Gene: GRAMD1C

54762
-
GRAM domain containing 1C
protein-coding
3q13.31
Ensembl:ENSG00000178075 Vega:OTTHUMG00000159340 UniprotKB:Q8IYS0
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.145e-1 (AD)  5.749e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2566980chr3:113841173 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TP53BP20.918
BMPR1B0.911
METTL7A0.907
GJA10.905
MSI20.893
ARHGEF260.893
RANBP3L0.89
GPAM0.889
STOX10.888
CYBRD10.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DUSP27-0.505
AGMAT-0.504
MCHR1-0.485
RTP1-0.48
HTR7-0.479
QRFPR-0.478
OSBPL10-0.466
CACNA1F-0.464
RHO-0.462
GABRG3-0.457

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of GRAMD1C mRNA"20453058
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GRAMD1C mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRAMD1C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRAMD1C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRAMD1C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRAMD1C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRAMD1C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRAMD1C mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GRAMD1C mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GRAMD1C mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GRAMD1C mRNA19770486
D000447AldehydesAldehydes results in increased expression of GRAMD1C mRNA25014914
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of GRAMD1C mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of GRAMD1C mRNA26377693
C006780bisphenol Abisphenol A results in decreased expression of GRAMD1C mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GRAMD1C gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of GRAMD1C mRNA26079696
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRAMD1C mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of GRAMD1C mRNA26272509
D016572CyclosporineCyclosporine results in decreased expression of GRAMD1C mRNA20106945|2798913
D002945CisplatinCisplatin results in increased expression of GRAMD1C mRNA27392435
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of GRAMD1C mRNA"27840820
D004237DiuronDiuron results in increased expression of GRAMD1C mRNA25152437
C118739entinostatentinostat results in increased expression of GRAMD1C mRNA27188386
D005485FlutamideFlutamide results in increased expression of GRAMD1C mRNA24793618
D017313FenretinideFenretinide results in increased expression of GRAMD1C mRNA28973697
D007052IbuprofenIbuprofen results in increased expression of GRAMD1C mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GRAMD1C mRNA26752646
C042720mercuric bromidemercuric bromide results in decreased expression of GRAMD1C mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRAMD1C mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GRAMD1C mRNA23179753|2718838
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GRAMD1C mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GRAMD1C mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GRAMD1C mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of GRAMD1C mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of GRAMD1C mRNA22714537
C046012pentanalpentanal results in increased expression of GRAMD1C mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GRAMD1C mRNA27153767
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRAMD1C mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GRAMD1C mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GRAMD1C mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of GRAMD1C mRNA23811191
D011374ProgesteroneProgesterone results in increased expression of GRAMD1C mRNA23012394
C005556propionaldehydepropionaldehyde results in increased expression of GRAMD1C mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of GRAMD1C mRNA24780913
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of GRAMD1C mRNA"21148743
C017947sodium arsenitesodium arsenite results in increased expression of GRAMD1C mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRAMD1C mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of GRAMD1C mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of GRAMD1C mRNA25975270
D013853ThioacetamideThioacetamide results in decreased expression of GRAMD1C mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GRAMD1C mRNA28065790
D014212TretinoinTretinoin results in increased expression of GRAMD1C mRNA21934132|2372400
C012589trichostatin Atrichostatin A affects the expression of GRAMD1C mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of GRAMD1C mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of GRAMD1C mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of GRAMD1C mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GRAMD1C mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased methylation of GRAMD1C gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GRAMD1C mRNA23179753|2493525
D014752Vinyl ChlorideVinyl Chloride results in increased expression of GRAMD1C mRNA18579281
C111237vorinostatvorinostat results in increased expression of GRAMD1C mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  25910212  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal