Gene: PPARD

5467
FAAR|NR1C2|NUC1|NUCI|NUCII|PPARB
peroxisome proliferator activated receptor delta
protein-coding
6p21.31
Ensembl:ENSG00000112033 MIM:600409 Vega:OTTHUMG00000014567 UniprotKB:Q03181
NG_012345.1
PubMed
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.424e-1 (AD)  5.127e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06029061chr6:35392246PPARDGene body8.539e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAF70.911
PRRC2A0.901
SKI0.9
KHSRP0.892
HGS0.89
SRF0.888
ACTN40.888
MTA10.887
MED150.887
ATN10.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.784
OR4F29-0.759
ODAM-0.232
HMX2-0.209
FOXB1-0.207
SOX14-0.207
CRNDE-0.205
SIM1-0.204
IRX5-0.199
TRDN-0.197

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00132Alpha-Linolenic AcidSmall Molecule463-40-1Approved|NutraceuticalTarget
DB00159IcosapentSmall Molecule10417-94-4Approved|NutraceuticalTarget
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnTarget
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalTarget
DB00374TreprostinilSmall Molecule81846-19-7Approved|InvestigationalTarget
DB00412RosiglitazoneSmall Molecule122320-73-4Approved|InvestigationalTarget
DB00605SulindacSmall Molecule38194-50-2Approved|InvestigationalTarget
DB01039FenofibrateSmall Molecule49562-28-9ApprovedTarget
DB01132PioglitazoneSmall Molecule111025-46-8Approved|InvestigationalTarget
DB01393BezafibrateSmall Molecule41859-67-0Approved|InvestigationalTarget
DB02746Phthalic AcidSmall Molecule88-99-3ExperimentalTarget
DB03338Heptyl-Beta-D-GlucopyranosideSmall MoleculeExperimentalTarget
DB04224Oleic AcidSmall Molecule112-80-1Approved|InvestigationalTarget
DB04801(11E)-OCTADEC-11-ENOIC ACIDSmall MoleculeExperimentalTarget
DB05187ElafibranorSmall Molecule923978-27-2InvestigationalTarget
DB05188KD3010Small Molecule-InvestigationalTarget
DB05416GW-501516Small Molecule317318-70-0InvestigationalTarget
DB07070(2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acidSmall MoleculeExperimentalTarget
DB076912-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acidSmall MoleculeExperimentalTarget
DB07724IndeglitazarSmall Molecule835619-41-5ExperimentalTarget
DB08078{4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acidSmall MoleculeExperimentalTarget
DB09006ClinofibrateSmall Molecule30299-08-2ApprovedTarget
DB09462GlycerinSmall Molecule56-81-5Approved|InvestigationalTarget
DB13873Fenofibric acidSmall Molecule42017-89-0ApprovedTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of PPARD mRNA"26377693
C0388061,4-dihydropyridine"1,4-dihydropyridine results in increased activity of PPARD protein"25257666
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARD protein"17341418
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"15-hydroxy-5,8,11,13-eicosatetraenoic acid binds to and results in increased activity of PPARD protein"12069687
C0620781-(carboxymethylthio)tetradecane1-(carboxymethylthio)tetradecane results in increased activity of PPARD protein21484566
C1039581-hydroxyvitamin D51-hydroxyvitamin D5 results in decreased expression of PPARD protein16051482
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of PPARD mRNA28329830
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PPARD mRNA"19114083
C5736932-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein22193206
C0227762-bromopalmitate2-bromopalmitate results in increased activity of PPARD protein21543282|2315072
C0227762-bromopalmitate2-bromopalmitate results in increased activity of [RXRA protein binds to PPARD protein]15997096
C0406682-ethylhexanoic acid2-ethylhexanoic acid affects the expression of PPARD mRNA15647598
C0406682-ethylhexanoic acid2-ethylhexanoic acid affects the expression of PPARD protein15647598
C4874012-methyl-c-5-(4-(5-methyl-2-(4-methylphenyl)-4-oxazolyl)butyl)-1,3-dioxane-r-2-carboxylic acid"2-methyl-c-5-(4-(5-methyl-2-(4-methylphenyl)-4-oxazolyl)butyl)-1,3-dioxane-r-2-carboxylic acid results in increased activity of PPARD protein"14982965
C4874012-methyl-c-5-(4-(5-methyl-2-(4-methylphenyl)-4-oxazolyl)butyl)-1,3-dioxane-r-2-carboxylic acid"2-methyl-c-5-(4-(5-methyl-2-(4-methylphenyl)-4-oxazolyl)butyl)-1,3-dioxane-r-2-carboxylic acid results in increased activity of PPARD protein"14982965
C0473683-methylquercetin3-methylquercetin results in increased activity of PPARD protein22992727
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid binds to and results in increased activity of PPARD protein10585473|2448978
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid binds to PPARD protein11779144
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased activity of PPARD protein17185614|2154328
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acidPPARD protein promotes the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of AKT1 protein]19906781
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acidPPARD protein promotes the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of NOS3 protein]19906781
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid binds to PPARD protein17726147
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid promotes the reaction [PPARD protein binds to RELA protein]15721863
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased activity of PPARD protein10585473|1572186
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid[4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased activity of PPARD protein] which results in decreased susceptibility to Phenylephrine15721863
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of PPARD mRNA10585473|1251204
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid binds to and results in increased activity of PPARD protein17437057|1859960
C5729614-(4-(3-(4-trifluoromethoxy-phenyl)ureido)cyclohexyloxy)benzoic acid4-(4-(3-(4-trifluoromethoxy-phenyl)ureido)cyclohexyloxy)benzoic acid results in increased activity of PPARD protein25377915
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [TNF protein results in increased expression of and results in increased phosphorylation of PPARD protein]12512042
C5479574-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 promotes the reaction [PPARD protein binds to ANGPTL4 promoter]]20516370
C5479574-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 promotes the reaction [PPARD protein binds to PLIN2 promoter]]20516370
C5479574-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW 501516 results in increased expression of PPARD mRNA]20516370
C5479574-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide[4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide results in increased activity of PPARD protein] promotes the reaction [PPARD protein binds to ANGPTL4 promoter]20516370
C5479574-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide[4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide results in increased activity of PPARD protein] promotes the reaction [PPARD protein binds to PLIN2 promoter]20516370
C5479574-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide results in increased susceptibility to PPARD protein20516370
C5479574-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamideGW0742 inhibits the reaction [4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide promotes the reaction [PPARD protein binds to ANGPTL4 promoter]]20516370
C5479574-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamideGW0742 inhibits the reaction [4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide promotes the reaction [PPARD protein binds to PLIN2 promoter]]20516370
C5479574-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamidePPARD gene mutant form inhibits the reaction [4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 results in increased expression of ANGPTL4 mRNA]]20516370
C5479574-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamidePPARD gene mutant form inhibits the reaction [4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 results in increased expression of PLIN2 mRNA]]20516370
C5479574-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide binds to and results in decreased activity of PPARD protein20516370
C0476288-hydroxyeicosatetraenoic acid8-hydroxyeicosatetraenoic acid binds to and results in increased activity of PPARD protein12069687
D000082AcetaminophenAcetaminophen results in increased expression of PPARD mRNA21420995|2223033
D017962alpha-Linolenic Acidalpha-Linolenic Acid results in increased expression of PPARD mRNA19667161
D017962alpha-Linolenic AcidCalcitriol results in increased expression of [alpha-Linolenic Acid results in increased expression of PPARD mRNA]19667161
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PPARD mRNA16483693
D000894Anti-Inflammatory Agents, Non-Steroidal"Anti-Inflammatory Agents, Non-Steroidal results in increased activity of PPARD protein"19748995
C061374antimoniteantimonite results in increased expression of PPARD mRNA17400267
C061374antimonitetyrphostin AG 1478 inhibits the reaction [antimonite results in increased expression of PPARD mRNA]17400267
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PPARD mRNA24449571
D016718Arachidonic AcidArachidonic Acid results in increased expression of PPARD mRNA11172467
C015001arsenitearsenite results in increased expression of PPARD mRNA17400267
C015001arsenitetyrphostin AG 1478 inhibits the reaction [arsenite results in increased expression of PPARD mRNA]17400267
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of PPARD mRNA"17331233
D001241AspirinAspirin results in decreased activity of PPARD protein15646027
D001241AspirinAspirin results in decreased expression of PPARD protein18678619
D001241AspirinAspirin results in increased expression of PPARD mRNA15646027
D001241AspirinAspirin results in increased expression of PPARD mRNA12800193
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of PPARD mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PPARD mRNA18164116
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of PPARD mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPARD mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PPARD mRNA19770486
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of PPARD mRNA18192240
D001629BezafibrateBezafibrate binds to PPARD protein11779144
D001629BezafibrateBezafibrate results in increased activity of [PPARD protein binds to RXRA protein]11779144
D001629BezafibrateBezafibrate results in increased expression of PPARD mRNA11172467|1920141
D001629BezafibrateBezafibrate results in increased expression of PPARD protein11172467
D001629BezafibrateCalcitriol promotes the reaction [Bezafibrate results in increased expression of PPARD mRNA]19667161
D001629BezafibrateBezafibrate binds to PPARD protein12782154|2168792
D001629BezafibrateBezafibrate results in decreased expression of PPARD mRNA19124612
D001629BezafibrateBezafibrate results in increased expression of PPARD19214135
D001629BezafibrateBezafibrate results in increased expression of PPARD mRNA19201410
D001629BezafibratePPARD protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form]12782154
D001629BezafibratePPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]12782154
D001629BezafibratePPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA]12782154
D001629BezafibratePPARD protein affects the reaction [Bezafibrate results in increased expression of CD36 mRNA]12782154
D001629BezafibrateBezafibrate binds to and results in increased activity of PPARD protein16193754
D001629BezafibrateBezafibrate results in increased activity of PPARD protein10585473
D001629BezafibrateBezafibrate binds to and results in increased activity of PPARD protein17190905
D001629BezafibrateBezafibrate binds to PPARD protein10753628|2475975
D001629BezafibrateBezafibrate results in increased activity of PPARD protein12759900|1616805
C006780bisphenol Abisphenol A affects the methylation of PPARD promoter27334623
C006780bisphenol Abisphenol A results in increased expression of PPARD mRNA21932408
C006780bisphenol Abisphenol A results in decreased expression of PPARD mRNA23399309|2518105
C006780bisphenol Awortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARD mRNA]23399309
D000069286BortezomibPPARD gene SNP results in increased susceptibility to Bortezomib20864405
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PPARD mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of PPARD mRNA26079696
D020148Butyric AcidButyric Acid results in increased expression of PPARD mRNA12800193
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PPARD promoter22457795
D002211CapsaicinCapsaicin results in decreased expression of PPARD mRNA18769453
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of BAX mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of BCL2A1A mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of BCL2A1B mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of BCL2A1C mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of BCL2L1 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of BDKRB1 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]18622026
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CCND1 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CCR5 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CD14 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CD74 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CSF3 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CXCR5 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CYP2B10 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of ELF3 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of F3 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of GADD45B mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of ICAM1 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of IL1RN mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of IRF2BP2 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP12 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP9 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of NFKB1 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of RELA protein]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of S100A6 mRNA]18038451|1862202
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TAP1 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TGM2 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNC mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]18622026
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNFRSF12A mRNA]18038451|1862202
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNFRSF12A protein]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNIP1 mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of VIM mRNA]18038451
D002251Carbon TetrachloridePPARD protein affects the susceptibility to Carbon Tetrachloride18622026
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased activity of PPARD protein25858767
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PPARD mRNA25478064
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PPARD protein25478064
D002251Carbon TetrachlorideRutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD mRNA]25478064
D002251Carbon TetrachlorideRutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD protein]25478064
C054133casticincasticin results in decreased expression of PPARD mRNA27862857
D000068579CelecoxibCelecoxib analog results in decreased expression of PPARD protein19682443
D000068579CelecoxibCelecoxib results in decreased expression of PPARD protein19682443
C065927cilnidipinecilnidipine results in decreased activity of PPARD protein25257666
D002994ClofibrateClofibrate results in increased activity of [PPARD protein binds to RXRA protein]11779144
D002995Clofibric AcidClofibric Acid binds to PPARD protein11779144
C018021cobaltous chloridecobaltous chloride results in decreased expression of PPARD mRNA15708366
D019327Copper SulfateCopper Sulfate results in increased expression of PPARD mRNA19549813
D003474CurcuminCurcumin results in decreased expression of PPARD mRNA19294764
D003474CurcuminCurcumin results in decreased expression of PPARD protein19294764
D016572CyclosporineCyclosporine results in increased expression of PPARD mRNA20106945|2556210
D003630DaunorubicinDaunorubicin results in decreased activity of PPARD protein25257666
D003630Daunorubicin[Enalaprilat co-treated with Daunorubicin] results in increased expression of PPARD mRNA23834779
D015255IdarubicinIdarubicin results in decreased activity of PPARD protein25257666
D003907DexamethasoneDexamethasone results in decreased expression of PPARD mRNA25047013
D003907DexamethasoneDexamethasone results in increased expression of PPARD mRNA19022236
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of PPARD mRNA28962523
C000944dicrotophosdicrotophos results in increased expression of PPARD mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of PPARD mRNA18457598|2244768
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] affects the expression of PPARD mRNA26055348
D004041Dietary FatsDietary Fats results in decreased expression of PPARD protein26055348
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in decreased expression of PPARD protein]26055348
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PPARD protein16455614
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of PPARD mRNA15647598
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of PPARD protein15647598
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PPARD mRNA18164116
D002117Calcitriol[Calcitriol co-treated with GW 501516] results in increased expression of PPARD mRNA19667161
D002117Calcitriol[Calcitriol co-treated with pirinixic acid] results in increased expression of PPARD mRNA19667161
D002117CalcitriolCalcitriol promotes the reaction [Bezafibrate results in increased expression of PPARD mRNA]19667161
D002117CalcitriolCalcitriol promotes the reaction [Docosahexaenoic Acids results in increased expression of PPARD mRNA]19667161
D002117CalcitriolCalcitriol results in increased expression of [alpha-Linolenic Acid results in increased expression of PPARD mRNA]19667161
D002117CalcitriolCalcitriol results in increased expression of PPARD mRNA15890193|1966716
C042080diisodecyl phthalatediisodecyl phthalate results in increased expression of PPARD mRNA25825955
D004143Dioctyl Sulfosuccinic AcidDioctyl Sulfosuccinic Acid results in increased activity of PPARD protein26135921
C076126disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of PPARD mRNA"20184727
D004281Docosahexaenoic AcidsCalcitriol promotes the reaction [Docosahexaenoic Acids results in increased expression of PPARD mRNA]19667161
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in increased expression of PPARD mRNA11172467|1966716
D004281Docosahexaenoic AcidsPPARD protein promotes the reaction [Docosahexaenoic Acids results in increased expression of LPIN2 mRNA]19805517
D004281Docosahexaenoic AcidsPPARD protein promotes the reaction [Docosahexaenoic Acids results in increased expression of ST3GAL5 mRNA]19805517
D004317DoxorubicinDoxorubicin results in decreased activity of PPARD protein25257666
D004317DoxorubicinDoxorubicin results in decreased expression of PPARD mRNA16404146
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of PPARD mRNA"23811387
D015118Eicosapentaenoic AcidEicosapentaenoic Acid results in increased expression of PPARD mRNA11172467
D015118Eicosapentaenoic AcidEicosapentaenoic Acid binds to and results in increased activity of PPARD protein10753628
D004610Ellagic AcidEllagic Acid results in decreased expression of PPARD mRNA12002526
D015773Enalaprilat[Enalaprilat co-treated with Daunorubicin] results in increased expression of PPARD mRNA23834779
D000431EthanolEthanol results in increased expression of PPARD mRNA28986285
D000431EthanolPPARD gene mutant form inhibits the reaction [Ethanol affects the localization of PPARGC1A protein]27765815
D000431EthanolPPARD gene mutant form inhibits the reaction [Ethanol promotes the reaction [SP1 protein binds to CYP2B10 promoter]]27765815
D000431EthanolPPARD gene mutant form results in decreased expression of [Ethanol results in increased expression of CYP2B10 mRNA]27765815
D000431EthanolPPARD gene mutant form results in decreased expression of [Ethanol results in increased expression of CYP2B10 protein]27765815
D000431EthanolPPARD gene mutant form results in increased susceptibility to Ethanol23851158
D000431Ethanol[PPARD gene mutant form results in increased susceptibility to Ethanol] which results in increased activity of SREBF1 protein23851158
D000431EthanolEthanol results in increased expression of PPARD mRNA26854922
D000431Ethanol[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in increased expression of PPARD mRNA26854922
C504648ethyl(E,E,E)-7-(2-n-propoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-3-yl)-6-fluorp-3-methylocta-2,4,6-trienoate"ethyl(E,E,E)-7-(2-n-propoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-3-yl)-6-fluorp-3-methylocta-2,4,6-trienoate results in increased activity of [RXRA protein binds to PPARD protein]"15997096
D005227Fatty AcidsPPARD protein affects the metabolism of Fatty Acids20075336
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of PPARD mRNA"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of PPARD mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of PPARD mRNA]"23333450
D005230Fatty Acids, Nonesterified"Fatty Acids, Nonesterified promotes the reaction [PPARD protein binds to LPIN2 enhancer]"19805517
D005230Fatty Acids, Nonesterified"Fatty Acids, Nonesterified promotes the reaction [PPARD protein binds to ST3GAL5 enhancer]"19805517
D015736FelodipineFelodipine results in increased activity of PPARD protein25257666
D011345FenofibrateFenofibrate results in increased expression of PPARD mRNA19201410
D011345FenofibrateFenofibrate results in increased expression of PPARD mRNA19201410
C006012fenofibric acidfenofibric acid results in increased activity of [PPARD protein binds to RXRA protein]11779144
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of PPARD mRNA28329830
C061365flusilazoleflusilazole results in increased activity of PPARD protein20143881
C039281furanfuran results in decreased expression of PPARD mRNA26194646
C039281furanfuran results in increased methylation of PPARD gene22079235
C056507gemcitabinegemcitabine affects the expression of PPARD mRNA19427843
D015248GemfibrozilGemfibrozil results in increased expression of PPARD mRNA19201410
D015248GemfibrozilGemfibrozil results in increased expression of PPARD mRNA19201410
D005947GlucoseGlucose affects the expression of PPARD mRNA24349266
D006118GriseofulvinGriseofulvin results in increased expression of PPARD mRNA9548566
C529769GSK0660GSK0660 inhibits the reaction [GW0742 results in increased activity of PPARD protein]22992727
C529769GSK0660GSK0660 binds to and results in decreased activity of PPARD protein19906781
C529769GSK0660GSK0660 results in decreased activity of PPARD protein21499286
C479979GW0742GSK0660 inhibits the reaction [GW0742 results in increased activity of PPARD protein]22992727
C479979GW0742GW0742 binds to and results in increased activity of PPARD protein16326050|1839343
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of ANGPTL4 mRNA28962521
C479979GW0742[GW0742 co-treated with PPARD protein] results in increased expression of ANGPTL4 mRNA24464939
C479979GW0742[GW0742 co-treated with PPARD protein] results in increased expression of RELA protein24464939
C479979GW0742GW0742 results in increased activity of PPARD protein21543282|2299272
C479979GW0742monobutyl phthalate inhibits the reaction [GW0742 binds to and results in increased activity of PPARD protein]16326050
C479979GW0742norathyriol inhibits the reaction [GW0742 results in increased activity of PPARD protein]18393431
C479979GW0742PPARD protein promotes the reaction [GW0742 results in increased phosphorylation of AKT1 protein]19906781
C479979GW0742PPARD protein promotes the reaction [GW0742 results in increased phosphorylation of NOS3 protein]19906781
C479979GW0742Quercetin inhibits the reaction [GW0742 results in increased activity of PPARD protein]18393431
C479979GW07424-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 promotes the reaction [PPARD protein binds to ANGPTL4 promoter]]20516370
C479979GW07424-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 promotes the reaction [PPARD protein binds to PLIN2 promoter]]20516370
C479979GW0742GW0742 binds to and results in increased activity of PPARD protein18593727|1957761
C479979GW0742[[GW0742 binds to and results in increased activity of PPARD protein] co-treated with [nimesulide results in decreased activity of PTGS2 protein]] results in increased expression of KRT10 mRNA19748995
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CDK1 mRNA]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CDK1 protein]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CENPA protein]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CHEK1 mRNA]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CHEK1 protein]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of H2AFZ mRNA]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of H2AFZ protein]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of NEK2 protein]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] which results in decreased expression of CCNB1 protein22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] which results in decreased expression of CDK1 protein22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] which results in decreased expression of CHEK1 protein22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] which results in decreased expression of E2F1 protein22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] which results in decreased expression of H2AFZ protein22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of KRT10 mRNA19748995
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of KRT1 mRNA19748995
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of PLIN2 mRNA19748995
C479979GW0742GW0742 inhibits the reaction [4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide promotes the reaction [PPARD protein binds to ANGPTL4 promoter]]20516370
C479979GW0742GW0742 inhibits the reaction [4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide promotes the reaction [PPARD protein binds to PLIN2 promoter]]20516370
C479979GW0742GW0742 inhibits the reaction [Lipopolysaccharides results in increased expression of PPARD mRNA]27427494
C479979GW0742GW0742 results in increased activity of PPARD protein20516370|2742749
C479979GW0742[GW0742 results in increased activity of PPARD protein] promotes the reaction [PPARD protein binds to ANGPTL4 promoter]20516370
C479979GW0742[GW0742 results in increased activity of PPARD protein] promotes the reaction [PPARD protein binds to PLIN2 promoter]20516370
C479979GW0742[[nimesulide results in decreased activity of PTGS2 protein] co-treated with [GW0742 binds to and results in increased activity of PPARD protein]] results in decreased abundance of Dinoprostone19748995
C479979GW0742PPARD gene mutant form inhibits the reaction [4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 results in increased expression of ANGPTL4 mRNA]]20516370
C479979GW0742PPARD gene mutant form inhibits the reaction [4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 results in increased expression of PLIN2 mRNA]]20516370
C479979GW0742PPARD gene mutant form inhibits the reaction [GW0742 results in increased expression of ANGPTL4 mRNA]20516370|2776581
C479979GW0742PPARD promotes the reaction [GW0742 results in increased expression of LIPE protein]20176998
C479979GW0742PPARD protein affects the susceptibility to GW074218622026
C479979GW0742PPARD protein mutant form inhibits the reaction [[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of KRT10 mRNA]19748995
C479979GW0742PPARD protein mutant form inhibits the reaction [[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of KRT1 mRNA]19748995
C479979GW0742PPARD protein mutant form inhibits the reaction [[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of PLIN2 mRNA]19748995
C479979GW0742PPARD protein mutant form inhibits the reaction [GW0742 results in increased expression of PLIN2 mRNA]27427494
C479979GW0742PPARD protein promotes the reaction [GW0742 results in increased expression of SLC25A20 mRNA]19577614
C479979GW0742GW0742 binds to and results in increased activity of PPARD protein18622026|1974899
C479979GW0742GW0742 results in increased activity of PPARD protein21159610
C110636GW 2433GW 2433 binds to PPARD protein17290005
C110636GW 2433Ro 41-5253 inhibits the reaction [GW 2433 binds to PPARD protein]17290005
C425931GW 501516GW 501516 binds to and results in increased activity of PPARD protein16239165
C425931GW 501516[Calcitriol co-treated with GW 501516] results in increased expression of PPARD mRNA19667161
C425931GW 501516GW 501516 binds to and results in increased activity of PPARD protein23391484
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of ABHD3 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of ACADM mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of ACADVL mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of ANGPTL4 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of CEBPA mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of CPT1A mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of DDIT4 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of ECH1 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of FABP1 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of HADHA mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of HMGCS2 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of HSDL2 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of KIZ mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of LIPC mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of NEDD9 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of PCK1 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of PDZK1 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of PLIN2 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of PLTP mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of RNU7-65P mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of SERPINE1 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of SLC22A7 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of SLC30A10 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of SULT2A1 mRNA16197558
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of TRIB2 mRNA16197558
C425931GW 501516GW 501516 promotes the reaction [PPARD protein results in increased expression of SIRT1 mRNA]20160399
C425931GW 501516GW 501516 results in increased activity of PPARD protein27551952
C425931GW 501516GW 501516 results in increased expression of PPARD mRNA19201410
C425931GW 501516PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]23737761
C425931GW 501516PPARD mutant form inhibits the reaction [GW 501516 results in increased expression of PLIN2 mRNA]23737761
C425931GW 5015164-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW 501516 results in increased expression of PPARD mRNA]20516370
C425931GW 501516GW 501516 binds to and results in increased activity of PPARD protein18292206|2196647
C425931GW 501516[GW 501516 co-treated with PPARD protein] results in increased expression of PPARGC1A mRNA17275789
C425931GW 501516GW 501516 results in increased expression of PPARD mRNA19201410|2051637
C425931GW 501516GW 501516 binds to PPARD protein18701451
C425931GW 501516[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]18701451
C425931GW 501516[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]18701451
C425931GW 501516[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]18701451
C425931GW 501516GW 501516 binds to and results in increased activity of PPARD protein16574099|1734141
C425931GW 501516GW 501516 results in increased activity of PPARD protein21484566
C503394GW 610742GW 610742 results in increased activity of PPARD protein17290005
C453899GW 7647GW 7647 results in increased activity of PPARD protein20143881
D006538Heptanoic AcidsHeptanoic Acids results in increased activity of PPARD protein23391484
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid binds to and results in increased activity of PPARD protein"12069687
D007213IndomethacinIndomethacin results in decreased activity of PPARD protein10555149
D007213IndomethacinIndomethacin results in decreased expression of PPARD protein18678619
D007213IndomethacinIndomethacin results in increased expression of PPARD mRNA19415698
D007213IndomethacinIndomethacin results in increased expression of PPARD protein17341418|1941569
D007213IndomethacinPPARD protein affects the reaction [Indomethacin results in decreased expression of YWHAE protein]17409426
D007213Indomethacinpyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of PPARD protein]17341418
D007213IndomethacinSB 203580 inhibits the reaction [Indomethacin results in increased expression of PPARD protein]17341418
C060285lacidipinelacidipine results in increased activity of PPARD protein25257666
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of PPARD mRNA"24972896
D008070LipopolysaccharidesGW0742 inhibits the reaction [Lipopolysaccharides results in increased expression of PPARD mRNA]27427494
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PPARD mRNA27427494
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PPARD mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [RELA protein binds to PPARD protein]15728586
C479889LY 518674LY 518674 results in increased expression of PPARD mRNA19201410
C479889LY 518674LY 518674 results in increased expression of PPARD mRNA19201410
D008727MethotrexateMethotrexate results in decreased expression of PPARD mRNA17400583
D008727MethotrexateMethotrexate results in increased expression of PPARD mRNA21678067
D008731MethoxychlorMethoxychlor results in increased methylation of PPARD gene23303685
C066998methoxy-morpholinyl-doxorubicinmethoxy-morpholinyl-doxorubicin results in decreased activity of PPARD protein25257666
D008752Methylene ChlorideMethylene Chloride results in decreased expression of PPARD mRNA28392392
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PPARD mRNA23103053
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased activity of PPARD protein27551952
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of PPARD mRNA15647598
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of PPARD protein15647598
C103325mono-benzyl phthalatemono-benzyl phthalate results in increased activity of PPARD protein27551952
C028577monobutyl phthalatemonobutyl phthalate inhibits the reaction [GW0742 binds to and results in increased activity of PPARD protein]16326050
C471400monoisononylphthalatemonoisononylphthalate results in increased activity of PPARD protein27551952
C523799MRK 003PPARD results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PPARD mRNA"25620056
D009285NaphthoquinonesNaphthoquinones results in increased expression of PPARD mRNA23811387
D009534NiclosamideNiclosamide results in increased expression of PPARD mRNA22576131
D009537Nicotinamide MononucleotideNicotinamide Mononucleotide inhibits the reaction [MIR34A mRNA results in decreased expression of PPARD mRNA]23834033
C012655nimesulidenimesulide results in increased expression of PPARD mRNA19415698
C012655nimesulidenimesulide results in increased expression of PPARD protein19415698
C012655nimesulide[[GW0742 binds to and results in increased activity of PPARD protein] co-treated with [nimesulide results in decreased activity of PTGS2 protein]] results in increased expression of KRT10 mRNA19748995
C012655nimesulide[[nimesulide results in decreased activity of PTGS2 protein] co-treated with [GW0742 binds to and results in increased activity of PPARD protein]] results in decreased abundance of Dinoprostone19748995
C012655nimesulidenimesulide results in increased activity of and results in increased expression of PPARD21159610
C012655nimesulidePPARD protein affects the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]19748995
C012655nimesulidePPARD protein mutant form inhibits the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]19748995
C012655nimesulidePPARD results in increased susceptibility to nimesulide21159610
C069053norathyriolnorathyriol inhibits the reaction [GW0742 results in increased activity of PPARD protein]18393431
D019787Linoleic AcidLinoleic Acid results in decreased expression of PPARD mRNA15708366
D019787Linoleic AcidLinoleic Acid results in increased activity of PPARD protein25786526
D019787Linoleic AcidLinoleic Acid results in increased expression of PPARD mRNA11172467
D019301Oleic AcidOleic Acid results in increased expression of PPARD mRNA11172467
D019301Oleic Acid[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in increased expression of PPARD mRNA26854922
D019301Oleic AcidOleic Acid results in decreased expression of PPARD mRNA24349266
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of PPARD mRNA20184727
D000069463Olive OilOlive Oil inhibits the reaction [Streptozocin results in decreased expression of PPARD mRNA]25246140
D000069463Olive OilOlive Oil results in increased expression of PPARD mRNA25246140
D019308Palmitic Acid[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in increased expression of PPARD mRNA26854922
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of PPARD mRNA18593933
C108042perfluorobutaneperfluorobutane results in increased expression of PPARD mRNA23567314
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of PPARD mRNA23567314
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of PPARD mRNA23567314
C479228perfluorohexanoic acidperfluorohexanoic acid results in increased expression of PPARD mRNA23567314
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of PPARD mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PPARD mRNA22057587
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased activity of PPARD protein17047030
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PPARD mRNA23567314
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased activity of PPARD protein23391484
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased activity of PPARD protein17047030
D015232Dinoprostone[[nimesulide results in decreased activity of PTGS2 protein] co-treated with [GW0742 binds to and results in increased activity of PPARD protein]] results in decreased abundance of Dinoprostone19748995
D015232DinoprostonePPARD protein affects the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]19748995
D015232DinoprostonePPARD protein mutant form inhibits the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]19748995
D010634PhenobarbitalPhenobarbital affects the expression of PPARD mRNA23091169
D010656Phenylephrine[4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased activity of PPARD protein] which results in decreased susceptibility to Phenylephrine15721863
D010656Phenylephrine[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]18701451
D010656Phenylephrine[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]18701451
D010656Phenylephrine[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]18701451
C060836pioglitazonepioglitazone binds to PPARD protein11779144
C060836pioglitazonepioglitazone results in increased activity of PPARD protein23150725
C060836pioglitazonepioglitazone results in increased activity of [PPARD protein binds to RXRA protein]11779144
C060836pioglitazonepioglitazone results in increased expression of PPARD mRNA19201410
C060836pioglitazonepioglitazone results in increased expression of PPARD mRNA19201410
C027260pirarubicinpirarubicin results in decreased activity of PPARD protein25257666
C006253pirinixic acid[Calcitriol co-treated with pirinixic acid] results in increased expression of PPARD mRNA19667161
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PPARD mRNA19710929
C006253pirinixic acidpirinixic acid results in increased activity of PPARD protein26135921|9703482
C006253pirinixic acidpirinixic acid results in increased expression of PPARD mRNA19667161
C006253pirinixic acidpirinixic acid promotes the reaction [PPARD protein binds to NFKBIA promoter]19438714
C006253pirinixic acidpirinixic acid results in increased activity of [PPARD protein co-treated with RXRA protein]8700121
C006253pirinixic acid[pirinixic acid results in increased activity of PPARD protein] which results in increased expression of NFKBIA mRNA19438714
C108475pitavastatinpitavastatin results in increased expression of PPARD mRNA21554872
D008926PlicamycinPlicamycin inhibits the reaction [PPARD protein results in increased expression of SIRT1 mRNA]20160399
D011441PropylthiouracilPropylthiouracil results in decreased expression of PPARD mRNA24780913
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of PPARD protein]17341418
D011794QuercetinQuercetin inhibits the reaction [GW0742 results in increased activity of PPARD protein]18393431
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]25554529
C059514resveratrolresveratrol analog results in increased expression of PPARD mRNA24759758
C059514resveratrolresveratrol results in decreased expression of PPARD mRNA12002526|1256957
C059514resveratrol[Dietary Fats co-treated with resveratrol] affects the expression of PPARD mRNA26055348
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in decreased expression of PPARD protein]26055348
C059514resveratrolresveratrol results in increased expression of PPARD23790948
C059514resveratrolresveratrol analog binds to PPARD protein24759758
C084904Ro 41-5253Ro 41-5253 binds to PPARD protein17290005
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [GW 2433 binds to PPARD protein]17290005
C089730rosiglitazonerosiglitazone binds to PPARD protein11779144
C089730rosiglitazonerosiglitazone results in increased expression of PPARD mRNA17310221
D012431RutinRutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD mRNA]25478064
D012431RutinRutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD protein]25478064
C093642SB 203580SB 203580 inhibits the reaction [Indomethacin results in increased expression of PPARD protein]17341418
D020123SirolimusPPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein]24898257
D020123SirolimusPPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of HSPA5 protein]24898257
D012999SomanSoman results in increased expression of PPARD mRNA19281266
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]25554529
D013311StreptozocinOlive Oil inhibits the reaction [Streptozocin results in decreased expression of PPARD mRNA]25246140
D013311StreptozocinStreptozocin results in decreased expression of PPARD mRNA25246140
D013467SulindacSulindac results in increased expression of PPARD protein21400612
D013467SulindacPPARD protein affects the susceptibility to Sulindac10866668
C025462sulindac sulfidePPARD protein affects the reaction [sulindac sulfide results in decreased expression of YWHAE protein]17409426
C025462sulindac sulfidePPARD protein inhibits the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]16091736
C025462sulindac sulfidesulindac sulfide binds to and results in decreased activity of PPARD protein16091736
C025462sulindac sulfidesulindac sulfide results in decreased activity of PPARD protein10555149
C025462sulindac sulfidesulindac sulfide results in decreased expression of PPARD mRNA17409426|1867861
C025462sulindac sulfidesulindac sulfide results in decreased expression of PPARD protein17409426|1867861
C025462sulindac sulfidesulindac sulfide results in increased expression of PPARD mRNA11948457
C025462sulindac sulfidesulindac sulfide results in increased expression of PPARD protein21400612
C025463sulindac sulfonesulindac sulfone results in increased expression of PPARD mRNA11948457
C084178telmisartanPPARD promotes the reaction [telmisartan results in increased expression of LIPE protein]20176998
C084178telmisartanPPARD promotes the reaction [telmisartan results in increased expression of UCP1 protein]20176998
C084178telmisartanPPARD promotes the reaction [telmisartan results in increased expression of UCP2 protein]20176998
C084178telmisartanPPARD promotes the reaction [telmisartan results in increased expression of UCP3 protein]20176998
C084178telmisartantelmisartan results in increased expression of PPARD protein20176998
C084178telmisartantelmisartan results in increased expression of PPARD protein20176998
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PPARD mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PPARD protein21410761
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of PPARD mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PPARD mRNA24058054
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of PPARD mRNA28973375
D013755Tetradecanoylphorbol AcetatePPARD protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNB1 mRNA]10866668
D013755Tetradecanoylphorbol AcetatePPARD protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDK1 mRNA]10866668
D013755Tetradecanoylphorbol AcetatePPARD protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDK4 mRNA]10866668
D013755Tetradecanoylphorbol AcetatePPARD protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of PCNA mRNA]10866668
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of PPARD mRNA10866668
C410666tetradecylselenoacetic acidtetradecylselenoacetic acid results in increased activity of PPARD protein17185614
D013792ThalidomidePPARD gene SNP results in increased susceptibility to Thalidomide21245421
D014212TretinoinTretinoin results in increased expression of PPARD mRNA23724009
D014212TretinoinTretinoin results in increased expression of PPARD mRNA24977338
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PPARD mRNA28973375
C001899triptolidetriptolide results in decreased expression of PPARD protein26219505
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PPARD mRNA"26179874
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [antimonite results in increased expression of PPARD mRNA]17400267
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [arsenite results in increased expression of PPARD mRNA]17400267
D014520UrethaneUrethane results in increased expression of PPARD mRNA28818685
D014635Valproic AcidValproic Acid binds to and results in increased activity of PPARD protein24489787
D014635Valproic AcidValproic Acid results in increased expression of PPARD mRNA24935251
C009687wortmanninwortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARD mRNA]23399309
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of PPARD mRNA18593933
C088658zoledronic acidzoledronic acid results in increased expression of PPARD mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001103RNA polymerase II repressing transcription factor binding-IBA21873635  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-ISS-  
GO:0003677DNA binding-ISS-  
GO:0003700DNA-binding transcription factor activityCONTRIBUTES_TOIBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA12955147  
GO:0003700DNA-binding transcription factor activity-NAS11551955  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0003713transcription coactivator activity-IEA-  
GO:0004879nuclear receptor activity-IBA21873635  
GO:0004879nuclear receptor activity-IDA12955147  
GO:0005504fatty acid binding-IBA21873635  
GO:0005515protein binding-IPI23455924  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-IPI26504087  
GO:0008144drug binding-IBA21873635  
GO:0008144drug binding-IDA9113987  10198642  
GO:0008270zinc ion binding-IEA-  
GO:0008289lipid binding-IBA21873635  
GO:0008289lipid binding-IDA12955147  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IBA21873635  
GO:0043565sequence-specific DNA binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0051059NF-kappaB binding-IEA-  
GO:0070539linoleic acid binding-IDA10198642  
GO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0006006glucose metabolic process-NAS15793256  
GO:0006029proteoglycan metabolic process-IEA-  
GO:0006091generation of precursor metabolites and energy-TAS1333051  
GO:0006357regulation of transcription by RNA polymerase II-TAS1333051  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006629lipid metabolic process-ISS-  
GO:0006631fatty acid metabolic process-IBA21873635  
GO:0006635fatty acid beta-oxidation-ISS-  
GO:0006635fatty acid beta-oxidation-TAS15192438  15803109  
GO:0006776vitamin A metabolic process-IEA-  
GO:0006915apoptotic process-IMP12909723  
GO:0007275multicellular organism development-IBA21873635  
GO:0007507heart development-IEA-  
GO:0007566embryo implantation-TAS11551955  
GO:0008203cholesterol metabolic process-TAS15192438  
GO:0008283cell proliferation-ISS-  
GO:0008283cell proliferation-TAS11847022  
GO:0008366axon ensheathment-ISS-  
GO:0008654phospholipid biosynthetic process-IEA-  
GO:0009062fatty acid catabolic process-TAS15192438  
GO:0009299mRNA transcription-IEA-  
GO:0009749response to glucose-IEA-  
GO:0009755hormone-mediated signaling pathway-IBA21873635  
GO:0010887negative regulation of cholesterol storage-IBA21873635  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IEA-  
GO:0014823response to activity-IEA-  
GO:0014842regulation of skeletal muscle satellite cell proliferation-IEA-  
GO:0014912negative regulation of smooth muscle cell migration-IEA-  
GO:0015908fatty acid transport-ISS-  
GO:0019216regulation of lipid metabolic process-IBA21873635  
GO:0030154cell differentiation-IBA21873635  
GO:0030154cell differentiation-IEA-  
GO:0030308negative regulation of cell growth-IEA-  
GO:0030522intracellular receptor signaling pathway-IEA-  
GO:0031589cell-substrate adhesion-IEA-  
GO:0031667response to nutrient levels-IBA21873635  
GO:0032024positive regulation of insulin secretion-IEA-  
GO:0032966negative regulation of collagen biosynthetic process-IEA-  
GO:0033189response to vitamin A-IEA-  
GO:0033993response to lipid-IBA21873635  
GO:0042060wound healing-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0043415positive regulation of skeletal muscle tissue regeneration-IEA-  
GO:0043616keratinocyte proliferation-IEA-  
GO:0045600positive regulation of fat cell differentiation-NAS10991946  
GO:0045662negative regulation of myoblast differentiation-IEA-  
GO:0045684positive regulation of epidermis development-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IBA21873635  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA12955147  
GO:0045923positive regulation of fatty acid metabolic process-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0046697decidualization-TAS11551955  
GO:0048662negative regulation of smooth muscle cell proliferation-IEA-  
GO:0050680negative regulation of epithelial cell proliferation-IEA-  
GO:0050728negative regulation of inflammatory response-IBA21873635  
GO:0050728negative regulation of inflammatory response-IEA-  
GO:0051546keratinocyte migration-IEA-  
GO:0060612adipose tissue development-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071396cellular response to lipid-IBA21873635  
GO:0071456cellular response to hypoxia-IEA-  
GO:0097190apoptotic signaling pathway-IMP11551955  
GO:0097755positive regulation of blood vessel diameter-IEA-  
GO:1902894negative regulation of pri-miRNA transcription by RNA polymerase II-ISS-  
GO:1904659glucose transmembrane transport-NAS15793256  
GO:2000288positive regulation of myoblast proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-ISS-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-NAS11551955  
GO:0005654nucleoplasm-TAS-  
GO:0090575RNA polymerase II transcription factor complex-IBA21873635  
KEGG ID KEGG Term
hsa03320PPAR signaling pathway
hsa04310Wnt signaling pathway
hsa05200Pathways in cancer
hsa05221Acute myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-200425Import of palmitoyl-CoA into the mitochondrial matrixTAS
R-HSA-204174Regulation of pyruvate dehydrogenase (PDH) complexTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-5362517Signaling by Retinoic AcidTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-70268Pyruvate metabolismTAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28287878Association of peroxisome proliferator-activated receptor delta and additional gene-smoking interaction on cardiovascular disease. (2017)Yang WClin Exp Hypertens
21176135Peroxisome proliferator-activated receptor delta +294T > C polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. (2010 Dec 21)Miao LLipids Health Dis
22606049Interactions of several lipid-related gene polymorphisms and cigarette smoking on blood pressure levels. (2012)Yin RXInt J Biol Sci
28737528Genetic variants of increased waist circumference in psychosis. (2017 Dec)Hukic DSPsychiatr Genet
25516156Peroxisome proliferator-activated receptors alpha and gamma are linked with alcohol consumption in mice and withdrawal and dependence in humans. (2015 Jan)Blednov YAAlcohol Clin Exp Res
24378001[Roles of peroxisome proliferator-activated receptors polymorphisms, haplotypes, levels on C-reactive protein and their interactions with abnormal body weight]. (2013 Oct)Yu LGZhonghua Liu Xing Bing Xue Za Zhi