Gene: CNTLN

54875
C9orf101|C9orf39|bA340N12.1
centlein
protein-coding
9p22.2
Ensembl:ENSG00000044459 MIM:611870 Vega:OTTHUMG00000019599 UniprotKB:Q9NXG0
NC_000009.12
SNP Mapped
AD
0   
4.513e-1 (AD)  6.603e-2 (ND)   (Frontal_Cortex)
9.432e-1 (AD)  6.553e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2441997chr9:17474087 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD2AP0.832
BNIP20.807
KDELC20.807
NEDD40.797
IRAK40.796
FAM111A0.795
TMOD30.792
ATP11C0.792
NEDD10.787
CD580.786

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSG1-0.5
ADRA1D-0.487
ABCC12-0.455
KCNIP3-0.451
CRH-0.446
CORT-0.444
RTN4R-0.439
KCNG2-0.437
CPLX3-0.429
HAS1-0.428

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CNTLN mRNA"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CNTLN mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CNTLN mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CNTLN mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CNTLN mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CNTLN mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CNTLN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTLN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTLN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CNTLN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTLN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTLN mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CNTLN mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CNTLN mRNA17562736
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CNTLN mRNA22316170
C006780bisphenol Abisphenol A affects the expression of CNTLN mRNA22574217
C006780bisphenol Abisphenol A affects the expression of CNTLN mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CNTLN mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CNTLN mRNA24982889
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CNTLN gene20938992
D003703DemecolcineDemecolcine results in decreased expression of CNTLN mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CNTLN mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CNTLN mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CNTLN mRNA27392435
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CNTLN mRNA22079256
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CNTLN gene20938992
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CNTLN mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CNTLN mRNA27392435
C045463leflunomideleflunomide results in increased expression of CNTLN mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CNTLN gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CNTLN mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CNTLN mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CNTLN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CNTLN mRNA"25554681
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CNTLN mRNA"25510870
C046012pentanalpentanal results in decreased expression of CNTLN mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CNTLN mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CNTLN mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of CNTLN mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of CNTLN mRNA21334430
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CNTLN mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CNTLN mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of CNTLN mRNA19690047
D012293RifampinRifampin results in increased expression of CNTLN mRNA24552687
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CNTLN mRNA22574217
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTLN mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CNTLN mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTLN mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CNTLN mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CNTLN mRNA27188386|2800136
D014635Valproic AcidValproic Acid results in increased expression of CNTLN mRNA26272509
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CNTLN gene25560391
D014750VincristineVincristine results in decreased expression of CNTLN mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0019901protein kinase binding-IPI24554434  
GO:0019904protein domain specific binding-IPI24554434  
GO:0030674protein binding, bridging-IMP24554434  
GO ID GO Term Qualifier Evidence PubMed
GO:0010457centriole-centriole cohesion-IMP24554434  
GO:0033365protein localization to organelle-IMP24554434  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA24554434  
GO:0005813centrosome-IDA-  
GO:0005814centriole-IDA24554434  
GO:0005829cytosol-IDA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal