Gene: LEPROT

54741
LEPR|OB-RGRP|OBRGRP|VPS55
leptin receptor overlapping transcript
protein-coding
1p31.3
Ensembl:ENSG00000213625 MIM:613461 Vega:OTTHUMG00000009065 UniprotKB:O15243
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
3.412e-2 (AD)  9.852e-1 (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSDL20.887
CPNE30.887
FERMT20.88
PDLIM50.879
TSPAN60.875
CYBRD10.872
TIMP30.868
BDH20.867
SUCLG20.865
RAB340.861

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALHM1-0.51
ABCC12-0.495
HAS1-0.482
KCNB2-0.479
OPRD1-0.479
RTP1-0.479
CACNA1F-0.471
AGMAT-0.466
IL12RB2-0.465
GABRG3-0.464

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of LEPROT mRNA28329830
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LEPROT mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of LEPROT mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LEPROT mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LEPROT mRNA16483693
C015001arsenitearsenite results in increased methylation of LEPROT promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LEPROT mRNA19770486
C038328BEP protocolBEP protocol results in increased expression of LEPROT mRNA18987330
D004958EstradiolEstradiol affects the expression of LEPROT mRNA15598610
D001663BilirubinBilirubin results in decreased expression of LEPROT mRNA20196124
C006780bisphenol Abisphenol A results in decreased expression of LEPROT mRNA28159858
C006780bisphenol Abisphenol A results in increased expression of LEPROT mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of LEPROT mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the methylation of LEPROT promoter22457795
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LEPROT mRNA20360939
D019327Copper SulfateCopper Sulfate results in decreased expression of LEPROT mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of LEPROT mRNA25562108|2798913
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of LEPROT mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LEPROT mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of LEPROT mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LEPROT mRNA20360939
D002117CalcitriolCalcitriol results in increased expression of LEPROT mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of LEPROT mRNA21592394
D005419FlavonoidsFlavonoids results in increased expression of LEPROT mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of LEPROT mRNA28329830
D005557FormaldehydeFormaldehyde results in increased expression of LEPROT mRNA23649840
C492448ICG 001ICG 001 results in increased expression of LEPROT mRNA26191083
D010634PhenobarbitalPhenobarbital affects the expression of LEPROT mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LEPROT mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LEPROT mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of LEPROT mRNA17426115
D011441PropylthiouracilPropylthiouracil results in increased expression of LEPROT mRNA24780913
D012999SomanSoman results in increased expression of LEPROT mRNA19281266
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of LEPROT mRNA21592394
D013739TestosteroneTestosterone results in increased expression of LEPROT mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LEPROT mRNA21570461
D014635Valproic AcidValproic Acid results in increased expression of LEPROT mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LEPROT gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of LEPROT mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO:0005102signaling receptor binding-IDA18042720  
GO:0005515protein binding-IPI18042720  
GO ID GO Term Qualifier Evidence PubMed
GO:0032511late endosome to vacuole transport via multivesicular body sorting pathway-IBA21873635  
GO:0046426negative regulation of JAK-STAT cascade-IBA21873635  
GO:0046426negative regulation of JAK-STAT cascade-IDA18042720  
GO:0060400negative regulation of growth hormone receptor signaling pathway-IBA21873635  
GO:0060400negative regulation of growth hormone receptor signaling pathway-IDA19907080  
GO:1903955positive regulation of protein targeting to mitochondrion-HMP24270810  
GO:2000009negative regulation of protein localization to cell surface-IBA21873635  
GO:2000009negative regulation of protein localization to cell surface-IDA18042720  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005768endosome-IBA21873635  
GO:0005768endosome-IDA18042720  
GO:0005794Golgi apparatus-IDA18042720  
GO:0010008endosome membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23875062The methylation of the LEPR/LEPROT genotype at the promoter and body regions influence concentrations of leptin in girls and BMI at age 18 years if their mother smoked during pregnancy. (2013)Yousefi MInt J Mol Epidemiol Genet