Gene: PIGG

54872
GPI7|LAS21|MRT53|PRO4405|RLGS1930
phosphatidylinositol glycan anchor biosynthesis class G
protein-coding
4p16.3
Ensembl:ENSG00000174227 MIM:616918 Vega:OTTHUMG00000112457 UniprotKB:Q5H8A4
NG_051621.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.352e-1 (AD)  4.067e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7678962chr4:523409 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SETDB10.911
ASXL10.905
CREBZF0.904
WDR910.897
METTL30.897
RBM250.893
ZZEF10.89
SRSF110.888
RBM50.885
GTF3C20.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.554
OR4F29-0.533
MTRNR2L6-0.308
MTRNR2L9-0.296
OR4F16-0.266
MTRNR2L10-0.26
KLRC2-0.255
MOGAT2-0.214
RNF223-0.202
TTLL10-0.202

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PIGG mRNA"19114083
C496492abrineabrine results in decreased expression of PIGG mRNA22595364
D001151ArsenicArsenic affects the methylation of PIGG gene25304211
C006780bisphenol Abisphenol A affects the expression of PIGG mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PIGG mRNA28628672
D002220CarbamazepineCarbamazepine affects the expression of PIGG mRNA25979313
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PIGG mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PIGG mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PIGG mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PIGG mRNA28628672
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PIGG mRNA23649840
D012643SeleniumSelenium results in decreased expression of PIGG mRNA19244175
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PIGG mRNA25613284
D014520UrethaneUrethane results in increased expression of PIGG mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PIGG mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of PIGG gene29154799
D014810Vitamin EVitamin E results in decreased expression of PIGG mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016780phosphotransferase activity, for other substituted phosphate groups-TAS-  
GO:0051267CP2 mannose-ethanolamine phosphotransferase activity-IBA21873635  
GO:0051267CP2 mannose-ethanolamine phosphotransferase activity-IDA15632136  
GO ID GO Term Qualifier Evidence PubMed
GO:0006506GPI anchor biosynthetic process-IBA21873635  
GO:0006506GPI anchor biosynthetic process-IDA15632136  
GO:0016254preassembly of GPI anchor in ER membrane-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA15632136  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030176integral component of endoplasmic reticulum membrane-IBA21873635  
KEGG ID KEGG Term
hsa00563Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-162710Synthesis of glycosylphosphatidylinositol (GPI)TAS
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25865730Journal abstracts from current research in the field of child and adolescent mental health. (2009 Dec)-J Child Adolesc Ment Health
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (2011 May)Kendler KSAlcohol Clin Exp Res