Gene: CASZ1

54897
CAS11|CST|SRG|ZNF693|dJ734G22.1
castor zinc finger 1
protein-coding
1p36.22
Ensembl:ENSG00000130940 MIM:609895 Vega:OTTHUMG00000002035 UniprotKB:Q86V15
NC_000001.11
SNP Mapped
12   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.066e-1 (AD)  7.442e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs61776326chr1:10682063 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11121604chr1:10669945 (GRCh38.p7)A>C / A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs284320chr1:10666963 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs284322chr1:10665441 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs476164chr1:10659509 (GRCh38.p7)T>A / T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2242287chr1:10654854 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs284295chr1:10652040 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs284296chr1:10652032 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs284298chr1:10650198 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs284300chr1:10649252 (GRCh38.p7)C>A / C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs778228chr1:10648085 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs284243chr1:10645823 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02396224chr1:10698794CASZ13'UTR5.678e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FNDC3B0.722
SPPL2A0.716
ELMSAN10.703
TXNRD10.701
XBP10.697
BOC0.693
SHC10.691
HELB0.69
IL18BP0.686
SENP10.685

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNX22-0.397
GPR17-0.335
BCHE-0.319
NEU4-0.31
ACY3-0.277
KIF26B-0.271
COL20A1-0.266
HES5-0.258
PCDH15-0.257
PLD5-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CASZ1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CASZ1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CASZ1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CASZ1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CASZ1 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASZ1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASZ1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CASZ1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CASZ1 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents affects the expression of CASZ1 mRNA24449571
D001151ArsenicArsenic affects the methylation of CASZ1 gene25304211
D001280AtrazineAtrazine results in increased expression of CASZ1 mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of CASZ1 mRNA26377693
C006780bisphenol Abisphenol A affects the expression of CASZ1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CASZ1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CASZ1 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CASZ1 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CASZ1 gene20938992
C031180chrysenechrysene results in increased expression of CASZ1 mRNA26377693
D003471CuprizoneCuprizone results in decreased expression of CASZ1 mRNA27523638
C014347decitabinedecitabine results in increased expression of CASZ1 mRNA17940511
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CASZ1 mRNA]27941970
C000944dicrotophosdicrotophos results in increased expression of CASZ1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of CASZ1 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CASZ1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of CASZ1 mRNA]19850644
D002117CalcitriolCalcitriol results in increased expression of CASZ1 mRNA26485663
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CASZ1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CASZ1 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CASZ1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of CASZ1 mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of CASZ1 mRNA22634610
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASZ1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of CASZ1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CASZ1 mRNA25307878
D007854LeadLead affects the expression of CASZ1 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CASZ1 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CASZ1 gene20938992
D008727MethotrexateMethotrexate results in increased expression of CASZ1 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CASZ1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CASZ1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CASZ1 mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CASZ1 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CASZ1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CASZ1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of CASZ1 mRNA19167457
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CASZ1 mRNA"25510870
C006253pirinixic acidpirinixic acid results in increased expression of CASZ1 mRNA23811191
D053260SootSoot results in decreased expression of CASZ1 mRNA26551751
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASZ1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CASZ1 mRNA23557971
C024746tobacco tartobacco tar results in decreased expression of CASZ1 mRNA19559774
D014212TretinoinTretinoin results in decreased expression of CASZ1 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of CASZ1 mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of CASZ1 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of CASZ1 mRNA17940511|2493525
D014635Valproic AcidValproic Acid results in decreased expression of CASZ1 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASZ1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CASZ1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of CASZ1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0045664regulation of neuron differentiation-IBA21873635  
GO:0045893positive regulation of transcription, DNA-templated-IDA27693370  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal