Gene: MED1

5469
CRSP1|CRSP200|DRIP205|DRIP230|PBP|PPARBP|PPARGBP|RB18A|TRAP220|TRIP2
mediator complex subunit 1
protein-coding
17q12
Ensembl:ENSG00000125686 MIM:604311 Vega:OTTHUMG00000133216 UniprotKB:Q15648
NG_046996.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.409e-1 (AD)  2.947e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7501488chr17:39420164 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12452509chr17:39418469 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6503513chr17:39405360 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SON0.915
CNOT10.911
SCAF80.898
GOSR10.895
NUP1530.895
COPB20.895
SETX0.891
PROSER10.891
FAM120A0.89
EP3000.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.581
OR4F29-0.541
NANOGNB-0.287
KLRC2-0.239
KLRC3-0.207
TNFRSF13B-0.2
OR4F16-0.191
APOA1-0.191
OR6C74-0.19
HMHB1-0.175

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04891BecocalcidiolSmall Molecule524067-21-8InvestigationalTarget
ID Drug Name Action PubMed
C0979491,25-dihydroxyvitamin D"[1,25-dihydroxyvitamin D co-treated with Okadaic Acid] promotes the reaction [VDR protein mutant form binds to MED1 protein]"16059639
C4080471,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3"1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3 promotes the reaction [VDR protein mutant form binds to MED1 protein]"16059639
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [MED1 protein binds to and results in increased activity of NR1I3 protein]"16109766
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [MED1 protein binds to CYP2B10 promoter]"17962186
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased localization of MED1 protein"16109766
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"MED1 gene mutant form results in increased susceptibility to 1,4-bis(2-(3,5-dichloropyridyloxy))benzene"16109766
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"MED1 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP1A2 mRNA]"16109766
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"MED1 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B10 mRNA]"16109766
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"MED1 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP3A11 mRNA]"16109766
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to MED1 protein]"17962186
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"ciprofibrate inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to MED1 protein]]"17962186
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"pirinixic acid inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to MED1 protein]]"17962186
C09724015-deoxy-delta(12,14)-prostaglandin J2"MED1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]"16324150
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased phosphorylation of MED1 protein25068892
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MED1 mRNA"19114083
C04048826,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3"26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3 analog promotes the reaction [VDR protein mutant form binds to MED1 protein]"16059639
C0106423,3',5-triiodothyroacetic acid"MED1 protein promotes the reaction [3,3',5-triiodothyroacetic acid results in increased activity of THRA protein]"16324150
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of MED1 mRNA"20702594
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MED1 protein modified form]"28751236
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to MED1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MED1 protein]26598702
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide results in increased expression of MED1 mRNA20829426
C5705395-(3-((3-(5-methoxybenzisoxazol-3-yl)benzimidazol-1-yl)methyl)phenyl)-5-methyloxazolidinedione5-(3-((3-(5-methoxybenzisoxazol-3-yl)benzimidazol-1-yl)methyl)phenyl)-5-methyloxazolidinedione analog binds to and results in increased activity of MED1 protein22070604
D000082AcetaminophenAcetaminophen results in increased expression of MED1 mRNA27761495
C008088alfacalcidolalfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to MED1 protein modified form]20947021
D001151ArsenicArsenic results in decreased expression of MED1 mRNA19654921
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MED1 protein]26598702
D001280AtrazineAtrazine results in decreased expression of MED1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MED1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MED1 mRNA20127859|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MED1 mRNA"20018196
D004958EstradiolEstradiol promotes the reaction [NR1I2 protein binds to MED1 protein]15650019
C543008bis(4-hydroxyphenyl)sulfone[bis(4-hydroxyphenyl)sulfone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MED1 protein modified form]28751236
C006780bisphenol Abisphenol A affects the expression of MED1 mRNA21786754
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MED1 protein modified form]28751236
C006780bisphenol Abisphenol A promotes the reaction [MED1 protein binds to and results in increased activity of NR1I2 protein]22214767
C006780bisphenol Abisphenol A results in increased expression of MED1 mRNA14664715
C006780bisphenol Abisphenol A results in increased expression of MED1 protein14664715
C006780bisphenol Abisphenol A results in increased expression of MED1 mRNA25181051
C006780bisphenol Abisphenol A promotes the reaction [ESR2 protein binds to MED1 protein]14664715
C004605butambenbutamben promotes the reaction [NR1I2.L protein binds to MED1 protein]12198127
C004605butambenbutamben promotes the reaction [NR1I2.S protein binds to MED1 protein]12198127
D002330CarmustineCarmustine results in decreased expression of MED1 mRNA15980968
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MED1 mRNA23650126
D002737ChloropreneChloroprene results in increased expression of MED1 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of MED1 mRNA20350560
D004390ChlorpyrifosChlorpyrifos results in decreased expression of MED1 mRNA18668222
C019304ciprofibrate"ciprofibrate inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to MED1 protein]]"17962186
C019304ciprofibrateciprofibrate inhibits the reaction [NR1I3 protein binds to MED1 protein]17962186
C018021cobaltous chloridecobaltous chloride results in increased expression of MED1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of MED1 mRNA18579281
D016572CyclosporineCyclosporine results in decreased expression of MED1 mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of MED1 mRNA24921660
D017373Cyproterone Acetate[Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form]28751236
D003907DexamethasoneMED1 affects the susceptibility to Dexamethasone19630272
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MED1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MED1 mRNA21266533
D002945CisplatinCisplatin promotes the reaction [NR1I2 protein binds to MED1 protein]15650019
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of MED1 mRNA26924002
D004052DiethylnitrosamineMED1 protein results in increased susceptibility to Diethylnitrosamine20007298
D002117CalcitriolCalcitriol promotes the reaction [[VDR protein binds to MED1 protein] which binds to CYP24A1 promoter]15919092
D002117CalcitriolCalcitriol affects the localization of MED1 protein15647825
D002117CalcitriolCalcitriol promotes the reaction [MED1 protein binds to CYP24A1 promoter]15647825
D002117CalcitriolCalcitriol promotes the reaction [MED1 protein binds to SPP1 promoter]15647825
D002117CalcitriolCalcitriol results in increased expression of MED1 mRNA16324150
D002117CalcitriolMED1 protein promotes the reaction [Calcitriol results in increased activity of VDR protein]16324150
C118756dihydroxy-vitamin D3dihydroxy-vitamin D3 promotes the reaction [[VDR protein binds to RXRA protein] which binds to MED1 protein modified form]20947021
D004237DiuronDiuron results in decreased expression of MED1 mRNA25152437
C547512eldecalcitoleldecalcitol promotes the reaction [[VDR protein binds to RXRA protein] which binds to MED1 protein modified form]20947021
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MED1 protein23301498
C422415farglitazarfarglitazar binds to and results in increased activity of MED1 protein22070604
C039281furanfuran results in increased methylation of MED1 gene22079235
D017313FenretinideFenretinide results in increased expression of MED1 mRNA28973697
C541917INT 131INT 131 binds to MED1 protein28611668
C541917INT 131INT 131 binds to MED1 protein modified form19452630
C541917INT 131[INT 131 binds to MED1 protein modified form] which binds to PPARG protein19452630
C541917INT 131INT 131 inhibits the reaction [[rosiglitazone binds to MED1 protein modified form] which binds to PPARG protein]19452630
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MED1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to MED1 protein]26735014
D007854LeadLead affects the expression of MED1 mRNA28903495
C045463leflunomideleflunomide results in increased expression of MED1 mRNA28988120
D008731MethoxychlorMethoxychlor results in increased expression of MED1 mRNA20829426
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form]28751236
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate promotes the reaction [PPARA protein binds to MED1 protein]20123618
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MED1 mRNA26924002
C028007nickel monoxidenickel monoxide results in decreased expression of MED1 mRNA19167457
D019319Okadaic Acid"[1,25-dihydroxyvitamin D co-treated with Okadaic Acid] promotes the reaction [VDR protein mutant form binds to MED1 protein]"16059639
D017239PaclitaxelPaclitaxel promotes the reaction [NR1I2 protein binds to MED1 protein]15650019
D010424PentobarbitalMED1 protein affects the localization of [Pentobarbital binds to NR1I3 protein]16828057
D010634PhenobarbitalMED1 gene mutant form results in increased susceptibility to Phenobarbital16109766
D010634PhenobarbitalMED1 protein promotes the reaction [Phenobarbital results in increased expression of CYP1A2 mRNA]16109766
D010634PhenobarbitalMED1 protein promotes the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]16109766
D010634PhenobarbitalMED1 protein promotes the reaction [Phenobarbital results in increased expression of CYP3A11 mRNA]16109766
D010634PhenobarbitalMED1 protein promotes the reaction [Phenobarbital results in increased localization of and results in increased activity of NR1I3 protein]16109766
D010634PhenobarbitalPhenobarbital results in increased localization of MED1 protein16109766
C031637phenothiazinephenothiazine inhibits the reaction [BRD4 protein binds to MED1 protein]26735014
C032279phthalic acidphthalic acid promotes the reaction [NR1I2 protein binds to MED1 protein]15650019
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MED1 mRNA19710929
C006253pirinixic acidpirinixic acid promotes the reaction [PPARA protein binds to MED1 protein]20123618
C006253pirinixic acidMED1 protein promotes the reaction [pirinixic acid affects the localization of NR1I3 protein]17962186
C006253pirinixic acidMED1 protein results in increased susceptibility to pirinixic acid20007298
C006253pirinixic acidpirinixic acid promotes the reaction [PPARA protein binds to MED1 protein]20123618
C006253pirinixic acid"pirinixic acid inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to MED1 protein]]"17962186
C006253pirinixic acidpirinixic acid inhibits the reaction [NR1I3 protein binds to MED1 protein]17962186
C019536potassium bromatepotassium bromate results in decreased phosphorylation of MED1 protein25068892
D012293RifampinRifampin promotes the reaction [MED1 protein binds to and results in increased activity of NR1I2 protein]22214767
D012293RifampinRifampin promotes the reaction [MED1 protein binds to HNF4A protein]21292004
D012293RifampinRifampin results in decreased expression of MED1 mRNA24552687
C089730rosiglitazoneINT 131 inhibits the reaction [[rosiglitazone binds to MED1 protein modified form] which binds to PPARG protein]19452630
C089730rosiglitazonerosiglitazone binds to MED1 protein28611668
C089730rosiglitazonerosiglitazone binds to MED1 protein modified form19452630
C089730rosiglitazone[rosiglitazone binds to MED1 protein modified form] which binds to PPARG protein19452630
C089730rosiglitazonerosiglitazone binds to and results in increased activity of MED1 protein22070604
C480767SB219994SB219994 binds to and results in increased activity of MED1 protein22070604
D012822Silicon DioxideSilicon Dioxide results in increased expression of MED1 mRNA23221170
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of MED1 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MED1 mRNA20702594|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MED1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MED1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of MED1 mRNA23557971
D014212TretinoinTretinoin promotes the reaction [MED1 protein binds to HAS2 promoter]17307735
D014212TretinoinMED1 protein affects the reaction [Tretinoin results in increased expression of RARB mRNA alternative form]16723356
D014212TretinoinMED1 protein affects the susceptibility to Tretinoin16723356
D014212TretinoinTretinoin results in increased expression of MED1 mRNA16324150
D014241TrichloroethyleneTrichloroethylene results in decreased expression of MED1 mRNA28013219
D014415TunicamycinTunicamycin results in decreased expression of MED1 mRNA17127020
D014638VanadatesVanadates results in decreased expression of MED1 mRNA22714537
C025643vinclozolinvinclozolin affects the expression of MED1 mRNA19015723
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of MED1 mRNA18579281
D014810Vitamin EVitamin E results in decreased expression of MED1 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of MED1 mRNA27188386
D015049ZoxazolamineMED1 gene mutant form results in increased susceptibility to Zoxazolamine16109766

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding-IDA17641689  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISS-  
GO:0001047core promoter binding-IDA24245781  
GO:0003682chromatin binding-IMP17641689  
GO:0003712transcription coregulator activity-IDA10198638  12218053  
GO:0003713transcription coactivator activity-IDA9653119  12037571  16314496  19497978  
GO:0003713transcription coactivator activity-IMP17223341  24245781  
GO:0005515protein binding-IPI9653119  15848166  17132730  17254542  17641689  18391015  
19786558  21478865  24245781  24882805  25303530  
GO:0008134transcription factor binding-IPI17641689  19497978  
GO:0016922ligand-dependent nuclear receptor binding-IDA18391015  
GO:0016922ligand-dependent nuclear receptor binding-IPI9653119  
GO:0030331estrogen receptor binding-IPI9653119  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IMP17641689  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-NAS10235266  
GO:0030375thyroid hormone receptor coactivator activity-IBA21873635  
GO:0030375thyroid hormone receptor coactivator activity-IMP18391015  
GO:0031490chromatin DNA binding-IEA-  
GO:0035257nuclear hormone receptor binding-IPI10478845  
GO:0036033mediator complex binding-IDA18391015  
GO:0038023signaling receptor activity-IDA12218053  
GO:0042809vitamin D receptor binding-IBA21873635  
GO:0042809vitamin D receptor binding-IPI9653119  
GO:0042809vitamin D receptor binding-NAS10235266  
GO:0042809vitamin D receptor binding-TAS17223341  
GO:0042974retinoic acid receptor binding-IBA21873635  
GO:0042974retinoic acid receptor binding-IPI9653119  
GO:0042975peroxisome proliferator activated receptor binding-IPI9653119  
GO:0046966thyroid hormone receptor binding-IBA21873635  
GO:0046966thyroid hormone receptor binding-IDA10198638  
GO:0046966thyroid hormone receptor binding-IPI9653119  
GO:0050693LBD domain binding-IPI17827210  
GO:0061630ubiquitin protein ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0000902cell morphogenesis-IMP17223341  
GO:0001525angiogenesis-ISS-  
GO:0001889liver development-IEA-  
GO:0001892embryonic placenta development-IEA-  
GO:0002088lens development in camera-type eye-ISS-  
GO:0002154thyroid hormone mediated signaling pathway-IMP16314496  
GO:0003222ventricular trabecula myocardium morphogenesis-IEA-  
GO:0003406retinal pigment epithelium development-IEA-  
GO:0006356regulation of transcription by RNA polymerase I-IDA16314496  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006367transcription initiation from RNA polymerase II promoter-IDA12218053  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006590thyroid hormone generation-IEA-  
GO:0006702androgen biosynthetic process-IMP19497978  
GO:0007420brain development-IEA-  
GO:0007595lactation-IEA-  
GO:0010628positive regulation of gene expression-IDA17827210  
GO:0010628positive regulation of gene expression-IMP17223341  
GO:0010839negative regulation of keratinocyte proliferation-IMP17223341  
GO:0016567protein ubiquitination-IEA-  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0030216keratinocyte differentiation-IMP17223341  
GO:0030224monocyte differentiation-IEA-  
GO:0030518intracellular steroid hormone receptor signaling pathway-IDA11867769  
GO:0030521androgen receptor signaling pathway-IDA12218053  
GO:0031100animal organ regeneration-IEA-  
GO:0033148positive regulation of intracellular estrogen receptor signaling pathway-IEA-  
GO:0033160positive regulation of protein import into nucleus, translocation-IEA-  
GO:0033601positive regulation of mammary gland epithelial cell proliferation-IEA-  
GO:0035050embryonic heart tube development-IEA-  
GO:0035116embryonic hindlimb morphogenesis-IEA-  
GO:0035162embryonic hemopoiesis-IEA-  
GO:0035357peroxisome proliferator activated receptor signaling pathway-IEA-  
GO:0035729cellular response to hepatocyte growth factor stimulus-IEA-  
GO:0035855megakaryocyte development-ISS-  
GO:0042789mRNA transcription by RNA polymerase II-ISS-  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0045444fat cell differentiation-IDA12037571  
GO:0045618positive regulation of keratinocyte differentiation-IMP17082781  
GO:0045648positive regulation of erythrocyte differentiation-IMP24245781  
GO:0045665negative regulation of neuron differentiation-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA10198638  16314496  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9653119  12037571  17827210  19497978  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP17082781  17641689  
GO:0048821erythrocyte development-ISS-  
GO:0048822enucleate erythrocyte development-IEA-  
GO:0051726regulation of cell cycle-NAS16314496  
GO:0060335positive regulation of interferon-gamma-mediated signaling pathway-IEA-  
GO:0060744mammary gland branching involved in thelarche-IEA-  
GO:0060745mammary gland branching involved in pregnancy-IEA-  
GO:0060750epithelial cell proliferation involved in mammary gland duct elongation-IEA-  
GO:0070318positive regulation of G0 to G1 transition-IEA-  
GO:0070371ERK1 and ERK2 cascade-IDA18391015  
GO:0070562regulation of vitamin D receptor signaling pathway-IEA-  
GO:0071364cellular response to epidermal growth factor stimulus-IDA16314496  
GO:0071383cellular response to steroid hormone stimulus-IDA18391015  
GO:0097067cellular response to thyroid hormone stimulus-IBA21873635  
GO:0097067cellular response to thyroid hormone stimulus-IDA18391015  
GO:2000273positive regulation of signaling receptor activity-IMP18391015  
GO:2000347positive regulation of hepatocyte proliferation-IEA-  
GO:2001141regulation of RNA biosynthetic process-IMP17223341  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-IEA-  
GO:0000785chromatin-IEA-  
GO:0005634nucleus-IDA10235267  16314496  17223341  17827210  19497978  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA16314496  
GO:0016020membrane-HDA19946888  
GO:0016592mediator complex-IBA21873635  
GO:0016592mediator complex-IDA10198638  12037571  14638676  
GO:0016592mediator complex-IMP17641689  
GO:0032993protein-DNA complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1368082RORA activates gene expressionTAS
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-1989781PPARA activates gene expressionIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)IEA
R-HSA-400253Circadian ClockTAS
R-HSA-400253Circadian ClockIEA
R-HSA-556833Metabolism of lipidsTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal