Gene: CYP2W1

54905
-
cytochrome P450 family 2 subfamily W member 1
protein-coding
7p22.3
Ensembl:ENSG00000073067 MIM:615967 Vega:OTTHUMG00000074071 UniprotKB:Q8TAV3
NG_007934.1
PubMed
1   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.285e-1 (AD)  2.655e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3817576chr7:983555 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARIH2OS0.389
S100A20.379
ID10.373
TMEM150A0.367
IGSF10.357
ACAP10.356
LOXL10.354
SERINC20.349
IL17RC0.346
SAMD110.346

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF385D-0.286
KIT-0.285
HAPLN1-0.271
IGF1-0.266
VIP-0.262
PLD5-0.262
GRIN2A-0.25
LYPD6B-0.248
PTHLH-0.245
STEAP1-0.245

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5078162-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole"CYP2W1 protein results in increased oxidation of 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole"22734839
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazoleCYP2W1 protein results in increased oxidation of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole22734839
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazole[CYP2W1 protein results in increased oxidation of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole] which results in increased chemical synthesis of Hydroxylamine22734839
D000082AcetaminophenAcetaminophen results in decreased expression of CYP2W1 mRNA22230336
C094428AQ4N[CYP2W1 protein co-treated with Oxygen deficiency] results in increased reduction of AQ4N23682735
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of CYP2W1 mRNA16985168
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CYP2W1 mRNA22316170|2623829
C006780bisphenol Abisphenol A results in decreased expression of CYP2W1 mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of CYP2W1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CYP2W1 mRNA25562108
D004397FonofosFonofos results in increased methylation of CYP2W1 promoter22847954
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CYP2W1 mRNA20044591
D019811Hydroxylamine[CYP2W1 protein results in increased oxidation of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole] which results in increased chemical synthesis of Hydroxylamine22734839
D010100Oxygen[CYP2W1 protein co-treated with Oxygen deficiency] results in increased reduction of AQ4N23682735
D010278ParathionParathion results in increased methylation of CYP2W1 promoter22847954
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CYP2W1 protein26879310
C012568terbufosterbufos results in increased methylation of CYP2W1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP2W1 mRNA16985168
D014212TretinoinTretinoin results in decreased expression of CYP2W1 mRNA16985168
D014520UrethaneUrethane results in decreased expression of CYP2W1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of CYP2W1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0008395steroid hydroxylase activity-IBA21873635  
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen-IBA21873635  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006082organic acid metabolic process-IBA21873635  
GO:0006805xenobiotic metabolic process-IBA21873635  
GO:0006805xenobiotic metabolic process-IDA16551781  
GO:0042738exogenous drug catabolic process-IBA21873635  
GO:0043390aflatoxin B1 metabolic process-IDA16551781  
GO:0055114oxidation-reduction process-IBA21873635  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005788endoplasmic reticulum lumen-IDA20805301  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0009986cell surface-IDA20805301  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211958Miscellaneous substratesTAS
R-HSA-211981XenobioticsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25872594Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking. (2015 May)Toselli FAlcohol Clin Exp Res
22631658CYP2W1, CYP4F11 and CYP8A1 polymorphisms and interaction of CYP2W1 genotypes with risk factors in Mexican women with breast cancer. (2012)Cardenas-Rodriguez NAsian Pac J Cancer Prev
26095139Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR. (2015)Toselli FXenobiotica