Gene: TET2

54790
KIAA1546|MDS
tet methylcytosine dioxygenase 2
protein-coding
4q24
Ensembl:ENSG00000168769 MIM:612839 Vega:OTTHUMG00000131213 UniprotKB:Q6N021
NG_028191.1
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.571e-2 (AD)  3.660e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMC40.838
BRWD30.833
BTAF10.829
POLK0.828
SENP70.822
ZKSCAN80.82
ELK40.818
ARID20.817
VPS13C0.816
GPATCH2L0.815

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NANOS3-0.356
OR4F5-0.355
OR4F29-0.339
MUC12-0.323
TNFRSF18-0.292
ASPDH-0.286
NPW-0.283
LCN1-0.269
ZNF771-0.251
HAGHL-0.241

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of TET2 mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TET2 mRNA"19114083
C0445782,3,5,6-tetrachlorohydroquinone"TET2 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased chemical synthesis of 5-hydroxymethylcytosine]"24214992
C0445782,3,5,6-tetrachlorohydroquinone"TET2 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased oxidation of 5-Methylcytosine]"24214992
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TET2 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TET2 mRNA"27188386
C0118655-hydroxymethylcytosine"TET2 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased chemical synthesis of 5-hydroxymethylcytosine]"24214992
C0118655-hydroxymethylcytosineTET2 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]24214992
C0118655-hydroxymethylcytosineTET2 protein results in increased chemical synthesis of 5-hydroxymethylcytosine24619417
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TET2 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of TET2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TET2 gene27153756
D000452AldrinTET2 gene SNP results in increased susceptibility to Aldrin23593118
D001151ArsenicArsenic affects the methylation of TET2 gene25304211
C547126AZM551248AZM551248 results in decreased expression of TET2 mRNA22323515
C006780bisphenol Abisphenol A affects the expression of TET2 mRNA27101439
C006780bisphenol Abisphenol A affects the expression of TET2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of TET2 mRNA26079696
D002703ChloranilTET2 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]24214992
D002703ChloranilTET2 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine]24214992
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of TET2 mRNA27188386
C029892cupric chloridecupric chloride results in decreased expression of TET2 mRNA24650576
D003676DeferoxamineDeferoxamine results in decreased expression of TET2 protein23483119
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TET2 mRNA27392435
D004317DoxorubicinDoxorubicin results in increased expression of TET2 mRNA25896364
C118739entinostatentinostat results in decreased expression of TET2 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TET2 mRNA22079256
D005557FormaldehydeFormaldehyde results in decreased expression of TET2 mRNA20655997
C001277geldanamycingeldanamycin results in increased expression of TET2 mRNA26705709
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TET2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TET2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of TET2 mRNA27392435
C045463leflunomideleflunomide results in increased expression of TET2 mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TET2 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] affects the expression of TET2 mRNA26378955
D0445035-Methylcytosine"TET2 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased oxidation of 5-Methylcytosine]"24214992
D0445035-MethylcytosineTET2 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine]24214992
D0445035-MethylcytosineTET2 protein results in increased hydroxylation of 5-Methylcytosine24619417
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TET2 mRNA28001369
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of TET2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TET2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TET2 mRNA"25554681
C046012pentanalpentanal results in decreased expression of TET2 mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TET2 mRNA27153767
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TET2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TET2 mRNA22079256|2271453
C005556propionaldehydepropionaldehyde results in decreased expression of TET2 mRNA26079696
C009277sodium arsenatesodium arsenate results in increased expression of TET2 mRNA21795629
C017947sodium arsenitesodium arsenite affects the reaction [CTCF protein binds to TET2 promoter]29175454
C017947sodium arsenitesodium arsenite results in increased expression of TET2 mRNA29175454
D012969Sodium FluorideSodium Fluoride results in decreased expression of TET2 mRNA27862939
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TET2 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] affects the expression of TET2 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TET2 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TET2 mRNA21632981
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TET2 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of TET2 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TET2 mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in decreased expression of TET2 mRNA25549359|2761814
D014241TrichloroethyleneTrichloroethylene results in decreased expression of TET2 mRNA27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TET2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TET2 mRNA24935251|2627250
D014501UraniumUranium results in decreased expression of TET2 mRNA29024790
D014520UrethaneUrethane results in increased expression of TET2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TET2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TET2 mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TET2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TET2 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of TET2 mRNA26682919
C111237vorinostatvorinostat results in decreased expression of TET2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0005506iron ion binding-IBA21873635  
GO:0005515protein binding-IPI23222540  23353889  
GO:0008198ferrous iron binding-IDA24315485  
GO:0008270zinc ion binding-IDA24315485  
GO:0070579methylcytosine dioxygenase activity-IBA21873635  
GO:0070579methylcytosine dioxygenase activity-IDA24315485  
GO:0070579methylcytosine dioxygenase activity-IMP21057493  23222540  
GO:0070579methylcytosine dioxygenase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:00062115-methylcytosine catabolic process-IBA21873635  
GO:00062115-methylcytosine catabolic process-IDA24315485  
GO:0006493protein O-linked glycosylation-IDA23222540  
GO:0006493protein O-linked glycosylation-IMP23353889  
GO:0007049cell cycle-IEA-  
GO:0014070response to organic cyclic compound-IEA-  
GO:0030099myeloid cell differentiation-IBA21873635  
GO:0030099myeloid cell differentiation-IMP21057493  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP23222540  23353889  
GO:0055114oxidation-reduction process-IEA-  
GO:0070989oxidative demethylation-IBA21873635  
GO:0080111DNA demethylation-IBA21873635  
GO:0080111DNA demethylation-IDA24315485  
GO:0080182histone H3-K4 trimethylation-IMP23353889  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-5221030TET1,2,3 and TDG demethylate DNAIEA
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26873401Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. (2016 May)Sawada GGastroenterology
23985253[Association of TET2, LMTK2 and FAM84B gene expression with prostate cancer risk in Chinese patients]. (2013 Apr)Wang NNZhonghua Zhong Liu Za Zhi
28483762Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly. (2017 Aug 10)Zink FBlood
27459457Epidemiological Assessments of Skin Outcomes in the Nurses' Health Studies. (2016 Sep)Li WQAm J Public Health
26423011Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. (2015 Oct)Wain LVLancet Respir Med
27927582Clonal haemopoiesis and therapy-related myeloid malignancies in elderly patients: a proof-of-concept, case-control study. (2017 Jan)Gillis NKLancet Oncol