Gene: APTX

54840
AOA|AOA1|AXA1|EAOH|EOAHA|FHA-HIT
aprataxin
protein-coding
9p21.1
Ensembl:ENSG00000137074 MIM:606350 Vega:OTTHUMG00000019759 UniprotKB:Q7Z2E3
NG_012821.1
SNP Mapped
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.408e-1 (AD)  7.360e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DKC10.906
BOD10.904
EIF2S20.904
CCT30.903
CNPY20.902
CCT6A0.901
GPBP10.9
HAX10.9
EIF3I0.9
MRPS50.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.721
OR4F29-0.705
P2RY14-0.284
C8orf74-0.241
MROH9-0.241
MTRNR2L6-0.239
KLRB1-0.231
TTLL10-0.23
MTRNR2L10-0.23
CYSLTR2-0.228

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of APTX mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of APTX mRNA]28655636
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of APTX mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of APTX mRNA"23994337
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of APTX mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of APTX mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to APTX protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to APTX protein]26598702
D000082AcetaminophenAcetaminophen affects the expression of APTX mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of APTX mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of APTX mRNA24449571
D001104ArbutinArbutin results in decreased expression of APTX mRNA17103032
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to APTX protein]26598702
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of APTX mRNA23994337
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of APTX mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of APTX mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of APTX mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of APTX mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of APTX mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of APTX promoter22457795
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of APTX mRNA21878529
D002945CisplatinCisplatin results in increased expression of APTX mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of APTX mRNA28302478
D004026DieldrinDieldrin results in decreased expression of APTX mRNA23041725
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of APTX mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of APTX mRNA19467301
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of APTX mRNA23649840
C011890kojic acidkojic acid results in decreased expression of APTX mRNA16595896
D008727MethotrexateMethotrexate results in decreased expression of APTX mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of APTX mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of APTX mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of APTX mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of APTX mRNA"25554681
C025589ochratoxin Aochratoxin A results in decreased expression of APTX mRNA23358140
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of APTX mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of APTX mRNA28655636
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of APTX mRNA23948077
C006253pirinixic acidpirinixic acid results in increased expression of APTX mRNA18301758|2081375
D010936Plant ExtractsPlant Extracts results in increased expression of APTX mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of APTX mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of APTX mRNA15328365|2399433
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of APTX mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in increased methylation of APTX gene27618143
D014635Valproic AcidValproic Acid results in increased expression of APTX mRNA29154799
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of APTX mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of APTX mRNA28655636

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IDA15044383  
GO:0003684damaged DNA binding-IDA14755728  
GO:0003690double-stranded DNA binding-IDA16547001  17276982  
GO:0003697single-stranded DNA binding-IBA21873635  
GO:0003725double-stranded RNA binding-IBA21873635  
GO:0003725double-stranded RNA binding-IDA16547001  
GO:0005515protein binding-IPI14755728  15044383  15367657  15380105  15555565  16439205  
16713569  16777843  25416956  
GO:0008967phosphoglycolate phosphatase activity-IDA17519253  
GO:0030983mismatched DNA binding-IBA21873635  
GO:0033699DNA 5'-adenosine monophosphate hydrolase activity-IBA21873635  
GO:0033699DNA 5'-adenosine monophosphate hydrolase activity-IDA16547001  16964241  17276982  17519253  
GO:0046872metal ion binding-IEA-  
GO:0047485protein N-terminus binding-IPI16777843  
GO:0051219phosphoprotein binding-IPI20008512  
GO:0070566adenylyltransferase activity-IBA21873635  
GO:0120108DNA-3'-diphospho-5'-guanosine diphosphatase-IEA-  
GO:1990165single-strand break-containing DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000012single strand break repair-IBA21873635  
GO:0000012single strand break repair-IDA17519253  
GO:0006266DNA ligation-IEA-  
GO:0006302double-strand break repair-IBA21873635  
GO:0006796phosphate-containing compound metabolic process-IBA21873635  
GO:0006974cellular response to DNA damage stimulus-IMP15044383  
GO:0016311dephosphorylation-IEA-  
GO:0031647regulation of protein stability-IMP16777843  
GO:0042542response to hydrogen peroxide-IDA15044383  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-IDA15044383  
GO:0000790nuclear chromatincolocalizes_withIDA20008512  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA15044383  16777843  
GO:0005730nucleolus-IDA15044383  16777843  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal