Gene: TRPM4

54795
LTrpC4|PFHB1B|TRPM4B|hTRPM4
transient receptor potential cation channel subfamily M member 4
protein-coding
19q13.33
Ensembl:ENSG00000130529 MIM:606936 Vega:OTTHUMG00000183184 UniprotKB:Q8TD43
NG_027551.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.827e-1 (AD)  1.422e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TUT10.735
CNTROB0.733
POFUT20.729
RNPEP0.725
PLXNB20.721
UNC45A0.717
DCAF150.715
DHX580.715
RNF310.713
LMF20.711

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.473
OR4F29-0.466
MTRNR2L10-0.228
KLRC2-0.227
MTRNR2L6-0.227
MTRNR2L9-0.225
TACR3-0.219
IAPP-0.219
OR51I2-0.218
SCGB2A1-0.213

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TRPM4 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPM4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPM4 mRNA"27188386
D000255Adenosine TriphosphateAdenosine Triphosphate results in decreased activity of TRPM4 protein17188667
D000255Adenosine TriphosphateAdenosine Triphosphate results in decreased activity of TRPM4 protein16966582
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TRPM4 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRPM4 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TRPM4 mRNA16483693
D001241AspirinAspirin results in increased expression of TRPM4 mRNA11906190
D001280AtrazineAtrazine results in increased expression of TRPM4 mRNA25929836
D001280AtrazineAtrazine results in increased expression of TRPM4 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TRPM4 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of TRPM4 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of TRPM4 mRNA29097150
C584509C646 compoundC646 compound results in increased expression of TRPM4 mRNA26191083
D002118CalciumCalcium results in increased activity of TRPM4 protein17188667
D002118CalciumCalcium binds to and results in increased activity of TRPM4 protein16966582
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRPM4 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TRPM4 mRNA28472532
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TRPM4 mRNA17602206
D016572CyclosporineCyclosporine results in decreased expression of TRPM4 mRNA19770486
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of TRPM4 mRNA]21095227
D003976DiazinonDiazinon results in increased methylation of TRPM4 gene22964155
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of TRPM4 mRNA28962523
C051716dichloroacetonitrileTRPM4 gene SNP affects the susceptibility to dichloroacetonitrile25622337
D004041Dietary FatsDietary Fats results in increased expression of TRPM4 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TRPM4 mRNA24535843
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of TRPM4 gene23968726
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TRPM4 mRNA17602206
C112943dioctanoyl-phosphatidylinositol 4,5-bisphosphate"dioctanoyl-phosphatidylinositol 4,5-bisphosphate affects the activity of TRPM4 protein"17599963
C118739entinostatentinostat results in increased expression of TRPM4 mRNA27188386
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of TRPM4 gene27776689
D005439Flufenamic AcidFlufenamic Acid results in decreased activity of TRPM4 protein17188667
D005439Flufenamic AcidFlufenamic Acid results in decreased activity of TRPM4 protein16966582
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRPM4 mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of TRPM4 mRNA19167457
C039281furanfuran results in increased expression of TRPM4 mRNA25539665
D005905GlyburideGlyburide results in decreased activity of TRPM4 protein17188667
D005905GlyburideGlyburide results in decreased activity of TRPM4 protein16966582
C000625835HFPO2 compoundHFPO2 compound results in increased expression of TRPM4 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of TRPM4 mRNA27553808
D017313FenretinideFenretinide results in increased expression of TRPM4 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of TRPM4 mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of TRPM4 mRNA21396975
C544151jinfukangjinfukang results in increased expression of TRPM4 mRNA27392435
C045463leflunomideleflunomide results in increased expression of TRPM4 mRNA28988120
D008345ManganeseManganese results in increased expression of TRPM4 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of TRPM4 mRNA17175027
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRPM4 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TRPM4 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TRPM4 mRNA24810058
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of TRPM4 promoter18448484
C028007nickel monoxidenickel monoxide results in increased expression of TRPM4 mRNA19167457
D000073878Palm OilPalm Oil results in increased expression of TRPM4 mRNA18042831
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPM4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TRPM4 mRNA26272509
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of TRPM4 gene23968726
C006253pirinixic acidpirinixic acid results in increased expression of TRPM4 mRNA18301758|2081375
D010936Plant ExtractsPlant Extracts results in decreased expression of TRPM4 mRNA23557933
D011188PotassiumTRPM4 protein results in increased transport of Potassium17188667
D011188PotassiumTRPM4 protein results in increased transport of Potassium16966582
D011374ProgesteroneProgesterone results in decreased expression of TRPM4 mRNA21540246
D011441PropylthiouracilPropylthiouracil results in decreased expression of TRPM4 mRNA24780913
D019269Phosphatidylinositol 4,5-Diphosphate"Phosphatidylinositol 4,5-Diphosphate results in increased activity of TRPM4 protein"17188667
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TRPM4 mRNA25895662
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of TRPM4 mRNA]21095227
D012964SodiumTRPM4 protein results in increased transport of Sodium17188667
D012964SodiumTRPM4 protein results in increased transport of Sodium16966582
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of TRPM4 promoter18448484
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TRPM4 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TRPM4 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRPM4 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TRPM4 mRNA21215274
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TRPM4 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TRPM4 mRNA29024780
D014520UrethaneUrethane results in increased expression of TRPM4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TRPM4 mRNA25979313
C025643vinclozolinvinclozolin results in decreased expression of TRPM4 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005227calcium activated cation channel activity-IDA27207958  29211723  
GO:0005227calcium activated cation channel activity-ISS-  
GO:0005262calcium channel activity-IEA-  
GO:0005272sodium channel activity-TAS-  
GO:0005509calcium ion binding-IDA29217581  
GO:0005516calmodulin binding-IEA-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0002407dendritic cell chemotaxis-ISS-  
GO:0002724regulation of T cell cytokine production-IDA20656926  
GO:0007204positive regulation of cytosolic calcium ion concentration-ISS-  
GO:0008284positive regulation of cell proliferation-IDA20625999  
GO:0010460positive regulation of heart rate-ISS-  
GO:0016925protein sumoylation-IDA19726882  
GO:0019722calcium-mediated signaling-IDA27207958  
GO:0030502negative regulation of bone mineralization-ISS-  
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus-ISS-  
GO:0042310vasoconstriction-IEA-  
GO:0045600positive regulation of fat cell differentiation-ISS-  
GO:0045668negative regulation of osteoblast differentiation-ISS-  
GO:0045907positive regulation of vasoconstriction-ISS-  
GO:0051289protein homotetramerization-IDA29211723  29217581  
GO:0070588calcium ion transmembrane transport-TAS-  
GO:0071318cellular response to ATP-IEA-  
GO:0086045membrane depolarization during AV node cell action potential-IMP27207958  
GO:0086047membrane depolarization during Purkinje myocyte cell action potential-IMP27207958  
GO:0086048membrane depolarization during bundle of His cell action potential-IMP27207958  
GO:0086091regulation of heart rate by cardiac conduction-IMP27207958  
GO:0090263positive regulation of canonical Wnt signaling pathway-IDA20625999  
GO:0098662inorganic cation transmembrane transport-IDA29211723  
GO:0098719sodium ion import across plasma membrane-IDA27207958  
GO:0098911regulation of ventricular cardiac muscle cell action potential-IMP27207958  
GO:1903949positive regulation of atrial cardiac muscle cell action potential-ISS-  
GO:1904179positive regulation of adipose tissue development-ISS-  
GO:1904199positive regulation of regulation of vascular smooth muscle cell membrane depolarization-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005783endoplasmic reticulum-IDA19945433  
GO:0005794Golgi apparatus-IDA19945433  
GO:0005829cytosol-ISS-  
GO:0005886plasma membrane-IDA19945433  
GO:0005886plasma membrane-TAS-  
GO:0034706sodium channel complex-IDA27207958  
GO:0043025neuronal cell body-ISS-  
GO:0044214spanning component of plasma membrane-IDA29211723  
GO:0089717spanning component of membrane-IDA29217581  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27134767Genome-wide time-to-event analysis on smoking progression stages in a family-based study. (2016 May)He LBrain Behav