Gene: SDHAF2

54949
C11orf79|PGL2|SDH5
succinate dehydrogenase complex assembly factor 2
protein-coding
11q12.2
Ensembl:ENSG00000167985 MIM:613019 Vega:OTTHUMG00000168279 UniprotKB:Q9NX18
NG_023393.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.414e-1 (AD)  5.622e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POP40.906
PSMB70.904
COMMD10.9
COPZ10.896
NDUFV20.894
HAX10.893
VPS250.889
PSMB30.889
MRPL160.888
MRPS150.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.712
OR4F29-0.671
MTRNR2L9-0.271
MTRNR2L6-0.269
KLRB1-0.263
IFNG-0.251
MAGEA12-0.242
TTLL10-0.239
EBF1-0.236
FZD10-0.234

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of SDHAF2 mRNA"24680724
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SDHAF2 gene27153756
D001280AtrazineAtrazine results in decreased expression of SDHAF2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SDHAF2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SDHAF2 mRNA22300585
C006780bisphenol Abisphenol A affects the expression of SDHAF2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SDHAF2 mRNA25181051
D002104CadmiumCadmium results in increased expression of SDHAF2 mRNA26187450
C089595cylindrospermopsincylindrospermopsin results in increased expression of SDHAF2 mRNA24921660
C000944dicrotophosdicrotophos results in decreased expression of SDHAF2 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SDHAF2 mRNA22079256
D018120FinasterideFinasteride results in increased expression of SDHAF2 mRNA24136188
C045463leflunomideleflunomide results in decreased expression of SDHAF2 mRNA28988120
C006253pirinixic acidpirinixic acid results in increased expression of SDHAF2 mRNA23811191
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SDHAF2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SDHAF2 mRNA22079256
D018038Sodium SeleniteSodium Selenite results in increased expression of SDHAF2 mRNA18175754
D014635Valproic AcidValproic Acid affects the expression of SDHAF2 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of SDHAF2 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SDHAF2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19628817  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0006099tricarboxylic acid cycle-IBA21873635  
GO:0006121mitochondrial electron transport, succinate to ubiquinone-IBA21873635  
GO:0006121mitochondrial electron transport, succinate to ubiquinone-IMP19628817  
GO:0006470protein dephosphorylation-IGI23983127  
GO:0010719negative regulation of epithelial to mesenchymal transition-IMP23983127  
GO:0018293protein-FAD linkage-IBA21873635  
GO:0018293protein-FAD linkage-IMP19628817  
GO:0034553mitochondrial respiratory chain complex II assembly-IBA21873635  
GO:0090090negative regulation of canonical Wnt signaling pathway-IGI23983127  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA19628817  
GO:0005759mitochondrial matrix-IEA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301715Hereditary Paraganglioma-Pheochromocytoma Syndromes (1993)Kirmani S-