Gene: KIF1A

547
ATSV|C2orf20|HSN2C|MRD9|SPG30|UNC104
kinesin family member 1A
protein-coding
2q37.3
Ensembl:ENSG00000130294 MIM:601255 Vega:OTTHUMG00000151940 UniprotKB:Q12756
NG_029724.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.904e-1 (AD)  6.563e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF1B0.898
EEF20.887
CDC42BPB0.883
MLLT60.88
SUPT5H0.88
PINK10.877
ILF30.875
PRRC2A0.874
ATN10.869
TNK20.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.856
OR4F5-0.848
ODAM-0.26
AGTR1-0.235
IRX5-0.233
FOXB1-0.219
SIM1-0.216
HMX2-0.215
OTP-0.212
LHX5-0.211

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03909Adenosine-5'-[Beta, Gamma-Methylene]TriphosphateSmall MoleculeExperimentalTarget
DB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KIF1A mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
D000244Adenosine DiphosphateKIF1A protein binds to Adenosine Diphosphate analog15286375
D000266Adenylyl ImidodiphosphateKIF1A protein binds to Adenylyl Imidodiphosphate15286375
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of KIF1A gene27153756
D001280AtrazineAtrazine results in decreased expression of KIF1A mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to KIF1A promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KIF1A mRNA22610609
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of KIF1A mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of KIF1A mRNA]25566086
D004958EstradiolEstradiol results in decreased expression of KIF1A mRNA20068009
C044887beta-methylcholinebeta-methylcholine affects the expression of KIF1A mRNA21179406
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of KIF1A mRNA"20162321
C006780bisphenol Abisphenol A results in increased expression of KIF1A mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of KIF1A mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of KIF1A mRNA29097150
C018475butyraldehydebutyraldehyde results in increased expression of KIF1A mRNA25014914|2607969
C584509C646 compoundC646 compound results in increased expression of KIF1A mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of KIF1A mRNA17484886
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of KIF1A mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KIF1A mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KIF1A gene20938992
D002994ClofibrateClofibrate results in increased expression of KIF1A mRNA17585979
D003609DactinomycinDactinomycin results in increased expression of KIF1A mRNA21527772
D003630DaunorubicinKIF1A affects the susceptibility to Daunorubicin17545624
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of KIF1A mRNA23914054
D013759DronabinolDronabinol results in decreased expression of KIF1A mRNA12237329
D003907DexamethasoneDexamethasone results in decreased expression of KIF1A mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of KIF1A mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of KIF1A mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of KIF1A mRNA21266533
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of KIF1A mRNA21527772
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of KIF1A mRNA"21527772
C118739entinostatentinostat results in increased expression of KIF1A mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
D000431EthanolEthanol results in decreased expression of KIF1A mRNA29018328
D005047EtoposideEtoposide results in increased expression of KIF1A mRNA21527772
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KIF1A mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KIF1A gene20938992
D004397FonofosFonofos results in increased methylation of KIF1A promoter22847954
D005839GentamicinsGentamicins results in decreased expression of KIF1A mRNA22061828
D005947GlucoseGlucose results in increased expression of KIF1A protein23776493
C492448ICG 001ICG 001 results in increased expression of KIF1A mRNA26191083
C544151jinfukangjinfukang results in increased expression of KIF1A mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KIF1A mRNA24796395
C008261lead acetatelead acetate affects the expression of KIF1A mRNA21147602
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KIF1A mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KIF1A gene20938992
C030667methylazoxymethanolmethylazoxymethanol results in increased expression of KIF1A mRNA17107856
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KIF1A mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KIF1A mRNA21527772
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of KIF1A mRNA"26251327
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF1A mRNA"15329391
D009151Mustard GasMustard Gas results in decreased expression of KIF1A mRNA15674843
D010278ParathionParathion results in increased methylation of KIF1A promoter22847954
C046012pentanalpentanal results in increased expression of KIF1A mRNA25014914|2607969
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of KIF1A mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of KIF1A mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF1A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of KIF1A mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of KIF1A mRNA21061450
D011192Potassium DichromatePotassium Dichromate results in decreased expression of KIF1A protein23718831
D011192Potassium DichromatePotassium Dichromate results in increased expression of KIF1A mRNA23608068
C005556propionaldehydepropionaldehyde results in increased expression of KIF1A mRNA25014914|2607969
D012402RotenoneRotenone results in increased expression of KIF1A mRNA19013527
D053260SootSoot results in increased expression of KIF1A mRNA26551751
C012568terbufosterbufos results in increased methylation of KIF1A promoter22847954
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of KIF1A mRNA]20032058
D013849ThimerosalThimerosal results in decreased expression of KIF1A mRNA27188386
D014118Toxins, Biological"Toxins, Biological affects the expression of KIF1A mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of KIF1A mRNA21934132
C057693troglitazonetroglitazone results in increased expression of KIF1A mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of KIF1A mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of KIF1A mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of KIF1A gene29154799
D014635Valproic AcidValproic Acid affects the expression of KIF1A mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KIF1A gene25560391
C025643vinclozolinvinclozolin results in increased expression of KIF1A mRNA22570695
C111237vorinostatvorinostat results in decreased expression of KIF1A mRNA27188386
D015034Zinc OxideZinc Oxide analog results in decreased expression of KIF1A mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of KIF1A mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003774motor activity-TAS7539720  
GO:0003777microtubule motor activity-IBA21873635  
GO:0005524ATP binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-IEA-  
GO:0008574ATP-dependent microtubule motor activity, plus-end-directed-IBA21873635  
GO:0016887ATPase activity-IBA21873635  
GO:0042802identical protein binding-IPI15014437  22863567  
GO:0042803protein homodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007018microtubule-based movement-IBA21873635  
GO:0008089anterograde axonal transport-TAS7539720  
GO:0016192vesicle-mediated transport-IBA21873635  
GO:0022027interkinetic nuclear migration-IEA-  
GO:0030705cytoskeleton-dependent intracellular transport-IBA21873635  
GO:0098840protein transport along microtubule-IEA-  
GO:1990048anterograde neuronal dense core vesicle transport-ISS-  
GO:1990049retrograde neuronal dense core vesicle transport-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IEA-  
GO:0005871kinesin complex-IBA21873635  
GO:0005874microtubule-IBA21873635  
GO:0005874microtubule-IEA-  
GO:0008021synaptic vesicle-IEA-  
GO:0030424axon-IBA21873635  
GO:0030425dendrite-IBA21873635  
GO:0030425dendrite-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043025neuronal cell body-IEA-  
GO:0098794postsynapse-IEA-  
GO:1904115axon cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6811434COPI-dependent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-983189KinesinsTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20592015Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR. (2010 Jul 1)Ostrow KLClin Cancer Res
28814981CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel. (2017)Morandi LClin Epigenetics