Gene: RHBDL2

54933
RRP2
rhomboid like 2
protein-coding
1p34.3
Ensembl:ENSG00000158315 MIM:608962 Vega:OTTHUMG00000000487 UniprotKB:Q9NX52
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.388e-1 (AD)  9.637e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2094081chr1:38927359 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ST180.881
ASPA0.876
S1PR50.866
DNAH170.863
FAM107B0.858
BTBD160.857
ERMN0.856
ANLN0.854
SLC44A10.853
NKX6-20.849

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.515
PCDH8-0.495
DOC2B-0.465
CNTN5-0.464
HCN4-0.46
GALNTL6-0.454
SDK1-0.453
CNGB1-0.453
GPR153-0.452
TP53I11-0.452

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in decreased expression of RHBDL2 mRNA"26238291
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of RHBDL2 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RHBDL2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RHBDL2 gene27153756
D001507BeclomethasoneBeclomethasone results in decreased expression of RHBDL2 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RHBDL2 mRNA22316170|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RHBDL2 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of RHBDL2 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of RHBDL2 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of RHBDL2 mRNA26191083
D019327Copper SulfateCopper Sulfate results in decreased expression of RHBDL2 mRNA19789285
D019327Copper SulfateCopper Sulfate results in decreased expression of RHBDL2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of RHBDL2 mRNA20106945|2163298
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RHBDL2 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RHBDL2 mRNA21266533
D004026DieldrinDieldrin results in decreased expression of RHBDL2 mRNA20584760|2304172
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RHBDL2 mRNA22129741
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RHBDL2 mRNA22079256
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of RHBDL2 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of RHBDL2 mRNA21233418
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RHBDL2 mRNA17557909
D005472FluorouracilRHBDL2 protein affects the susceptibility to Fluorouracil16217747
C039281furanfuran results in increased expression of RHBDL2 mRNA27387713
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of RHBDL2 mRNA21179406
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RHBDL2 mRNA22129741
C028007nickel monoxidenickel monoxide results in increased expression of RHBDL2 mRNA19167457
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RHBDL2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RHBDL2 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of RHBDL2 mRNA19690047
C005556propionaldehydepropionaldehyde results in increased expression of RHBDL2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of RHBDL2 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of RHBDL2 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RHBDL2 mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of RHBDL2 mRNA21795629
D053260SootSoot results in increased expression of RHBDL2 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RHBDL2 mRNA21632981|2315218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RHBDL2 mRNA21570461
D013779TetrodotoxinTetrodotoxin results in increased expression of RHBDL2 mRNA26436198
C009495titanium dioxidetitanium dioxide analog results in increased expression of RHBDL2 mRNA25111187
D014212TretinoinTretinoin results in increased expression of RHBDL2 mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RHBDL2 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of RHBDL2 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IDA19850051  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA19850051  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal