Gene: FNDC8

54752
-
fibronectin type III domain containing 8
protein-coding
17q12
Ensembl:ENSG00000073598 Vega:OTTHUMG00000132932 UniprotKB:Q8TC99
NG_054719.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.491e-1 (AD)  9.908e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17629188chr17:35130009 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTBD180.478
SIGLEC60.452
NYAP20.426
OR3A10.424
FAM47A0.422
OR10K10.42
TAS2R430.419
COL6A60.417
GPR870.417
ANKS4B0.415

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NKX6-1-0.277
GLIPR1L2-0.274
HEY2-0.251
RARRES2-0.251
SNHG18-0.244
LRRIQ3-0.24
ANXA13-0.239
TCF15-0.235
COPZ2-0.231
C9orf43-0.23

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A results in decreased expression of FNDC8 mRNA25181051
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FNDC8 mRNA27392435
C069837fullerene C60fullerene C60 results in decreased expression of FNDC8 mRNA19167457
C039281furanfuran results in decreased expression of FNDC8 mRNA25539665
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FNDC8 mRNA27392435
C568376MT19c compoundMT19c compound results in decreased expression of FNDC8 mRNA21781307
C008588N-(1-naphthyl)ethylenediamineFNDC8 gene SNP affects the susceptibility to N-(1-naphthyl)ethylenediamine25622337
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FNDC8 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in increased expression of FNDC8 protein28918527
D014520UrethaneUrethane results in decreased expression of FNDC8 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal