Gene: ANKHD1

54882
MASK|MASK1|PP2500|VBARP
ankyrin repeat and KH domain containing 1
protein-coding
5q31.3
Ensembl:ENSG00000131503 MIM:610500 Vega:OTTHUMG00000161610 UniprotKB:Q8IWZ3
NC_000005.10
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TAF10.924
PRRC2C0.916
SON0.91
ARNT0.901
UBR50.9
SPG110.897
BAZ2A0.895
ANKFY10.894
CTNND10.892
CNOT10.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.591
OR4F29-0.573
KLRC2-0.207
LCN1-0.197
APOA1-0.19
NANOGNB-0.185
HES5-0.18
MUC12-0.17
AVP-0.164
OXT-0.16

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKHD1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of ANKHD1 mRNA"19561079
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to ANKHD1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ANKHD1 protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKHD1 mRNA"27188386
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ANKHD1 protein]26598702
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANKHD1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ANKHD1 mRNA"26238291
D004958EstradiolEstradiol results in decreased expression of ANKHD1 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of ANKHD1 mRNA27571134
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ANKHD1 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ANKHD1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of ANKHD1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of ANKHD1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ANKHD1 mRNA20106945
D003703DemecolcineDemecolcine results in increased expression of ANKHD1 mRNA23649840
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ANKHD1 protein23301498
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ANKHD1 gene20938992
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ANKHD1 mRNA17183730
C544151jinfukangjinfukang results in decreased expression of ANKHD1 mRNA27392435
D007854LeadLead results in decreased expression of ANKHD1 mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ANKHD1 mRNA"24972896
D008628MercuryMercury results in increased expression of ANKHD1 mRNA16823088
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ANKHD1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ANKHD1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ANKHD1 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ANKHD1 mRNA"25554681
D010634PhenobarbitalPhenobarbital affects the expression of ANKHD1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKHD1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ANKHD1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of ANKHD1 mRNA20813756
D011374ProgesteroneProgesterone results in increased expression of ANKHD1 mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of ANKHD1 mRNA21278054
D011794QuercetinQuercetin results in decreased expression of ANKHD1 mRNA21632981
D015474IsotretinoinIsotretinoin results in decreased expression of ANKHD1 mRNA20436886
C009277sodium arsenatesodium arsenate results in increased expression of ANKHD1 mRNA21795629
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of ANKHD1 mRNA"26680231
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of ANKHD1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ANKHD1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ANKHD1 mRNA21354282
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ANKHD1 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ANKHD1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ANKHD1 mRNA28973697
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ANKHD1 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of ANKHD1 mRNA19101580
D014750VincristineVincristine results in increased expression of ANKHD1 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI14743216  21988832  
GO ID GO Term Qualifier Evidence PubMed
GO:0045087innate immune response-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27903268Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA). (2016 Dec 1)Chi GCEnviron Health