 protein results in increased glucuronidation of Luteolin16738032
D008528Mefenamic AcidUGT1A3 protein results in increased glucuronidation of Mefenamic Acid15117964
D008731MethoxychlorUGT1A3 protein results in increased glucuronidation of Methoxychlor metabolite15205390
D008748MethylcholanthreneMethylcholanthrene results in increased expression of UGT1A3 mRNA19118567|2860143
C033069methyl salicylateUGT1A3 protein results in increased glucuronidation of methyl salicylate15117964
C518174MK-0524UGT1A3 protein results in increased glucuronidation of MK-052417132765
C016599mono-(2-ethylhexyl)phthalateUGT1A3 protein results in increased glucuronidation of mono-(2-ethylhexyl)phthalate27071666
D009020MorphineUGT1A3 protein results in increased glucuronidation of Morphine12920162
C104727moxifloxacinUGT1A3 protein results in increased glucuronidation of moxifloxacin15769885
C500085muraglitazarUGT1A3 protein results in increased glucuronidation of muraglitazar17898154
D009288NaproxenUGT1A3 protein results in increased glucuronidation of Naproxen15535975|1584349
D009538NicotineUGT1A3 protein results in increased glucuronidation of Nicotine14570768
D015242OfloxacinUGT1A3 protein results in increased glucuronidation of Ofloxacin15769885
D009853OmeprazoleOmeprazole results in increased expression of UGT1A3 mRNA19118567
D008939MitotaneMitotane results in increased expression of UGT1A3 mRNA25542188
D010634PhenobarbitalGW 7647 promotes the reaction [Phenobarbital results in increased expression of UGT1A3 mRNA]19631232
D010634PhenobarbitalPhenobarbital results in increased expression of UGT1A3 mRNA19631232
D010634Phenobarbitalpirinixic acid promotes the reaction [Phenobarbital results in increased expression of UGT1A3 mRNA]19631232
D010653PhenylbutazonePhenylbutazone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Diethylstilbestrol]23126256
C006253pirinixic acidpirinixic acid results in increased expression of UGT1A3 mRNA17058234|1715118
C006253pirinixic acidpirinixic acid promotes the reaction [Phenobarbital results in increased expression of UGT1A3 mRNA]19631232
C006253pirinixic acidpirinixic acid results in increased expression of UGT1A3 mRNA19631232
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in decreased expression of UGT1A3 mRNA16474171
C008999ponasterone Aponasterone A results in increased expression of UGT1A3 protein17058234
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UGT1A3 mRNA16155002
D011339ProbenecidUGT1A3 affects the susceptibility to Probenecid17880178
C107773pterostilbeneUGT1A3 protein results in increased glucuronidation of pterostilbene23965644
C033607puerarinUGT1A3 protein results in increased metabolism of puerarin22648071
D011794QuercetinUGT1A3 mutant form affects the glucuronidation of Quercetin16738032
D011794QuercetinUGT1A3 protein results in increased glucuronidation of Quercetin15609409|1673803
C115070ranirestatUGT1A3 protein results in increased glucuronidation of ranirestat15013842
C115070ranirestatUGT1A3 protein results in increased glycosylation of ranirestat15013842
C059514resveratrolUGT1A3 protein affects the glucuronidation of resveratrol23965644
D012293RifampinRifampin results in increased expression of UGT1A3 mRNA25313206
D012293RifampinRifampin results in increased expression of UGT1A3 mRNA25542188
C057006Ro 21-5104Ro 21-5104 results in increased expression of UGT1A3 mRNA25313206
C089730rosiglitazonerosiglitazone results in increased expression of UGT1A3 mRNA25572481
D020156Salicylic AcidUGT1A3 protein results in increased glucuronidation of Salicylic Acid15117964
D012603ScopoletinUGT1A3 protein results in increased glucuronidation of Scopoletin15802387
C009250sevofluranesevoflurane affects the expression of UGT1A3 mRNA15967596
C076246sitafloxacinUGT1A3 protein results in increased glucuronidation of sitafloxacin15769885
D013467SulindacUGT1A3 protein results in increased glucuronidation of Sulindac15843492
C025463sulindac sulfoneUGT1A3 protein results in increased glucuronidation of sulindac sulfone15843492
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of UGT1A3 protein16155002
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT1A3 mRNA16155002
C009540triclocarbanNR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A3 mRNA]22761658
C009540triclocarbantriclocarban results in increased expression of UGT1A3 mRNA22761658
D014635Valproic AcidValproic Acid results in decreased methylation of UGT1A3 gene29154799
D014641Vanillic AcidUGT1A3 protein results in increased glucuronidation of Vanillic Acid15117964
C100058vanillinUGT1A3 protein results in increased glucuronidation of vanillin15117964
C111237vorinostatUGT1A3 protein results in increased glucuronidation of vorinostat25393417
C111237vorinostat[Warfarin binds to and results in increased activity of UGT1A3 protein] which results in increased glucuronidation of vorinostat25393417
C111237vorinostatWarfarin promotes the reaction [UGT1A3 protein results in increased glucuronidation of vorinostat]25393417
D014859WarfarinWarfarin binds to and results in increased activity of UGT1A3 protein25393417
D014859Warfarin[Warfarin binds to and results in increased activity of UGT1A3 protein] which results in increased glucuronidation of vorinostat25393417
D014859WarfarinWarfarin promotes the reaction [UGT1A3 protein results in increased glucuronidation of vorinostat]25393417
D015032ZincZinc deficiency results in increased expression of UGT1A3 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001972retinoic acid binding-IDA20308471  
GO:0008194UDP-glycosyltransferase activity-IBA21873635  
GO:0015020glucuronosyltransferase activity-IDA17179145  18052087  20056724  20308471  22579593  
GO:0042803protein homodimerization activity-IDA17179145  
GO:0046982protein heterodimerization activity-IDA17179145  
GO ID GO Term Qualifier Evidence PubMed
GO:0042573retinoic acid metabolic process-IC20308471  
GO:0052695cellular glucuronidation-IDA17179145  22579593  
GO:0052696flavonoid glucuronidation-IBA21873635  
GO:0052696flavonoid glucuronidation-IDA20056724  
GO:0052697xenobiotic glucuronidation-IBA21873635  
GO:0052697xenobiotic glucuronidation-IDA20056724  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA17179145  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa00053Ascorbate and aldarate metabolism
hsa00140Steroid hormone biosynthesis
hsa00500Starch and sucrose metabolism
hsa00514Other types of O-glycan biosynthesis
hsa00830Retinol metabolism
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156588GlucuronidationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22813462Deep understanding of the interaction between thienorphine and UDP-glucuronosyltransferase (UGT) isoforms. (2013 Feb)Dong RHXenobiotica
12167564N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. (2002 Sep)Ghosheh ODrug Metab Dispos