Gene: FNBP1L

54874
C1orf39|TOCA1
formin binding protein 1 like
protein-coding
1p22.1
Ensembl:ENSG00000137942 MIM:608848 Vega:OTTHUMG00000010863 UniprotKB:Q5T0N5
NC_000001.11
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.413e-1 (AD)  8.157e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4847431chr1:93519247 (GRCh38.p7)G>A / G>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs11164938chr1:93474313 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNKS20.806
CLINT10.805
SREK10.802
STRN30.791
AFF40.791
NAA500.788
WDR260.788
ZNF2070.786
ZNF6550.785
MMGT10.784

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.584
OR4F29-0.553
LCN1-0.235
FXYD4-0.203
ANXA13-0.2
AKR1B15-0.193
POU2AF1-0.19
NUTM2E-0.184
CTNNA3-0.182
TRPV5-0.181

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FNBP1L mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FNBP1L mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FNBP1L mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FNBP1L mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FNBP1L mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FNBP1L mRNA"25510870
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of FNBP1L mRNA"20816883
D020106AcrylamideAcrylamide results in decreased expression of FNBP1L mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FNBP1L gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FNBP1L mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of FNBP1L mRNA21757418
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of FNBP1L mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of FNBP1L mRNA15761015
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FNBP1L mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FNBP1L mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of FNBP1L mRNA21786754
C006780bisphenol Abisphenol A affects the expression of FNBP1L mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FNBP1L mRNA24982889
D002220CarbamazepineCarbamazepine affects the expression of FNBP1L mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FNBP1L mRNA27339419
D002922CiguatoxinsCiguatoxins affects the expression of FNBP1L mRNA18353800
D019327Copper SulfateCopper Sulfate results in increased expression of FNBP1L mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FNBP1L mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of FNBP1L mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of FNBP1L mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of FNBP1L mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FNBP1L mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of FNBP1L mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of FNBP1L mRNA16002434
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FNBP1L mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FNBP1L mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FNBP1L mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FNBP1L mRNA17942748
D005557FormaldehydeFormaldehyde results in increased expression of FNBP1L mRNA23649840
C039281furanfuran results in increased methylation of FNBP1L gene22079235
D017313FenretinideFenretinide results in increased expression of FNBP1L mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FNBP1L mRNA20044591
D007213IndomethacinIndomethacin results in decreased expression of FNBP1L mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FNBP1L mRNA25613284
C410337K 7174K 7174 results in increased expression of FNBP1L mRNA24086573
D007854LeadLead affects the splicing of FNBP1L mRNA28903495
C045463leflunomideleflunomide results in increased expression of FNBP1L mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FNBP1L mRNA23649840
D009151Mustard GasMustard Gas results in increased expression of FNBP1L mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FNBP1L mRNA"25554681
D009532NickelNickel results in decreased expression of FNBP1L mRNA25583101
D000073878Palm OilPalm Oil results in increased expression of FNBP1L mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FNBP1L mRNA"25510870
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FNBP1L mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FNBP1L mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FNBP1L mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of FNBP1L mRNA24780913
D011794QuercetinQuercetin results in increased expression of FNBP1L mRNA21632981
C017947sodium arsenitesodium arsenite results in decreased expression of FNBP1L mRNA28595984
D018038Sodium SeleniteSodium Selenite results in decreased expression of FNBP1L mRNA18175754
D013629TamoxifenTamoxifen affects the expression of FNBP1L mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FNBP1L mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FNBP1L mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FNBP1L mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FNBP1L mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of FNBP1L mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of FNBP1L mRNA23557971
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FNBP1L mRNA"26179874
D014520UrethaneUrethane results in increased expression of FNBP1L mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of FNBP1L mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of FNBP1L mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FNBP1L gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16630611  19798448  20730103  
GO:0008289lipid binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO:0051020GTPase binding-IPI19798448  
GO ID GO Term Qualifier Evidence PubMed
GO:0006900vesicle budding from membrane-IDA20730103  
GO:0006914autophagy-IEA-  
GO:0010324membrane invagination-IDA20730103  
GO:0016050vesicle organization-IDA20730103  
GO:0030050vesicle transport along actin filament-IDA20730103  
GO:0051491positive regulation of filopodium assembly-IDA20730103  
GO:0060271cilium assembly-IMP22684256  
GO:0061024membrane organization-TAS-  
GO:0072583clathrin-dependent endocytosis-IDA20730103  
GO:0097320plasma membrane tubulation-IDA20730103  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA22684256  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0005938cell cortex-IEA-  
GO:0031410cytoplasmic vesicle-IDA20730103  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal