Gene: WBP1L

54838
C10orf26|OPA1L|OPAL1
WW domain binding protein 1 like
protein-coding
10q24.32
Ensembl:ENSG00000166272 MIM:611129 Vega:OTTHUMG00000018968 UniprotKB:Q9NX94
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.822e-2 (AD)  5.586e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KDELR10.91
RPN20.903
SLC35A40.902
SEC61A10.899
P4HB0.893
TMBIM60.89
ENO10.889
RAB5C0.887
FYN0.882
RAF10.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.815
OR4F29-0.768
OR6C74-0.236
C17orf112-0.165
HMHB1-0.162
TDGF1-0.155
CETP-0.148
RNASE8-0.141
CLEC6A-0.141
AFM-0.139

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of WBP1L mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of WBP1L mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of WBP1L mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WBP1L mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of WBP1L mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WBP1L mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of WBP1L mRNA25181051
D002065BuspironeBuspirone results in increased expression of WBP1L mRNA24136188
D002994ClofibrateClofibrate results in increased expression of WBP1L mRNA23811191
D003024ClozapineClozapine results in decreased expression of WBP1L mRNA14647396
D016572CyclosporineCyclosporine results in decreased expression of WBP1L mRNA20106945
D004041Dietary FatsDietary Fats results in decreased expression of WBP1L mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of WBP1L mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of WBP1L mRNA21592394
D005485FlutamideFlutamide results in decreased expression of WBP1L mRNA24136188
C039281furanfuran results in increased expression of WBP1L mRNA26194646
D006220HaloperidolHaloperidol results in decreased expression of WBP1L mRNA14647396
D007854LeadLead affects the expression of WBP1L mRNA28903495
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to WBP1L promoter]20348232
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of WBP1L mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of WBP1L mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of WBP1L promoter"26251327
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of WBP1L promoter18448484
C028007nickel monoxidenickel monoxide results in increased expression of WBP1L mRNA19167457
D000073878Palm OilPalm Oil results in decreased expression of WBP1L mRNA18042831
C006253pirinixic acidpirinixic acid results in increased expression of WBP1L mRNA18301758|2381119
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of WBP1L mRNA28903501
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of WBP1L mRNA25626140
D011794QuercetinQuercetin results in increased expression of WBP1L mRNA21632981
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of WBP1L promoter18448484
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of WBP1L mRNA21592394
D013739TestosteroneTestosterone results in increased expression of WBP1L mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of WBP1L mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WBP1L mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WBP1L mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WBP1L mRNA21215274
D013853ThioacetamideThioacetamide results in decreased expression of WBP1L mRNA23411599
C080163trovafloxacintrovafloxacin results in increased expression of WBP1L mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of WBP1L mRNA23179753
C025643vinclozolinvinclozolin results in increased expression of WBP1L mRNA20566332
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of WBP1L mRNA18579281

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27591263Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy. (2016 Oct)Morales EInt J Epidemiol