Gene: CRLS1

54675
C20orf155|CLS|CLS1|GCD10|dJ967N21.6
cardiolipin synthase 1
protein-coding
20p12.3
Ensembl:ENSG00000088766 MIM:608188 Vega:OTTHUMG00000031823 UniprotKB:Q9UJA2
NC_000020.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.052e-1 (AD)  5.841e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMG20.89
TSG1010.883
MICU20.877
ORMDL10.866
MNAT10.866
ANXA70.864
EIF3M0.861
PSMB10.858
MBIP0.856
SRSF20.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.663
OR4F29-0.647
MTRNR2L9-0.224
MTRNR2L6-0.22
RNF223-0.182
CETP-0.172
C8orf74-0.17
CXCL17-0.169
MTRNR2L10-0.165
MTRNR2L3-0.16

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CRLS1 mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of CRLS1 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of CRLS1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CRLS1 gene27153756
D001280AtrazineAtrazine results in increased expression of CRLS1 mRNA25929836
D001280AtrazineAtrazine results in increased expression of CRLS1 mRNA22378314
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CRLS1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CRLS1 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of CRLS1 mRNA19484750
C044887beta-methylcholinebeta-methylcholine affects the expression of CRLS1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of CRLS1 mRNA25181051
C054133casticincasticin results in decreased expression of CRLS1 mRNA28444820
D005576ColforsinColforsin results in increased expression of CRLS1 mRNA16751804
D016572CyclosporineCyclosporine results in decreased expression of CRLS1 mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CRLS1 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CRLS1 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of CRLS1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of CRLS1 mRNA18042831
D002117CalcitriolCalcitriol results in decreased expression of CRLS1 mRNA16002434
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CRLS1 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CRLS1 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of CRLS1 mRNA23649840
C039281furanfuran results in increased methylation of CRLS1 gene22079235
D005897GlafenineGlafenine results in decreased expression of CRLS1 mRNA24136188
D017313FenretinideFenretinide results in increased expression of CRLS1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CRLS1 mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CRLS1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of CRLS1 mRNA27392435
C410337K 7174K 7174 results in decreased expression of CRLS1 mRNA24086573
D007649KetamineKetamine results in decreased expression of CRLS1 mRNA20080153
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CRLS1 mRNA20652826
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CRLS1 mRNA20652826
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CRLS1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CRLS1 mRNA23649840
D015741MetriboloneMetribolone results in increased expression of CRLS1 mRNA16751804
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CRLS1 mRNA"25620056
C029938nickel sulfatenickel sulfate results in decreased expression of CRLS1 mRNA22714537
D000073878Palm OilPalm Oil results in decreased expression of CRLS1 mRNA18042831
C016030pantogabpantogab results in increased expression of CRLS1 mRNA17379144
C006253pirinixic acidpirinixic acid results in increased expression of CRLS1 mRNA20813756
D011794QuercetinQuercetin results in decreased expression of CRLS1 mRNA21632981
C017947sodium arsenitesodium arsenite results in decreased expression of CRLS1 mRNA22714537
D013629TamoxifenTamoxifen affects the expression of CRLS1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CRLS1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CRLS1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CRLS1 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CRLS1 mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CRLS1 mRNA18796159
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CRLS1 mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of CRLS1 mRNA23557971
C012589trichostatin Atrichostatin A results in increased expression of CRLS1 mRNA26272509
D014501UraniumUranium affects the expression of CRLS1 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of CRLS1 mRNA15672453
D014520UrethaneUrethane results in decreased expression of CRLS1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of CRLS1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CRLS1 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CRLS1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of CRLS1 mRNA23034163
C088658zoledronic acidzoledronic acid results in decreased expression of CRLS1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-TAS-  
GO:0008808cardiolipin synthase activity-IBA21873635  
GO:0043337CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity-TAS-  
GO:00471442-acylglycerol-3-phosphate O-acyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0032049cardiolipin biosynthetic process-IBA21873635  
GO:0032049cardiolipin biosynthetic process-TAS-  
GO:0036148phosphatidylglycerol acyl-chain remodeling-TAS-  
GO:0046474glycerophospholipid biosynthetic process-IBA21873635  
GO:0097068response to thyroxine-IEA-  
GO:1905711response to phosphatidylethanolamine-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482925Acyl chain remodelling of PGTAS
R-HSA-1483076Synthesis of CLTAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29434989Expression and potential mechanism of metabolism-related genes and CRLS1 in non-small cell lung cancer. (2018 Feb)Feng HMOncol Lett