Gene: BCOR

54880
ANOP2|MAA2|MCOPS2
BCL6 corepressor
protein-coding
Xp11.4
Ensembl:ENSG00000183337 MIM:300485 Vega:OTTHUMG00000024100 UniprotKB:Q6W2J9
NG_008880.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07764473chrX:40037510BCOR1.300e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RYBP0.794
DCP1A0.794
DHX150.793
OTUD40.79
KDM4C0.783
INTS60.782
KDM2A0.782
PDS5A0.778
PPP1R15B0.777
CDK120.776

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.452
OR4F29-0.426
HES5-0.248
S100A1-0.242
ALDH1L1-AS2-0.24
NXNL1-0.229
C16orf74-0.222
TPPP2-0.211
GLI1-0.206
BTBD17-0.202

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCOR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCOR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCOR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCOR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCOR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCOR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCOR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCOR mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of BCOR mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of BCOR gene27153756
D001280AtrazineAtrazine results in decreased expression of BCOR mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BCOR mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BCOR mRNA"19150397
C006780bisphenol Abisphenol A affects the methylation of BCOR promoter27334623
C006780bisphenol Abisphenol A results in increased expression of BCOR mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of BCOR mRNA26079696
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCOR mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of BCOR mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCOR gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of BCOR mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of BCOR mRNA19789285
D003474CurcuminCurcumin results in increased expression of BCOR mRNA17198877
D016572CyclosporineCyclosporine results in decreased expression of BCOR mRNA25562108
C014347decitabinedecitabine results in increased expression of BCOR mRNA27915011
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of BCOR mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of BCOR mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of BCOR mRNA28302478
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of BCOR gene23968726
C118739entinostatentinostat results in increased expression of BCOR mRNA27188386
C024565ethylene dichlorideethylene dichloride results in increased expression of BCOR mRNA28189721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCOR gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of BCOR mRNA20655997
C001277geldanamycingeldanamycin results in increased expression of BCOR mRNA26705709
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of BCOR mRNA27392435
C544151jinfukangjinfukang results in decreased expression of BCOR mRNA27392435
C045463leflunomideleflunomide results in increased expression of BCOR mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of BCOR mRNA21212295
D008070LipopolysaccharidesLipopolysaccharides results in increased methylation of BCOR gene21212295
D008628MercuryMercury results in increased expression of BCOR mRNA16823088
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCOR gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of BCOR mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of BCOR mRNA24810058
D010100OxygenOxygen deficiency results in increased expression of BCOR mRNA24205000
D010634PhenobarbitalPhenobarbital affects the expression of BCOR mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCOR mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of BCOR mRNA26272509
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of BCOR gene23968726
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of BCOR mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of BCOR mRNA28903501
D011794QuercetinQuercetin results in decreased expression of BCOR mRNA21632981
C059514resveratrolresveratrol results in decreased expression of BCOR mRNA25905778
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of BCOR mRNA21427059
D012834SilverSilver affects the expression of BCOR mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BCOR mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCOR mRNA21570461
D013849ThimerosalThimerosal results in decreased expression of BCOR mRNA27188386
D014212TretinoinTretinoin results in increased expression of BCOR mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCOR mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of BCOR mRNA26272509
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCOR mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of BCOR mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in increased methylation of BCOR gene29154799
D014635Valproic AcidValproic Acid affects the expression of BCOR mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of BCOR mRNA21427059
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of BCOR mRNA16330358
C025643vinclozolinvinclozolin affects the expression of BCOR mRNA19015723
D014750VincristineVincristine results in increased expression of BCOR mRNA23649840
C111237vorinostatvorinostat results in decreased expression of BCOR mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO:0003714transcription corepressor activity-IDA10898795  
GO:0003714transcription corepressor activity-IMP15878880  
GO:0004842ubiquitin-protein transferase activitycontributes_toIDA16943429  
GO:0005515protein binding-IPI10898795  16713569  16943429  26496610  26687479  27505670  
27705803  
GO:0008134transcription factor binding-IPI10898795  
GO:0031072heat shock protein binding-IDA16943429  
GO:0042826histone deacetylase binding-IPI10898795  
GO:0044212transcription regulatory region DNA binding-IMP19578371  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP19578371  
GO:0000415negative regulation of histone H3-K36 methylation-IMP19578371  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007507heart development-IMP17517692  
GO:0030502negative regulation of bone mineralization-IMP19578371  
GO:0035518histone H2A monoubiquitination-IDA16943429  
GO:0042476odontogenesis-IMP17517692  
GO:0045892negative regulation of transcription, DNA-templated-IDA10898795  
GO:0045892negative regulation of transcription, DNA-templated-IMP15878880  
GO:0051572negative regulation of histone H3-K4 methylation-IMP19578371  
GO:0060021roof of mouth development-IMP17517692  
GO:0065001specification of axis polarity-IMP17517692  
GO:0070171negative regulation of tooth mineralization-IMP19578371  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10898795  25331958  
GO:0031519PcG protein complexcolocalizes_withIDA16943429  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26913089X chromosome-wide analysis identifies DNA methylation sites influenced by cigarette smoking. (2016)Klebaner DClin Epigenetics