Gene: KLHL24

54800
DRE1|EBSSH|KRIP6
kelch like family member 24
protein-coding
3q27.1
Ensembl:ENSG00000114796 MIM:611295 Vega:OTTHUMG00000156911 UniprotKB:Q6TFL4
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
4.356e-1 (AD)  6.939e-1 (ND)   (Frontal_Cortex)
2.896e-1 (AD)  4.418e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6807489chr3:183676674 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSWIM60.854
NIPBL0.84
LRRC580.827
PHIP0.823
CEP3500.823
ARID20.822
BROX0.817
KIAA19580.814
CEP85L0.809
ZNF6440.808

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.585
OR4F29-0.546
PNOC-0.226
FER1L6-0.224
ITIH6-0.221
CETP-0.219
IBSP-0.213
KRT78-0.213
SPRR2B-0.211
NCCRP1-0.208

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of KLHL24 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of KLHL24 mRNA"19095052
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KLHL24 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of KLHL24 mRNA"19167446
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of KLHL24 mRNA"20638727
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of KLHL24 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL24 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL24 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL24 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL24 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of KLHL24 mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of KLHL24 mRNA21420995|2669055
D000082AcetaminophenAcetaminophen affects the expression of KLHL24 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KLHL24 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KLHL24 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of KLHL24 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KLHL24 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of KLHL24 mRNA20458559|2435693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of KLHL24 mRNA"18687144
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLHL24 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KLHL24 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLHL24 mRNA"20018196
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of KLHL24 mRNA20660070
C006780bisphenol Abisphenol A results in decreased expression of KLHL24 mRNA20678512
C006780bisphenol Abisphenol A results in increased expression of KLHL24 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of KLHL24 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of KLHL24 mRNA29097150
D002065BuspironeBuspirone results in increased expression of KLHL24 mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of KLHL24 mRNA26079696
C584509C646 compoundC646 compound affects the expression of KLHL24 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of KLHL24 mRNA20883709
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KLHL24 mRNA18654764
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KLHL24 mRNA18654764
C018021cobaltous chloridecobaltous chloride results in increased expression of KLHL24 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of KLHL24 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of KLHL24 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of KLHL24 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of KLHL24 mRNA19167446
C029892cupric chloridecupric chloride results in decreased expression of KLHL24 mRNA24650576
C029892cupric chloridecupric chloride results in increased expression of KLHL24 mRNA24650576
D003474CurcuminCurcumin results in decreased expression of KLHL24 mRNA17198877
D016572CyclosporineCyclosporine results in increased methylation of KLHL24 promoter27989131
D016572CyclosporineCyclosporine results in decreased expression of KLHL24 mRNA19770486
C014347decitabinedecitabine affects the expression of KLHL24 mRNA23300844
D003703DemecolcineDemecolcine results in increased expression of KLHL24 mRNA23649840
D003976DiazinonDiazinon results in increased expression of KLHL24 mRNA24356939
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of KLHL24 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of KLHL24 mRNA24893172
D002945CisplatinCisplatin affects the expression of KLHL24 mRNA23300844
D004026DieldrinDieldrin results in increased expression of KLHL24 mRNA28385952
D004237DiuronDiuron metabolite results in increased expression of KLHL24 mRNA24172598
D004317DoxorubicinDoxorubicin results in increased expression of KLHL24 mRNA25896364
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of KLHL24 mRNA"23811387
C118739entinostatentinostat results in decreased expression of KLHL24 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KLHL24 mRNA29097150
C024565ethylene dichlorideethylene dichloride results in decreased expression of KLHL24 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of KLHL24 mRNA23649840
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride results in increased expression of KLHL24 mRNA24356939
D005472FluorouracilFluorouracil results in increased expression of KLHL24 mRNA16510598
D005473FluoxetineFluoxetine results in increased expression of KLHL24 mRNA24356939
D005557FormaldehydeFormaldehyde results in increased expression of KLHL24 mRNA23649840
C001277geldanamycingeldanamycin results in increased expression of KLHL24 mRNA26705709
D019833GenisteinGenistein results in increased expression of KLHL24 mRNA18847459
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of KLHL24 mRNA22634610
D017313FenretinideFenretinide results in decreased expression of KLHL24 mRNA28973697
D017313FenretinideFenretinide results in increased expression of KLHL24 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of KLHL24 mRNA20044591
C492448ICG 001ICG 001 affects the expression of KLHL24 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLHL24 mRNA25613284
C051890irinotecanirinotecan analog results in increased expression of KLHL24 mRNA18927307
D007545IsoproterenolIsoproterenol results in increased expression of KLHL24 mRNA20003209
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of KLHL24 mRNA25307878
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of KLHL24 mRNA21889194|2429786
D007649KetamineKetamine results in decreased expression of KLHL24 mRNA20080153
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KLHL24 mRNA18654764
D001556LindaneLindane results in increased expression of KLHL24 mRNA24356939
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of KLHL24 mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of KLHL24 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KLHL24 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KLHL24 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of KLHL24 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KLHL24 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KLHL24 mRNA"25554681|2562005
D009285NaphthoquinonesNaphthoquinones results in increased expression of KLHL24 mRNA23811387
C022838nickel chloridenickel chloride results in increased expression of KLHL24 mRNA21455298
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of KLHL24 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of KLHL24 mRNA25729387
C016030pantogabpantogab results in increased expression of KLHL24 mRNA17379144
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of KLHL24 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of KLHL24 mRNA19095052
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of KLHL24 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of KLHL24 mRNA19270015|1948288
D010634PhenobarbitalPhenobarbital results in increased expression of KLHL24 mRNA19270015
D010656PhenylephrinePhenylephrine results in decreased expression of KLHL24 mRNA18158353
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KLHL24 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of KLHL24 mRNA18301758
D010936Plant ExtractsPlant Extracts results in increased expression of KLHL24 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of KLHL24 mRNA21334430
D011239PrednisolonePrednisolone results in increased expression of KLHL24 mRNA24356939
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of KLHL24 mRNA20660070
C045950propiconazolepropiconazole results in decreased expression of KLHL24 mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of KLHL24 mRNA26079696
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of KLHL24 mRNA19429434
D012402RotenoneRotenone results in increased expression of KLHL24 mRNA19013527
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of KLHL24 mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of KLHL24 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KLHL24 mRNA25895662
D012834SilverSilver results in increased expression of KLHL24 mRNA26014281
D020123Sirolimus[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of KLHL24 mRNA25307878
D020123SirolimusSirolimus results in increased expression of KLHL24 mRNA24356939
C009277sodium arsenatesodium arsenate results in increased expression of KLHL24 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of KLHL24 mRNA28595984
C017947sodium arsenitesodium arsenite results in increased expression of KLHL24 mRNA20883709
D013739TestosteroneTestosterone affects the expression of KLHL24 mRNA20403060
C004648testosterone enanthatetestosterone enanthate affects the expression of KLHL24 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLHL24 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLHL24 mRNA23238561
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLHL24 mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLHL24 mRNA23238561
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of KLHL24 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLHL24 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of KLHL24 mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of KLHL24 mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of KLHL24 mRNA23409001
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of KLHL24 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of KLHL24 mRNA23228038
D014212TretinoinTretinoin results in increased expression of KLHL24 mRNA23724009|2383079
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL24 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of KLHL24 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of KLHL24 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of KLHL24 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KLHL24 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of KLHL24 mRNA28973697
C080163trovafloxacintrovafloxacin results in increased expression of KLHL24 mRNA24136188
D014520UrethaneUrethane results in increased expression of KLHL24 mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of KLHL24 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL24 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of KLHL24 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of KLHL24 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of KLHL24 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KLHL24 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of KLHL24 mRNA25423262
C025643vinclozolinvinclozolin affects the expression of KLHL24 mRNA19015723
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of KLHL24 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of KLHL24 mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of KLHL24 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI27798626  
GO ID GO Term Qualifier Evidence PubMed
GO:0016567protein ubiquitination-IDA27798626  
GO:0045109intermediate filament organization-IMP27889062  
GO:0051865protein autoubiquitination-IMP27798626  
GO:2000312regulation of kainate selective glutamate receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA27889062  
GO:0005912adherens junction-IDA27889062  
GO:0030057desmosome-IDA27889062  
GO:0030424axon-IEA-  
GO:0031463Cul3-RING ubiquitin ligase complex-IMP27798626  
GO:0043204perikaryon-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal