Gene: CNGB3

54714
ACHM1
cyclic nucleotide gated channel beta 3
protein-coding
8q21.3
Ensembl:ENSG00000170289 MIM:605080 Vega:OTTHUMG00000163738 UniprotKB:Q9NQW8
NG_016980.1
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.846e-1 (AD)  5.665e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2362267chr8:86614235 (GRCh38.p7)G>A / G>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs1992405chr8:86592903 (GRCh38.p7)T>C / T>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POU6F20.736
PKD2L10.698
CADPS20.694
INSM20.684
OTOL10.679
FOXP20.677
LSM110.675
ZNF385B0.674
TSHZ20.669
MKX0.668

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MDFI-0.484
LYPD1-0.467
AQP5-0.444
NTN1-0.432
PDLIM3-0.431
RHOD-0.424
BCL7C-0.419
PINLYP-0.415
FGF11-0.413
TMEM102-0.413

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of CNGB3 mRNA"23829299
C496492abrineabrine results in decreased expression of CNGB3 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of CNGB3 mRNA26690555
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CNGB3 mRNA22316170
C006780bisphenol Abisphenol A results in increased expression of CNGB3 mRNA25594700
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CNGB3 mRNA26846883
C008261lead acetatelead acetate results in decreased expression of CNGB3 mRNA22641619
D009151Mustard GasMustard Gas results in increased expression of CNGB3 mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CNGB3 mRNA"25554681
D012834SilverSilver results in decreased expression of CNGB3 mRNA26551752
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CNGB3 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CNGB3 mRNA28111298
D015032ZincZinc deficiency results in decreased expression of CNGB3 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005222intracellular cAMP activated cation channel activity-IBA21873635  
GO:0005223intracellular cGMP activated cation channel activity-IBA21873635  
GO:0005223intracellular cGMP activated cation channel activity-IDA24164424  
GO:0030553cGMP binding-IBA21873635  
GO:0030553cGMP binding-IDA24164424  
GO ID GO Term Qualifier Evidence PubMed
GO:0006812cation transport-IDA24164424  
GO:0007165signal transduction-NAS10888875  
GO:0007601visual perception-IEA-  
GO:0071805potassium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-IEA-  
GO:1902495transmembrane transporter complex-IDA24164424  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal