Gene: NDE1

54820
HOM-TES-87|LIS4|MHAC|NDE|NUDE|NUDE1
nudE neurodevelopment protein 1
protein-coding
16p13.11
Ensembl:ENSG00000072864 MIM:609449 Vega:OTTHUMG00000129885 UniprotKB:Q9NXR1
NG_021210.1
PubMed
0   ANCO-SNPs
AD
2   
9.626e-1 (AD)  6.131e-1 (ND)   (Frontal_Cortex)
4.967e-1 (AD)  4.617e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08118908chr16:15787920NDE15.400e-26Smoking27651444
cg06361984chr16:15787940NDE11.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LDLRAP10.875
CLMN0.872
CDC42EP10.86
SH3TC20.856
TMC60.854
PLD10.853
DOCK50.852
HSPA20.852
C10orf900.85
TFEB0.85

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.451
PCDH8-0.433
PRTN3-0.428
KCNK3-0.419
GALNTL6-0.414
HCN4-0.411
FBLN7-0.406
CNGB1-0.405
CNTN5-0.399
CDH22-0.397

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of NDE1 mRNA28329830
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of NDE1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NDE1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NDE1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NDE1 mRNA"27188386
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of NDE1 mRNA14583596
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NDE1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NDE1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of NDE1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NDE1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NDE1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NDE1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NDE1 mRNA24449571
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of NDE1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NDE1 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NDE1 mRNA"19150397|2038263
D004958EstradiolEstradiol results in increased expression of NDE1 mRNA19167446
C006780bisphenol Abisphenol A results in increased expression of NDE1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of NDE1 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of NDE1 mRNA26191083
D002104CadmiumCadmium results in decreased expression of NDE1 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of NDE1 promoter22457795
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NDE1 mRNA23650126
D002994ClofibrateClofibrate results in decreased expression of NDE1 mRNA17585979
D019327Copper SulfateCopper Sulfate results in increased expression of NDE1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of NDE1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of NDE1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of NDE1 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of NDE1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of NDE1 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of NDE1 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NDE1 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NDE1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of NDE1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of NDE1 mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of NDE1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of NDE1 mRNA21592394
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NDE1 protein23301498
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of NDE1 mRNA28329830
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of NDE1 mRNA22634610
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NDE1 mRNA27392435
C002950methylformamidemethylformamide analog results in decreased expression of NDE1 mRNA17040096
C002950methylformamidemethylformamide results in decreased expression of NDE1 mRNA17040096
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NDE1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NDE1 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NDE1 mRNA25729387
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NDE1 mRNA"27188386
D010936Plant ExtractsPlant Extracts results in increased expression of NDE1 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of NDE1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of NDE1 mRNA27029645
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of NDE1 mRNA19167446
C059514resveratrolresveratrol results in increased expression of NDE1 mRNA19167446
D053260SootSoot results in increased expression of NDE1 mRNA26551751
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of NDE1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of NDE1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NDE1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NDE1 mRNA27913140
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NDE1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NDE1 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NDE1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NDE1 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of NDE1 mRNA23179753|2800136
C025643vinclozolinvinclozolin results in increased expression of NDE1 mRNA23034163
D014750VincristineVincristine results in increased expression of NDE1 mRNA23649840
D024483Vitamin K 3Vitamin K 3 affects the expression of NDE1 mRNA20044591
C088658zoledronic acidzoledronic acid results in increased expression of NDE1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16682949  17600710  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-ISS-  
GO:0019904protein domain specific binding-IEA-  
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0000132establishment of mitotic spindle orientation-IBA21873635  
GO:0000132establishment of mitotic spindle orientation-IMP19468067  
GO:0001764neuron migration-IEA-  
GO:0007020microtubule nucleation-IBA21873635  
GO:0007059chromosome segregation-IBA21873635  
GO:0007100mitotic centrosome separation-IBA21873635  
GO:0007405neuroblast proliferation-IEA-  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0016477cell migration-IBA21873635  
GO:0021987cerebral cortex development-IMP21529752  
GO:0047496vesicle transport along microtubule-IBA21873635  
GO:0051298centrosome duplication-ISS-  
GO:0051301cell division-IEA-  
GO:0051303establishment of chromosome localization-IBA21873635  
GO:0051303establishment of chromosome localization-IMP17600710  
GO:0051642centrosome localization-IBA21873635  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO:2000574regulation of microtubule motor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochore-IBA21873635  
GO:0000776kinetochore-IDA17600710  
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA21399614  21529752  
GO:0005829cytosol-TAS-  
GO:0005871kinesin complex-IBA21873635  
GO:0005874microtubule-IEA-  
GO:0016020membrane-HDA19946888  
GO:0031616spindle pole centrosome-ISS-  
GO:0032154cleavage furrow-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-380259Loss of Nlp from mitotic centrosomesTAS
R-HSA-380270Recruitment of mitotic centrosome proteins and complexesTAS
R-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeTAS
R-HSA-380287Centrosome maturationTAS
R-HSA-380320Recruitment of NuMA to mitotic centrosomesTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-8854518AURKA Activation by TPX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23747354Over-expression of the miRNA cluster at chromosome 14q32 in the alcoholic brain correlates with suppression of predicted target mRNA required for oligodendrocyte proliferation. (2013 Sep 10)Manzardo AMGene
19786961Copy number variations of chromosome 16p13.1 region associated with schizophrenia. (2011 Jan)Ingason AMol Psychiatry