Gene: FOCAD

54914
KIAA1797
focadhesin
protein-coding
9p21.3
Ensembl:ENSG00000188352 MIM:614606 Vega:OTTHUMG00000066930 UniprotKB:Q5VW36
NC_000009.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
4.821e-1 (AD)  1.498e-1 (ND)   (Frontal_Cortex)
3.059e-1 (AD)  2.102e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6475490chr9:20945208 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
INPP4A0.958
ARHGAP260.956
TBC1D300.954
ATP8A20.954
MYCBP20.953
LMTK20.951
PPIP5K10.949
CACNA1B0.949
HECW10.949
NBEA0.949

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.564
COPZ2-0.557
MYL3-0.552
RAB13-0.546
YES1-0.543
ROM1-0.524
REST-0.507
RAI14-0.507
RNF135-0.498
CSAG1-0.489

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FOCAD mRNA"19114083
D020106AcrylamideAcrylamide results in decreased expression of FOCAD mRNA28959563
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FOCAD mRNA20064835|2163298
C006780bisphenol Abisphenol A affects the expression of FOCAD mRNA25181051
D016572CyclosporineCyclosporine results in increased expression of FOCAD mRNA20106945|2556210
D002945CisplatinCisplatin results in decreased expression of FOCAD mRNA19561079
D002117CalcitriolCalcitriol results in increased expression of FOCAD mRNA16002434
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FOCAD mRNA22079256
D005485FlutamideFlutamide results in increased expression of FOCAD mRNA24136188
D017313FenretinideFenretinide results in decreased expression of FOCAD mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FOCAD mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FOCAD mRNA28001369
D019319Okadaic AcidOkadaic Acid results in decreased expression of FOCAD mRNA25270620
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FOCAD mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FOCAD mRNA22079256
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FOCAD mRNA21632981
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FOCAD mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FOCAD mRNA28065790
D014635Valproic AcidValproic Acid affects the expression of FOCAD mRNA25979313
C025643vinclozolinvinclozolin affects the expression of FOCAD mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of FOCAD mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI22427331  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005925focal adhesion-IDA22427331  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25637605Genetic variation associates with susceptibility for cigarette smoke-induced neutrophilia in mice. (2015 Apr 1)Pouwels SDAm J Physiol Lung Cell Mol Physiol