Gene: TRPM7

54822
ALSPDC|CHAK|CHAK1|LTRPC7|LTrpC-7|TRP-PLIK
transient receptor potential cation channel subfamily M member 7
protein-coding
15q21.2
Ensembl:ENSG00000092439 MIM:605692 Vega:OTTHUMG00000172449 UniprotKB:Q96QT4
NG_021363.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.652e-1 (AD)  6.827e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7173321chr15:50630403 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTUD40.907
SMG10.904
AP4E10.902
PCF110.902
UBR20.897
ZFC3H10.892
KANSL1L0.885
LCOR0.883
SUPT20H0.882
MLLT100.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.42
OR4F29-0.403
HES5-0.344
S100A1-0.326
BTBD17-0.322
PLA2G5-0.317
RBP1-0.307
TNNT1-0.283
REN-0.273
HPDL-0.267

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09481Magnesium carbonateSmall Molecule546-93-0Approved|InvestigationalTransporter
DB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall MoleculeExperimentalTarget
DB044471,4-DithiothreitolSmall Molecule3483-12-3ExperimentalTarget
ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of TRPM7 mRNA19041380
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [TGFB1 protein results in increased expression of TRPM7 protein]25150141
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate results in decreased activity of TRPM7 protein23958495
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TRPM7 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in increased expression of TRPM7 protein]"25150141
C5085046,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride"6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [TGFB1 protein results in increased expression of TRPM7 protein]"25150141
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of TRPM7 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TRPM7 mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of TRPM7 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRPM7 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TRPM7 mRNA16483693
D001280AtrazineAtrazine results in increased expression of TRPM7 mRNA25929836
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TRPM7 mRNA28628672
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of TRPM7 mRNA15912405
C006780bisphenol Abisphenol A affects the expression of TRPM7 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TRPM7 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRPM7 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of TRPM7 mRNA25181051|2757113
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TRPM7 mRNA28628672
D002104CadmiumMagnesium deficiency promotes the reaction [TRPM7 protein results in increased import of Cadmium]20932883
D002104CadmiumMagnesium inhibits the reaction [TRPM7 protein results in increased import of Cadmium]20932883
D002104CadmiumTRPM7 protein results in increased import of Cadmium20932883
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TRPM7 mRNA23741332
D002118CalciumMagnesium inhibits the reaction [TRPM7 protein results in increased abundance of Calcium]19515901
D002118CalciumTRPM7 protein results in increased abundance of Calcium19515901
D002118Calcium"Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [PSEN1 protein mutant form inhibits the reaction [TRPM7 protein affects the transport of Calcium]]"22102510
D002118CalciumPSEN1 gene mutant form promotes the reaction [TRPM7 protein affects the transport of Calcium]22102510
D002118CalciumPSEN1 protein mutant form inhibits the reaction [TRPM7 protein affects the transport of Calcium]22102510
D002118CalciumPSEN2 gene mutant form promotes the reaction [TRPM7 protein affects the transport of Calcium]22102510
D002118CalciumTRPM7 protein affects the transport of Calcium22102510
D002136Calcium, Dietary"TRPM7 gene polymorphism affects the susceptibility to [Magnesium co-treated with Calcium, Dietary]"17823441
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TRPM7 mRNA23958495
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TRPM7 protein23958495
C073316carvacrolcarvacrol results in decreased activity of TRPM7 protein19135721
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TRPM7 mRNA23650126
D002922CiguatoxinsCiguatoxins affects the expression of TRPM7 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of TRPM7 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TRPM7 mRNA]17585979
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TRPM7 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRPM7 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TRPM7 mRNA28628672
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TRPM7 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of TRPM7 mRNA19467301
D004317DoxorubicinDoxorubicin results in increased expression of TRPM7 mRNA25896364
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TRPM7 mRNA23649840
D005947GlucoseGlucose results in increased expression of and results in increased activity of TRPM7 protein24223965
D005947GlucoseGlucose results in increased expression of TRPM7 mRNA24223965
D005947GlucoseTRPM7 affects the reaction [Glucose results in decreased expression of NOS3 protein]24223965
D005947GlucoseU 0126 inhibits the reaction [TRPM7 affects the reaction [Glucose results in decreased expression of NOS3 protein]]24223965
C071834glycidamideglycidamide results in increased expression of TRPM7 mRNA17822822
C412815GW 4064GW 4064 promotes the reaction [NR1H4 protein binds to TRPM7 gene]20091679
D017313FenretinideFenretinide results in increased expression of TRPM7 mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TRPM7 protein18951874
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TRPM7 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRPM7 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TRPM7 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TRPM7 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRPM7 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TRPM7 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of TRPM7 mRNA27392435
C410337K 7174K 7174 results in increased expression of TRPM7 mRNA24086573
C002385linsidominelinsidomine results in increased oxidation of TRPM7 protein28086193
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of TRPM7 mRNA"24972896
D008274MagnesiumMagnesium inhibits the reaction [TRPM7 protein results in increased abundance of Calcium]19515901
D008274Magnesium"TRPM7 gene polymorphism affects the susceptibility to [Magnesium co-treated with Calcium, Dietary]"17823441
D008274MagnesiumMagnesium deficiency promotes the reaction [TRPM7 protein results in increased import of Cadmium]20932883
D008274MagnesiumMagnesium inhibits the reaction [TRPM7 protein results in increased import of Cadmium]20932883
D008274MagnesiumOxygen deficiency promotes the reaction [TRPM7 protein affects the transport of Magnesium]21487014
D008274MagnesiumTRPM7 protein affects the abundance of Magnesium21487014
D008274MagnesiumTRPM7 protein affects the transport of Magnesium21487014
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TRPM7 mRNA26378955
D008345ManganeseTRPM7 protein results in increased uptake of Manganese16428268
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TRPM7 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TRPM7 mRNA23649840
D0156551-Methyl-4-phenylpyridiniumTRPM7 gene mutant form results in increased susceptibility to 1-Methyl-4-phenylpyridinium24291744
C025256nonylphenolnonylphenol results in increased expression of TRPM7 mRNA22982499
D010100OxygenOxygen deficiency promotes the reaction [TRPM7 protein affects the transport of Magnesium]21487014
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TRPM7 mRNA27153767
D010634PhenobarbitalPhenobarbital results in decreased expression of TRPM7 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of TRPM7 mRNA12832660
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of TRPM7 mRNA21334430
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TRPM7 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TRPM7 mRNA23608068
D019269Phosphatidylinositol 4,5-Diphosphate"Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [PSEN1 protein mutant form inhibits the reaction [TRPM7 protein affects the transport of Calcium]]"22102510
D011794QuercetinQuercetin results in decreased activity of TRPM7 protein24647664
D011794QuercetinQuercetin results in decreased activity of TRPM7 protein24647664|2596787
D011794QuercetinTRPM7 protein results in increased susceptibility to Quercetin24647664
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TRPM7 mRNA26378955
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of TRPM7 mRNA"26680231
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TRPM7 protein18951874
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TRPM7 mRNA28111298
C113580U 0126U 0126 inhibits the reaction [TRPM7 affects the reaction [Glucose results in decreased expression of NOS3 protein]]24223965
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TRPM7 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TRPM7 mRNA23034163
D015032ZincPSEN1 protein mutant form inhibits the reaction [TRPM7 protein affects the transport of Zinc]22102510
D015032ZincTRPM7 protein affects the transport of Zinc22102510

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005262calcium channel activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0017022myosin binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010961cellular magnesium ion homeostasis-IEA-  
GO:0016340calcium-dependent cell-matrix adhesion-IEA-  
GO:0031032actomyosin structure organization-IEA-  
GO:0046777protein autophosphorylation-IEA-  
GO:0051262protein tetramerization-IEA-  
GO:0070266necroptotic process-IMP24316671  
GO:0070588calcium ion transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19644062Gene variation of the transient receptor potential cation channel, subfamily M, member 7 (TRPM7), and risk of incident ischemic stroke: prospective, nested, case-control study. (2009 Sep)Romero JRStroke