Gene: HYDIN

54768
CILD5|HYDIN1|HYDIN2|PPP1R31
HYDIN, axonemal central pair apparatus protein
protein-coding
16q22.2
Ensembl:ENSG00000157423 MIM:610812 Vega:OTTHUMG00000137584 UniprotKB:Q4G0P3
NG_033116.2
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.765e-1 (AD)  1.664e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2042423chr16:71201086 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF5870.833
MDN10.814
VPS13B0.813
TRRAP0.812
ZNF7930.81
RNPC30.808
MPHOSPH90.807
PHC10.806
EP4000.801
UBN20.8

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLRC2-0.355
KLRC3-0.324
PRRX2-0.323
PPP1R14B-0.315
CD8B-0.308
PGF-0.307
NANOGNB-0.303
CD3G-0.299
XCL2-0.296
S100A14-0.292

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of HYDIN mRNA"26377693
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HYDIN mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of HYDIN mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of HYDIN mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HYDIN gene27153756
C006780bisphenol Abisphenol A results in decreased expression of HYDIN mRNA25181051|2909715
C018475butyraldehydebutyraldehyde results in increased expression of HYDIN mRNA26079696
D004390ChlorpyrifosChlorpyrifos results in decreased expression of HYDIN protein16790487
D003471CuprizoneCuprizone results in increased expression of HYDIN mRNA26577399
C052570cyfluthrincyfluthrin results in decreased expression of HYDIN protein16790487
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of HYDIN mRNA27392435
D002945CisplatinCisplatin results in decreased expression of HYDIN mRNA27392435
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HYDIN mRNA17942748
D004397FonofosFonofos results in increased methylation of HYDIN promoter22847954
D017313FenretinideFenretinide results in increased expression of HYDIN mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of HYDIN mRNA26846883
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of HYDIN mRNA27392435
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HYDIN mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HYDIN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HYDIN mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of HYDIN mRNA19167457
D010278ParathionParathion results in increased methylation of HYDIN promoter22847954
D052638Particulate Matter[HYDIN gene mutant form affects the susceptibility to Particulate Matter] which results in increased expression of HYDIN mRNA21222557|2122255
D010936Plant ExtractsPlant Extracts results in decreased expression of HYDIN mRNA23557933
C017947sodium arsenitesodium arsenite affects the methylation of HYDIN gene28589171
C012568terbufosterbufos results in increased methylation of HYDIN promoter22847954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HYDIN mRNA17942748
C009495titanium dioxidetitanium dioxide results in decreased expression of HYDIN mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in decreased expression of HYDIN mRNA25549359
D014635Valproic AcidValproic Acid results in decreased methylation of HYDIN gene29154799
D014635Valproic AcidValproic Acid affects the expression of HYDIN mRNA17292431
D001335Vehicle Emissions[HYDIN gene mutant form affects the susceptibility to Vehicle Emissions] which results in increased expression of HYDIN mRNA21222557|2122255
C025643vinclozolinvinclozolin results in decreased expression of HYDIN mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0002064epithelial cell development-IEA-  
GO:0003341cilium movement-IEA-  
GO:0021591ventricular system development-IEA-  
GO:0060438trachea development-IEA-  
GO:1904158axonemal central apparatus assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:1990718axonemal central pair projection-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal