Gene: PPEF2

5470
PPP7CB
protein phosphatase with EF-hand domain 2
protein-coding
4q21.1
Ensembl:ENSG00000156194 MIM:602256 Vega:OTTHUMG00000160915 UniprotKB:O14830
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.326e-1 (AD)  8.568e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPC1L10.766
TLR90.731
ADCY100.707
KLK140.666
CYP2C190.663
NANOS20.663
ESPNL0.662
CNTD20.652
FGFR40.644
CXorf670.639

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDE11A-0.348
SNX22-0.344
RMDN1-0.336
LRRCC1-0.331
ELAC1-0.329
HSD17B8-0.325
METTL8-0.317
CTSO-0.312
CCT6B-0.306
EPM2A-0.303

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PPEF2 promoter22457795
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of PPEF2 mRNA"27840820
C008261lead acetatelead acetate results in decreased expression of PPEF2 mRNA22641619
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PPEF2 mRNA12057914
C028007nickel monoxidenickel monoxide results in decreased expression of PPEF2 mRNA19167457
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PPEF2 mRNA19710929
C034028vanadyl sulfatevanadyl sulfate results in increased expression of PPEF2 mRNA16330358
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PPEF2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004722protein serine/threonine phosphatase activity-IBA21873635  
GO:0004722protein serine/threonine phosphatase activity-TAS9326663  
GO:0005506iron ion binding-IEA-  
GO:0005509calcium ion binding-IEA-  
GO:0030145manganese ion binding-IEA-  
GO:0030544Hsp70 protein binding-IDA20674765  
GO:0031435mitogen-activated protein kinase kinase kinase binding-IPI20674765  
GO:0051879Hsp90 protein binding-IBA21873635  
GO:0051879Hsp90 protein binding-IDA20674765  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-TAS9326663  
GO:0007601visual perception-IEA-  
GO:0010801negative regulation of peptidyl-threonine phosphorylation-IDA20674765  
GO:0043405regulation of MAP kinase activity-IC20674765  
GO:0043409negative regulation of MAPK cascade-IBA21873635  
GO:0043409negative regulation of MAPK cascade-IDA20674765  
GO:0043506regulation of JUN kinase activity-IC20674765  
GO:0050906detection of stimulus involved in sensory perception-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-IEA-  
GO:0001917photoreceptor inner segment-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0005829cytosol-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24964093Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. (2014)Breton CVPLoS One