Gene: RNF43

54894
RNF124|SSPCS|URCC
ring finger protein 43
protein-coding
17q22
Ensembl:ENSG00000108375 MIM:612482 Vega:OTTHUMG00000179077 UniprotKB:Q68DV7
NG_042894.1
SNP Mapped
2   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.008e-1 (AD)  3.392e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs114469297chr17:58411019 (GRCh38.p7)A>C / A>Gcocaine dependenceSNV(Single Nucleotide Variation)
rs113212925chr17:58373093 (GRCh38.p7)C>G / C>Tcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLCO1C10.821
PRDM160.82
OTX10.802
ZNRF30.793
SLC15A20.785
FAM167A0.785
GLI30.78
ATP13A40.78
PAX60.78
GPC50.779

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENPP6-0.45
TMEFF2-0.441
L3MBTL4-0.423
CHN2-0.417
SYNJ2-0.413
LIPH-0.405
C9orf3-0.403
KCNK2-0.399
SLC7A14-0.395
SEMA3E-0.394

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RNF43 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RNF43 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RNF43 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RNF43 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RNF43 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RNF43 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of RNF43 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RNF43 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RNF43 mRNA22100608
D004958EstradiolEstradiol results in decreased expression of RNF43 mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of RNF43 mRNA25181051
D002737ChloropreneChloroprene results in decreased expression of RNF43 mRNA23125180
C031180chrysenechrysene results in increased expression of RNF43 mRNA26377693
D019327Copper SulfateCopper Sulfate results in decreased expression of RNF43 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of RNF43 mRNA20106945|2556210
D002117CalcitriolCalcitriol results in decreased expression of RNF43 mRNA16002434
C118739entinostatentinostat results in increased expression of RNF43 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
D000431EthanolEthanol results in increased expression of RNF43 mRNA19167417
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of RNF43 mRNA20846436
C069837fullerene C60fullerene C60 results in decreased expression of RNF43 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of RNF43 mRNA22061828
D017313FenretinideFenretinide results in increased expression of RNF43 mRNA28973697
C045463leflunomideleflunomide results in increased expression of RNF43 mRNA28988120
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RNF43 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RNF43 mRNA"25554681|2562005
C028007nickel monoxidenickel monoxide results in decreased expression of RNF43 mRNA19167457
C030110oxaliplatinoxaliplatin results in increased expression of RNF43 mRNA16510598
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of RNF43 mRNA26272509
C016030pantogabpantogab results in decreased expression of RNF43 mRNA17379144
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RNF43 mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of RNF43 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
C006253pirinixic acidpirinixic acid results in decreased expression of RNF43 mRNA20813756
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of RNF43 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of RNF43 mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of RNF43 mRNA22238285
C045950propiconazolepropiconazole results in decreased expression of RNF43 mRNA21278054
D011794QuercetinQuercetin results in decreased expression of RNF43 mRNA21632981
D012834SilverSilver results in decreased expression of RNF43 mRNA26014281
D053260SootSoot results in decreased expression of RNF43 mRNA26551751
D013629TamoxifenTamoxifen affects the expression of RNF43 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RNF43 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RNF43 promoter]19654925
D013849ThimerosalThimerosal results in decreased expression of RNF43 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of RNF43 mRNA23411599
D014212TretinoinTretinoin results in increased expression of RNF43 mRNA23830798
D014241TrichloroethyleneTrichloroethylene results in decreased expression of RNF43 mRNA28973375
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of RNF43 mRNA24935251|2627250
D014520UrethaneUrethane results in decreased expression of RNF43 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNF43 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RNF43 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RNF43 mRNA23179753|2352703
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RNF43 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of RNF43 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-IDA22575959  22895187  
GO:0005109frizzled binding-IBA21873635  
GO:0005109frizzled binding-IPI22895187  
GO:0005515protein binding-IPI18313049  19690564  
GO:0046872metal ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO:0061630ubiquitin protein ligase activity-TAS24431302  
GO ID GO Term Qualifier Evidence PubMed
GO:0006511ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0006511ubiquitin-dependent protein catabolic process-IDA22895187  
GO:0016055Wnt signaling pathway-IEA-  
GO:0016567protein ubiquitination-IDA22575959  
GO:0016567protein ubiquitination-IEA-  
GO:0030178negative regulation of Wnt signaling pathway-IBA21873635  
GO:0030178negative regulation of Wnt signaling pathway-IMP22575959  22895187  
GO:0038018Wnt receptor catabolic process-IBA21873635  
GO:0038018Wnt receptor catabolic process-IDA22895187  
GO:0038018Wnt receptor catabolic process-TAS24431302  
GO:0072089stem cell proliferation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IEA-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA22575959  22895187  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-4641263Regulation of FZD by ubiquitinationTAS
R-HSA-4791275Signaling by WNT in cancerTAS
R-HSA-5340588RNF mutants show enhanced WNT signaling and proliferationTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal