Gene: FEV

54738
HSRNAFEV|PET-1
FEV, ETS transcription factor
protein-coding
2q35
Ensembl:ENSG00000163497 MIM:607150 Vega:OTTHUMG00000133080 UniprotKB:Q99581
NG_023323.1
PubMed
ND|AD
314   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.440e-1 (AD)  1.497e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OPN40.521
DNAI10.52
HRH30.509
PCP40.508
SPEF10.501
LRRC560.501
GRM40.5
WNT10A0.493
TMEM120B0.491
BCL11B0.489

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDKN2B-0.376
WWTR1-0.355
TNFRSF11B-0.352
CD44-0.343
KIAA0040-0.34
APOL4-0.335
LYN-0.332
ELK3-0.33
BCL2A1-0.329
CR1-0.329

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FEV mRNA"19114083
D020106AcrylamideAcrylamide results in decreased expression of FEV mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FEV gene27153756
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in decreased expression of FEV mRNA17785943
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of FEV mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FEV mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to FEV promoter]19654925
C006780bisphenol Abisphenol A affects the methylation of FEV promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of FEV mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FEV mRNA24982889
D003042CocaineCocaine results in decreased expression of FEV mRNA17898221
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of FEV mRNA"20188158
C568376MT19c compoundMT19c compound results in decreased expression of FEV mRNA21781307
D012524SarinSarin results in decreased expression of FEV mRNA19522546
D012524SarinSarin results in increased expression of FEV mRNA19522546
D012834SilverSilver affects the expression of FEV mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of FEV gene28589171
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of FEV mRNA16214533
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FEV mRNA24058054|2468072
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FEV gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003700DNA-binding transcription factor activity-TAS9121764  
GO:0003714transcription corepressor activity-TAS9121764  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-TAS9121764  
GO:0010628positive regulation of gene expression-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0042551neuron maturation-IEA-  
GO:0048665neuron fate specification-IEA-  
GO:1903507negative regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19787468[How exactly can we predict the prognosis of COPD]. (2009)Atis STuberk Toraks
18565956Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. (2008 Sep 1)Patel BDAm J Respir Crit Care Med
14521798[Retrospective studies on 713 cases chronic obstructive pulmonary disease]. (2003 Aug)Li ZPZhonghua Liu Xing Bing Xue Za Zhi
20581172A novel insight into adaptive immunity in chronic obstructive pulmonary disease: B cell activating factor belonging to the tumor necrosis factor family. (2010 Oct 15)Polverino FAm J Respir Crit Care Med
19741063Altered surfactant protein-A expression in type II pneumocytes in COPD. (2010 Jan)Vlachaki EMChest
11500348Bronchodilator responsiveness in normal infants and young children. (2001 Aug 1)Goldstein ABAm J Respir Crit Care Med
10588612Eotaxin and impaired lung function in asthma. (1999 Dec)Nakamura HAm J Respir Crit Care Med
20832926[Geographical variations in the prevalence of COPD in Spain: relationship to smoking, death rates and other determining factors]. (2010 Oct)Soriano JBArch Bronconeumol
21897003Analysis of sputum markers in the evaluation of lung inflammation and functional impairment in symptomatic smokers and COPD patients. (2011)Paone GDis Markers
11713419Linkage analysis of alpha 1-antitrypsin deficiency: lessons for complex diseases. (2001)Silverman EKHum Hered
23238697Combined effect of lung function level and decline increases morbidity and mortality risks. (2012 Dec)Baughman PEur J Epidemiol
20646637[Interleukin-17 expression and significance in normal lung function smokers and chronic obstructive pulmonary disease patients]. (2010 May 25)Zhang JQZhonghua Yi Xue Za Zhi
17825547Bronchial airflow limitation, smoking, body mass index, and statin use are strongly associated with the C-reactive protein level in the elderly. The Tromso Study 2001. (2007 Dec)Melbye HRespir Med
19210659Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD. (2009 Mar)Kim WJRespirology
19414677Connective tissue-activating peptide III: a novel blood biomarker for early lung cancer detection. (2009 Jun 10)Yee JJ Clin Oncol
19811383Hypertension, systemic inflammation and body weight in relation to lung function impairment-an epidemiological study. (2009 Aug)Margretardottir OBCOPD
17673016[The effects of recombinant human tumor necrosis factor-Fc on pulmonary function in a rat model of chronic obstructive pulmonary disease]. (2007 Jun)Zhang CZhonghua Jie He He Hu Xi Za Zhi
11153034The shape of the maximum expiratory flow-volume curve reflects exposure in farming. (2000)Omland OAnn Agric Environ Med
11112130Gender-related differences in severe, early-onset chronic obstructive pulmonary disease. (2000 Dec)Silverman EKAm J Respir Crit Care Med
22958175Association of dopamine-related gene alleles, smoking behavior and decline in FEV1 in subjects with COPD: findings from the lung health study. (2012 Dec)Tashkin DPCOPD
25035127Sputum-to-serum hydrogen sulfide ratio in COPD. (2014 Oct)Saito JThorax
17072055Differences in responses upon corticosteroid therapy between smoking and non-smoking patients with COPD. (2006 Sep)Van Overveld FJJ Physiol Pharmacol
23289993[The role of 4-hydroxynonenal in assessment of chronic obstructive pulmonary disease severity]. (2012 Oct)Liu HZhonghua Jie He He Hu Xi Za Zhi
23217400CCR1 and CCR5 expression on inflammatory cells is related to cigarette smoking and chronic obstructive pulmonary disease severity. (2012 Dec)Wang FChin Med J (Engl)
28838624[Systemic inflammatory profile of smokers with and without COPD]. (2017 Sep)Mosrane YRev Pneumol Clin
20448057Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease. (2011 Mar)Foreman MGAm J Respir Cell Mol Biol
19716960Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials. (2009 Aug 29)Calverley PMLancet
23290038[Expression of beta-catenin in human pulmonary tissues of smokers with and without chronic obstructive pulmonary disease]. (2012 Nov)Liu QXZhonghua Jie He He Hu Xi Za Zhi
22156439Serum 25-hydroxyvitamin D and pulmonary function in older disabled community-dwelling women. (2012 Jun)Semba RDJ Gerontol A Biol Sci Med Sci
17961312Urinary protein 1/Clara cell 16 concentrations and lung functions in male subjects with pneumoconiosis. (2007 Nov)Kotani KAnn Clin Biochem
7351457Chronic obstructive pulmonary disease: rehabilitation program with continuation on an outpatient basis. (1980 Feb)Alkalay IJ Am Geriatr Soc
16088434A review of alpha-1 antitrypsin deficiency. (2005 Apr)Ranes JSemin Respir Crit Care Med
22088612Interaction between filaggrin null mutations and tobacco smoking in relation to asthma. (2012 Feb)Berg NDJ Allergy Clin Immunol
21624643Thrombin generation in chronic obstructive pulmonary disease: dependence on plasma factor composition. (2011 Oct)Undas AThromb Res
15454649Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysis. (2004 Oct)Hersh CPThorax
26369547Old dilemma: asthma with irreversible airway obstruction or COPD. (2015 Nov)Fattahi FVirchows Arch
20538817Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. (2010 Nov)Doe CChest
24920894Prevalence of airflow limitation in outpatients with cardiovascular diseases in Japan. (2014)Onishi KInt J Chron Obstruct Pulmon Dis
19539457IL-18 in induced sputum and airway hyperresponsiveness in mild asthmatics: effect of smoking. (2009 Dec)Rovina NRespir Med
20546196Association between beta-adrenoceptor gene polymorphisms and relative response to beta 2-agonists and anticholinergic drugs in Japanese asthmatic patients. (2010 Jul)Asano KRespirology
17988548[Expressions of and the effect of smoking on vascular endothelial growth factor and induced nitric oxide synthase in lung tissues of chronic obstructive pulmonary disease patients]. (2007 Aug)Huo JMZhonghua Jie He He Hu Xi Za Zhi
20541383Global muscle dysfunction as a risk factor of readmission to hospital due to COPD exacerbations. (2010 Dec)Vilaro JRespir Med
21618155Concurrent training and pulmonary function in smokers. (2011 Oct)Shaw IInt J Sports Med
20006363Baseline forced expiratory volume in the first second as an independent predictor of development of the metabolic syndrome. (2010 Jun)Hsiao FCMetabolism
19755444Cross-sectional study on respiratory effect of toner-exposed work in manufacturing plants, Japan: pulmonary function, blood cells, and biochemical markers. (2009 Jun)Kitamura HHum Exp Toxicol
11802990[The relationship between eosinophils, activated T lymphocyte, leukotreine and the exercise-induced asthma]. (2001 Jun)Guo YZhonghua Jie He He Hu Xi Za Zhi
19878584PLAUR polymorphisms and lung function in UK smokers. (2009 Oct 31)Stewart CEBMC Med Genet
20659577Combined treatment with formoterol and tiotropium is more efficacious than treatment with tiotropium alone in patients with chronic obstructive pulmonary disease, regardless of smoking status, inhaled corticosteroid use, baseline severity, or gender. (2011 Feb)Tashkin DPPulm Pharmacol Ther
22387199Genetic variation in antioxidant enzymes and lung function. (2012 May 1)Bentley ARFree Radic Biol Med
20156745Time for new reference values for ventilatory lung function. (2009 Dec 7)Marek WEur J Med Res
18779194Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancer. (2008 Sep)Sin DDChest
16199147Predictors of lung function and its decline in mild to moderate COPD in association with gender: results from the Euroscop study. (2006 Apr)Watson LRespir Med
19856871[Prevalence and difficulties in chronic obstructive pulmonary disease diagnosis in patients suffering from severe peripheral arterial disease]. (2009 Aug)Sleszycka JPol Merkur Lekarski
18446601Lung function and cytokine levels in professional athletes. (2008 May)Rong CJ Asthma
23226539Airway hyperresponsiveness and quality of life in Western red cedar asthmatics removed from exposure. (2012)He JQPLoS One
19233139A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD. (2009 Apr 17)Takabatake NBiochem Biophys Res Commun
16617357[Change and clinical implication of urotensin II in plasma and induced sputum of chronic obstructive pulmonary disease]. (2006 Apr 18)Lu MBeijing Da Xue Xue Bao Yi Xue Ban
20531437Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function. (2010 Aug)Wood LGEur J Clin Nutr
18466678Inhibition of tumor necrosis factor-alpha reduces alveolar septal cell apoptosis in passive smoking rats. (2008 Apr 5)Zhang CChin Med J (Engl)
16907910Different inflammatory cell pattern and macrophage phenotype in chronic obstructive pulmonary disease patients, smokers and non-smokers. (2006 Sep)Lofdahl JMClin Exp Immunol
1523734Lung function and exposure to paper dust in bookbinders--a pilot study. (1992)Dahlqvist MUps J Med Sci
12853554Emphysema due to alpha-antitrypsin deficiency: familial study of the YBARCELONA variant. (2003 Jul)Miravitlles MChest
15117741Association of chronic obstructive pulmonary disease severity and Pneumocystis colonization. (2004 Aug 15)Morris AAm J Respir Crit Care Med
20337997Serum levels of matrix metalloproteinase-9, tissue inhibitors of metalloproteinase-1 and their ratio are associated with impaired lung function in the elderly: a population-based study. (2010 Apr)Olafsdottir ISRespirology
121868264-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. (2002 Aug 15)Rahman IAm J Respir Crit Care Med
3789518Lung function after acute chlorine exposure. (1986 Dec)Jones RNAm Rev Respir Dis
15130905Bronchiectasis, exacerbation indices, and inflammation in chronic obstructive pulmonary disease. (2004 Aug 15)Patel ISAm J Respir Crit Care Med
20079227[The changes and significance of interleukin-16 and CXC chemokine receptor 3 expression in pulmonary artery of smokers with chronic obstructive pulmonary disease]. (2009 Oct)Wan PZhonghua Nei Ke Za Zhi
10843974Prevalence of airways obstruction in a general population: European Respiratory Society vs American Thoracic Society definition. (2000 May)Viegi GChest
15705996The interactions between cigarette smoking and reduced lung function on systemic inflammation. (2005 Feb)Gan WQChest
15302720Characteristics of airway inflammation and bronchodilator reversibility in COPD: a potential guide to treatment. (2004 Aug)Perng DWChest
22982023Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD. (2012 Dec 5)Budulac SEEur J Pharmacol
20725845Relevance of lower airway bacterial colonization, airway inflammation, and pulmonary function in the stable stage of chronic obstructive pulmonary disease. (2010 Dec)Zhang MEur J Clin Microbiol Infect Dis
22795506Predictors of oxygen saturation Vold MLRespir Med
18544192Worldwide burden of COPD in high- and low-income countries. Part II. Burden of chronic obstructive lung disease in Latin America: the PLATINO study. (2008 Jul)Menezes AMInt J Tuberc Lung Dis
11742922Smoking and airway inflammation in patients with mild asthma. (2001 Dec)Chalmers GWChest
10835931[Respiratory function impairment in patients with Parkinson's disease--a consideration on the possible pathogenetic relation to autonomic dysfunction]. (2000 Feb)Yamada HRinsho Shinkeigaku
17255565Cured meat consumption, lung function, and chronic obstructive pulmonary disease among United States adults. (2007 Apr 15)Jiang RAm J Respir Crit Care Med
22034646Subclinical atherosclerosis, airflow obstruction and emphysema: the MESA Lung Study. (2012 Apr)Barr RGEur Respir J
21163806Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies. (2011 Oct)Castaldi PJThorax
20371646Prevalence and underdiagnosis of chronic obstructive pulmonary disease among patients at risk in primary care. (2010 Apr 20)Hill KCMAJ
16166617Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia. (2005 Dec 1)Yende SAm J Respir Crit Care Med
20966906Leptin is inversely associated with lung function in African Americans, independent of adiposity: the Jackson Heart Study. (2011 May)Hickson DAObesity (Silver Spring)
20981182Assessment of visual evoked potentials in stable COPD patients with no visual impairment. (2010 Oct)Gupta PPAnn Thorac Med
17697030Bronchial responsiveness in bakery workers: relation to airway symptoms, IgE sensitization, nasal indices of inflammation, flour dust exposure and smoking. (2007 Sep)Storaas TClin Physiol Funct Imaging
22537113Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population. (2012 Aug)Ro MScand J Immunol
3181770Effect of smoking on regional cerebral blood flow in the normal aged volunteers. (1988)Yamashita KGerontology
16740433Enzyme catalytic activities in chronic obstructive pulmonary disease. (2006 Jul)Cepelak IArch Med Res
23600594Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission. (2013 Aug)Wark PARespirology
16393673Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. (2006 Feb)de Boer WIAm J Clin Pathol
16615017[Success of smoking cessation in patients with chronic obstructive pulmonary disease]. (2006)Aytemur Solak ZTuberk Toraks
22355401Respiratory and immune response to maximal physical exertion following exposure to secondhand smoke in healthy adults. (2012)Flouris ADPLoS One
29516697[Effect of Different Concentrations of Moxa-smoke on Lung Function and TNF-alpha and IL-1 beta Levels in Serum and Lung Tissues in Normal Rats]. (2018 Feb 25)Duan WXZhen Ci Yan Jiu
28142050Relationship between pulmonary function and elevated glycated hemoglobin levels in health checkups: A cross-sectional observational study in Japanese participants. (2017 Nov)Baba SJ Epidemiol
16710697Irritative effects of fumes and aerosols of bitumen on the airways: results of a cross-shift study. (2007 Jan)Raulf-Heimsoth MArch Toxicol
15184197Glutathione S-transferase variants and their interaction with smoking on lung function. (2004 Aug 15)He JQAm J Respir Crit Care Med
21380479High mobility group protein B1 (HMGB1) in Asthma: comparison of patients with chronic obstructive pulmonary disease and healthy controls. (2011)Hou CMol Med
12149531Respiratory symptoms and lung function in young adults with severe alpha(1)-antitrypsin deficiency (PiZZ). (2002 Aug)Piitulainen EThorax
22678356Airway hyperresponsiveness is negatively associated with obesity or overweight status in patients with asthma. (2012)Kwon JWInt Arch Allergy Immunol
21332421Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls. (2011 Apr)Holguin FJ Asthma
16608935Airway blood flow reactivity in healthy smokers and in ex-smokers with or without COPD. (2006 Apr)Mendes ESChest
21216136Prevalence of COPD in Abu Dhabi, United Arab Emirates. (2011 Apr)Al Zaabi ARespir Med
6291385Accelerated loss of FEV- in polyurethane production workers: a four-year prospective study. (1982)Wegman DHAm J Ind Med
19696441Long-term outcomes in mild/moderate chronic obstructive pulmonary disease in the European community respiratory health survey. (2009 Nov 15)de Marco RAm J Respir Crit Care Med
19343615[Lung function in the elderly: do we need new reference values?]. (2009 Apr)Marek WPneumologie
19124959[C-reactive protein levels in patients with chronic obstructive pulmonary disease and asthma]. (2008)Urboniene DMedicina (Kaunas)
19042672Agricultural exposures in patients with COPD in health systems serving rural areas. (2007)Bailey KLJ Agromedicine
16304263Endogenous hydrogen sulfide in patients with COPD. (2005 Nov)Chen YHChest
18570007What role may symptoms play in the diagnosis of airflow limitation? A study in an elderly population. (2008)Medbo AScand J Prim Health Care
19010993High-sensitive C-reactive protein is associated with reduced lung function in young adults. (2009 Feb)Rasmussen FEur Respir J
19438587Increased levels of angiopoietin-2 in induced sputum from smoking asthmatic patients. (2009 Sep)Kanazawa HClin Exp Allergy
20583895Malondialdehyde and superoxide dismutase correlate with FEV(1) in patients with COPD associated with wood smoke exposure and tobacco smoking. (2010 Aug)Montano MInhal Toxicol
19388965Altered respiratory function is associated with increased metabolic risk, independently of adiposity, fitness and physical activity. (2009 Apr)Steele RMDiabet Med
17959643Increased activation of p38 MAPK in COPD. (2008 Jan)Renda TEur Respir J
16207395[Characteristics of non-symptomatic chronic obstructive pulmonary disease patients]. (2005 Aug)Yao WZZhonghua Jie He He Hu Xi Za Zhi
19111454Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. (2009 Apr)Kim WJRespir Med
17064412Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease. (2006 Oct 25)Peltoniemi MJRespir Res
21942975Biomarkers of therapeutic response in patients with chronic obstructive pulmonary disease: a critical review of the literature. (2011 Oct 1)Yoon HIDrugs
19130933Cardiovascular disease risk associated with asthma and respiratory morbidity might be mediated by short-acting beta2-agonists. (2009 Jan)Appleton SLJ Allergy Clin Immunol
17428813Beta2-Adrenoceptor polymorphisms and asthma phenotypes: interactions with passive smoking. (2007 Jul)Zhang GEur Respir J
23291023[The expression of macrophage migration inhibition factor in pulmonary tissues of smokers with or without chronic obstructive pulmonary disease]. (2012 Nov)She WBZhonghua Nei Ke Za Zhi
19249197Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease. (2009 Aug)Higashimoto YRespir Med
10976856Lung function, respiratory symptoms, and mortality: results from the Busselton Health Study. (1999 Jul)Knuiman MWAnn Epidemiol
12403691Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum. (2002 Nov 1)Vernooy JHAm J Respir Crit Care Med
16554379Plasma fibrinogen and lung function: the CARDIA Study. (2006 Aug)Thyagarajan BInt J Epidemiol
23688726Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function. (2013 Oct)Tang WFree Radic Biol Med
19726494Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency. (2009 Oct 15)Castaldi PJAm J Epidemiol
18261894Changes in obesity status and lung function decline in a general population sample. (2008 May)Pistelli FRespir Med
20831471Putative association of SMAPIL polymorphisms with risk of aspirin intolerance in asthmatics. (2010 Nov)Kim JYJ Asthma
17885263Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease. (2007 Dec 15)McAllister DAAm J Respir Crit Care Med
10607796Ongoing airway inflammation in patients with COPD who do not currently smoke. (2000 Jan)Rutgers SRThorax
19010990Do childhood respiratory infections continue to influence adult respiratory morbidity? (2009 Feb)Dharmage SCEur Respir J
14651761Exacerbations of chronic obstructive pulmonary disease. (2003 Dec)Wedzicha JARespir Care
18556001Interleukin-6 and incident coronary heart disease: results from the British Women's Heart and Health Study. (2009 Feb)Fraser AAtherosclerosis
8359293Chronic obstructive pulmonary disease and abdominal aortic aneurysms. (1993 Jul)van Laarhoven CJEur J Vasc Surg
20597081Baseline characteristics and factors associated with nutritional and pulmonary status at enrollment in the cystic fibrosis EPIC observational cohort. (2010 Sep)Rosenfeld MPediatr Pulmonol
19929430Gender-related tumor necrosis factor-alpha responses in naive volunteers with Toll-like receptor 4 polymorphisms exposed in a swine confinement facility. (2009 Dec)Senthilselvan AJ Interferon Cytokine Res
20693256Surfactant protein B polymorphisms, pulmonary function and COPD in 10,231 individuals. (2011 Apr)Baekvad-Hansen MEur Respir J
22609858Health hazards among workers in plastic industry. (2013 Oct)Helal SFToxicol Ind Health
17389752Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiency. (2007 Sep)Demeo DLThorax
22438921Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD. (2012)Budulac SEPLoS One
11587987Elevated plasma fibrinogen associated with reduced pulmonary function and increased risk of chronic obstructive pulmonary disease. (2001 Sep 15)Dahl MAm J Respir Crit Care Med
18788439[Overlap syndrome involving obstructive sleep apnea syndrome associated with chronic obstructive pulmonary disease]. (2008 Aug)Matsuura YNihon Kokyuki Gakkai Zasshi
17204725Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. (2007 Apr 15)Lazarus SCAm J Respir Crit Care Med
25791068Primary care providers' views on using lung age as an aid to smoking cessation counseling for patients with chronic obstructive pulmonary disease. (2015 Jun)Parker DRLung
22521224Downregulation of lung mitochondrial prohibitin in COPD. (2012 Jul)Soulitzis NRespir Med
19251780Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2. (2009 Aug)Bridevaux POEur Respir J
17158282Regular physical activity modifies smoking-related lung function decline and reduces risk of chronic obstructive pulmonary disease: a population-based cohort study. (2007 Mar 1)Garcia-Aymerich JAm J Respir Crit Care Med
19484668A MCh test pre-post esophageal acidification in detecting GER-related asthma. (2009 May)Dal Negro RWJ Asthma
22333024[Levels of HMGB1 in induced sputum from patients with asthma and chronic obstructive pulmonary disease]. (2011 Nov 15)Cheng ZZhonghua Yi Xue Za Zhi
24342032The impact of metabolic parameters on the change of pulmonary function in obese patients. (2014 Jan-Feb)Wei YFSurg Obes Relat Dis
20045536Association between low pulmonary function and metabolic risk factors in Korean adults: the Korean National Health and Nutrition Survey. (2010 Sep)Paek YJMetabolism
23044449The impact of total antioxidant capacity on pulmonary function in asthma patients. (2012 Nov)Yoon SYInt J Tuberc Lung Dis
18930648A technological advance comparing epithelial lining fluid from different regions of the lung in smokers. (2009 Jan)Kodama TRespir Med
19581277Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality risk. (2009 Oct)Guerra SThorax
17326992[The risk factors for chronic obstructive pulmonary disease in females in Chinese rural areas]. (2006 Dec)Ran PXZhonghua Nei Ke Za Zhi
22459775The relationship between pulmonary emphysema and kidney function in smokers. (2012 Sep)Chandra DChest
19341424Oral N-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in rats. (2009 Apr)Cai SRespirology
22524621Lack of association between GTF2H4 genetic variants and AERD development and FEV1 decline by aspirin provocation. (2012 Dec)Kim JYInt J Immunogenet
22652026Brain structure and function in chronic obstructive pulmonary disease: a multimodal cranial magnetic resonance imaging study. (2012 Aug 1)Dodd JWAm J Respir Crit Care Med
15286446Soluble interleukin-5 receptor alpha is increased in acute exacerbation of chronic obstructive pulmonary disease. (2004 Sep)Rohde GInt Arch Allergy Immunol
19741261Burden and pathogenesis of chronic obstructive pulmonary disease. (2009 Sep 15)Stockley RAProc Am Thorac Soc
20007924The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema. (2010 Mar 1)Lambrechts DAm J Respir Crit Care Med
19125996Study of the burden on patients with chronic obstructive pulmonary disease. (2009 Jan)Izquierdo JLInt J Clin Pract
10727989Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD. (2000 Apr)de Boer WIJ Pathol
14666352[Lung volume reduction surgery (LVRS): criteria for selecting patient in Antonio Pedro Hospital, Federal Fluminense University, Niter i city, Rio de Janeiro, Brazil]. (2003 Jul-Sep)Behrsin RFRev Assoc Med Bras (1992)
17460799Exposure, lung function decline and systemic inflammatory response in asphalt workers. (2007 Apr)Ulvestad BScand J Work Environ Health
11112116Short-term supplementation therapy does not affect elastin degradation in severe alpha(1)-antitrypsin deficiency. The American-Italian AATD Study Group. (2000 Dec)Gottlieb DJAm J Respir Crit Care Med
23424753[Smoke-free by ramadan: experience with a low-threshold prevention offer on smoking cessation for persons with migration background]. (2012 Jun 28)Gebhardt RMMW Fortschr Med
25571720[Regulation of Thl/Th2 cells by T cell-mediated transcription factor in rats with chronic obstructive pulmonary disease]. (2014 Nov)Wang CYSichuan Da Xue Xue Bao Yi Xue Ban
16502343Increased oxidative stress and altered levels of antioxidants in chronic obstructive pulmonary disease. (2005 Feb)Nadeem AInflammation
19225066Association of circulating adhesion molecules with lung function. The CARDIA study. (2009 Jun)Thyagarajan BChest
28732839Exacerbations and duration of smoking abstinence are associated with the annual loss of FEV1 in individuals with PiZZ alpha-1-antitrypsin deficiency. (2017 Aug)Fahndrich SRespir Med
23284291Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (2012)Hancock DBPLoS Genet
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