Gene: ELOVL2

54898
SSC2
ELOVL fatty acid elongase 2
protein-coding
6p24.2
Ensembl:ENSG00000197977 MIM:611814 Vega:OTTHUMG00000014252 UniprotKB:Q9NXB9
NC_000006.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.032e-1 (AD)  4.522e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21572722chr6:11044894ELOVL28.000e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC4A40.948
SLC1A30.939
PREX20.921
SPON10.921
HEPH0.918
BMPR1B0.915
GPC50.913
ARHGEF260.912
SOX90.91
TP53BP20.909

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F-0.449
NRG1-0.415
TRABD2A-0.41
CYP27C1-0.389
CCDC68-0.388
AGMAT-0.387
MCHR1-0.385
QRFPR-0.385
OSBPL10-0.377
DUSP27-0.376

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ELOVL2 mRNA"28903501
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of ELOVL2 mRNA"22101062
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of ELOVL2 mRNA"19095052
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ELOVL2 mRNA"19167446
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ELOVL2 mRNA16788091
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of ELOVL2 mRNA"21218783
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ELOVL2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL2 mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of ELOVL2 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ELOVL2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of ELOVL2 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ELOVL2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ELOVL2 mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of ELOVL2 mRNA28959563
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of ELOVL2 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ELOVL2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ELOVL2 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ELOVL2 mRNA28522335
C006632arsenic trioxidearsenic trioxide results in decreased expression of ELOVL2 mRNA26705709
C015001arsenitearsenite results in increased methylation of ELOVL2 promoter23974009
D001280AtrazineAtrazine results in decreased expression of ELOVL2 mRNA22378314
C487081belinostatbelinostat results in decreased expression of ELOVL2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL2 mRNA"27188386
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ELOVL2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of ELOVL2 mRNA19167446|1961957
C006780bisphenol Abisphenol A results in decreased expression of ELOVL2 mRNA17912697
C006780bisphenol Abisphenol A affects the expression of ELOVL2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ELOVL2 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of ELOVL2 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of ELOVL2 mRNA24752500
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ELOVL2 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of ELOVL2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ELOVL2 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of ELOVL2 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ELOVL2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of ELOVL2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of ELOVL2 mRNA19167446
D003520CyclophosphamideELOVL2 protein affects the susceptibility to Cyclophosphamide16217747
D016572CyclosporineCyclosporine results in decreased expression of ELOVL2 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of ELOVL2 mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ELOVL2 mRNA23640034
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of ELOVL2 mRNA]21095227
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ELOVL2 mRNA]27941970
C016366dibenzothiophenedibenzothiophene results in decreased expression of ELOVL2 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ELOVL2 mRNA21266533
D004008DiclofenacDiclofenac affects the expression of ELOVL2 mRNA24752500
D004041Dietary FatsDietary Fats affects the expression of ELOVL2 mRNA19680557
C118739entinostatentinostat results in increased expression of ELOVL2 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ELOVL2 mRNA22079256
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of ELOVL2 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of ELOVL2 mRNA21233418
D000431EthanolEthanol results in increased expression of ELOVL2 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ELOVL2 mRNA17912697
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in decreased expression of ELOVL2 mRNA"23333450
D005231Fatty Acids, Unsaturated"ELOVL2 protein results in increased metabolism of and affects the abundance of Fatty Acids, Unsaturated"21106902
D005231Fatty Acids, Unsaturated"ELOVL2 protein results in increased metabolism of Fatty Acids, Unsaturated"16790840
C082360fipronilfipronil results in increased expression of ELOVL2 mRNA23962444
C039281furanfuran results in increased expression of ELOVL2 mRNA26194646
C492448ICG 001ICG 001 results in decreased expression of ELOVL2 mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of ELOVL2 mRNA28201806
C544151jinfukangjinfukang results in decreased expression of ELOVL2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ELOVL2 mRNA24796395
C410337K 7174K 7174 results in decreased expression of ELOVL2 mRNA24086573
D007854LeadLead affects the expression of ELOVL2 mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ELOVL2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ELOVL2 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ELOVL2 mRNA"25620056
C051752nefazodonenefazodone results in increased expression of ELOVL2 mRNA24136188
C022838nickel chloridenickel chloride results in decreased expression of ELOVL2 mRNA24612858
C029938nickel sulfatenickel sulfate results in increased expression of ELOVL2 mRNA22714537
C464660obeticholic acidobeticholic acid results in increased expression of ELOVL2 mRNA27939613
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in decreased expression of ELOVL2 mRNA"23333450
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL2 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of ELOVL2 mRNA26272509
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of ELOVL2 mRNA17097637
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL2 mRNA"27188386
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ELOVL2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ELOVL2 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of ELOVL2 mRNA15375163
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ELOVL2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ELOVL2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ELOVL2 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ELOVL2 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of ELOVL2 mRNA23018184
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of ELOVL2 mRNA19167446
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of ELOVL2 mRNA21427059
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of ELOVL2 mRNA]21095227
C017947sodium arsenitesodium arsenite results in increased expression of ELOVL2 mRNA22714537
C016104sodium bichromatesodium bichromate results in decreased expression of ELOVL2 mRNA24612858
C013698tallowtallow affects the expression of ELOVL2 mRNA19680557
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ELOVL2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ELOVL2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ELOVL2 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ELOVL2 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ELOVL2 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ELOVL2 mRNA19770486|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ELOVL2 mRNA21215274
D013752TetracyclineTetracycline results in decreased expression of ELOVL2 mRNA24489787
D019284ThapsigarginThapsigargin results in decreased expression of ELOVL2 mRNA22378314
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ELOVL2 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of ELOVL2 mRNA24935251|2718838
D014520UrethaneUrethane results in decreased expression of ELOVL2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ELOVL2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ELOVL2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of ELOVL2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ELOVL2 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of ELOVL2 mRNA21427059
D014638VanadatesVanadates results in decreased expression of ELOVL2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ELOVL2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of ELOVL2 mRNA26682919
C111237vorinostatvorinostat results in increased expression of ELOVL2 mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of ELOVL2 mRNA"23246600
D015034Zinc OxideZinc Oxide affects the expression of ELOVL2 mRNA28648595

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20937905  
GO:0009922fatty acid elongase activity-EXP10970790  12371743  14636670  
GO:0009922fatty acid elongase activity-IBA21873635  
GO:0009922fatty acid elongase activity-IDA12371743  
GO:0009922fatty acid elongase activity-TAS-  
GO:01023363-oxo-arachidoyl-CoA synthase activity-IEA-  
GO:01023373-oxo-cerotoyl-CoA synthase activity-IEA-  
GO:01023383-oxo-lignoceronyl-CoA synthase activity-IEA-  
GO:0102756very-long-chain 3-ketoacyl-CoA synthase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006636unsaturated fatty acid biosynthetic process-IEA-  
GO:0019367fatty acid elongation, saturated fatty acid-IBA21873635  
GO:0030148sphingolipid biosynthetic process-IBA21873635  
GO:0034625fatty acid elongation, monounsaturated fatty acid-IBA21873635  
GO:0034626fatty acid elongation, polyunsaturated fatty acid-IBA21873635  
GO:0034626fatty acid elongation, polyunsaturated fatty acid-IDA12371743  20937905  
GO:0035338long-chain fatty-acyl-CoA biosynthetic process-TAS-  
GO:0036109alpha-linolenic acid metabolic process-TAS-  
GO:0042761very long-chain fatty acid biosynthetic process-IBA21873635  
GO:0042761very long-chain fatty acid biosynthetic process-IDA12371743  20937905  
GO:0043651linoleic acid metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA20937905  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0030176integral component of endoplasmic reticulum membrane-IBA21873635  
KEGG ID KEGG Term
hsa01040Biosynthesis of unsaturated fatty acids
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2046104alpha-linolenic (omega3) and linoleic (omega6) acid metabolismTAS
R-HSA-2046105Linoleic acid (LA) metabolismTAS
R-HSA-2046106alpha-linolenic acid (ALA) metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75105Fatty acyl-CoA biosynthesisTAS
R-HSA-75876Synthesis of very long-chain fatty acyl-CoAsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28874809Forensic age prediction for saliva samples using methylation-sensitive high resolution melting: exploratory application for cigarette butts. (2017 Sep 5)Hamano YSci Rep
26333835Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration. (2015 Dec)Scheinfeldt LBAm J Med Genet B Neuropsychiatr Genet