Gene: PGPEP1

54858
PAP-I|PGI|PGP|PGP-I|PGPI|Pcp
pyroglutamyl-peptidase I
protein-coding
19p13.11
Ensembl:ENSG00000130517 MIM:610694 Vega:OTTHUMG00000183358 UniprotKB:Q9NXJ5
NG_051188.1
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.201e-1 (AD)  3.815e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMARCC10.834
MAP40.83
PHF21A0.826
CRTAP0.825
ZCCHC240.825
MAP4K40.819
WWC30.819
WNK10.818
ANKRD400.806
HIPK20.801

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.524
OR4F5-0.45
NMU-0.372
CNTN5-0.37
PPEF1-0.368
F7-0.366
ADRA1D-0.365
CBLN4-0.362
SOWAHB-0.361
FBLN7-0.359

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PGPEP1 mRNA"26377693
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PGPEP1 mRNA"25614096
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PGPEP1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of PGPEP1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of PGPEP1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of PGPEP1 mRNA28959563
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PGPEP1 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of PGPEP1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PGPEP1 mRNA22610609
D004958EstradiolEstradiol results in increased expression of PGPEP1 mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of PGPEP1 mRNA25047013|2768578
C006780bisphenol Abisphenol A results in increased expression of PGPEP1 mRNA25181051
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of PGPEP1 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PGPEP1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of PGPEP1 mRNA24612858
D019327Copper SulfateCopper Sulfate results in decreased expression of PGPEP1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of PGPEP1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of PGPEP1 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PGPEP1 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PGPEP1 mRNA27392435
D004026DieldrinDieldrin results in increased expression of PGPEP1 mRNA28385952
D004041Dietary FatsDietary Fats results in increased expression of PGPEP1 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of PGPEP1 mRNA18164116
D002117CalcitriolCalcitriol results in increased expression of PGPEP1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of PGPEP1 mRNA21592394
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PGPEP1 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PGPEP1 mRNA23649840
D018120FinasterideFinasteride results in increased expression of PGPEP1 mRNA24136188
D005485FlutamideFlutamide results in decreased expression of PGPEP1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PGPEP1 gene20938992
D019833GenisteinGenistein results in increased expression of PGPEP1 mRNA23019147
D017313FenretinideFenretinide results in increased expression of PGPEP1 mRNA28973697
D007052IbuprofenIbuprofen results in decreased expression of PGPEP1 mRNA28201806
D007213IndomethacinIndomethacin results in increased expression of PGPEP1 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PGPEP1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PGPEP1 mRNA24796395
D007649KetamineKetamine results in decreased expression of PGPEP1 mRNA20080153
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of PGPEP1 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PGPEP1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PGPEP1 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PGPEP1 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PGPEP1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PGPEP1 mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of PGPEP1 mRNA24136188
D000073878Palm OilPalm Oil results in increased expression of PGPEP1 mRNA18042831
C006253pirinixic acidpirinixic acid results in decreased expression of PGPEP1 mRNA18445702|2381119
D010938Plant OilsPlant Oils results in decreased expression of PGPEP1 mRNA23370395
C059514resveratrolresveratrol results in increased expression of PGPEP1 protein25505154
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PGPEP1 mRNA25351596
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of PGPEP1 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of PGPEP1 mRNA17555576|2093736
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of PGPEP1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of PGPEP1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PGPEP1 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PGPEP1 mRNA21570461
D013849ThimerosalThimerosal results in decreased expression of PGPEP1 mRNA27188386
D014212TretinoinTretinoin results in increased expression of PGPEP1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of PGPEP1 mRNA20488242
C012589trichostatin Atrichostatin A affects the expression of PGPEP1 mRNA28542535
D014635Valproic AcidValproic Acid results in decreased expression of PGPEP1 mRNA23527032
D014635Valproic AcidValproic Acid results in increased expression of PGPEP1 mRNA19101580|2317975
C025643vinclozolinvinclozolin results in decreased expression of PGPEP1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of PGPEP1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008234cysteine-type peptidase activity-IEA-  
GO:0016920pyroglutamyl-peptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal