Gene: KLHL28

54813
BTBD5
kelch like family member 28
protein-coding
14q21.2
Ensembl:ENSG00000179454 Vega:OTTHUMG00000140263 UniprotKB:Q9NXS3
NC_000014.9
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.091e-1 (AD)  2.717e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11848799chr14:44946394 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNX130.922
TMF10.907
LTN10.9
APPBP20.899
KLHL90.898
PHF60.895
EDEM30.894
GTF2A10.893
RAB3GAP20.893
HSPA130.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.467
OR4F29-0.411
CSAG1-0.39
RSPO1-0.387
MTRNR2L10-0.36
MTRNR2L9-0.333
MTRNR2L6-0.331
RNF223-0.314
HIGD1B-0.313
MTRNR2L3-0.31

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of KLHL28 mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of KLHL28 mRNA"19095052
D000082AcetaminophenAcetaminophen results in increased expression of KLHL28 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KLHL28 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KLHL28 mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of KLHL28 mRNA19774075
D001280AtrazineAtrazine results in increased expression of KLHL28 mRNA22378314
C006780bisphenol Abisphenol A results in decreased expression of KLHL28 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of KLHL28 mRNA26191083
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of KLHL28 mRNA20971185
D016572CyclosporineCyclosporine results in increased expression of KLHL28 mRNA25562108
D003703DemecolcineDemecolcine results in increased expression of KLHL28 mRNA23649840
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of KLHL28 mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of KLHL28 mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of KLHL28 mRNA16931933
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KLHL28 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KLHL28 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of KLHL28 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of KLHL28 mRNA23649840
D019469Indinavir[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of KLHL28 mRNA16931933
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLHL28 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of KLHL28 mRNA27392435
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of KLHL28 mRNA27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of KLHL28 mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KLHL28 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KLHL28 mRNA"25554681
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of KLHL28 mRNA19074003
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of KLHL28 mRNA20971185
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of KLHL28 mRNA19095052
C012526quercitrinquercitrin results in increased expression of KLHL28 mRNA25193878
D019258Saquinavir[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of KLHL28 mRNA16931933
C009277sodium arsenatesodium arsenate results in decreased expression of KLHL28 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of KLHL28 gene28589171
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of KLHL28 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLHL28 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLHL28 mRNA24680724
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KLHL28 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLHL28 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of KLHL28 mRNA28065790
C012589trichostatin Atrichostatin A affects the expression of KLHL28 mRNA28542535
D014520UrethaneUrethane results in increased expression of KLHL28 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of KLHL28 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KLHL28 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased methylation of KLHL28 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of KLHL28 mRNA20546886
D014750VincristineVincristine results in increased expression of KLHL28 mRNA23649840
C111237vorinostatvorinostat results in decreased expression of KLHL28 mRNA27188386
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of KLHL28 mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of KLHL28 mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of KLHL28 mRNA16931933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016567protein ubiquitination-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal